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Fusion gene ID: 6927 |
FusionGeneSummary for CGNL1_HTN3 |
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Fusion gene information | Fusion gene name: CGNL1_HTN3 | Fusion gene ID: 6927 | Hgene | Tgene | Gene symbol | CGNL1 | HTN3 | Gene ID | 84952 | 3347 |
Gene name | cingulin like 1 | histatin 3 | |
Synonyms | JACOP|PCING | HIS2|HTN2|HTN5 | |
Cytomap | 15q21.3 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cingulin-like protein 1junction-associated coiled-coil proteinparacingulin | histatin-3PBbasic histidine-rich proteinhistatin-4histatin-5histatin-6histatin-7histatin-8histatin-9histidine-rich protein 3hst | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q0VF96 | P15516 | |
Ensembl transtripts involved in fusion gene | ENST00000281282, ENST00000557813, | ENST00000526767, ENST00000530128, ENST00000381057, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CGNL1 [Title/Abstract] AND HTN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK130503 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000281282 | ENST00000526767 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
intron-5UTR | ENST00000281282 | ENST00000530128 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
intron-5UTR | ENST00000281282 | ENST00000381057 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
intron-5UTR | ENST00000557813 | ENST00000526767 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
intron-5UTR | ENST00000557813 | ENST00000530128 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
intron-5UTR | ENST00000557813 | ENST00000381057 | CGNL1 | chr15 | 57816385 | + | HTN3 | chr4 | 70894176 | + |
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FusionProtFeatures for CGNL1_HTN3 |
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Hgene | Tgene |
CGNL1 | HTN3 |
May be involved in anchoring the apical junctionalcomplex, especially tight junctions, to actin-based cytoskeletons.{ECO:0000269|PubMed:22891260}. | Histatins are salivary proteins that are considered tobe major precursors of the protective proteinaceous structure ontooth surfaces (enamel pellicle). In addition, histatins exhibitantibacterial and antifungal activities. His3-(20-43)-peptide(histatin-5) is especially effective against C.albicans andC.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB)from P.gingivalis. In addition, His3-(20-43)-peptide is a potentinhibitor of metalloproteinases MMP2 and MMP9.{ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CGNL1_HTN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CGNL1_HTN3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CGNL1_HTN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CGNL1_HTN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CGNL1 | C0036341 | Schizophrenia | 1 | PSYGENET |