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Fusion gene ID: 6821 |
FusionGeneSummary for CEP44_PRLR |
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Fusion gene information | Fusion gene name: CEP44_PRLR | Fusion gene ID: 6821 | Hgene | Tgene | Gene symbol | CEP44 | PRLR | Gene ID | 80817 | 5618 |
Gene name | centrosomal protein 44 | prolactin receptor | |
Synonyms | KIAA1712|PS1TP3 | HPRL|MFAB|RI-PRLR|hPRLrI | |
Cytomap | 4q34.1 | 5p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | centrosomal protein of 44 kDaHBV PreS1-transactivated protein 3centrosomal protein 44kDa | prolactin receptorhPRL receptorsecreted prolactin binding protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9C0F1 | P16471 | |
Ensembl transtripts involved in fusion gene | ENST00000457424, ENST00000426172, ENST00000503780, ENST00000296519, | ENST00000342362, ENST00000382002, ENST00000231423, ENST00000513753, ENST00000397391, ENST00000348262, ENST00000542609, ENST00000310101, ENST00000511486, ENST00000509934, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 4=120 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CEP44 [Title/Abstract] AND PRLR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PRLR | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | 10585417 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG184506 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000457424 | ENST00000342362 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000382002 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000231423 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000513753 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000397391 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000348262 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000542609 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000310101 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000511486 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000457424 | ENST00000509934 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000342362 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000382002 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000231423 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000513753 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000397391 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000348262 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000542609 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000310101 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000511486 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000426172 | ENST00000509934 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000342362 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000382002 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000231423 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000513753 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000397391 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000348262 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000542609 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000310101 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000511486 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000503780 | ENST00000509934 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000342362 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000382002 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000231423 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000513753 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000397391 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000348262 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000542609 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000310101 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000511486 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
intron-intron | ENST00000296519 | ENST00000509934 | CEP44 | chr4 | 175223641 | - | PRLR | chr5 | 35195131 | + |
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FusionProtFeatures for CEP44_PRLR |
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Hgene | Tgene |
CEP44 | PRLR |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CEP44_PRLR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CEP44_PRLR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CEP44_PRLR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PRLR | P16471 | DB01185 | Fluoxymesterone | Prolactin receptor | small molecule | approved|illicit |
Tgene | PRLR | P16471 | DB00052 | Somatotropin | Prolactin receptor | biotech | approved|investigational |
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RelatedDiseases for CEP44_PRLR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PRLR | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | PRLR | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | PRLR | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | PRLR | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | PRLR | C0020514 | Hyperprolactinemia | 1 | HPO;ORPHANET;UNIPROT |
Tgene | PRLR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PRLR | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | PRLR | C3809918 | MULTIPLE FIBROADENOMAS OF THE BREAST | 1 | ORPHANET;UNIPROT |