![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 6994 |
FusionGeneSummary for CHD6_CHD6 |
![]() |
Fusion gene information | Fusion gene name: CHD6_CHD6 | Fusion gene ID: 6994 | Hgene | Tgene | Gene symbol | CHD6 | CHD6 | Gene ID | 84181 | 84181 |
Gene name | chromodomain helicase DNA binding protein 6 | chromodomain helicase DNA binding protein 6 | |
Synonyms | CHD-6|CHD5|RIGB | CHD-6|CHD5|RIGB | |
Cytomap | 20q12 | 20q12 | |
Type of gene | protein-coding | protein-coding | |
Description | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TD26 | Q8TD26 | |
Ensembl transtripts involved in fusion gene | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | |
Fusion gene scores | * DoF score | 22 X 14 X 10=3080 | 8 X 9 X 4=288 |
# samples | 25 | 10 | |
** MAII score | log2(25/3080*10)=-3.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHD6 [Title/Abstract] AND CHD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA120241 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - | ||
ChiTaRS3.1 | AK026022 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - | ||
ChiTaRS3.1 | AI312497 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000373233 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000373233 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000373233 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
5CDS-intron | ENST00000373233 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000309279 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000309279 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000309279 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
5CDS-intron | ENST00000309279 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000373222 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000373222 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
Frame-shift | ENST00000373222 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
5CDS-intron | ENST00000373222 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
intron-3CDS | ENST00000480022 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
intron-3CDS | ENST00000480022 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
intron-3CDS | ENST00000480022 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
intron-intron | ENST00000480022 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40162211 | - |
intron-5UTR | ENST00000373233 | ENST00000373233 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000373233 | ENST00000309279 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000373233 | ENST00000373222 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000373233 | ENST00000480022 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000309279 | ENST00000373233 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000309279 | ENST00000309279 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000309279 | ENST00000373222 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000309279 | ENST00000480022 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000373222 | ENST00000373233 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000373222 | ENST00000309279 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000373222 | ENST00000373222 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000373222 | ENST00000480022 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000480022 | ENST00000373233 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-5UTR | ENST00000480022 | ENST00000309279 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000480022 | ENST00000373222 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
intron-intron | ENST00000480022 | ENST00000480022 | CHD6 | chr20 | 40050694 | - | CHD6 | chr20 | 40247063 | - |
In-frame | ENST00000373233 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
In-frame | ENST00000373233 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
In-frame | ENST00000373233 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
5CDS-intron | ENST00000373233 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
In-frame | ENST00000309279 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
In-frame | ENST00000309279 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
In-frame | ENST00000309279 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
5CDS-intron | ENST00000309279 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
Frame-shift | ENST00000373222 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
Frame-shift | ENST00000373222 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
Frame-shift | ENST00000373222 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
5CDS-intron | ENST00000373222 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
intron-3CDS | ENST00000480022 | ENST00000373233 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
intron-3CDS | ENST00000480022 | ENST00000309279 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
intron-3CDS | ENST00000480022 | ENST00000373222 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
intron-intron | ENST00000480022 | ENST00000480022 | CHD6 | chr20 | 40141485 | - | CHD6 | chr20 | 40143593 | - |
Top |
FusionProtFeatures for CHD6_CHD6 |
![]() |
Hgene | Tgene |
CHD6 | CHD6 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 93_202 | 319 | 374 | Compositional bias | Note=Lys-rich |
Hgene | CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 93_202 | 284 | 2716 | Compositional bias | Note=Lys-rich |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 1449_1503 | 219 | 374 | Domain | Note=Myb-like |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 292_343 | 219 | 374 | Domain | Chromo 1 |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 375_439 | 219 | 374 | Domain | Chromo 2 |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 473_647 | 219 | 374 | Domain | Helicase ATP-binding |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 787_956 | 219 | 374 | Domain | Helicase C-terminal |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 1449_1503 | 184 | 2716 | Domain | Note=Myb-like |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 292_343 | 184 | 2716 | Domain | Chromo 1 |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 375_439 | 184 | 2716 | Domain | Chromo 2 |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 473_647 | 184 | 2716 | Domain | Helicase ATP-binding |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 787_956 | 184 | 2716 | Domain | Helicase C-terminal |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 598_601 | 219 | 374 | Motif | Note=DEAH box |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 598_601 | 184 | 2716 | Motif | Note=DEAH box |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 486_493 | 219 | 374 | Nucleotide binding | ATP |
Tgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 486_493 | 184 | 2716 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 1449_1503 | 319 | 374 | Domain | Note=Myb-like |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 292_343 | 319 | 374 | Domain | Chromo 1 |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 375_439 | 319 | 374 | Domain | Chromo 2 |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 473_647 | 319 | 374 | Domain | Helicase ATP-binding |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 787_956 | 319 | 374 | Domain | Helicase C-terminal |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 1449_1503 | 284 | 2716 | Domain | Note=Myb-like |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 292_343 | 284 | 2716 | Domain | Chromo 1 |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 375_439 | 284 | 2716 | Domain | Chromo 2 |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 473_647 | 284 | 2716 | Domain | Helicase ATP-binding |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 787_956 | 284 | 2716 | Domain | Helicase C-terminal |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 598_601 | 319 | 374 | Motif | Note=DEAH box |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 598_601 | 284 | 2716 | Motif | Note=DEAH box |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 486_493 | 319 | 374 | Nucleotide binding | ATP |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 486_493 | 284 | 2716 | Nucleotide binding | ATP |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 5 | 7 | 1_747 | 319 | 374 | Region | Note=Required for DNA-dependent ATPase activity |
Hgene | >CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 5 | 37 | 1_747 | 284 | 2716 | Region | Note=Required for DNA-dependent ATPase activity |
Tgene | CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 93_202 | 219 | 374 | Compositional bias | Note=Lys-rich |
Tgene | CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 93_202 | 184 | 2716 | Compositional bias | Note=Lys-rich |
Tgene | CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373222 | - | 2 | 7 | 1_747 | 219 | 374 | Region | Note=Required for DNA-dependent ATPase activity |
Tgene | CHD6 | chr20:40141485 | chr20:40143593 | ENST00000373233 | - | 2 | 37 | 1_747 | 184 | 2716 | Region | Note=Required for DNA-dependent ATPase activity |
Top |
FusionGeneSequence for CHD6_CHD6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CHD6_CHD6 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CHD6 | AIRE, ARAF, TOLLIP, CHD3, ATXN1L, ZFYVE9, SOX2, HIST3H3, HIST1H2BG, SEC16A, RACGAP1, PAPD5, CDCA5, ESR1, EGFR | CHD6 | AIRE, ARAF, TOLLIP, CHD3, ATXN1L, ZFYVE9, SOX2, HIST3H3, HIST1H2BG, SEC16A, RACGAP1, PAPD5, CDCA5, ESR1, EGFR |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CHD6_CHD6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CHD6_CHD6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHD6 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | CHD6 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | CHD6 | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | CHD6 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Tgene | CHD6 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Tgene | CHD6 | C0027819 | Neuroblastoma | 1 | CTD_human |