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Fusion gene ID: 6872 |
FusionGeneSummary for CERS6_QSER1 |
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Fusion gene information | Fusion gene name: CERS6_QSER1 | Fusion gene ID: 6872 | Hgene | Tgene | Gene symbol | CERS6 | QSER1 | Gene ID | 253782 | 79832 |
Gene name | ceramide synthase 6 | glutamine and serine rich 1 | |
Synonyms | CERS5|LASS6 | - | |
Cytomap | 2q24.3 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | ceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6 | glutamine and serine-rich protein 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6ZMG9 | Q2KHR3 | |
Ensembl transtripts involved in fusion gene | ENST00000305747, ENST00000392687, | ENST00000399302, ENST00000527250, ENST00000527788, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 4 X 5 X 3=60 |
# samples | 6 | 5 | |
** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CERS6 [Title/Abstract] AND QSER1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE085594 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000305747 | ENST00000399302 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
intron-intron | ENST00000305747 | ENST00000527250 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
intron-intron | ENST00000305747 | ENST00000527788 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
intron-intron | ENST00000392687 | ENST00000399302 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
intron-intron | ENST00000392687 | ENST00000527250 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
intron-intron | ENST00000392687 | ENST00000527788 | CERS6 | chr2 | 169406305 | - | QSER1 | chr11 | 32926552 | + |
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FusionProtFeatures for CERS6_QSER1 |
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Hgene | Tgene |
CERS6 | QSER1 |
May be involved in sphingolipid synthesis or itsregulation. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CERS6_QSER1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CERS6_QSER1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CERS6_QSER1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CERS6_QSER1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CERS6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |