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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6847

FusionGeneSummary for CEP95_RBM11

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP95_RBM11
Fusion gene ID: 6847
HgeneTgene
Gene symbol

CEP95

RBM11

Gene ID

90799

54033

Gene namecentrosomal protein 95RNA binding motif protein 11
SynonymsCCDC45-
Cytomap

17q23.3

21q11.2

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 95 kDacentrosomal protein 95kDacoiled-coil domain containing 45coiled-coil domain-containing protein 45splicing regulator RBM11putative RNA-binding protein 11
Modification date2018051920180523
UniProtAcc

Q96GE4

P57052

Ensembl transtripts involved in fusion geneENST00000556440, ENST00000553412, 
ENST00000581056, ENST00000577476, 
ENST00000468643, ENST00000400577, 
Fusion gene scores* DoF score5 X 5 X 2=503 X 2 X 3=18
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CEP95 [Title/Abstract] AND RBM11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBM11

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

21984414

TgeneRBM11

GO:0034599

cellular response to oxidative stress

21984414


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A250-01ACEP95chr17

62503234

+RBM11chr21

15593418

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000556440ENST00000468643CEP95chr17

62503234

+RBM11chr21

15593418

+
5CDS-3UTRENST00000556440ENST00000400577CEP95chr17

62503234

+RBM11chr21

15593418

+
5UTR-3UTRENST00000553412ENST00000468643CEP95chr17

62503234

+RBM11chr21

15593418

+
5UTR-3UTRENST00000553412ENST00000400577CEP95chr17

62503234

+RBM11chr21

15593418

+
5CDS-3UTRENST00000581056ENST00000468643CEP95chr17

62503234

+RBM11chr21

15593418

+
5CDS-3UTRENST00000581056ENST00000400577CEP95chr17

62503234

+RBM11chr21

15593418

+
intron-3UTRENST00000577476ENST00000468643CEP95chr17

62503234

+RBM11chr21

15593418

+
intron-3UTRENST00000577476ENST00000400577CEP95chr17

62503234

+RBM11chr21

15593418

+

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FusionProtFeatures for CEP95_RBM11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP95

Q96GE4

RBM11

P57052

Tissue-specific splicing factor with potentialimplication in the regulation of alternative splicing duringneuron and germ cell differentiation. Antagonizes SRSF1-mediatedBCL-X splicing. May affect the choice of alternative 5' splicesites by binding to specific sequences in exons and antagonizingthe SR protein SRSF1. {ECO:0000269|PubMed:21984414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CEP95_RBM11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CEP95_RBM11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CEP95YWHAE, YWHAG, LSM3, MTUS2, FAM9B, SPERT, MOV10, NXF1, C1orf111, LTBR, CLK1, PCM1, CEP120, SPICE1, CEP128, CEP135, NINL, CAV3RBM11RHOXF2, PCBP1, LYN, GABPB1, SNRPC, QKI, ZNF774, SF3B2, SKIV2L2, USP7, SLC4A1AP, ZCCHC8, TTC33, APP, MED4, DAZAP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEP95_RBM11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEP95_RBM11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource