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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6873

FusionGeneSummary for CERS6_SPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CERS6_SPP1
Fusion gene ID: 6873
HgeneTgene
Gene symbol

CERS6

SPP1

Gene ID

253782

30827

Gene nameceramide synthase 6CXXC finger protein 1
SynonymsCERS5|LASS62410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBP
Cytomap

2q24.3

18q21.1

Type of geneprotein-codingprotein-coding
Descriptionceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6CXXC-type zinc finger protein 1CXXC finger 1 (PHD domain)CpG binding proteinDNA-binding protein with PHD finger and CXXC domainPHD finger and CXXC domain-containing protein 1cpG-binding proteinzinc finger, CpG binding-type containing 1
Modification date2018052320180523
UniProtAcc

Q6ZMG9

P10451

Ensembl transtripts involved in fusion geneENST00000305747, ENST00000392687, 
ENST00000237623, ENST00000395080, 
ENST00000360804, ENST00000509659, 
Fusion gene scores* DoF score6 X 5 X 3=902 X 2 X 1=4
# samples 62
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: CERS6 [Title/Abstract] AND SPP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPP1

GO:0006355

regulation of transcription, DNA-templated

10688657

TgeneSPP1

GO:0045893

positive regulation of transcription, DNA-templated

10688657

TgeneSPP1

GO:0051568

histone H3-K4 methylation

17355966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE815041CERS6chr2

169630062

-SPP1chr4

88904333

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000305747ENST00000237623CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-3UTRENST00000305747ENST00000395080CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-intronENST00000305747ENST00000360804CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-3UTRENST00000305747ENST00000509659CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-3UTRENST00000392687ENST00000237623CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-3UTRENST00000392687ENST00000395080CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-intronENST00000392687ENST00000360804CERS6chr2

169630062

-SPP1chr4

88904333

+
3UTR-3UTRENST00000392687ENST00000509659CERS6chr2

169630062

-SPP1chr4

88904333

+

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FusionProtFeatures for CERS6_SPP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CERS6

Q6ZMG9

SPP1

P10451

May be involved in sphingolipid synthesis or itsregulation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CERS6_SPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CERS6_SPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CERS6_SPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CERS6_SPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCERS6C0236969Substance-Related Disorders1CTD_human
TgeneSPP1C0001418Adenocarcinoma2CTD_human
TgeneSPP1C0003949Asbestosis2CTD_human
TgeneSPP1C0006663Calcinosis2CTD_human
TgeneSPP1C0022650Kidney Calculi2CTD_human
TgeneSPP1C0024121Lung Neoplasms2CTD_human
TgeneSPP1C0025500Mesothelioma2CTD_human
TgeneSPP1C1458155Mammary Neoplasms2CTD_human
TgeneSPP1C2609414Acute kidney injury2CTD_human
TgeneSPP1C0006118Brain Neoplasms1CTD_human
TgeneSPP1C0017638Glioma1CTD_human
TgeneSPP1C0017668Focal glomerulosclerosis1CTD_human
TgeneSPP1C0018799Heart Diseases1CTD_human
TgeneSPP1C0018824Heart valve disease1CTD_human
TgeneSPP1C0020517Hypersensitivity1CTD_human
TgeneSPP1C0022658Kidney Diseases1CTD_human
TgeneSPP1C0023890Liver Cirrhosis1CTD_human
TgeneSPP1C0023896Alcoholic Liver Diseases1CTD_human
TgeneSPP1C0023904Liver Neoplasms, Experimental1CTD_human
TgeneSPP1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSPP1C0027627Neoplasm Metastasis1CTD_human
TgeneSPP1C0027659Neoplasms, Experimental1CTD_human
TgeneSPP1C0030286Pancreatic Diseases1CTD_human
TgeneSPP1C0032229Pleural Neoplasms1CTD_human
TgeneSPP1C0032285Pneumonia1CTD_human
TgeneSPP1C0033687Proteinuria1CTD_human
TgeneSPP1C0034069Pulmonary Fibrosis1CTD_human
TgeneSPP1C0041755Adverse reaction to drug1CTD_human
TgeneSPP1C0041948Uremia1CTD_human
TgeneSPP1C0162820Dermatitis, Allergic Contact1CTD_human
TgeneSPP1C0221204Lytic lesion1CTD_human
TgeneSPP1C0270612Leukoencephalopathies1CTD_human
TgeneSPP1C0853897Diabetic Cardiomyopathies1CTD_human
TgeneSPP1C2937358Cerebral Hemorrhage1CTD_human
TgeneSPP1C4277682Chemical and Drug Induced Liver Injury1CTD_human