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Fusion gene ID: 6879 |
FusionGeneSummary for CES2_GPATCH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CES2_GPATCH2 | Fusion gene ID: 6879 | Hgene | Tgene | Gene symbol | CES2 | GPATCH2 | Gene ID | 8824 | 55105 |
| Gene name | carboxylesterase 2 | G-patch domain containing 2 | |
| Synonyms | CE-2|CES2A1|PCE-2|iCE | CT110|GPATC2|PPP1R30|Pfa1 | |
| Cytomap | 16q22.1 | 1q41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cocaine esterasecarboxylesterase 2 (intestine, liver)hCE-2intestinal carboxylesterase; liver carboxylesterase-2methylumbelliferyl-acetate deacetylase 2 | G patch domain-containing protein 2cancer/testis antigen 110protein phosphatase 1, regulatory subunit 30 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O00748 | Q9NW75 | |
| Ensembl transtripts involved in fusion gene | ENST00000417689, ENST00000317091, | ENST00000366935, ENST00000489246, ENST00000366934, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 4 X 4 X 3=48 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CES2 [Title/Abstract] AND GPATCH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CES2 | GO:0006693 | prostaglandin metabolic process | 21049984 |
| Tgene | GPATCH2 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A109-01A | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000417689 | ENST00000366935 | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
| 5CDS-intron | ENST00000417689 | ENST00000489246 | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
| 5CDS-intron | ENST00000417689 | ENST00000366934 | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
| In-frame | ENST00000317091 | ENST00000366935 | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
| 5CDS-intron | ENST00000317091 | ENST00000489246 | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
| 5CDS-intron | ENST00000317091 | ENST00000366934 | CES2 | chr16 | 66972144 | + | GPATCH2 | chr1 | 217622679 | - |
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FusionProtFeatures for CES2_GPATCH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CES2 | GPATCH2 |
| Involved in the detoxification of xenobiotics and in theactivation of ester and amide prodrugs. Shows high catalyticefficiency for hydrolysis of cocaine, 4-methylumbelliferylacetate, heroin and 6-monoacetylmorphine.{ECO:0000269|PubMed:9169443}. | Enhances the ATPase activity of DHX15 in vitro.{ECO:0000269|PubMed:19432882}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GPATCH2 | chr16:66972144 | chr1:217622679 | ENST00000366934 | - | 0 | 6 | 467_513 | -37 | 377 | Domain | G-patch |
| Tgene | >GPATCH2 | chr16:66972144 | chr1:217622679 | ENST00000366935 | - | 7 | 10 | 467_513 | 425 | 529 | Domain | G-patch |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CES2 | chr16:66972144 | chr1:217622679 | ENST00000317091 | + | 2 | 12 | 556_559 | 157 | 624 | Motif | Prevents secretion from ER |
| Hgene | >CES2 | chr16:66972144 | chr1:217622679 | ENST00000417689 | + | 2 | 12 | 556_559 | 157 | 608 | Motif | Prevents secretion from ER |
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FusionGeneSequence for CES2_GPATCH2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CES2_ENST00000417689_chr16_66972144_+_GPATCH2_ENST00000366935_chr1_217622679_-_261aa MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQG QDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMQTSMHLGSLCTGDIKRRRKAAP >In-frame_CES2_ENST00000317091_chr16_66972144_+_GPATCH2_ENST00000366935_chr1_217622679_-_261aa MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQG QDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMQTSMHLGSLCTGDIKRRRKAAP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CES2_ENST00000417689_chr16_66972144_+_GPATCH2_ENST00000366935_chr1_217622679_-_783nt ATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACCCCGCTGACTCCCTGCCCAGTCCAAACTCCA AGGCTGGGCAAGGCACTGATCCACTGCTGGACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACC AGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGGCTTCTGCTGCTTCTTGTCCGGGGCCAGGGC CAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAATCTTGGAGTGGTGTGAGG GATGGAACCACCCATCCGGCCATGCAAACAAGCATGCATTTAGGATCCTTATGCACGGGAGATATCAAACGGAGAAGAAAAGCTGCACCT TTGCCTGGACCTACTACTGCAGGATTTGTAGGTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCTTCAGAATATG GGCTGGACGCCTGGGTCAGGCCTTGGACGAGATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGGATTAGGACTT >In-frame_CES2_ENST00000317091_chr16_66972144_+_GPATCH2_ENST00000366935_chr1_217622679_-_783nt ATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACCCCGCTGACTCCCTGCCCAGTCCAAACTCCA AGGCTGGGCAAGGCACTGATCCACTGCTGGACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACC AGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGGCTTCTGCTGCTTCTTGTCCGGGGCCAGGGC CAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAATCTTGGAGTGGTGTGAGG GATGGAACCACCCATCCGGCCATGCAAACAAGCATGCATTTAGGATCCTTATGCACGGGAGATATCAAACGGAGAAGAAAAGCTGCACCT TTGCCTGGACCTACTACTGCAGGATTTGTAGGTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCTTCAGAATATG GGCTGGACGCCTGGGTCAGGCCTTGGACGAGATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGGATTAGGACTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CES2_ENST00000417689_chr16_66972144_+_GPATCH2_ENST00000366935_chr1_217622679_-_5936nt GTGGCGTGGCGACGGAGTCGCGCGAGGGACACGCCGCGTTGTGGGTTCTCGGCCTGAGGTGCGAGAGAAGCGGTGACCGCGGCCCTGGCT GCTCGGACCCGGGAACATGATGGTCGCTGGAGCAGAAGGCGCTGAGAAGGGACCACGGCGGCGCTGGGTCGTGCGAGCCAGTAGCGGGCT GAAACGTAGAGGCCAGAACCAGGTCTCAGGGGGCACTAAAGGCGGTCGGAGGTAATCCCCACACCGCTTCCTCCTGGAAGTCAGGCTGGC CGGGAGCTCCCGTATCCAGGACGGTTGGTCGCCTCTGGCCTGGCAGGGATCCTAGTGTCTCGGGACCTCCCGGTGACGCGCCTGCCTCCC CTGCTGCACCATAGGCCCGGGAGTACGGCGTCCCCACAGCTTGGACCGGCAGGGGCTCGTGAAATGTTTGTCAAGTGGATAAATGACCAT GGCCGTGGTCTCCGCGGGAGGTGAGGAAACTGAAAGCCACCGAGGAAAAGGGGGGCGCTCCTTAAGAAGTGCCGCGGTCACGTGTACGTT TCAAAAGAATGGCGTGACTGAGTAGGGAGGGGACCGCGGAGACCCTCAGACCCTGGACTGTAAGGAGATGAGGGGCCGTGAAGGGGAACC CAGGAAACTGAGTCCTGAAAGCAAGGAGGAACTTCCAGAATGAAGGGCGCCGACACTCCTTCCTGCCTTTGCTCAAGCGGTTCCTTCACC CCGATCAAGTTCCTTCCCATTTCTCCATCTGGGGGATCCTGAACGTGCACATCCTCAGAGAAGCCCTCCTGGGGTCTCCAATTCTAGTTT ATTGCCCCCTCCTATCGATCCCCCAGCGCGCTCATCGGGCCTGTGGACAAGGACAGGTTTGAAGAGAGGATTCCCTGGATCGCGGAAGGG CTGCAGGAATGGCACAGCCCCTTCCGAGGATGCCAAAGGAGCCCGGGCAAAGGAAAGTGGCCGTGCCCGGGCCTGCCTACCACTAGATCC CCACCCACCTATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACCCCGCTGACTCCCTGCCCAGT CCAAACTCCAAGGCTGGGCAAGGCACTGATCCACTGCTGGACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCG AACCGAGACCAGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGGCTTCTGCTGCTTCTTGTCCG GGGCCAGGGCCAGGACTCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGC CGGGGTCCAAACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAATCTTGGAG TGGTGTGAGGGATGGAACCACCCATCCGGCCATGCAAACAAGCATGCATTTAGGATCCTTATGCACGGGAGATATCAAACGGAGAAGAAA AGCTGCACCTTTGCCTGGACCTACTACTGCAGGATTTGTAGGTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCT TCAGAATATGGGCTGGACGCCTGGGTCAGGCCTTGGACGAGATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGG ATTAGGACTTGGATTTCCTCTACCAAAAAGTACTTCCGCAACTACTACCCCCAATGCAGGAAAATCCGCCTAAGAAAAGCAAAGAAGAAA TGTTTTACAGACTTTATTCACTATGTCCCATTGTTCTAAAATGATAACATGACTTCTGTTTTTGAAGCAAAAATCTACATTGCCTCAAAC ACATCACTCTAGCTTCCTTACTGCATACAGTCCTGCCATAGTGAGAGAAATGGGATTTCATCACAATTCATGGTGCTAAAATGAAAACCT CTGCACTTTAATTTTTTTCAGTAATTTCCAGCTATTTCTAGGTATAAAGAGCAGCTCGTTTCTCTTATTTATTTTAGTCTCATGTGTCAA TACTTTCCGATGCTTTGCTTAATTCATGTATGTGTGCAGTGCTGCAATGCCCAGACAAACGTGAGCACACCCACCAGTTTCTAAAATGGA ATAGACAGGAAAAGATTGTGTTTTATATCATCCCTATCTATTGTAACCCAAAAGACCTACCATCGCATCAGTGAAGTCCGAACACATCTT TGTTTGAAAGGCTTGTCAATTTCATATTCCTTGAATTGGCTTCTTGGTGAGGATTTTCTGACAGAGTGATACCCATCAATTTTCTATCCT TAGACAATGTAGTGTGAAGTTCACAGTTGACAAACAACAATTAATGTTTCCCTTGGATGTTTTGACAAAAATAAACCTCATCGTTGTTAT CACCAGAGTGCCCTCTACCTTACTTTAATGCAGATTTTATAAATTTTACCTCATTTAGAACATAAAATAATTATTGAAAGAAAAATGTAT TTTTTAAATTCACCGTGATTGAACTGTAAATTCTATTAATCCAGATGTACTTCTACCTCTGTTTTCCCAAAGATTGATATTATTTTTAAG ATCAACTCAAGTGTAGTAAACGGATTTAAAATTTTAATCATTGGAGTAATTTATTACAATATTGAATCAATTTACATGAAAAGTTAAATG GCTCTCCCAGAACTCAGATTTCTGGCAATGACCCAACCCATTTAGAAGGTGAACAAAAGAAGTAAATGGTACTGATTTGCCCTTTCTAGG ACCCAAGATGTTACTTTAAAACCTAGCAAAAGAGGTCGTTTGTATTACGTGCCTAGTATTGAGCTGTTTCTGAGTCATTTGCTTCATAGT ATCAGAAATTCTAAATTGCTTTTAGTTTAGAAGATCTTTATTTATTATCTTCATTATTAACAACTTATTATGATGATGATTATTATCATT CTATTTATAATGGCCTTTGCTGGTTGAGTAAAGACTGAGATAACACATGTGAATCACCTTTCTAATGGGTTTTTAAAATCTTGTCACTTT CCAAAAGAGTTTTTTTGTTTCTTTTTTTTTTTTTTTTTTTTTGACAGAGTCTGCCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCACTCT CGGCTCACTGCAGCCTCCCCCTCCTGGGTTCAAGTGATTGTTCTGCCTCAGCCTCCCAAATAGCAGGGATTACAGGCACCCACGACCATA CCCGGATAATTTTTGTATTTTTAGTATAGACGGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCA CCTTGGCCTCCCAAAGAGCTGGGATTACAGGCATGAACCACAGCGCCCAGCCCCCAGAAGAGTTTTTAAAAGGTGTTAAAGGAGGTTTAT GCACGTAACAGACCTTTCTCAGGTGGTCCCCTAAAAAAAATCCTGCCAACTAGGGAGGGGAAGTCCAACCTGCTATTTGAAAGCCTTCAC GGTTTGCCAAATGTACATTTCTTGAGAATTATCTTCTTTCCCAGGGATATTGTACCTAGAGGACAGGTTGGTTAGGGAACTATGGACGAC CAGAAGAGATGTTCTTTTGAAGCATTCTTACTGGATAAAGTAACCCCATGGTATCATTACTTTCTACAAGTTTTTTACTTACAAATTTGC CATTTTTTTAACTGATATTTTCTAAATGCTCATTCTGTCTATGTAGCCGGGGGGAGATTATATACAAGTTTTAAAACTTCTTTGTGATAG TGTATTGTGCTCTGGGGTCTATTCAAAATTTGGTGTTTGAGGTTTTGTTAATTTGATTGCCTGGAGATCTGCTAAAATCCTAGAATCTCA AAAAGCCAAGTTTGAAGCCACTGAGAGCAAACAATGAGGTCATTGTTAGCCTGGTTCCACACTCCTGAGGACTTGGCTGTTCTTTTTCAC CTTATTATGTTCTAATGGAAGTAAAAACCCTCATAGTGAAGAAGAGCAGTATATACACCAGACTAGTGTATAGGAACTTCTTCATTAAAT ATTGCAGTCCTTATGAGTGCTCTTTATTGTTGCTGTTCTGGACAGGTACAAATCTTCTGAAGCAACTTCTGTGGGATGTTAACTTAGCTT CTCTAACACCTAAAAAAATTCTTCTTTGTATTTTCAGCTAATAGAAGACAGTTCTTCTTCATCTTGACACCTAGAGCCCTCTATGTGATT CACAGAGGACTTAAAATACTTCTTACTCTGTTGAAGTGTTTAATTGTACAGAATATATGTACTCTACAGTATATGTGAATCAGCACTCAA AGCAGAGAAGTGATAACATCCCAAGCTTCCCCCATACTTCTACTGACATGCCCTCAGTCTTTAAGAAAACTCAGTACAGACCTGATGTTC TGGTTGTACCTGAACTTAATTGGAGAAACAAACGCAATTAAAATACGAATTTTTTAGTGCAAATCAAATGTCTTTCACCATCTGAAGCCC ACTAATTTGTCTTTTATATATAGTTAATTTTTTGCCAGTTACAACGTCCATAGAACCCCAAGATTTAGAATGTATCATTTATATTTCCTC TAAAAGGTAGTAAGATATTTCTTCTGCTGTTTTGTGAAGCCACTCTTCTACAGTATCTGTAGCCTTATAGCAAATTAATTGGTTGTACTA AAAATTTTAGAGACTGCATAGGTCTCCCTTTTCTATCCTAATTACCTGCAATAGCCTAGAGACGCTGAGCATGATTACATTAGCAACTTG ACTGTTTAAAAAATTTGTTATACTTGATAATGACCAGACTGTGTGCTGGAGTCATTTGTTTCCTTCTTTTCTGCTCCCCGAATACACTAT TTAATTTGGTTACTTTTATTTTTAAACTATATGGCACCCTTTTAAATAAACATTCATTGCTAATTAAAATCTGCCAATAAATTGGTCTCA GCATTTAAATACCATATATTTTATAACTCATACTGTGGCTATCAAACAGAAGTTAACACAGTAGGGGTAAAGATATACATAATGTGTACC TATAGGTGTATTTATAATGCCTGTGTGCAGTATACAGACATAATTACAAAATACTGCATTTTATTAATGTTTATTTTAATATTGAGAATT GGCATTCTTGTAAATTGAACTGACAATTGCTTCTATTCAGTACACTTTATTTTGAGCAGATATTTCCGAAAAGAGAAAAAATCACTGTTG ACATGCTTTTTAAAACTGTTTTCACCTGTATTTTGTCTTTCAAAAAGAAAAGTGATCTAAGTTGGCATTGTAAAGAAATTGTTAGCAAAG AATATTTTTTTTTATTTTTTCTTTTGGTAGAAAGTCATGTTAATAGTACAACAAAGAATCAAAGAATAAAACATAATGTTTAAGAACATT ATTTATAAGTAGTCATTGTCTTTGTGCTTTAAATGTTTCCCTTTTACCTTAGAGTTATTTTTTAAAAGTTGAAAGTACTTTAAAAATTGG TTTAAATGAGTACCCATTGACAATTATCATTTAATAGTGCAGTTAAGTTCAGCGAAAAATTTCAATATCTCAAAAAAATTAGAGAAAAAT ATTGGTAAATGTATTTGATTCACAAATGTATTCATAGCCGATTGTGAGCTGCTCTACCACATTTTCCTGTTTTTATTGTTTCTGTGAAGC TTGATTAGACTAACTTGCTTAAGGTCTCTTTCCCCTCAAGGATTCTGTGATTCTAATGTAACAAGGTACACACGCTCTCTCTGACCACTT AAAGTATCAGAGTTCAAATCTGTTACAATCACTCCATTTCCTTTTGGAAAGTTGTGCCTCTCATAAAGCTGCTTGGACATTTTAAGTGTT >In-frame_CES2_ENST00000317091_chr16_66972144_+_GPATCH2_ENST00000366935_chr1_217622679_-_5920nt GTCGCGCGAGGGACACGCCGCGTTGTGGGTTCTCGGCCTGAGGTGCGAGAGAAGCGGTGACCGCGGCCCTGGCTGCTCGGACCCGGGAAC ATGATGGTCGCTGGAGCAGAAGGCGCTGAGAAGGGACCACGGCGGCGCTGGGTCGTGCGAGCCAGTAGCGGGCTGAAACGTAGAGGCCAG AACCAGGTCTCAGGGGGCACTAAAGGCGGTCGGAGGTAATCCCCACACCGCTTCCTCCTGGAAGTCAGGCTGGCCGGGAGCTCCCGTATC CAGGACGGTTGGTCGCCTCTGGCCTGGCAGGGATCCTAGTGTCTCGGGACCTCCCGGTGACGCGCCTGCCTCCCCTGCTGCACCATAGGC CCGGGAGTACGGCGTCCCCACAGCTTGGACCGGCAGGGGCTCGTGAAATGTTTGTCAAGTGGATAAATGACCATGGCCGTGGTCTCCGCG GGAGGTGAGGAAACTGAAAGCCACCGAGGAAAAGGGGGGCGCTCCTTAAGAAGTGCCGCGGTCACGTGTACGTTTCAAAAGAATGGCGTG ACTGAGTAGGGAGGGGACCGCGGAGACCCTCAGACCCTGGACTGTAAGGAGATGAGGGGCCGTGAAGGGGAACCCAGGAAACTGAGTCCT GAAAGCAAGGAGGAACTTCCAGAATGAAGGGCGCCGACACTCCTTCCTGCCTTTGCTCAAGCGGTTCCTTCACCCCGATCAAGTTCCTTC CCATTTCTCCATCTGGGGGATCCTGAACGTGCACATCCTCAGAGAAGCCCTCCTGGGGTCTCCAATTCTAGTTTATTGCCCCCTCCTATC GATCCCCCAGCGCGCTCATCGGGCCTGTGGACAAGGACAGGTTTGAAGAGAGGATTCCCTGGATCGCGGAAGGGCTGCAGGAATGGCACA GCCCCTTCCGAGGATGCCAAAGGAGCCCGGGCAAAGGAAAGTGGCCGTGCCCGGGCCTGCCTACCACTAGATCCCCACCCACCTATGACT GCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACCCCGCTGACTCCCTGCCCAGTCCAAACTCCAAGGCTG GGCAAGGCACTGATCCACTGCTGGACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACCAGCGAG CCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGGCTTCTGCTGCTTCTTGTCCGGGGCCAGGGCCAGGAC TCAGCCAGTCCCATCCGGACCACACACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAAACCTTC CTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCTGAGCCCCCTGAATCTTGGAGTGGTGTGAGGGATGGA ACCACCCATCCGGCCATGCAAACAAGCATGCATTTAGGATCCTTATGCACGGGAGATATCAAACGGAGAAGAAAAGCTGCACCTTTGCCT GGACCTACTACTGCAGGATTTGTAGGTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCTTCAGAATATGGGCTGG ACGCCTGGGTCAGGCCTTGGACGAGATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGGATTAGGACTTGGATTT CCTCTACCAAAAAGTACTTCCGCAACTACTACCCCCAATGCAGGAAAATCCGCCTAAGAAAAGCAAAGAAGAAATGTTTTACAGACTTTA TTCACTATGTCCCATTGTTCTAAAATGATAACATGACTTCTGTTTTTGAAGCAAAAATCTACATTGCCTCAAACACATCACTCTAGCTTC CTTACTGCATACAGTCCTGCCATAGTGAGAGAAATGGGATTTCATCACAATTCATGGTGCTAAAATGAAAACCTCTGCACTTTAATTTTT TTCAGTAATTTCCAGCTATTTCTAGGTATAAAGAGCAGCTCGTTTCTCTTATTTATTTTAGTCTCATGTGTCAATACTTTCCGATGCTTT GCTTAATTCATGTATGTGTGCAGTGCTGCAATGCCCAGACAAACGTGAGCACACCCACCAGTTTCTAAAATGGAATAGACAGGAAAAGAT TGTGTTTTATATCATCCCTATCTATTGTAACCCAAAAGACCTACCATCGCATCAGTGAAGTCCGAACACATCTTTGTTTGAAAGGCTTGT CAATTTCATATTCCTTGAATTGGCTTCTTGGTGAGGATTTTCTGACAGAGTGATACCCATCAATTTTCTATCCTTAGACAATGTAGTGTG AAGTTCACAGTTGACAAACAACAATTAATGTTTCCCTTGGATGTTTTGACAAAAATAAACCTCATCGTTGTTATCACCAGAGTGCCCTCT ACCTTACTTTAATGCAGATTTTATAAATTTTACCTCATTTAGAACATAAAATAATTATTGAAAGAAAAATGTATTTTTTAAATTCACCGT GATTGAACTGTAAATTCTATTAATCCAGATGTACTTCTACCTCTGTTTTCCCAAAGATTGATATTATTTTTAAGATCAACTCAAGTGTAG TAAACGGATTTAAAATTTTAATCATTGGAGTAATTTATTACAATATTGAATCAATTTACATGAAAAGTTAAATGGCTCTCCCAGAACTCA GATTTCTGGCAATGACCCAACCCATTTAGAAGGTGAACAAAAGAAGTAAATGGTACTGATTTGCCCTTTCTAGGACCCAAGATGTTACTT TAAAACCTAGCAAAAGAGGTCGTTTGTATTACGTGCCTAGTATTGAGCTGTTTCTGAGTCATTTGCTTCATAGTATCAGAAATTCTAAAT TGCTTTTAGTTTAGAAGATCTTTATTTATTATCTTCATTATTAACAACTTATTATGATGATGATTATTATCATTCTATTTATAATGGCCT TTGCTGGTTGAGTAAAGACTGAGATAACACATGTGAATCACCTTTCTAATGGGTTTTTAAAATCTTGTCACTTTCCAAAAGAGTTTTTTT GTTTCTTTTTTTTTTTTTTTTTTTTTGACAGAGTCTGCCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCACTCTCGGCTCACTGCAGCCT CCCCCTCCTGGGTTCAAGTGATTGTTCTGCCTCAGCCTCCCAAATAGCAGGGATTACAGGCACCCACGACCATACCCGGATAATTTTTGT ATTTTTAGTATAGACGGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTTGGCCTCCCAAAG AGCTGGGATTACAGGCATGAACCACAGCGCCCAGCCCCCAGAAGAGTTTTTAAAAGGTGTTAAAGGAGGTTTATGCACGTAACAGACCTT TCTCAGGTGGTCCCCTAAAAAAAATCCTGCCAACTAGGGAGGGGAAGTCCAACCTGCTATTTGAAAGCCTTCACGGTTTGCCAAATGTAC ATTTCTTGAGAATTATCTTCTTTCCCAGGGATATTGTACCTAGAGGACAGGTTGGTTAGGGAACTATGGACGACCAGAAGAGATGTTCTT TTGAAGCATTCTTACTGGATAAAGTAACCCCATGGTATCATTACTTTCTACAAGTTTTTTACTTACAAATTTGCCATTTTTTTAACTGAT ATTTTCTAAATGCTCATTCTGTCTATGTAGCCGGGGGGAGATTATATACAAGTTTTAAAACTTCTTTGTGATAGTGTATTGTGCTCTGGG GTCTATTCAAAATTTGGTGTTTGAGGTTTTGTTAATTTGATTGCCTGGAGATCTGCTAAAATCCTAGAATCTCAAAAAGCCAAGTTTGAA GCCACTGAGAGCAAACAATGAGGTCATTGTTAGCCTGGTTCCACACTCCTGAGGACTTGGCTGTTCTTTTTCACCTTATTATGTTCTAAT GGAAGTAAAAACCCTCATAGTGAAGAAGAGCAGTATATACACCAGACTAGTGTATAGGAACTTCTTCATTAAATATTGCAGTCCTTATGA GTGCTCTTTATTGTTGCTGTTCTGGACAGGTACAAATCTTCTGAAGCAACTTCTGTGGGATGTTAACTTAGCTTCTCTAACACCTAAAAA AATTCTTCTTTGTATTTTCAGCTAATAGAAGACAGTTCTTCTTCATCTTGACACCTAGAGCCCTCTATGTGATTCACAGAGGACTTAAAA TACTTCTTACTCTGTTGAAGTGTTTAATTGTACAGAATATATGTACTCTACAGTATATGTGAATCAGCACTCAAAGCAGAGAAGTGATAA CATCCCAAGCTTCCCCCATACTTCTACTGACATGCCCTCAGTCTTTAAGAAAACTCAGTACAGACCTGATGTTCTGGTTGTACCTGAACT TAATTGGAGAAACAAACGCAATTAAAATACGAATTTTTTAGTGCAAATCAAATGTCTTTCACCATCTGAAGCCCACTAATTTGTCTTTTA TATATAGTTAATTTTTTGCCAGTTACAACGTCCATAGAACCCCAAGATTTAGAATGTATCATTTATATTTCCTCTAAAAGGTAGTAAGAT ATTTCTTCTGCTGTTTTGTGAAGCCACTCTTCTACAGTATCTGTAGCCTTATAGCAAATTAATTGGTTGTACTAAAAATTTTAGAGACTG CATAGGTCTCCCTTTTCTATCCTAATTACCTGCAATAGCCTAGAGACGCTGAGCATGATTACATTAGCAACTTGACTGTTTAAAAAATTT GTTATACTTGATAATGACCAGACTGTGTGCTGGAGTCATTTGTTTCCTTCTTTTCTGCTCCCCGAATACACTATTTAATTTGGTTACTTT TATTTTTAAACTATATGGCACCCTTTTAAATAAACATTCATTGCTAATTAAAATCTGCCAATAAATTGGTCTCAGCATTTAAATACCATA TATTTTATAACTCATACTGTGGCTATCAAACAGAAGTTAACACAGTAGGGGTAAAGATATACATAATGTGTACCTATAGGTGTATTTATA ATGCCTGTGTGCAGTATACAGACATAATTACAAAATACTGCATTTTATTAATGTTTATTTTAATATTGAGAATTGGCATTCTTGTAAATT GAACTGACAATTGCTTCTATTCAGTACACTTTATTTTGAGCAGATATTTCCGAAAAGAGAAAAAATCACTGTTGACATGCTTTTTAAAAC TGTTTTCACCTGTATTTTGTCTTTCAAAAAGAAAAGTGATCTAAGTTGGCATTGTAAAGAAATTGTTAGCAAAGAATATTTTTTTTTATT TTTTCTTTTGGTAGAAAGTCATGTTAATAGTACAACAAAGAATCAAAGAATAAAACATAATGTTTAAGAACATTATTTATAAGTAGTCAT TGTCTTTGTGCTTTAAATGTTTCCCTTTTACCTTAGAGTTATTTTTTAAAAGTTGAAAGTACTTTAAAAATTGGTTTAAATGAGTACCCA TTGACAATTATCATTTAATAGTGCAGTTAAGTTCAGCGAAAAATTTCAATATCTCAAAAAAATTAGAGAAAAATATTGGTAAATGTATTT GATTCACAAATGTATTCATAGCCGATTGTGAGCTGCTCTACCACATTTTCCTGTTTTTATTGTTTCTGTGAAGCTTGATTAGACTAACTT GCTTAAGGTCTCTTTCCCCTCAAGGATTCTGTGATTCTAATGTAACAAGGTACACACGCTCTCTCTGACCACTTAAAGTATCAGAGTTCA AATCTGTTACAATCACTCCATTTCCTTTTGGAAAGTTGTGCCTCTCATAAAGCTGCTTGGACATTTTAAGTGTTTTGTAATATGCATTGA |
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FusionGenePPI for CES2_GPATCH2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CES2 | APP | GPATCH2 | CSNK2A2, PICK1, XPO1, EGFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CES2_GPATCH2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CES2_GPATCH2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CES2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CES2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Hgene | CES2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
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