FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6930

FusionGeneSummary for CGREF1_TRMT44

check button Fusion gene summary
Fusion gene informationFusion gene name: CGREF1_TRMT44
Fusion gene ID: 6930
HgeneTgene
Gene symbol

CGREF1

TRMT44

Gene ID

10669

152992

Gene namecell growth regulator with EF-hand domain 1tRNA methyltransferase 44 homolog
SynonymsCGR11C4orf23|METTL19|TRM44
Cytomap

2p23.3

4p16.1

Type of geneprotein-codingprotein-coding
Descriptioncell growth regulator with EF hand domain protein 1cell growth regulatory gene 11 proteinhydrophobestinprobable tRNA (uracil-O(2)-)-methyltransferasemethyltransferase like 19methyltransferase-like protein 19
Modification date2018032920180523
UniProtAcc

Q99674

Q8IYL2

Ensembl transtripts involved in fusion geneENST00000402550, ENST00000452318, 
ENST00000402394, ENST00000405600, 
ENST00000312734, ENST00000404694, 
ENST00000260595, 		ENST00000513449, 
ENST00000389737, ENST00000511366, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 1 X 2=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: CGREF1 [Title/Abstract] AND TRMT44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-57-1582-01ACGREF1chr2

27327155

-TRMT44chr4

8494993

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000402550ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000402550ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-3UTRENST00000402550ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+
intron-intronENST00000452318ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
intron-intronENST00000452318ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
intron-3UTRENST00000452318ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000402394ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000402394ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-3UTRENST00000402394ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000405600ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000405600ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-3UTRENST00000405600ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000312734ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000312734ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-3UTRENST00000312734ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000404694ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000404694ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-3UTRENST00000404694ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000260595ENST00000513449CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-intronENST00000260595ENST00000389737CGREF1chr2

27327155

-TRMT44chr4

8494993

+
5CDS-3UTRENST00000260595ENST00000511366CGREF1chr2

27327155

-TRMT44chr4

8494993

+

Top

FusionProtFeatures for CGREF1_TRMT44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CGREF1

Q99674

TRMT44

Q8IYL2

Mediates cell-cell adhesion in a calcium-dependentmanner (By similarity). Able to inhibit growth in several celllines. {ECO:0000250}. Probable adenosyl-L-methionine (AdoMet)-dependent tRNA(uracil-O(2)-)-methyltransferase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CGREF1_TRMT44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CGREF1_TRMT44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CGREF1TRMT44HLA-DQB2, TSHR, KLK5, BCAT1, ANTXR1, SKAP1, IL12RB1, LOC554223, THBS3, CCNJL, MUC20, LYPD4, PLA2G10, P4HA2, F9, PRKAB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CGREF1_TRMT44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CGREF1_TRMT44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource