FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6893

FusionGeneSummary for CFDP1_WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: CFDP1_WWOX
Fusion gene ID: 6893
HgeneTgene
Gene symbol

CFDP1

WWOX

Gene ID

10428

51741

Gene namecraniofacial development protein 1WW domain containing oxidoreductase
SynonymsBCNT|BUCENTAUR|CENP-29|CP27|SWC5|Yeti|p97D16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

16q23.1

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptioncraniofacial development protein 1centromere protein 29phosphoprotein (Bucentaur)WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2018051920180523
UniProtAcc

Q9UEE9

Q9NZC7

Ensembl transtripts involved in fusion geneENST00000283882, ENST00000564286, 
ENST00000566780, ENST00000406884, 
ENST00000539474, ENST00000402655, 
ENST00000408984, ENST00000355860, 
ENST00000565791, ENST00000569818, 
Fusion gene scores* DoF score4 X 4 X 4=6414 X 7 X 7=686
# samples 616
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/686*10)=-2.10013667128545
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CFDP1 [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A9T0-01ACFDP1chr16

75428988

-WWOXchr16

79245505

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000283882ENST00000566780CFDP1chr16

75428988

-WWOXchr16

79245505

+
In-frameENST00000283882ENST00000406884CFDP1chr16

75428988

-WWOXchr16

79245505

+
Frame-shiftENST00000283882ENST00000539474CFDP1chr16

75428988

-WWOXchr16

79245505

+
Frame-shiftENST00000283882ENST00000402655CFDP1chr16

75428988

-WWOXchr16

79245505

+
5CDS-intronENST00000283882ENST00000408984CFDP1chr16

75428988

-WWOXchr16

79245505

+
5CDS-intronENST00000283882ENST00000355860CFDP1chr16

75428988

-WWOXchr16

79245505

+
5CDS-intronENST00000283882ENST00000565791CFDP1chr16

75428988

-WWOXchr16

79245505

+
5CDS-intronENST00000283882ENST00000569818CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-3CDSENST00000564286ENST00000566780CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-3CDSENST00000564286ENST00000406884CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-3CDSENST00000564286ENST00000539474CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-3CDSENST00000564286ENST00000402655CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-intronENST00000564286ENST00000408984CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-intronENST00000564286ENST00000355860CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-intronENST00000564286ENST00000565791CFDP1chr16

75428988

-WWOXchr16

79245505

+
intron-intronENST00000564286ENST00000569818CFDP1chr16

75428988

-WWOXchr16

79245505

+

Top

FusionProtFeatures for CFDP1_WWOX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFDP1

Q9UEE9

WWOX

Q9NZC7

May play a role during embryogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFDP1chr16:75428988chr16:79245505ENST00000283882-572_161216300Compositional biasNote=Glu-rich
HgeneCFDP1chr16:75428988chr16:79245505ENST00000283882-57178_217216300RegionNote=Hydrophilic
TgeneWWOXchr16:75428988chr16:79245505ENST00000355860+0616_49-34190DomainWW 1
TgeneWWOXchr16:75428988chr16:79245505ENST00000355860+0657_90-34190DomainWW 2
TgeneWWOXchr16:75428988chr16:79245505ENST00000408984+01016_49-29311DomainWW 1
TgeneWWOXchr16:75428988chr16:79245505ENST00000408984+01057_90-29311DomainWW 2
TgeneWWOXchr16:75428988chr16:79245505ENST00000569818+0116_49-3537DomainWW 1
TgeneWWOXchr16:75428988chr16:79245505ENST00000569818+0157_90-3537DomainWW 2
TgeneWWOXchr16:75428988chr16:79245505ENST00000355860+0650_55-34190MotifNuclear localization signal
TgeneWWOXchr16:75428988chr16:79245505ENST00000408984+01050_55-29311MotifNuclear localization signal
TgeneWWOXchr16:75428988chr16:79245505ENST00000569818+0150_55-3537MotifNuclear localization signal
TgeneWWOXchr16:75428988chr16:79245505ENST00000355860+06131_137-34190Nucleotide bindingNADP
TgeneWWOXchr16:75428988chr16:79245505ENST00000408984+010131_137-29311Nucleotide bindingNADP
TgeneWWOXchr16:75428988chr16:79245505ENST00000569818+01131_137-3537Nucleotide bindingNADP
TgeneWWOXchr16:75428988chr16:79245505ENST00000355860+06209_273-34190RegionMediates targeting to the mitochondria
TgeneWWOXchr16:75428988chr16:79245505ENST00000402655+35209_273136312RegionMediates targeting to the mitochondria
TgeneWWOXchr16:75428988chr16:79245505ENST00000406884+46209_273172235RegionMediates targeting to the mitochondria
TgeneWWOXchr16:75428988chr16:79245505ENST00000408984+010209_273-29311RegionMediates targeting to the mitochondria
TgeneWWOXchr16:75428988chr16:79245505ENST00000569818+01209_273-3537RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWOXchr16:75428988chr16:79245505ENST00000402655+3516_49136312DomainWW 1
TgeneWWOXchr16:75428988chr16:79245505ENST00000402655+3557_90136312DomainWW 2
TgeneWWOXchr16:75428988chr16:79245505ENST00000406884+4616_49172235DomainWW 1
TgeneWWOXchr16:75428988chr16:79245505ENST00000406884+4657_90172235DomainWW 2
TgeneWWOXchr16:75428988chr16:79245505ENST00000566780+7916_49352415DomainWW 1
TgeneWWOXchr16:75428988chr16:79245505ENST00000566780+7957_90352415DomainWW 2
TgeneWWOXchr16:75428988chr16:79245505ENST00000402655+3550_55136312MotifNuclear localization signal
TgeneWWOXchr16:75428988chr16:79245505ENST00000406884+4650_55172235MotifNuclear localization signal
TgeneWWOXchr16:75428988chr16:79245505ENST00000566780+7950_55352415MotifNuclear localization signal
TgeneWWOXchr16:75428988chr16:79245505ENST00000402655+35131_137136312Nucleotide bindingNADP
TgeneWWOXchr16:75428988chr16:79245505ENST00000406884+46131_137172235Nucleotide bindingNADP
TgeneWWOXchr16:75428988chr16:79245505ENST00000566780+79131_137352415Nucleotide bindingNADP
TgeneWWOXchr16:75428988chr16:79245505ENST00000566780+79209_273352415RegionMediates targeting to the mitochondria


Top

FusionGeneSequence for CFDP1_WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CFDP1_ENST00000283882_chr16_75428988_-_WWOX_ENST00000566780_chr16_79245505_+_279aa
MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTQGKKRKAQSIPARKRRQGGLSLEEEEEEDANSESEGSSSEEE
DDAAEQEKGIGSEDARKKKEDELWASFLNDVGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTK
EVDATSKEAKSFFKQNEKEKPQANVPSALPSLPAGSGNRELPPPCTVLLSQNWRVWEGCTSTTAAAACPHQKLRAKRRPGPCGRSARGXS

>In-frame_CFDP1_ENST00000283882_chr16_75428988_-_WWOX_ENST00000406884_chr16_79245505_+_279aa
MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTQGKKRKAQSIPARKRRQGGLSLEEEEEEDANSESEGSSSEEE
DDAAEQEKGIGSEDARKKKEDELWASFLNDVGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTK
EVDATSKEAKSFFKQNEKEKPQANVPSALPSLPAGSGNRELPPPCTVLLSQNWRVWEGCTSTTAAAACPHQKLRAKRRPGPCGRSARGXS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CFDP1_ENST00000283882_chr16_75428988_-_WWOX_ENST00000566780_chr16_79245505_+_839nt
ATGGAGGAATTCGACTCCGAAGACTTCTCTACGTCGGAGGAGGACGAGGACTACGTGCCGTCGGGTGGAGAGTATAGTGAAGATGATGTA
AATGAATTAGTGAAGGAAGATGAAGTGGATGGTGAAGAGCAGACACAGAAAACCCAAGGGAAAAAAAGAAAGGCCCAGAGCATTCCAGCC
AGGAAGAGAAGACAAGGTGGCCTCTCATTAGAAGAAGAGGAAGAGGAGGATGCCAATTCAGAATCTGAGGGAAGCAGTAGTGAGGAGGAA
GATGACGCTGCAGAGCAGGAAAAAGGCATTGGATCAGAGGATGCCAGGAAAAAGAAGGAGGACGAACTCTGGGCCAGCTTCCTCAATGAT
GTGGGACCAAAATCAAAAGTGCCCCCAAGTACACAAGTTAAGAAAGGAGAGGAGACTGAAGAGACAAGTTCAAGTAAATTGTTGGTAAAA
GCAGAAGAGCTAGAGAAACCTAAAGAAACAGAAAAAGTTAAAATCACCAAGGTGTTTGATTTTGCTGGTGAAGAAGTAAGGGTAACTAAG
GAAGTGGATGCTACATCTAAAGAGGCCAAATCCTTCTTCAAGCAGAATGAGAAAGAAAAACCACAGGCTAATGTTCCTTCAGCTCTGCCA
TCACTCCCTGCCGGGTCAGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACT
TCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCC

>In-frame_CFDP1_ENST00000283882_chr16_75428988_-_WWOX_ENST00000406884_chr16_79245505_+_839nt
ATGGAGGAATTCGACTCCGAAGACTTCTCTACGTCGGAGGAGGACGAGGACTACGTGCCGTCGGGTGGAGAGTATAGTGAAGATGATGTA
AATGAATTAGTGAAGGAAGATGAAGTGGATGGTGAAGAGCAGACACAGAAAACCCAAGGGAAAAAAAGAAAGGCCCAGAGCATTCCAGCC
AGGAAGAGAAGACAAGGTGGCCTCTCATTAGAAGAAGAGGAAGAGGAGGATGCCAATTCAGAATCTGAGGGAAGCAGTAGTGAGGAGGAA
GATGACGCTGCAGAGCAGGAAAAAGGCATTGGATCAGAGGATGCCAGGAAAAAGAAGGAGGACGAACTCTGGGCCAGCTTCCTCAATGAT
GTGGGACCAAAATCAAAAGTGCCCCCAAGTACACAAGTTAAGAAAGGAGAGGAGACTGAAGAGACAAGTTCAAGTAAATTGTTGGTAAAA
GCAGAAGAGCTAGAGAAACCTAAAGAAACAGAAAAAGTTAAAATCACCAAGGTGTTTGATTTTGCTGGTGAAGAAGTAAGGGTAACTAAG
GAAGTGGATGCTACATCTAAAGAGGCCAAATCCTTCTTCAAGCAGAATGAGAAAGAAAAACCACAGGCTAATGTTCCTTCAGCTCTGCCA
TCACTCCCTGCCGGGTCAGGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACT
TCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CFDP1_ENST00000283882_chr16_75428988_-_WWOX_ENST00000566780_chr16_79245505_+_1843nt
GTGCAAAGCGCTGTCGGGGGCCGCCCTAGCTGCCGTCGCCGCCGCCGGGGCTCTATGGTCTCTCCCTAGAGCTTTGCCGTTGGAGGCGGC
TGCTGCGGTCTTGTGAGTTTGACCAGCGTCGAGCGGCAGCAACATGGAGGAATTCGACTCCGAAGACTTCTCTACGTCGGAGGAGGACGA
GGACTACGTGCCGTCGGGTGGAGAGTATAGTGAAGATGATGTAAATGAATTAGTGAAGGAAGATGAAGTGGATGGTGAAGAGCAGACACA
GAAAACCCAAGGGAAAAAAAGAAAGGCCCAGAGCATTCCAGCCAGGAAGAGAAGACAAGGTGGCCTCTCATTAGAAGAAGAGGAAGAGGA
GGATGCCAATTCAGAATCTGAGGGAAGCAGTAGTGAGGAGGAAGATGACGCTGCAGAGCAGGAAAAAGGCATTGGATCAGAGGATGCCAG
GAAAAAGAAGGAGGACGAACTCTGGGCCAGCTTCCTCAATGATGTGGGACCAAAATCAAAAGTGCCCCCAAGTACACAAGTTAAGAAAGG
AGAGGAGACTGAAGAGACAAGTTCAAGTAAATTGTTGGTAAAAGCAGAAGAGCTAGAGAAACCTAAAGAAACAGAAAAAGTTAAAATCAC
CAAGGTGTTTGATTTTGCTGGTGAAGAAGTAAGGGTAACTAAGGAAGTGGATGCTACATCTAAAGAGGCCAAATCCTTCTTCAAGCAGAA
TGAGAAAGAAAAACCACAGGCTAATGTTCCTTCAGCTCTGCCATCACTCCCTGCCGGGTCAGGCAACAGGGAGCTGCCACCACCGTGTAC
TGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAA
GAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGAT
GGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGA
GTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCT
GGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCC
TGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACT
GCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCA
TTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACAC
CCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGA
TTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGG
GGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGT

>In-frame_CFDP1_ENST00000283882_chr16_75428988_-_WWOX_ENST00000406884_chr16_79245505_+_1843nt
GTGCAAAGCGCTGTCGGGGGCCGCCCTAGCTGCCGTCGCCGCCGCCGGGGCTCTATGGTCTCTCCCTAGAGCTTTGCCGTTGGAGGCGGC
TGCTGCGGTCTTGTGAGTTTGACCAGCGTCGAGCGGCAGCAACATGGAGGAATTCGACTCCGAAGACTTCTCTACGTCGGAGGAGGACGA
GGACTACGTGCCGTCGGGTGGAGAGTATAGTGAAGATGATGTAAATGAATTAGTGAAGGAAGATGAAGTGGATGGTGAAGAGCAGACACA
GAAAACCCAAGGGAAAAAAAGAAAGGCCCAGAGCATTCCAGCCAGGAAGAGAAGACAAGGTGGCCTCTCATTAGAAGAAGAGGAAGAGGA
GGATGCCAATTCAGAATCTGAGGGAAGCAGTAGTGAGGAGGAAGATGACGCTGCAGAGCAGGAAAAAGGCATTGGATCAGAGGATGCCAG
GAAAAAGAAGGAGGACGAACTCTGGGCCAGCTTCCTCAATGATGTGGGACCAAAATCAAAAGTGCCCCCAAGTACACAAGTTAAGAAAGG
AGAGGAGACTGAAGAGACAAGTTCAAGTAAATTGTTGGTAAAAGCAGAAGAGCTAGAGAAACCTAAAGAAACAGAAAAAGTTAAAATCAC
CAAGGTGTTTGATTTTGCTGGTGAAGAAGTAAGGGTAACTAAGGAAGTGGATGCTACATCTAAAGAGGCCAAATCCTTCTTCAAGCAGAA
TGAGAAAGAAAAACCACAGGCTAATGTTCCTTCAGCTCTGCCATCACTCCCTGCCGGGTCAGGCAACAGGGAGCTGCCACCACCGTGTAC
TGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAA
GAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGAT
GGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGA
GTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCT
GGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCC
TGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACT
GCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCA
TTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACAC
CCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGA
TTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGG
GGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGT


Top

FusionGenePPI for CFDP1_WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CFDP1EWSR1, APP, DMAP1, SRCAP, SMAD3, TALDO1, HIST1H2BA, RUVBL1, RUVBL2, RBPJ, ID2WWOXTP53, CPSF6, TNK2, ERBB4, MDM2, TP63, MAPK8, LMNA, POLR2A, POLR2B, SMARCC1, TCERG1, CPSF1, CPSF2, CPSF3, NUDT21, FIP1L1, CPSF7, HNRNPK, RPRD2, PABPC1, SF3A1, SF3B1, SF3B3, SFPQ, SYMPK, WIPF2, WDR33, WBP2, SF3B2, KHSRP, CSTF3, HSPA4, DHX15, KRT4, MIA3, OTUD7B, PRPF8, ACIN1, PATL1, P4HA1, DSP, ANXA1, HSPA1A, PRRC2A, SERPINB3, COIL, PGD, DIAPH3, CSNK2A1, SNRNP200, DAZAP1, RPRD1B, HSPA8, ENAH, PABPC4, IGF2BP1, HSD17B10, HDLBP, DVL2, SF3A3, CCT2, SNRPD2, SMARCA4, CDC5L, YWHAZ, UBAP2, CANX, SNRPD1, JUP, RARA, PRMT5, U2SURP, TGM3, TDRD3, PKLR, NOLC1, YLPM1, WASL, CSTF2, MATR3, TOE1, BCL9, CRNN, HIST2H2AA3, DVL3, P3H1, PRPF3, CSNK2A2, SCAF4, DSG3, RBMX, CYFIP1, USP6NL, DDX6, XRN2, IVL, XAB2, AMOTL1, MPDZ, DDX3Y, HNRNPUL1, DHX9, POLR2E, FBRS, WDR77, SEC23A, ZMAT5, DGCR14, LZTS2, NOSIP, DCAF7, GEMIN5, PRPF40A, EIF4A3, INPPL1, LSM4, DDX17, IGF2BP3, RC3H1, MPP5, POLR2C, FARSA, HNRNPH3, DHX30, RPRD1A, ZG16B, NONO, PREB, PABPC3, LONP2, ATN1, GABARAPL2, HNRNPR, HNRNPCL1, CYFIP2, ELAVL1, ITCH, DRG1, SNRPD3, RPAP3, DROSHA, HNRNPU, SMN2, CAD, CCT7, PTPN14, PPP1CA, HNRNPA3, DDX39B, SCGB2A1, KRT75, DDX21, SPG20, CSDE1, HNRNPF, SRSF10, SEC23IP, ATP2A1, DIAPH1, LCN1, DOCK7, CXorf57, SF3A2, HSPB1, TARDBP, SF3B6, A2ML1, AMOT, THOC6, KIF2A, LUC7L3, MYH7, MYH1, MYH4, MYH16, DDX1, ENO1, TP73, CCT6A, SMARCE1, ANXA2, ACLY, SCAF8, ALDH3A1, PPIB, EDC4, RPL6, USP39, EIF3A, H2AFZ, RPL30, KDM3B, FUS, SERPINB5, DVL1, RAPGEF2, DHX36, HN1L, POLR2G, BAIAP2, WDR91, DCTPP1, IQSEC1, PRDX5, LZTS3, RPS15AP21, SRSF3, ZNF598, LACRT, IGF2BP2, PAICS, KIAA1522, SLC4A1AP, ATXN2, THRAP3, RBM39, CAPZA1, SEC24C, NOP56, SRPK1, DKC1, IK, HADHA, OGT, PRPF31, DIDO1, ATAD3A, PDCD7, HUWE1, ATM, TRIM28, HIF1A, LATS1, FAM189B, TMEM171, FAM189A2, WBP1, TMEM92, LDLRAD4, CLNK, BTRC, NUP133, CDH1, FKBP15, SERPINA5, ARRDC3, NME2, GORASP1, ZBTB33, LYZ, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr16:75428988chr16:79245505ENST00000355860+06125_414-34190MAPT
TgeneWWOXchr16:75428988chr16:79245505ENST00000408984+010125_414-29311MAPT
TgeneWWOXchr16:75428988chr16:79245505ENST00000569818+01125_414-3537MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr16:75428988chr16:79245505ENST00000402655+35125_414136312MAPT
TgeneWWOXchr16:75428988chr16:79245505ENST00000406884+46125_414172235MAPT
TgeneWWOXchr16:75428988chr16:79245505ENST00000566780+79125_414352415MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CFDP1_WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CFDP1_WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWWOXC0007137Squamous cell carcinoma1CTD_human
TgeneWWOXC0038356Stomach Neoplasms1CTD_human
TgeneWWOXC0042076Urologic Neoplasms1CTD_human
TgeneWWOXC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneWWOXC1458155Mammary Neoplasms1CTD_human
TgeneWWOXC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 121ORPHANET;UNIPROT
TgeneWWOXC3495559Juvenile arthritis1CTD_human
TgeneWWOXC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 281UNIPROT