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Fusion gene ID: 6793 |
FusionGeneSummary for CEP135_TRIM58 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CEP135_TRIM58 | Fusion gene ID: 6793 | Hgene | Tgene | Gene symbol | CEP135 | TRIM58 | Gene ID | 9662 | 25893 |
| Gene name | centrosomal protein 135 | tripartite motif containing 58 | |
| Synonyms | CEP4|KIAA0635|MCPH8 | BIA2 | |
| Cytomap | 4q12 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | centrosomal protein of 135 kDacentrosomal protein 135kDacentrosomal protein 4centrosome protein cep135 | E3 ubiquitin-protein ligase TRIM58RING-type E3 ubiquitin transferase TRIM58tripartite motif-containing protein 58 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q66GS9 | Q8NG06 | |
| Ensembl transtripts involved in fusion gene | ENST00000257287, ENST00000422247, | ENST00000366481, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 3 X 3=36 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CEP135 [Title/Abstract] AND TRIM58 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-ER-A197-06A | CEP135 | chr4 | 56847545 | + | TRIM58 | chr1 | 248023919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000257287 | ENST00000366481 | CEP135 | chr4 | 56847545 | + | TRIM58 | chr1 | 248023919 | + |
| intron-3CDS | ENST00000422247 | ENST00000366481 | CEP135 | chr4 | 56847545 | + | TRIM58 | chr1 | 248023919 | + |
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FusionProtFeatures for CEP135_TRIM58 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CEP135 | TRIM58 |
| Involved in early centrioleassembly/duplication/biogenesis/formation/. Required for centrioleelongation. Required for the recruitment of CEP295 to the proximalend of new-born centrioles at the centriolar microtubule wallduring early S phase in a PLK4-dependent manner.{ECO:0000269|PubMed:27185865}. Centrosomal protein involved in centriole biogenesis.Acts as a scaffolding protein during early centriole biogenesis.Required for the targeting of centriole satellite proteins tocentrosomes such as of PCM1, SSX2IP and CEP290 and recruitment ofWRAP73 to centrioles. Also required for centriole-centriolecohesion during interphase by acting as a platform protein forCEP250 at the centriole. Required for the recruitment of CEP295 tothe proximal end of new-born centrioles at the centriolarmicrotubule wall during early S phase in a PLK4-dependent manner.Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early Sphase in a PLK4-dependent manner (PubMed:27185865).{ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962,ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865}. | E3 ubiquitin ligase induced during late erythropoiesis.Directly binds and ubiquitinates the intermediate chain of themicrotubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating thedegradation of the dynein holoprotein complex. May participate inthe erythroblast enucleation process through regulation of nuclearpolarization. {ECO:0000269|PubMed:25241935}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CEP135 | chr4:56847545 | chr1:248023919 | ENST00000257287 | + | 13 | 26 | 195_420 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CEP135 | chr4:56847545 | chr1:248023919 | ENST00000257287 | + | 13 | 26 | 71_152 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TRIM58 | chr4:56847545 | chr1:248023919 | ENST00000366481 | + | 0 | 6 | 193_242 | 140 | 487 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >TRIM58 | chr4:56847545 | chr1:248023919 | ENST00000366481 | + | 0 | 6 | 273_463 | 140 | 487 | Domain | B30.2/SPRY |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CEP135 | chr4:56847545 | chr1:248023919 | ENST00000257287 | + | 13 | 26 | 1069_1116 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr1:248023919 | ENST00000257287 | + | 13 | 26 | 447_1039 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr1:248023919 | ENST00000422247 | + | 1 | 6 | 1069_1116 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr1:248023919 | ENST00000422247 | + | 1 | 6 | 195_420 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr1:248023919 | ENST00000422247 | + | 1 | 6 | 447_1039 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr1:248023919 | ENST00000422247 | + | 1 | 6 | 71_152 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TRIM58 | chr4:56847545 | chr1:248023919 | ENST00000366481 | + | 0 | 6 | 16_61 | 140 | 487 | Zinc finger | RING-type |
| Tgene | TRIM58 | chr4:56847545 | chr1:248023919 | ENST00000366481 | + | 0 | 6 | 91_132 | 140 | 487 | Zinc finger | B box-type |
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FusionGeneSequence for CEP135_TRIM58 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CEP135_ENST00000257287_chr4_56847545_+_TRIM58_ENST00000366481_chr1_248023919_+_940aa MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELM KLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLI AHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGI EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEM QRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAE NIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAE WGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CEP135_ENST00000257287_chr4_56847545_+_TRIM58_ENST00000366481_chr1_248023919_+_2820nt ATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCTGGGATACCGCCAGACTCTGACAGTGGAGTGTTTA CCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCAATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAA AGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAGTAGAGAAAATAATGAATTATACCTAGAGTTAATG AAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAAATGTGCACGTGAAACAGCTGATCTGAAATTTCTG AATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAATGAAAGAATTCAACAACTTCAAGAAAAGAATTTG CATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCAGCGTATGCAAATTGATGAACCGGTTCCTCCCTCT GAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCTTCAAGTGGCTGATAACAGGATTCAAGAACTTCAA CAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGACTATAGCAAGCAGATTGAGCTAAGAGAACGAGAG ATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCTGGAGTCTAGAAATAAAACCAATGAAAAGCTTATT GCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAAGCGTATACGAGAGCTTATGGAAACCAAGGAAACA GTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATTAACTGAAATAGATCAGTTAGCACAGCAGTTGGAA AGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAAAGAGATTAAAAGAAAGCTCTCTGAAATGCAGGAT CTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAAGGAGAGACTGAGTGATGAACTCCTTGTAAAATCA GACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAAAGTTGAAAGTTTTGCAGTTACAGAACGACAACTT ACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTCACCTTCTCGTTTAGATACATTTCTGAAAGGTATA GAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACAGCGAAGATCTTGCTCTACAAGTTATAGCGCACGT GAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCATCAGATCACAAGAGAAAGAGATGAACTTCAGCGT ATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATTGACAGCAGAAAGAGATAAACTAAGTGTCTTATAT AATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGCACCCCATAATATTGTTAGTCTTATGGAAAAGGAA AAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAGAGAAAAATTAGAGGTAAAGCTCCAGATGGCTCTG GAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAGAAAGTGGAAATG CAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGGCTGGAGGCGGAG GAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCGGATGAGCTGCAG GAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGGCTGGAAGCAGAG AACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTAAAGCTGGATCCC GCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCCAACAACCCTGAG CGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGAGAAGGAGCAGAG TGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCCCTGTGGCTGCTG AAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATTTTCTTGGACTAT GAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTTCTTCGGCCTTAC TTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGATCATTTAGATCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CEP135_ENST00000257287_chr4_56847545_+_TRIM58_ENST00000366481_chr1_248023919_+_4660nt GACGGAAGGAGCTAGTGGGGGACTCGAGGCCTGAGGGCAATGCGGCTGGAGGCGGAGGCAACGGCGGCTGGAGCTGCCGGACTTTAATTT TTGGAAGTGAATAAAACTTGTTTTAGAAGACGAGATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCT GGGATACCGCCAGACTCTGACAGTGGAGTGTTTACCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCA ATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAAAGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAG TAGAGAAAATAATGAATTATACCTAGAGTTAATGAAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAA ATGTGCACGTGAAACAGCTGATCTGAAATTTCTGAATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAA TGAAAGAATTCAACAACTTCAAGAAAAGAATTTGCATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCA GCGTATGCAAATTGATGAACCGGTTCCTCCCTCTGAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCT TCAAGTGGCTGATAACAGGATTCAAGAACTTCAACAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGA CTATAGCAAGCAGATTGAGCTAAGAGAACGAGAGATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCT GGAGTCTAGAAATAAAACCAATGAAAAGCTTATTGCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAA GCGTATACGAGAGCTTATGGAAACCAAGGAAACAGTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATT AACTGAAATAGATCAGTTAGCACAGCAGTTGGAAAGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAA AGAGATTAAAAGAAAGCTCTCTGAAATGCAGGATCTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAA GGAGAGACTGAGTGATGAACTCCTTGTAAAATCAGACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAA AGTTGAAAGTTTTGCAGTTACAGAACGACAACTTACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTC ACCTTCTCGTTTAGATACATTTCTGAAAGGTATAGAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACA GCGAAGATCTTGCTCTACAAGTTATAGCGCACGTGAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCA TCAGATCACAAGAGAAAGAGATGAACTTCAGCGTATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATT GACAGCAGAAAGAGATAAACTAAGTGTCTTATATAATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGC ACCCCATAATATTGTTAGTCTTATGGAAAAGGAAAAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAG AGAAAAATTAGAGGTAAAGCTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAA AAAGACTGTCATTTGGAAGGAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGA GGAGCAACGGCAGCTGAGGCGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAG CAAGGCCCTGAAGGAGCTGGCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAG CAGAAGTAAGGCTGTCACAAGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTT AAGGAAGTTCCAAGTGGATGTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGG AGAACCATGGAGGGATGTCCCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCA TTACTGGGAGGTTCTGGTGGGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATC TCCTGAGAATGGGGTCTGGGCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGA AAGTCCTCGCTGCATTGGGATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATT CAACCAACTCTTCTCTGGTCTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTC AGGAAATTGGGCATCCAGGGATCATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGTTCCCAAGATGCAGTCCTA GCGTAGCGAACGTTCCTGGAGTGGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGTCAGCACTTGATTCGTTGT TGCTGTGAAATATGTCCATGGGACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATAATAATTTTGTAAATGGAG CAATCTCAACCTCTATTTCTAGATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATAAGGATTTCTATGCATTCA TTATAATTTGTTATTCCTTTCAATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCTTAAATTGATTCAGAATGG TCTGATACTATTCCAGTATCACCTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCTCCTTCCCCGCTCTGTCTC TCTCTCCCTGTCACTCTCTCTCTCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCTTCCTTCTGGATTAATACA TTTAGAGCCATTCCTTTATATGGTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTCTGAGACTAATTTTTAAGA ATTACAAAGCTCATTCTTCTGAATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTTTAAGTAGGAATTTATCAG AATTTTCATTCAACTCGTTCTTTAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGC ACTTTGGGAGGCTGAGGCGGGTGGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAAAA AAAAAAAAATAGAAAAATTAGCTGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGACAGGAGAATTGCTTGAACC CTGGAGGCGGAGGTTGCAGTGAGCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAAAAAGAAAAAAGACCTCAA ACAACACTTCTCTCTCTCTTTTAGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTGTGTTATGGTAAATATTTA AGGTCATATTTGATATTGCTGGTTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAATCATGATAATATTTAACTT ATTTTTAAAGTATATTCTGTACCTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTCTTTGTATCACTGTCTTCT AAATAATTATTATGTCTGGGTACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAGGAGAT TGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGGTGGTGGGTGCCTGTTGTC CCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGC |
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FusionGenePPI for CEP135_TRIM58 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CEP135 | WRAP73, STK24, NCOA5, SMAD9, CBX6, CARD9, C17orf59, MED4, CEP128, CEP162, XKR4, AIMP1, MAPRE1, SPATA5, SREK1, SREK1IP1, ZMAT2, SPICE1, ADSL, ALDH3A2, ALMS1, ARHGAP21, ATP6V1B1, CEP131, PROSER3, C2CD3, CAMSAP1, CC2D1A, CCDC138, CCDC14, CCDC18, CCDC66, CCDC77, CCP110, CDK4, CEP120, CEP152, CEP170, CEP192, CEP350, CEP44, CEP55, CEP72, CEP85, CEP95, CEP97, COMMD3-BMI1, CSNK1A1, CSPP1, CTNND1, CTSV, CYLD, DHX35, DLG5, DVL1, DVL2, DVL3, ECH1, ERC1, FAM83B, FAM83H, FGFR1OP, FOPNL, GEN1, GLUD2, GPATCH1, GRIP1, GTPBP1, GYS1, HAUS1, HAUS3, HAUS4, HAUS6, HAUS7, HAUS8, IBTK, IFT74, ISOC1, KEAP1, KIAA0753, KIAA1671, KIF14, KIF7, LMO7, ERVK3-1, LRRC49, LUZP1, LZTS2, MAGED1, MAP7D3, MCTS1, MIIP, MPHOSPH9, MTPN, NAV1, NBR1, NCKAP5L, NDE1, NDEL1, NEDD1, NME7, NUP155, OFD1, PAFAH1B1, PCM1, PIBF1, PLEKHG1, PLK1, PRKCI, PRRC2B, RAB8A, RCOR1, RTTN, SDCCAG3, SEC23IP, SIPA1L1, SIPA1L2, SIPA1L3, SPATA2, SPATA24, SPATA2L, SQSTM1, SRP72, SRPK1, SSX2IP, SYNM, TBC1D19, TBK1, TCHP, TEX9, TJP1, TJP2, TMEM160, TMEM209, TNIP1, TNRC6A, TNRC6B, TP53, TP53BP2, TPGS1, TRIP6, TTK, TXLNA, TXLNG, USP54, TBC1D31, WDR83, XRN1, YTHDF1, YWHAH, ODF2, LZTS3, GOLGB1, PLD1, TRIM27, TTLL5, MIB1, KIAA1328, ELMO2, CEP290, CEP295, WDR90, HNRNPCL1, CCDC61, CDC14A, TXLNB, MIS18A | TRIM58 | DYNC1H1, DYNC1I1, DYNC2LI1, DYNC1LI2, TRIM58, UBE2D3, FBXW7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CEP135_TRIM58 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CEP135_TRIM58 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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