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Fusion gene ID: 6908 |
FusionGeneSummary for CFL2_NOSTRIN |
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Fusion gene information | Fusion gene name: CFL2_NOSTRIN | Fusion gene ID: 6908 | Hgene | Tgene | Gene symbol | CFL2 | NOSTRIN | Gene ID | 1073 | 115677 |
Gene name | cofilin 2 | nitric oxide synthase trafficking | |
Synonyms | NEM7 | DaIP2 | |
Cytomap | 14q13.1 | 2q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cofilin-2cofilin 2 (muscle)cofilin, muscle isoformnemaline myopathy type 7 | nostrinBM247 homologENOS traffic inducereNOS-trafficking inducerendothelial nitric oxide synthase traffic inducernitric oxide synthase traffic inducernitric oxide synthase traffickerortholog of mouse disabled 2 interacting proein 2 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9Y281 | Q8IVI9 | |
Ensembl transtripts involved in fusion gene | ENST00000341223, ENST00000298159, ENST00000555765, ENST00000556161, | ENST00000458381, ENST00000444448, ENST00000317647, ENST00000445023, ENST00000397206, ENST00000421711, ENST00000397209, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 3 | 4 | |
** MAII score | log2(3/1*10)=4.90689059560852 | log2(4/8*10)=2.32192809488736 | |
Context | PubMed: CFL2 [Title/Abstract] AND NOSTRIN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CFL2 | GO:0030042 | actin filament depolymerization | 19752190 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | R06328 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - | ||
ChiTaRS3.1 | R11359 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - | ||
ChiTaRS3.1 | BX102624 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000341223 | ENST00000458381 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000341223 | ENST00000444448 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000341223 | ENST00000317647 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000341223 | ENST00000445023 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000341223 | ENST00000397206 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000341223 | ENST00000421711 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000341223 | ENST00000397209 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000458381 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000444448 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000317647 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000445023 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000397206 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000421711 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000298159 | ENST00000397209 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000458381 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000444448 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000317647 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000445023 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000397206 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000421711 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000555765 | ENST00000397209 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000458381 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000444448 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000317647 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000445023 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000397206 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000421711 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
intron-intron | ENST00000556161 | ENST00000397209 | CFL2 | chr14 | 35180236 | - | NOSTRIN | chr2 | 169673712 | - |
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FusionProtFeatures for CFL2_NOSTRIN |
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Hgene | Tgene |
CFL2 | NOSTRIN |
Controls reversibly actin polymerization anddepolymerization in a pH-sensitive manner. Its F-actindepolymerization activity is regulated by association with CSPR3(PubMed:19752190). It has the ability to bind G- and F-actin in a1:1 ratio of cofilin to actin. It is the major component ofintranuclear and cytoplasmic actin rods. Required for musclemaintenance. May play a role during the exchange of alpha-actinforms during the early postnatal remodeling of the sarcomere (Bysimilarity). {ECO:0000250|UniProtKB:P45591,ECO:0000269|PubMed:19752190}. | Multivalent adapter protein which may decrease NOS3activity by inducing its translocation away from the plasmamembrane. {ECO:0000269|PubMed:12446846,ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CFL2_NOSTRIN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CFL2_NOSTRIN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CFL2_NOSTRIN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CFL2_NOSTRIN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CFL2 | C1853154 | Nemaline Myopathy 7 | 2 | CTD_human;UNIPROT |