FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6908

FusionGeneSummary for CFL2_NOSTRIN

check button Fusion gene summary
Fusion gene informationFusion gene name: CFL2_NOSTRIN
Fusion gene ID: 6908
HgeneTgene
Gene symbol

CFL2

NOSTRIN

Gene ID

1073

115677

Gene namecofilin 2nitric oxide synthase trafficking
SynonymsNEM7DaIP2
Cytomap

14q13.1

2q24.3

Type of geneprotein-codingprotein-coding
Descriptioncofilin-2cofilin 2 (muscle)cofilin, muscle isoformnemaline myopathy type 7nostrinBM247 homologENOS traffic inducereNOS-trafficking inducerendothelial nitric oxide synthase traffic inducernitric oxide synthase traffic inducernitric oxide synthase traffickerortholog of mouse disabled 2 interacting proein 2
Modification date2018052220180519
UniProtAcc

Q9Y281

Q8IVI9

Ensembl transtripts involved in fusion geneENST00000341223, ENST00000298159, 
ENST00000555765, ENST00000556161, 
ENST00000458381, ENST00000444448, 
ENST00000317647, ENST00000445023, 
ENST00000397206, ENST00000421711, 
ENST00000397209, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 34
** MAII scorelog2(3/1*10)=4.90689059560852log2(4/8*10)=2.32192809488736
Context

PubMed: CFL2 [Title/Abstract] AND NOSTRIN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCFL2

GO:0030042

actin filament depolymerization

19752190


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1R06328CFL2chr14

35180236

-NOSTRINchr2

169673712

-
ChiTaRS3.1R11359CFL2chr14

35180236

-NOSTRINchr2

169673712

-
ChiTaRS3.1BX102624CFL2chr14

35180236

-NOSTRINchr2

169673712

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000341223ENST00000458381CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000341223ENST00000444448CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000341223ENST00000317647CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000341223ENST00000445023CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000341223ENST00000397206CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000341223ENST00000421711CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000341223ENST00000397209CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000458381CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000444448CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000317647CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000445023CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000397206CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000421711CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000298159ENST00000397209CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000458381CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000444448CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000317647CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000445023CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000397206CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000421711CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000555765ENST00000397209CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000458381CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000444448CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000317647CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000445023CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000397206CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000421711CFL2chr14

35180236

-NOSTRINchr2

169673712

-
intron-intronENST00000556161ENST00000397209CFL2chr14

35180236

-NOSTRINchr2

169673712

-

Top

FusionProtFeatures for CFL2_NOSTRIN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFL2

Q9Y281

NOSTRIN

Q8IVI9

Controls reversibly actin polymerization anddepolymerization in a pH-sensitive manner. Its F-actindepolymerization activity is regulated by association with CSPR3(PubMed:19752190). It has the ability to bind G- and F-actin in a1:1 ratio of cofilin to actin. It is the major component ofintranuclear and cytoplasmic actin rods. Required for musclemaintenance. May play a role during the exchange of alpha-actinforms during the early postnatal remodeling of the sarcomere (Bysimilarity). {ECO:0000250|UniProtKB:P45591,ECO:0000269|PubMed:19752190}. Multivalent adapter protein which may decrease NOS3activity by inducing its translocation away from the plasmamembrane. {ECO:0000269|PubMed:12446846,ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CFL2_NOSTRIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CFL2_NOSTRIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CFL2_NOSTRIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CFL2_NOSTRIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCFL2C1853154Nemaline Myopathy 72CTD_human;UNIPROT