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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6911

FusionGeneSummary for CFLAR_NDUFB3

check button Fusion gene summary
Fusion gene informationFusion gene name: CFLAR_NDUFB3
Fusion gene ID: 6911
HgeneTgene
Gene symbol

CFLAR

NDUFB3

Gene ID

8837

4709

Gene nameCASP8 and FADD like apoptosis regulatorNADH:ubiquinone oxidoreductase subunit B3
SynonymsCASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPSB12|CI-B12
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
DescriptionCASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like inNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDaNADH-ubiquinone oxidoreductase B12 subunitcomplex I-B12
Modification date2018052320180523
UniProtAcc

O15519

O43676

Ensembl transtripts involved in fusion geneENST00000309955, ENST00000443227, 
ENST00000341222, ENST00000340870, 
ENST00000355558, ENST00000341582, 
ENST00000342795, ENST00000395148, 
ENST00000423241, ENST00000490965, 
ENST00000440180, ENST00000457277, 
ENST00000494258, ENST00000479953, 
ENST00000237889, ENST00000433898, 
ENST00000454214, 
Fusion gene scores* DoF score3 X 5 X 4=602 X 2 X 3=12
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CFLAR [Title/Abstract] AND NDUFB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCFLAR

GO:0060544

regulation of necroptotic process

21737330

HgeneCFLAR

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

HgeneCFLAR

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

9208847


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-P3-A6T4-01ACFLARchr2

202005162

+NDUFB3chr2

201950182

+
TCGARVUCSTCGA-QN-A5NN-01ACFLARchr2

202014558

+NDUFB3chr2

201950182

+
TCGARVUCSTCGA-N5-A59E-01ACFLARchr2

201981204

+NDUFB3chr2

201950182

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000309955ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000309955ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000309955ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000443227ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000443227ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000443227ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341222ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341222ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341222ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000340870ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000340870ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000340870ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000355558ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000355558ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000355558ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341582ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341582ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341582ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000342795ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000342795ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000342795ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000423241ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000423241ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000423241ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000440180ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000440180ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000440180ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000457277ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000457277ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000457277ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
Frame-shiftENST00000494258ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
Frame-shiftENST00000494258ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
Frame-shiftENST00000494258ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000479953ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000479953ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000479953ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
Frame-shiftENST00000309955ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000309955ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000309955ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000443227ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000443227ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000443227ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000341222ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000341222ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000341222ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000340870ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000340870ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000340870ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000355558ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000355558ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000355558ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000341582ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000341582ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000341582ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000342795ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000342795ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000342795ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000423241ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000423241ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000423241ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000457277ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000457277ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000457277ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000479953ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000479953ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000479953ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000309955ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000309955ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000309955ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000443227ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000443227ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000443227ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341222ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341222ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341222ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000340870ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000340870ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000340870ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000355558ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000355558ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000355558ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341582ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341582ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341582ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000342795ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000342795ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000342795ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000395148ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000395148ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000395148ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000423241ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000423241ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000423241ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000457277ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000457277ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000457277ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000479953ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000479953ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000479953ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+

Top

FusionProtFeatures for CFLAR_NDUFB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFLAR

O15519

NDUFB3

O43676

Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_73202481DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+51092_170202481DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_73202463DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+51092_170202463DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_73202222DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+5692_170202222DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_73202446DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+5892_170202446DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_73202293DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+5992_170202293DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_73202481DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+51092_170202481DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_73202222DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+4592_170202222DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_73106385DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_73202463DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+4992_170202463DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_73106367DomainDED 1
TgeneNDUFB3chr2:202005162chr2:201950182ENST00000237889+1366_884699TransmembraneHelical
TgeneNDUFB3chr2:202005162chr2:201950182ENST00000433898+2466_884699TransmembraneHelical
TgeneNDUFB3chr2:202005162chr2:201950182ENST00000454214+2466_884699TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+4992_170106385DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+3892_170106367DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_435202481RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510263_358202481RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_435202463RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510263_358202463RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_435202222RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56263_358202222RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_435202446RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58263_358202446RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_435202293RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59263_358202293RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_435202481RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510263_358202481RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_435202222RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45263_358202222RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_435106385RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49263_358106385RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_435202463RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49263_358202463RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_435106367RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38263_358106367RegionNote=Caspase


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FusionGeneSequence for CFLAR_NDUFB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CFLAR_NDUFB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CFLARSF3B3, DOK2, CASP8, CASP10, RIPK2, FADD, FAS, CASP3, TRAF1, TRAF2, CFLAR, TNFRSF10A, TNFRSF10B, NOD1, TRAF3, RIPK1, RAF1, BCL2L1, DEDD2, DEDD, MAP3K14, NOL3, TP53, ITCH, XRCC6, TNFSF10, ATG3, CBLB, DAXX, FASLG, STUB1, HSP90AA1, SPATS1, SMAD3, GSN, TICAM1, PLIN5, REV3L, USP8NDUFB3ATP5C1, APP, NDUFS3, ENPP6, FNDC4, NDUFA8, NDUFA12, NDUFA9, NDUFA11, NDUFA13, NDUFA4, C15orf48, NDUFB11, NDUFS6, YIPF3, NDUFB5, NDUFS7, OPRM1, DPEP1, LPAR1, CSGALNACT2, SLC22A9, VAPB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_195202481caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_195202463caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_195202222caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_195202446caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_195202293caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_195202481caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_195202222caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_195202463caspase-8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510192_435202481caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510192_435202463caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56192_435202222caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58192_435202446caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59192_435202293caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510192_435202481caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45192_435202222caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49192_435106385caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49192_435202463caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38192_435106367caspase-3
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510370_480202481caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510370_480202463caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56370_480202222caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58370_480202446caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59370_480202293caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510370_480202481caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45370_480202222caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_195106385caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49370_480106385caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49370_480202463caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_195106367caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38370_480106367caspase-8
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_305202481caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_305202463caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_305202222caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_305202446caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_305202293caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_305202481caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_305202222caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_305106385caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_305202463caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_305106367caspase-8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510217_480202481caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510217_480202463caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56217_480202222caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58217_480202446caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59217_480202293caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510217_480202481caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45217_480202222caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49217_480106385caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49217_480202463caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38217_480106367caspase-8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_227202481FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_227202463FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_227202222FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_227202446FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_227202293FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_227202481FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_227202222FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_227106385FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_227202463FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_227106367FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510192_480202481TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510192_480202463TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56192_480202222TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58192_480202446TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59192_480202293TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510192_480202481TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45192_480202222TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49192_480106385TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49192_480202463TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38192_480106367TRAF1 and TRAF2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CFLAR_NDUFB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CFLAR_NDUFB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCFLARC0019829Hodgkin Disease1CTD_human
HgeneCFLARC0023418leukemia1CTD_human
HgeneCFLARC0030297Pancreatic Neoplasm1CTD_human
HgeneCFLARC1955906Lymphoma, Extranodal NK-T-Cell1CTD_human
HgeneCFLARC3463824MYELODYSPLASTIC SYNDROME1CTD_human