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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6832

FusionGeneSummary for CEP70_TNFSF10

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP70_TNFSF10
Fusion gene ID: 6832
HgeneTgene
Gene symbol

CEP70

TNFSF10

Gene ID

80321

8743

Gene namecentrosomal protein 70TNF superfamily member 10
SynonymsBITEAPO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL
Cytomap

3q22.3

3q26.31

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 70 kDacentrosomal protein 70kDap10-binding proteintesticular tissue protein Li 36tumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superf
Modification date2018052220180522
UniProtAcc

Q8NHQ1

P50591

Ensembl transtripts involved in fusion geneENST00000264982, ENST00000542237, 
ENST00000489254, ENST00000484888, 
ENST00000481834, ENST00000478673, 
ENST00000464035, 
ENST00000241261, 
ENST00000420541, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 4 X 4=80
# samples 66
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP70 [Title/Abstract] AND TNFSF10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNFSF10

GO:0043065

positive regulation of apoptotic process

21525171

TgeneTNFSF10

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

21459798|21525171|22266862

TgeneTNFSF10

GO:0090200

positive regulation of release of cytochrome c from mitochondria

22266862

TgeneTNFSF10

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

20097879|21525171|22266862


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9O5-06ACEP70chr3

138216873

-TNFSF10chr3

172227111

-
TCGARVPRADTCGA-V1-A9O5-01ACEP70chr3

138216873

-TNFSF10chr3

172227111

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264982ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000264982ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
In-frameENST00000542237ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000542237ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
In-frameENST00000489254ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000489254ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
Frame-shitENST00000484888ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000484888ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-3CDSENST00000481834ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-intronENST00000481834ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-3CDSENST00000478673ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-intronENST00000478673ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-3CDSENST00000464035ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-intronENST00000464035ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-

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FusionProtFeatures for CEP70_TNFSF10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP70

Q8NHQ1

TNFSF10

P50591

Cytokine that binds to TNFRSF10A/TRAILR1,TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 andpossibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).Induces apoptosis. Its activity may be modulated by binding to thedecoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 andTNFRSF11B/OPG that cannot induce apoptosis.{ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP70chr3:138216873chr3:172227111ENST00000264982-1718254_326577598Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000264982-171875_179577598Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000484888-1718254_326577598Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000484888-171875_179577598Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000542237-1617254_326557578Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000542237-161775_179557578Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000264982-1718483_516577598RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000484888-1718483_516577598RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000542237-1617483_516557578RepeatNote=TPR
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000420541-031_17-31102Topological domainCytoplasmic
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000420541-0339_281-31102Topological domainExtracellular
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000420541-0318_38-31102TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP70chr3:138216873chr3:172227111ENST00000464035-16254_326-54213Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000464035-1675_179-54213Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000481834-116254_326-53555Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000481834-11675_179-53555Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000464035-16483_516-54213RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000481834-116483_516-53555RepeatNote=TPR
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000241261-251_17104282Topological domainCytoplasmic
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000241261-2539_281104282Topological domainExtracellular
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000241261-2518_38104282TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for CEP70_TNFSF10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CEP70_ENST00000264982_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_177aa
KSNKIFLP__EKEVLRE_QLT_LGPEEEATHCLLQTPRMKRLWAAK_TPGNHQGVGIHS_ATCT_GMVNWSSMKKGFTTSIPKHTFDFRR

>In-frame_CEP70_ENST00000542237_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_177aa
KSNKIFLP__EKEVLRE_QLT_LGPEEEATHCLLQTPRMKRLWAAK_TPGNHQGVGIHS_ATCT_GMVNWSSMKKGFTTSIPKHTFDFRR

>In-frame_CEP70_ENST00000489254_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_177aa
KSNKIFLP__EKEVLRE_QLT_LGPEEEATHCLLQTPRMKRLWAAK_TPGNHQGVGIHS_ATCT_GMVNWSSMKKGFTTSIPKHTFDFRR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CEP70_ENST00000264982_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_533nt
AAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACA
CATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGA
GCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGG
AAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAA
GTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACA

>In-frame_CEP70_ENST00000542237_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_533nt
AAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACA
CATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGA
GCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGG
AAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAA
GTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACA

>In-frame_CEP70_ENST00000489254_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_533nt
AAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACA
CATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGA
GCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGG
AAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAA
GTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CEP70_ENST00000264982_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_3516nt
ATTCGCAGGCCAAAGAGGGGCTGGCCCTCGACGCGCTCGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGG
CCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACA
TGAGACTCGTTGGGTGATCATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGTAACTATG
TTTCCGGTAGCCCCTAAACCCCAGGATTCCAGTCAACCATCAGACAGACTCATGACTGAAAAACAGCAGGAAGAAGCAGAATGGGAAAGC
ATAAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAG
TCATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAAT
CAACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGT
GTGAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAG
AAAACTTTACAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGA
TTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGA
CAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAA
GAAGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCT
AAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAG
CAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAA
GATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAAT
CCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCAT
CTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTA
CCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTT
GAAAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCT
TTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAA
TTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATG
CAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAAT
GATCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGG
ACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGG
AGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACA
TACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGAC
CCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTT
GAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTT
TTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAA
AAATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATTCTACA
ACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTA
GCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAG
AAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAG
AGAAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAACCCAAGGTGGGTAGAT
CACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCAC
ATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCA
CTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAA
AATTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACTCACTTGTTTCATAATATCAAGATT
ACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTA

>In-frame_CEP70_ENST00000542237_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_3334nt
AGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGAT
CATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGCAGGAAGAAGCAGAATGGGAAAGCAT
AAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAGTC
ATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAATCA
ACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGTGT
GAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAGAA
AACTTTACAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATT
AAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACA
GTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGA
AGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAA
GATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCA
GGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGA
TGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCC
AAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCT
TGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACC
TTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGA
AAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTT
AAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATT
AGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCA
GGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGA
TCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGAC
CAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAG
TGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATA
CTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCC
TATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGA
GCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTT
AGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAAAA
ATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATTCTACAAC
ACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTAGC
AGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAGAA
GAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAG
AAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAACCCAAGGTGGGTAGATCA
CGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCACAT
GCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACT
ACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAA
TTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACTCACTTGTTTCATAATATCAAGATTAC
TAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTAAT

>In-frame_CEP70_ENST00000489254_chr3_138216873_-_TNFSF10_ENST00000241261_chr3_172227111_-_3009nt
CGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGGCCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCT
GGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGATCATTTCATTGAGATCAACC
TGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAA
ACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTG
TGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAA
AGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATG
TCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGG
CCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATT
AATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAG
GTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAAT
AAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTAT
AAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTG
TTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTT
TCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAAC
AATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGG
CTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAG
GAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGA
GGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTG
GGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCAT
GAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTC
CAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATAT
GGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGAC
ATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGT
TTTCAGGATGATACACTATGAAGATGTTTCAAAAAATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATC
TGAGTAGAGCAGCCACAACCAAAAAATTCTACAACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGA
TCTTTCAGGACTCTACCTCATATCAGTTTGCTAGCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCT
GTCTTTATAATCTACTCCTTGTAAAGACTGTAGAAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTT
TCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAGAAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAA
TCCCAACATTTTGGGAACCCAAGGTGGGTAGATCACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACT
GAAAGTACAAAAATTAGCTGGGTGTGTTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGG
AGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAA
ACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAATTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGT
TTTAGTACTCACTTGTTTCATAATATCAAGATTACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATAT


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FusionGenePPI for CEP70_TNFSF10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CEP70MCM10, KAT7, RCOR3, UTP14A, NKAP, ZNF408, ZNF426, TRIM29, NRIP1, CCDC85B, KANSL1, ENKD1, ZBTB16, TCEB3B, ZBTB8A, ATXN7, MRPL44, C7orf25, CDC73, TAF1D, MEST, PLA2G2A, DAZAP2, SERPINH1, FAM118B, PAM16, SUV39H2, DNAJB11, STMN2, SRGN, C8orf33, COIL, ZNF136, C1orf35, PPFIA1, KDM1A, IQCE, TUBA3C, HNRNPU, HSPA5, ATP5O, BARD1, BYSL, DDX6, EMD, EMP1, ERCC3, GPX7, HSPD1, IK, KRT31, MFAP1, NOP2, PSMA1, RPL13, SMARCE1, SNRPD2, SUV39H1, TCEB3, TEAD4, ZNF148, ZNF227, ZNF239, AKAP17A, PPIG, ZSCAN12, ZBTB24, SSX3, STK25, LAMTOR5, SLU7, ZNF266, BRMS1, NIPSNAP3A, KANK2, PPP1R16B, PRPF31, DIEXF, ABT1, ARHGEF3, UTP11L, NUSAP1, DDX41, SYT17, FAM64A, ZCCHC10, GPATCH4, SETD5, C11orf57, CDCA7L, GPATCH2L, CCDC94, ZNF302, LIN37, GATAD2B, ZNF490, TSHZ3, ZNF410, SH2D4A, CARD9, METTL17, NOL12, LENG1, GCC1, ZNF329, PRKRIP1, FAM214B, CEP70, CLPB, TTC25, FAM161A, ZGPAT, BEX2, ZNF587, ZNF439, SYTL4, SYTL5, LENG8, HAUS1, SFR1, HMGB4, ZNF572, ZNF578, ZNF417, ZNF555, ZBTB49, ZNF366, TXLNB, ZNF169, ZFC3H1, FAM124A, CFAP53, FAM13C, TTLL10, TSGA10IP, CEP57L1, FAM133A, TRIM42, RHPN1, ZNF557, ZNF607, HDAC6, WT1TNFSF10ACP5, RBM48, TNFSF10, TNFRSF10D, TNFRSF10B, TNFRSF10A, CFLAR, CASP8, FADD, SOCS3, RIPK1, TNFAIP3, TRAF2, CASP3, ZDHHC17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CEP70_TNFSF10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CEP70_TNFSF10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNFSF10C0033578Prostatic Neoplasms4CTD_human
TgeneTNFSF10C0017638Glioma2CTD_human
TgeneTNFSF10C0027659Neoplasms, Experimental2CTD_human
TgeneTNFSF10C0027686Pathologic Neovascularization2CTD_human
TgeneTNFSF10C0000786Spontaneous abortion1CTD_human
TgeneTNFSF10C0007134Renal Cell Carcinoma1CTD_human
TgeneTNFSF10C0009375Colonic Neoplasms1CTD_human
TgeneTNFSF10C0009404Colorectal Neoplasms1CTD_human
TgeneTNFSF10C0014170Endometrial Neoplasms1CTD_human
TgeneTNFSF10C0017636Glioblastoma1CTD_human
TgeneTNFSF10C0021400Influenza1CTD_human
TgeneTNFSF10C0022665Kidney Neoplasm1CTD_human
TgeneTNFSF10C0023418leukemia1CTD_human
TgeneTNFSF10C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneTNFSF10C0023903Liver neoplasms1CTD_human
TgeneTNFSF10C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneTNFSF10C0027627Neoplasm Metastasis1CTD_human
TgeneTNFSF10C0027819Neuroblastoma1CTD_human
TgeneTNFSF10C0030297Pancreatic Neoplasm1CTD_human
TgeneTNFSF10C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneTNFSF10C0919267ovarian neoplasm1CTD_human
TgeneTNFSF10C1458155Mammary Neoplasms1CTD_human
TgeneTNFSF10C2239176Liver carcinoma1CTD_human