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Fusion gene ID: 6792 |
FusionGeneSummary for CEP135_POLR2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CEP135_POLR2B | Fusion gene ID: 6792 | Hgene | Tgene | Gene symbol | CEP135 | POLR2B | Gene ID | 9662 | 5431 |
| Gene name | centrosomal protein 135 | RNA polymerase II subunit B | |
| Synonyms | CEP4|KIAA0635|MCPH8 | POL2RB|RPB2|hRPB140 | |
| Cytomap | 4q12 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | centrosomal protein of 135 kDacentrosomal protein 135kDacentrosomal protein 4centrosome protein cep135 | DNA-directed RNA polymerase II subunit RPB2DNA-directed RNA polymerase II 140 kDa polypeptideDNA-directed RNA polymerase II subunit BRNA polymerase II second largest subunitRNA polymerase II subunit 2RNA polymerase II subunit B2polymerase (RNA) II ( | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q66GS9 | P30876 | |
| Ensembl transtripts involved in fusion gene | ENST00000257287, ENST00000422247, | ENST00000381227, ENST00000431623, ENST00000441246, ENST00000314595, ENST00000510355, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CEP135 [Title/Abstract] AND POLR2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POLR2B | GO:0006366 | transcription by RNA polymerase II | 9852112 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-S9-A89Z-01A | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000257287 | ENST00000381227 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| In-frame | ENST00000257287 | ENST00000431623 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| In-frame | ENST00000257287 | ENST00000441246 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| In-frame | ENST00000257287 | ENST00000314595 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| 5CDS-intron | ENST00000257287 | ENST00000510355 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| intron-3CDS | ENST00000422247 | ENST00000381227 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| intron-3CDS | ENST00000422247 | ENST00000431623 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| intron-3CDS | ENST00000422247 | ENST00000441246 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| intron-3CDS | ENST00000422247 | ENST00000314595 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
| intron-intron | ENST00000422247 | ENST00000510355 | CEP135 | chr4 | 56847545 | + | POLR2B | chr4 | 57865783 | + |
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FusionProtFeatures for CEP135_POLR2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CEP135 | POLR2B |
| Involved in early centrioleassembly/duplication/biogenesis/formation/. Required for centrioleelongation. Required for the recruitment of CEP295 to the proximalend of new-born centrioles at the centriolar microtubule wallduring early S phase in a PLK4-dependent manner.{ECO:0000269|PubMed:27185865}. Centrosomal protein involved in centriole biogenesis.Acts as a scaffolding protein during early centriole biogenesis.Required for the targeting of centriole satellite proteins tocentrosomes such as of PCM1, SSX2IP and CEP290 and recruitment ofWRAP73 to centrioles. Also required for centriole-centriolecohesion during interphase by acting as a platform protein forCEP250 at the centriole. Required for the recruitment of CEP295 tothe proximal end of new-born centrioles at the centriolarmicrotubule wall during early S phase in a PLK4-dependent manner.Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early Sphase in a PLK4-dependent manner (PubMed:27185865).{ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962,ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865}. | DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Second largest component of RNA polymerase II whichsynthesizes mRNA precursors and many functional non-coding RNAs.Proposed to contribute to the polymerase catalytic activity andforms the polymerase active center together with the largestsubunit. Pol II is the central component of the basal RNApolymerase II transcription machinery. It is composed of mobileelements that move relative to each other. RPB2 is part of thecore element with the central large cleft, the clamp element thatmoves to open and close the cleft and the jaws that are thought tograb the incoming DNA template (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CEP135 | chr4:56847545 | chr4:57865783 | ENST00000257287 | + | 13 | 26 | 195_420 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CEP135 | chr4:56847545 | chr4:57865783 | ENST00000257287 | + | 13 | 26 | 71_152 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >POLR2B | chr4:56847545 | chr4:57865783 | ENST00000314595 | + | 5 | 25 | 1119_1140 | 245 | 1175 | Zinc finger | Note=C4-type |
| Tgene | >POLR2B | chr4:56847545 | chr4:57865783 | ENST00000381227 | + | 6 | 26 | 1119_1140 | 245 | 1175 | Zinc finger | Note=C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CEP135 | chr4:56847545 | chr4:57865783 | ENST00000257287 | + | 13 | 26 | 1069_1116 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr4:57865783 | ENST00000257287 | + | 13 | 26 | 447_1039 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr4:57865783 | ENST00000422247 | + | 1 | 6 | 1069_1116 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr4:57865783 | ENST00000422247 | + | 1 | 6 | 195_420 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr4:57865783 | ENST00000422247 | + | 1 | 6 | 447_1039 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CEP135 | chr4:56847545 | chr4:57865783 | ENST00000422247 | + | 1 | 6 | 71_152 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for CEP135_POLR2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000381227_chr4_57865783_+_1523aa MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELM KLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLI AHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGI EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDR DILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRL LLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQA RAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMEN LEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQ LKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQA MGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKG FDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLN QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPF NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERD >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000431623_chr4_57865783_+_1523aa MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELM KLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLI AHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGI EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDR DILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRL LLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQA RAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMEN LEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQ LKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQA MGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKG FDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLN QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPF NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERD >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000441246_chr4_57865783_+_1523aa MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELM KLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLI AHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGI EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDR DILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRL LLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQA RAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMEN LEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQ LKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQA MGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKG FDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLN QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPF NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERD >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000314595_chr4_57865783_+_1523aa MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELM KLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLI AHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGI EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDR DILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRL LLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQA RAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMEN LEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQ LKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQA MGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKG FDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLN QEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPF NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000381227_chr4_57865783_+_4569nt ATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCTGGGATACCGCCAGACTCTGACAGTGGAGTGTTTA CCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCAATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAA AGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAGTAGAGAAAATAATGAATTATACCTAGAGTTAATG AAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAAATGTGCACGTGAAACAGCTGATCTGAAATTTCTG AATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAATGAAAGAATTCAACAACTTCAAGAAAAGAATTTG CATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCAGCGTATGCAAATTGATGAACCGGTTCCTCCCTCT GAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCTTCAAGTGGCTGATAACAGGATTCAAGAACTTCAA CAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGACTATAGCAAGCAGATTGAGCTAAGAGAACGAGAG ATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCTGGAGTCTAGAAATAAAACCAATGAAAAGCTTATT GCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAAGCGTATACGAGAGCTTATGGAAACCAAGGAAACA GTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATTAACTGAAATAGATCAGTTAGCACAGCAGTTGGAA AGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAAAGAGATTAAAAGAAAGCTCTCTGAAATGCAGGAT CTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAAGGAGAGACTGAGTGATGAACTCCTTGTAAAATCA GACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAAAGTTGAAAGTTTTGCAGTTACAGAACGACAACTT ACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTCACCTTCTCGTTTAGATACATTTCTGAAAGGTATA GAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACAGCGAAGATCTTGCTCTACAAGTTATAGCGCACGT GAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCATCAGATCACAAGAGAAAGAGATGAACTTCAGCGT ATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATTGACAGCAGAAAGAGATAAACTAAGTGTCTTATAT AATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGCACCCCATAATATTGTTAGTCTTATGGAAAAGGAA AAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAGAGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATT GGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTATTGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGA GATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGTTAAACCTTCTCTCGATGAAGCTTTTGTCATCCAA GAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTACTAAAGAGAAAAGAATTAAATATGCAAAGGAAGTT TTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAAAGCCTATTTCTTGGGATACATGGTTCATAGGTTA CTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAAGAGATTGGATCTTGCTGGGCCGCTGCTTGCATTC TTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAAATTTATTGATCGAGGAAAGGATTTTAACTTGGAG TTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGGAAACTGGGGTGATCAAAAGAAAGCTCATCAAGCC AGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCACCTGCGTCGTTTAAATTCTCCTATTGGTAGAGAC GGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCCTGCCGAGACCCCAGAGGGCCATGCTGTAGGACTT GTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAATTCTGGAATTTTTAGAAGAATGGAGTATGGAAAAT TTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGGCTGCTGGGTTGGAATACATAAAGATCCCGAACAA CTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGTTTCTATGATCAGAGATATTCGAGAGAGGGAGATT CGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACAAAAGCTACTTTTGAAGAAGAGGCATATTGACCAA TTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGTAGTGGAGTATATTGATACCCTGGAAGAAGAAACA GTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTCCACATATACACACTGTGAGATTCATCCCTCAATG ATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAGAAACACATACCAGTCTGCTATGGGTAAGCAGGCT ATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCTCTATTATCCTCAAAAGCCACTTGTGACTACACGG TCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGCCATTGCATCATACACTGGATATAATCAGGAAGAC TCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTATCGCTCATACAAAGAACAGGAGTCTAAAAAAGGA TTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAGGCATGCCATTTACGACAAGCTGGATGATGATGGT TTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGTCACCTTGCCTGAAAATGAAGATGAATTGGAGAGC ACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGACGGGCATTGTGGATCAGGTTATGGTAACTCTCAAT CAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGATTGGAGACAAATTTGCTAGTCGACATGGTCAAAAG GGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTATCACCCCTGATATCATCATCAATCCCCATGCCATC CCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGCTAACAAGGGTGAAATTGGTGATGCCACTCCATTT AATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCATCTCAGAGGAAATGAGGTCCTGTACAATGGGTTC ACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTTGAAGCATATGGTGGATGATAAGATTCACTCTCGT GCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGATGGTGGCCTGCGTTTTGGAGAAATGGAACGAGAT TGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATCAGATCCATATCAGGTTCATGTTTGCAATCTTTGT GGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCGCAATAAAACCCAGATTTCTTTGGTGCGAATGCCT >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000431623_chr4_57865783_+_4569nt ATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCTGGGATACCGCCAGACTCTGACAGTGGAGTGTTTA CCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCAATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAA AGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAGTAGAGAAAATAATGAATTATACCTAGAGTTAATG AAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAAATGTGCACGTGAAACAGCTGATCTGAAATTTCTG AATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAATGAAAGAATTCAACAACTTCAAGAAAAGAATTTG CATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCAGCGTATGCAAATTGATGAACCGGTTCCTCCCTCT GAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCTTCAAGTGGCTGATAACAGGATTCAAGAACTTCAA CAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGACTATAGCAAGCAGATTGAGCTAAGAGAACGAGAG ATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCTGGAGTCTAGAAATAAAACCAATGAAAAGCTTATT GCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAAGCGTATACGAGAGCTTATGGAAACCAAGGAAACA GTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATTAACTGAAATAGATCAGTTAGCACAGCAGTTGGAA AGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAAAGAGATTAAAAGAAAGCTCTCTGAAATGCAGGAT CTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAAGGAGAGACTGAGTGATGAACTCCTTGTAAAATCA GACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAAAGTTGAAAGTTTTGCAGTTACAGAACGACAACTT ACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTCACCTTCTCGTTTAGATACATTTCTGAAAGGTATA GAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACAGCGAAGATCTTGCTCTACAAGTTATAGCGCACGT GAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCATCAGATCACAAGAGAAAGAGATGAACTTCAGCGT ATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATTGACAGCAGAAAGAGATAAACTAAGTGTCTTATAT AATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGCACCCCATAATATTGTTAGTCTTATGGAAAAGGAA AAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAGAGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATT GGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTATTGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGA GATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGTTAAACCTTCTCTCGATGAAGCTTTTGTCATCCAA GAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTACTAAAGAGAAAAGAATTAAATATGCAAAGGAAGTT TTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAAAGCCTATTTCTTGGGATACATGGTTCATAGGTTA CTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAAGAGATTGGATCTTGCTGGGCCGCTGCTTGCATTC TTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAAATTTATTGATCGAGGAAAGGATTTTAACTTGGAG TTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGGAAACTGGGGTGATCAAAAGAAAGCTCATCAAGCC AGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCACCTGCGTCGTTTAAATTCTCCTATTGGTAGAGAC GGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCCTGCCGAGACCCCAGAGGGCCATGCTGTAGGACTT GTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAATTCTGGAATTTTTAGAAGAATGGAGTATGGAAAAT TTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGGCTGCTGGGTTGGAATACATAAAGATCCCGAACAA CTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGTTTCTATGATCAGAGATATTCGAGAGAGGGAGATT CGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACAAAAGCTACTTTTGAAGAAGAGGCATATTGACCAA TTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGTAGTGGAGTATATTGATACCCTGGAAGAAGAAACA GTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTCCACATATACACACTGTGAGATTCATCCCTCAATG ATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAGAAACACATACCAGTCTGCTATGGGTAAGCAGGCT ATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCTCTATTATCCTCAAAAGCCACTTGTGACTACACGG TCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGCCATTGCATCATACACTGGATATAATCAGGAAGAC TCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTATCGCTCATACAAAGAACAGGAGTCTAAAAAAGGA TTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAGGCATGCCATTTACGACAAGCTGGATGATGATGGT TTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGTCACCTTGCCTGAAAATGAAGATGAATTGGAGAGC ACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGACGGGCATTGTGGATCAGGTTATGGTAACTCTCAAT CAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGATTGGAGACAAATTTGCTAGTCGACATGGTCAAAAG GGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTATCACCCCTGATATCATCATCAATCCCCATGCCATC CCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGCTAACAAGGGTGAAATTGGTGATGCCACTCCATTT AATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCATCTCAGAGGAAATGAGGTCCTGTACAATGGGTTC ACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTTGAAGCATATGGTGGATGATAAGATTCACTCTCGT GCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGATGGTGGCCTGCGTTTTGGAGAAATGGAACGAGAT TGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATCAGATCCATATCAGGTTCATGTTTGCAATCTTTGT GGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCGCAATAAAACCCAGATTTCTTTGGTGCGAATGCCT >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000441246_chr4_57865783_+_4569nt ATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCTGGGATACCGCCAGACTCTGACAGTGGAGTGTTTA CCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCAATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAA AGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAGTAGAGAAAATAATGAATTATACCTAGAGTTAATG AAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAAATGTGCACGTGAAACAGCTGATCTGAAATTTCTG AATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAATGAAAGAATTCAACAACTTCAAGAAAAGAATTTG CATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCAGCGTATGCAAATTGATGAACCGGTTCCTCCCTCT GAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCTTCAAGTGGCTGATAACAGGATTCAAGAACTTCAA CAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGACTATAGCAAGCAGATTGAGCTAAGAGAACGAGAG ATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCTGGAGTCTAGAAATAAAACCAATGAAAAGCTTATT GCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAAGCGTATACGAGAGCTTATGGAAACCAAGGAAACA GTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATTAACTGAAATAGATCAGTTAGCACAGCAGTTGGAA AGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAAAGAGATTAAAAGAAAGCTCTCTGAAATGCAGGAT CTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAAGGAGAGACTGAGTGATGAACTCCTTGTAAAATCA GACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAAAGTTGAAAGTTTTGCAGTTACAGAACGACAACTT ACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTCACCTTCTCGTTTAGATACATTTCTGAAAGGTATA GAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACAGCGAAGATCTTGCTCTACAAGTTATAGCGCACGT GAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCATCAGATCACAAGAGAAAGAGATGAACTTCAGCGT ATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATTGACAGCAGAAAGAGATAAACTAAGTGTCTTATAT AATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGCACCCCATAATATTGTTAGTCTTATGGAAAAGGAA AAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAGAGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATT GGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTATTGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGA GATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGTTAAACCTTCTCTCGATGAAGCTTTTGTCATCCAA GAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTACTAAAGAGAAAAGAATTAAATATGCAAAGGAAGTT TTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAAAGCCTATTTCTTGGGATACATGGTTCATAGGTTA CTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAAGAGATTGGATCTTGCTGGGCCGCTGCTTGCATTC TTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAAATTTATTGATCGAGGAAAGGATTTTAACTTGGAG TTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGGAAACTGGGGTGATCAAAAGAAAGCTCATCAAGCC AGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCACCTGCGTCGTTTAAATTCTCCTATTGGTAGAGAC GGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCCTGCCGAGACCCCAGAGGGCCATGCTGTAGGACTT GTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAATTCTGGAATTTTTAGAAGAATGGAGTATGGAAAAT TTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGGCTGCTGGGTTGGAATACATAAAGATCCCGAACAA CTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGTTTCTATGATCAGAGATATTCGAGAGAGGGAGATT CGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACAAAAGCTACTTTTGAAGAAGAGGCATATTGACCAA TTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGTAGTGGAGTATATTGATACCCTGGAAGAAGAAACA GTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTCCACATATACACACTGTGAGATTCATCCCTCAATG ATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAGAAACACATACCAGTCTGCTATGGGTAAGCAGGCT ATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCTCTATTATCCTCAAAAGCCACTTGTGACTACACGG TCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGCCATTGCATCATACACTGGATATAATCAGGAAGAC TCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTATCGCTCATACAAAGAACAGGAGTCTAAAAAAGGA TTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAGGCATGCCATTTACGACAAGCTGGATGATGATGGT TTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGTCACCTTGCCTGAAAATGAAGATGAATTGGAGAGC ACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGACGGGCATTGTGGATCAGGTTATGGTAACTCTCAAT CAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGATTGGAGACAAATTTGCTAGTCGACATGGTCAAAAG GGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTATCACCCCTGATATCATCATCAATCCCCATGCCATC CCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGCTAACAAGGGTGAAATTGGTGATGCCACTCCATTT AATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCATCTCAGAGGAAATGAGGTCCTGTACAATGGGTTC ACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTTGAAGCATATGGTGGATGATAAGATTCACTCTCGT GCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGATGGTGGCCTGCGTTTTGGAGAAATGGAACGAGAT TGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATCAGATCCATATCAGGTTCATGTTTGCAATCTTTGT GGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCGCAATAAAACCCAGATTTCTTTGGTGCGAATGCCT >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000314595_chr4_57865783_+_4569nt ATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCTGGGATACCGCCAGACTCTGACAGTGGAGTGTTTA CCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCAATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAA AGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAGTAGAGAAAATAATGAATTATACCTAGAGTTAATG AAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAAATGTGCACGTGAAACAGCTGATCTGAAATTTCTG AATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAATGAAAGAATTCAACAACTTCAAGAAAAGAATTTG CATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCAGCGTATGCAAATTGATGAACCGGTTCCTCCCTCT GAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCTTCAAGTGGCTGATAACAGGATTCAAGAACTTCAA CAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGACTATAGCAAGCAGATTGAGCTAAGAGAACGAGAG ATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCTGGAGTCTAGAAATAAAACCAATGAAAAGCTTATT GCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAAGCGTATACGAGAGCTTATGGAAACCAAGGAAACA GTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATTAACTGAAATAGATCAGTTAGCACAGCAGTTGGAA AGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAAAGAGATTAAAAGAAAGCTCTCTGAAATGCAGGAT CTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAAGGAGAGACTGAGTGATGAACTCCTTGTAAAATCA GACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAAAGTTGAAAGTTTTGCAGTTACAGAACGACAACTT ACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTCACCTTCTCGTTTAGATACATTTCTGAAAGGTATA GAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACAGCGAAGATCTTGCTCTACAAGTTATAGCGCACGT GAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCATCAGATCACAAGAGAAAGAGATGAACTTCAGCGT ATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATTGACAGCAGAAAGAGATAAACTAAGTGTCTTATAT AATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGCACCCCATAATATTGTTAGTCTTATGGAAAAGGAA AAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAGAGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATT GGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTATTGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGA GATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGTTAAACCTTCTCTCGATGAAGCTTTTGTCATCCAA GAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTACTAAAGAGAAAAGAATTAAATATGCAAAGGAAGTT TTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAAAGCCTATTTCTTGGGATACATGGTTCATAGGTTA CTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAAGAGATTGGATCTTGCTGGGCCGCTGCTTGCATTC TTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAAATTTATTGATCGAGGAAAGGATTTTAACTTGGAG TTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGGAAACTGGGGTGATCAAAAGAAAGCTCATCAAGCC AGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCACCTGCGTCGTTTAAATTCTCCTATTGGTAGAGAC GGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCCTGCCGAGACCCCAGAGGGCCATGCTGTAGGACTT GTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAATTCTGGAATTTTTAGAAGAATGGAGTATGGAAAAT TTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGGCTGCTGGGTTGGAATACATAAAGATCCCGAACAA CTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGTTTCTATGATCAGAGATATTCGAGAGAGGGAGATT CGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACAAAAGCTACTTTTGAAGAAGAGGCATATTGACCAA TTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGTAGTGGAGTATATTGATACCCTGGAAGAAGAAACA GTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTCCACATATACACACTGTGAGATTCATCCCTCAATG ATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAGAAACACATACCAGTCTGCTATGGGTAAGCAGGCT ATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCTCTATTATCCTCAAAAGCCACTTGTGACTACACGG TCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGCCATTGCATCATACACTGGATATAATCAGGAAGAC TCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTATCGCTCATACAAAGAACAGGAGTCTAAAAAAGGA TTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAGGCATGCCATTTACGACAAGCTGGATGATGATGGT TTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGTCACCTTGCCTGAAAATGAAGATGAATTGGAGAGC ACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGACGGGCATTGTGGATCAGGTTATGGTAACTCTCAAT CAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGATTGGAGACAAATTTGCTAGTCGACATGGTCAAAAG GGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTATCACCCCTGATATCATCATCAATCCCCATGCCATC CCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGCTAACAAGGGTGAAATTGGTGATGCCACTCCATTT AATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCATCTCAGAGGAAATGAGGTCCTGTACAATGGGTTC ACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTTGAAGCATATGGTGGATGATAAGATTCACTCTCGT GCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGATGGTGGCCTGCGTTTTGGAGAAATGGAACGAGAT TGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATCAGATCCATATCAGGTTCATGTTTGCAATCTTTGT GGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCGCAATAAAACCCAGATTTCTTTGGTGCGAATGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000381227_chr4_57865783_+_4863nt GACGGAAGGAGCTAGTGGGGGACTCGAGGCCTGAGGGCAATGCGGCTGGAGGCGGAGGCAACGGCGGCTGGAGCTGCCGGACTTTAATTT TTGGAAGTGAATAAAACTTGTTTTAGAAGACGAGATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCT GGGATACCGCCAGACTCTGACAGTGGAGTGTTTACCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCA ATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAAAGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAG TAGAGAAAATAATGAATTATACCTAGAGTTAATGAAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAA ATGTGCACGTGAAACAGCTGATCTGAAATTTCTGAATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAA TGAAAGAATTCAACAACTTCAAGAAAAGAATTTGCATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCA GCGTATGCAAATTGATGAACCGGTTCCTCCCTCTGAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCT TCAAGTGGCTGATAACAGGATTCAAGAACTTCAACAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGA CTATAGCAAGCAGATTGAGCTAAGAGAACGAGAGATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCT GGAGTCTAGAAATAAAACCAATGAAAAGCTTATTGCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAA GCGTATACGAGAGCTTATGGAAACCAAGGAAACAGTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATT AACTGAAATAGATCAGTTAGCACAGCAGTTGGAAAGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAA AGAGATTAAAAGAAAGCTCTCTGAAATGCAGGATCTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAA GGAGAGACTGAGTGATGAACTCCTTGTAAAATCAGACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAA AGTTGAAAGTTTTGCAGTTACAGAACGACAACTTACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTC ACCTTCTCGTTTAGATACATTTCTGAAAGGTATAGAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACA GCGAAGATCTTGCTCTACAAGTTATAGCGCACGTGAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCA TCAGATCACAAGAGAAAGAGATGAACTTCAGCGTATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATT GACAGCAGAAAGAGATAAACTAAGTGTCTTATATAATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGC ACCCCATAATATTGTTAGTCTTATGGAAAAGGAAAAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAG AGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATTGGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTAT TGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGAGATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGT TAAACCTTCTCTCGATGAAGCTTTTGTCATCCAAGAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTAC TAAAGAGAAAAGAATTAAATATGCAAAGGAAGTTTTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAA AGCCTATTTCTTGGGATACATGGTTCATAGGTTACTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAA GAGATTGGATCTTGCTGGGCCGCTGCTTGCATTCTTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAA ATTTATTGATCGAGGAAAGGATTTTAACTTGGAGTTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGG AAACTGGGGTGATCAAAAGAAAGCTCATCAAGCCAGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCA CCTGCGTCGTTTAAATTCTCCTATTGGTAGAGACGGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCC TGCCGAGACCCCAGAGGGCCATGCTGTAGGACTTGTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAAT TCTGGAATTTTTAGAAGAATGGAGTATGGAAAATTTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGG CTGCTGGGTTGGAATACATAAAGATCCCGAACAACTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGT TTCTATGATCAGAGATATTCGAGAGAGGGAGATTCGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACA AAAGCTACTTTTGAAGAAGAGGCATATTGACCAATTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGT AGTGGAGTATATTGATACCCTGGAAGAAGAAACAGTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTC CACATATACACACTGTGAGATTCATCCCTCAATGATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAG AAACACATACCAGTCTGCTATGGGTAAGCAGGCTATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCT CTATTATCCTCAAAAGCCACTTGTGACTACACGGTCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGC CATTGCATCATACACTGGATATAATCAGGAAGACTCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTA TCGCTCATACAAAGAACAGGAGTCTAAAAAAGGATTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAG GCATGCCATTTACGACAAGCTGGATGATGATGGTTTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGT CACCTTGCCTGAAAATGAAGATGAATTGGAGAGCACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGAC GGGCATTGTGGATCAGGTTATGGTAACTCTCAATCAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGAT TGGAGACAAATTTGCTAGTCGACATGGTCAAAAGGGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTAT CACCCCTGATATCATCATCAATCCCCATGCCATCCCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGC TAACAAGGGTGAAATTGGTGATGCCACTCCATTTAATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCA TCTCAGAGGAAATGAGGTCCTGTACAATGGGTTCACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTT GAAGCATATGGTGGATGATAAGATTCACTCTCGTGCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGA TGGTGGCCTGCGTTTTGGAGAAATGGAACGAGATTGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATC AGATCCATATCAGGTTCATGTTTGCAATCTTTGTGGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCG CAATAAAACCCAGATTTCTTTGGTGCGAATGCCTTACGCATGCAAACTATTGTTTCAGGAACTTATGTCTATGAGTATTGCACCGCGAAT GATGAGTGTTTAGCTATTTTACAGGAGTCAACAAGATAATTAAATATCTTGGTGTCTTGTTTCTATTGTGTGGCTTTTTAAAAATGACAA ATATGTACTGTGTTGTGATAAAAAGTATTTTATTTGTTTAATGATATGCATGCTTTTCTTCTGTAAATATATAATAAATTTTTGTAGATA >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000431623_chr4_57865783_+_4863nt GACGGAAGGAGCTAGTGGGGGACTCGAGGCCTGAGGGCAATGCGGCTGGAGGCGGAGGCAACGGCGGCTGGAGCTGCCGGACTTTAATTT TTGGAAGTGAATAAAACTTGTTTTAGAAGACGAGATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCT GGGATACCGCCAGACTCTGACAGTGGAGTGTTTACCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCA ATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAAAGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAG TAGAGAAAATAATGAATTATACCTAGAGTTAATGAAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAA ATGTGCACGTGAAACAGCTGATCTGAAATTTCTGAATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAA TGAAAGAATTCAACAACTTCAAGAAAAGAATTTGCATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCA GCGTATGCAAATTGATGAACCGGTTCCTCCCTCTGAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCT TCAAGTGGCTGATAACAGGATTCAAGAACTTCAACAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGA CTATAGCAAGCAGATTGAGCTAAGAGAACGAGAGATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCT GGAGTCTAGAAATAAAACCAATGAAAAGCTTATTGCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAA GCGTATACGAGAGCTTATGGAAACCAAGGAAACAGTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATT AACTGAAATAGATCAGTTAGCACAGCAGTTGGAAAGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAA AGAGATTAAAAGAAAGCTCTCTGAAATGCAGGATCTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAA GGAGAGACTGAGTGATGAACTCCTTGTAAAATCAGACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAA AGTTGAAAGTTTTGCAGTTACAGAACGACAACTTACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTC ACCTTCTCGTTTAGATACATTTCTGAAAGGTATAGAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACA GCGAAGATCTTGCTCTACAAGTTATAGCGCACGTGAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCA TCAGATCACAAGAGAAAGAGATGAACTTCAGCGTATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATT GACAGCAGAAAGAGATAAACTAAGTGTCTTATATAATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGC ACCCCATAATATTGTTAGTCTTATGGAAAAGGAAAAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAG AGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATTGGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTAT TGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGAGATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGT TAAACCTTCTCTCGATGAAGCTTTTGTCATCCAAGAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTAC TAAAGAGAAAAGAATTAAATATGCAAAGGAAGTTTTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAA AGCCTATTTCTTGGGATACATGGTTCATAGGTTACTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAA GAGATTGGATCTTGCTGGGCCGCTGCTTGCATTCTTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAA ATTTATTGATCGAGGAAAGGATTTTAACTTGGAGTTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGG AAACTGGGGTGATCAAAAGAAAGCTCATCAAGCCAGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCA CCTGCGTCGTTTAAATTCTCCTATTGGTAGAGACGGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCC TGCCGAGACCCCAGAGGGCCATGCTGTAGGACTTGTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAAT TCTGGAATTTTTAGAAGAATGGAGTATGGAAAATTTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGG CTGCTGGGTTGGAATACATAAAGATCCCGAACAACTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGT TTCTATGATCAGAGATATTCGAGAGAGGGAGATTCGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACA AAAGCTACTTTTGAAGAAGAGGCATATTGACCAATTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGT AGTGGAGTATATTGATACCCTGGAAGAAGAAACAGTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTC CACATATACACACTGTGAGATTCATCCCTCAATGATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAG AAACACATACCAGTCTGCTATGGGTAAGCAGGCTATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCT CTATTATCCTCAAAAGCCACTTGTGACTACACGGTCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGC CATTGCATCATACACTGGATATAATCAGGAAGACTCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTA TCGCTCATACAAAGAACAGGAGTCTAAAAAAGGATTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAG GCATGCCATTTACGACAAGCTGGATGATGATGGTTTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGT CACCTTGCCTGAAAATGAAGATGAATTGGAGAGCACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGAC GGGCATTGTGGATCAGGTTATGGTAACTCTCAATCAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGAT TGGAGACAAATTTGCTAGTCGACATGGTCAAAAGGGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTAT CACCCCTGATATCATCATCAATCCCCATGCCATCCCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGC TAACAAGGGTGAAATTGGTGATGCCACTCCATTTAATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCA TCTCAGAGGAAATGAGGTCCTGTACAATGGGTTCACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTT GAAGCATATGGTGGATGATAAGATTCACTCTCGTGCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGA TGGTGGCCTGCGTTTTGGAGAAATGGAACGAGATTGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATC AGATCCATATCAGGTTCATGTTTGCAATCTTTGTGGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCG CAATAAAACCCAGATTTCTTTGGTGCGAATGCCTTACGCATGCAAACTATTGTTTCAGGAACTTATGTCTATGAGTATTGCACCGCGAAT GATGAGTGTTTAGCTATTTTACAGGAGTCAACAAGATAATTAAATATCTTGGTGTCTTGTTTCTATTGTGTGGCTTTTTAAAAATGACAA ATATGTACTGTGTTGTGATAAAAAGTATTTTATTTGTTTAATGATATGCATGCTTTTCTTCTGTAAATATATAATAAATTTTTGTAGATA >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000441246_chr4_57865783_+_4712nt GACGGAAGGAGCTAGTGGGGGACTCGAGGCCTGAGGGCAATGCGGCTGGAGGCGGAGGCAACGGCGGCTGGAGCTGCCGGACTTTAATTT TTGGAAGTGAATAAAACTTGTTTTAGAAGACGAGATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCT GGGATACCGCCAGACTCTGACAGTGGAGTGTTTACCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCA ATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAAAGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAG TAGAGAAAATAATGAATTATACCTAGAGTTAATGAAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAA ATGTGCACGTGAAACAGCTGATCTGAAATTTCTGAATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAA TGAAAGAATTCAACAACTTCAAGAAAAGAATTTGCATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCA GCGTATGCAAATTGATGAACCGGTTCCTCCCTCTGAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCT TCAAGTGGCTGATAACAGGATTCAAGAACTTCAACAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGA CTATAGCAAGCAGATTGAGCTAAGAGAACGAGAGATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCT GGAGTCTAGAAATAAAACCAATGAAAAGCTTATTGCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAA GCGTATACGAGAGCTTATGGAAACCAAGGAAACAGTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATT AACTGAAATAGATCAGTTAGCACAGCAGTTGGAAAGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAA AGAGATTAAAAGAAAGCTCTCTGAAATGCAGGATCTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAA GGAGAGACTGAGTGATGAACTCCTTGTAAAATCAGACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAA AGTTGAAAGTTTTGCAGTTACAGAACGACAACTTACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTC ACCTTCTCGTTTAGATACATTTCTGAAAGGTATAGAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACA GCGAAGATCTTGCTCTACAAGTTATAGCGCACGTGAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCA TCAGATCACAAGAGAAAGAGATGAACTTCAGCGTATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATT GACAGCAGAAAGAGATAAACTAAGTGTCTTATATAATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGC ACCCCATAATATTGTTAGTCTTATGGAAAAGGAAAAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAG AGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATTGGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTAT TGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGAGATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGT TAAACCTTCTCTCGATGAAGCTTTTGTCATCCAAGAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTAC TAAAGAGAAAAGAATTAAATATGCAAAGGAAGTTTTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAA AGCCTATTTCTTGGGATACATGGTTCATAGGTTACTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAA GAGATTGGATCTTGCTGGGCCGCTGCTTGCATTCTTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAA ATTTATTGATCGAGGAAAGGATTTTAACTTGGAGTTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGG AAACTGGGGTGATCAAAAGAAAGCTCATCAAGCCAGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCA CCTGCGTCGTTTAAATTCTCCTATTGGTAGAGACGGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCC TGCCGAGACCCCAGAGGGCCATGCTGTAGGACTTGTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAAT TCTGGAATTTTTAGAAGAATGGAGTATGGAAAATTTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGG CTGCTGGGTTGGAATACATAAAGATCCCGAACAACTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGT TTCTATGATCAGAGATATTCGAGAGAGGGAGATTCGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACA AAAGCTACTTTTGAAGAAGAGGCATATTGACCAATTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGT AGTGGAGTATATTGATACCCTGGAAGAAGAAACAGTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTC CACATATACACACTGTGAGATTCATCCCTCAATGATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAG AAACACATACCAGTCTGCTATGGGTAAGCAGGCTATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCT CTATTATCCTCAAAAGCCACTTGTGACTACACGGTCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGC CATTGCATCATACACTGGATATAATCAGGAAGACTCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTA TCGCTCATACAAAGAACAGGAGTCTAAAAAAGGATTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAG GCATGCCATTTACGACAAGCTGGATGATGATGGTTTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGT CACCTTGCCTGAAAATGAAGATGAATTGGAGAGCACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGAC GGGCATTGTGGATCAGGTTATGGTAACTCTCAATCAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGAT TGGAGACAAATTTGCTAGTCGACATGGTCAAAAGGGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTAT CACCCCTGATATCATCATCAATCCCCATGCCATCCCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGC TAACAAGGGTGAAATTGGTGATGCCACTCCATTTAATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCA TCTCAGAGGAAATGAGGTCCTGTACAATGGGTTCACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTT GAAGCATATGGTGGATGATAAGATTCACTCTCGTGCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGA TGGTGGCCTGCGTTTTGGAGAAATGGAACGAGATTGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATC AGATCCATATCAGGTTCATGTTTGCAATCTTTGTGGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCG CAATAAAACCCAGATTTCTTTGGTGCGAATGCCTTACGCATGCAAACTATTGTTTCAGGAACTTATGTCTATGAGTATTGCACCGCGAAT >In-frame_CEP135_ENST00000257287_chr4_56847545_+_POLR2B_ENST00000314595_chr4_57865783_+_4873nt GACGGAAGGAGCTAGTGGGGGACTCGAGGCCTGAGGGCAATGCGGCTGGAGGCGGAGGCAACGGCGGCTGGAGCTGCCGGACTTTAATTT TTGGAAGTGAATAAAACTTGTTTTAGAAGACGAGATGACTACAGCTGTAGAGAGAAAGTATATTAATATTAGGAAAAGGCTGGATCAGCT GGGATACCGCCAGACTCTGACAGTGGAGTGTTTACCTTTGGTAGAAAAACTTTTCAGCGACTTAGTTCATACAACTGAGAGCCTTCGGCA ATCAAAATTATCTGCTGTGAAAGCTGAAAAAGAAAGTGCCAATTTTGATTTTGTTTTGGAACCCTATAAACTTGAAAATGCAAGATTGAG TAGAGAAAATAATGAATTATACCTAGAGTTAATGAAACTGAGAGAACATTCAGACCAACACGTTAAAGAGTTGAAAACTTCATTGAAGAA ATGTGCACGTGAAACAGCTGATCTGAAATTTCTGAATAACCAATATGCTCATAAACTCAAACTGTTGGAGAAAGAGAGCAAAGCTAAGAA TGAAAGAATTCAACAACTTCAAGAAAAGAATTTGCATGCTGTAGTACAAACTCCAGGTGGCAAGAAAAGAAGTATTGCTTTCAGGCGCCA GCGTATGCAAATTGATGAACCGGTTCCTCCCTCTGAAGTCAGTTCATATCCAGTTCCTCAACCAGATGACCCTTACATTGCAGACCTCCT TCAAGTGGCTGATAACAGGATTCAAGAACTTCAACAGGAAGTCCACCAGCTACAAGAAAAGTTAGCAATGATGGAAAGTGGGGTGAGAGA CTATAGCAAGCAGATTGAGCTAAGAGAACGAGAGATAGAACGACTGTCAGTTGCTTTGGATGGTGGTCGGTCCCCTGATGTCCTTTCTCT GGAGTCTAGAAATAAAACCAATGAAAAGCTTATTGCTCATTTAAATATTCAGGTTGACTTTCTTCAGCAAGCTAATAAAGACCTGGAGAA GCGTATACGAGAGCTTATGGAAACCAAGGAAACAGTGACATCTGAAGTCGTTAATTTAAGTAACAAAAATGAAAAACTCTGCCAAGAATT AACTGAAATAGATCAGTTAGCACAGCAGTTGGAAAGACATAAAGAAGAAGTGCTTGAGACTGCTGATAAAGAGCTTGGGGAAGCAAAGAA AGAGATTAAAAGAAAGCTCTCTGAAATGCAGGATCTTGAAGAAACAATGGCAAAACTTCAGCTGGAATTGAACTTATGCCAGAAAGAAAA GGAGAGACTGAGTGATGAACTCCTTGTAAAATCAGACCTAGAAACTGTTGTTCATCAGCTTGAACAAGAAAAGCAAAGACTTAGCAAAAA AGTTGAAAGTTTTGCAGTTACAGAACGACAACTTACTCTGGAGGTTGAGAGGATGAGACTAGAACATGGAATAAAACGTCGAGACAGGTC ACCTTCTCGTTTAGATACATTTCTGAAAGGTATAGAAGAAGAACGAGATTATTATAAGAAAGAGCTAGAGAGACTCCAACATATAATACA GCGAAGATCTTGCTCTACAAGTTATAGCGCACGTGAAAAAAGTTCAATATTTAGAACACCAGAAAAGGGTGATTACAATTCAGAAATTCA TCAGATCACAAGAGAAAGAGATGAACTTCAGCGTATGCTAGAAAGATTTGAAAAATATATGGAAGATATACAGTCCAATGTTAAATTATT GACAGCAGAAAGAGATAAACTAAGTGTCTTATATAATGAAGCTCAGGAAGAATTATCTGCCCTAAGAAAGGAATCCACCCAAACCACAGC ACCCCATAATATTGTTAGTCTTATGGAAAAGGAAAAAGAACTTGCGTTATCTGACTTAAGAAGAATTATGGCAGAAAAGGAAGCTTTAAG AGAAAAATTAGAGGGTGCCAAGAAGAGTGCTATTGGTCAGCGCATTGTGGCAACTCTACCATATATCAAGCAAGAAGTTCCCATCATTAT TGTGTTCAGAGCATTAGGTTTTGTGTCCGACAGAGATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATGGT TAAACCTTCTCTCGATGAAGCTTTTGTCATCCAAGAACAGAATGTTGCACTAAATTTCATTGGTTCAAGAGGAGCAAAGCCTGGTGTTAC TAAAGAGAAAAGAATTAAATATGCAAAGGAAGTTTTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAAAA AGCCTATTTCTTGGGATACATGGTTCATAGGTTACTTCTGGCAGCTTTGGGTAGAAGAGAACTAGATGACAGAGATCACTATGGAAACAA GAGATTGGATCTTGCTGGGCCGCTGCTTGCATTCTTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAGAA ATTTATTGATCGAGGAAAGGATTTTAACTTGGAGTTGGCAATTAAAACACGGATCATATCTGATGGCCTAAAATACTCTTTAGCTACTGG AAACTGGGGTGATCAAAAGAAAGCTCATCAAGCCAGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCTCA CCTGCGTCGTTTAAATTCTCCTATTGGTAGAGACGGCAAGCTAGCAAAACCAAGACAGTTGCATAATACGTTGTGGGGAATGGTGTGTCC TGCCGAGACCCCAGAGGGCCATGCTGTAGGACTTGTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCAAT TCTGGAATTTTTAGAAGAATGGAGTATGGAAAATTTAGAAGAAATTTCTCCTGCAGCTATTGCTGATGCAACCAAGATTTTTGTTAATGG CTGCTGGGTTGGAATACATAAAGATCCCGAACAACTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAAGT TTCTATGATCAGAGATATTCGAGAGAGGGAGATTCGGATCTATACGGATGCAGGCCGTATTTGTAGACCACTTCTGATTGTGGAAAAACA AAAGCTACTTTTGAAGAAGAGGCATATTGACCAATTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGGGT AGTGGAGTATATTGATACCCTGGAAGAAGAAACAGTGATGCTTGCAATGACTCCAGATGATTTACAGGAGAAAGAAGTAGCTTATTGTTC CACATATACACACTGTGAGATTCATCCCTCAATGATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCTAG AAACACATACCAGTCTGCTATGGGTAAGCAGGCTATGGGAGTTTACATCACCAACTTCCATGTTCGCATGGACACATTGGCCCATGTTCT CTATTATCCTCAAAAGCCACTTGTGACTACACGGTCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTGGC CATTGCATCATACACTGGATATAATCAGGAAGACTCTGTTATCATGAATCGTTCAGCTGTAGACCGCGGCTTCTTCAGGTCTGTTTTCTA TCGCTCATACAAAGAACAGGAGTCTAAAAAAGGATTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATGAG GCATGCCATTTACGACAAGCTGGATGATGATGGTTTGATAGCTCCAGGGGTTCGTGTATCAGGAGATGATGTTATTATAGGCAAAACAGT CACCTTGCCTGAAAATGAAGATGAATTGGAGAGCACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGCGAGAC GGGCATTGTGGATCAGGTTATGGTAACTCTCAATCAGGAAGGATATAAATTTTGTAAAATAAGGGTACGCTCTGTTAGGATTCCACAGAT TGGAGACAAATTTGCTAGTCGACATGGTCAAAAGGGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGTAT CACCCCTGATATCATCATCAATCCCCATGCCATCCCCTCTCGTATGACTATTGGTCACTTAATTGAATGCCTTCAAGGGAAGGTATCGGC TAACAAGGGTGAAATTGGTGATGCCACTCCATTTAATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTATCA TCTCAGAGGAAATGAGGTCCTGTACAATGGGTTCACTGGTCGAAAAATCACATCACAAATATTTATTGGCCCCACTTATTACCAGCGTTT GAAGCATATGGTGGATGATAAGATTCACTCTCGTGCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGTGA TGGTGGCCTGCGTTTTGGAGAAATGGAACGAGATTGTCAGATTGCCCATGGAGCAGCCCAGTTTTTAAGGGAAAGATTGTTTGAGGCATC AGATCCATATCAGGTTCATGTTTGCAATCTTTGTGGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGCCG CAATAAAACCCAGATTTCTTTGGTGCGAATGCCTTACGCATGCAAACTATTGTTTCAGGAACTTATGTCTATGAGTATTGCACCGCGAAT GATGAGTGTTTAGCTATTTTACAGGAGTCAACAAGATAATTAAATATCTTGGTGTCTTGTTTCTATTGTGTGGCTTTTTAAAAATGACAA ATATGTACTGTGTTGTGATAAAAAGTATTTTATTTGTTTAATGATATGCATGCTTTTCTTCTGTAAATATATAATAAATTTTTGTAGATA |
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FusionGenePPI for CEP135_POLR2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CEP135 | WRAP73, STK24, NCOA5, SMAD9, CBX6, CARD9, C17orf59, MED4, CEP128, CEP162, XKR4, AIMP1, MAPRE1, SPATA5, SREK1, SREK1IP1, ZMAT2, SPICE1, ADSL, ALDH3A2, ALMS1, ARHGAP21, ATP6V1B1, CEP131, PROSER3, C2CD3, CAMSAP1, CC2D1A, CCDC138, CCDC14, CCDC18, CCDC66, CCDC77, CCP110, CDK4, CEP120, CEP152, CEP170, CEP192, CEP350, CEP44, CEP55, CEP72, CEP85, CEP95, CEP97, COMMD3-BMI1, CSNK1A1, CSPP1, CTNND1, CTSV, CYLD, DHX35, DLG5, DVL1, DVL2, DVL3, ECH1, ERC1, FAM83B, FAM83H, FGFR1OP, FOPNL, GEN1, GLUD2, GPATCH1, GRIP1, GTPBP1, GYS1, HAUS1, HAUS3, HAUS4, HAUS6, HAUS7, HAUS8, IBTK, IFT74, ISOC1, KEAP1, KIAA0753, KIAA1671, KIF14, KIF7, LMO7, ERVK3-1, LRRC49, LUZP1, LZTS2, MAGED1, MAP7D3, MCTS1, MIIP, MPHOSPH9, MTPN, NAV1, NBR1, NCKAP5L, NDE1, NDEL1, NEDD1, NME7, NUP155, OFD1, PAFAH1B1, PCM1, PIBF1, PLEKHG1, PLK1, PRKCI, PRRC2B, RAB8A, RCOR1, RTTN, SDCCAG3, SEC23IP, SIPA1L1, SIPA1L2, SIPA1L3, SPATA2, SPATA24, SPATA2L, SQSTM1, SRP72, SRPK1, SSX2IP, SYNM, TBC1D19, TBK1, TCHP, TEX9, TJP1, TJP2, TMEM160, TMEM209, TNIP1, TNRC6A, TNRC6B, TP53, TP53BP2, TPGS1, TRIP6, TTK, TXLNA, TXLNG, USP54, TBC1D31, WDR83, XRN1, YTHDF1, YWHAH, ODF2, LZTS3, GOLGB1, PLD1, TRIM27, TTLL5, MIB1, KIAA1328, ELMO2, CEP290, CEP295, WDR90, HNRNPCL1, CCDC61, CDC14A, TXLNB, MIS18A | POLR2B | MED10, MED9, MED29, MED19, MED28, MED26, POLR2C, POLR2E, POLR2L, POLR2H, POLR2K, BTF3, RECQL5, RPAP2, RPAP3, GTF2F2, POLR2G, POLR2J, RPAP1, RUVBL2, GPN1, GTF2F1, TCEA1, KDM1A, AIRE, POLR2A, LZTR1, IKBKG, ZSCAN1, CTDP1, INTS3, INTS5, INTS6, INTS1, ZC3H13, WDR82, TADA2A, MYC, SUB1, POLR2D, CALM1, SHFM1, INTS10, PIDD1, CUL3, CUL5, CAND1, CCNH, CDK7, MEN1, POLR2I, TUBA4A, TUBB4B, DCTN1, ATP6V1B2, POLR3F, BARD1, MDC1, VCP, HDAC11, CDK20, FBXO6, HECW2, ITCH, NEDD4, WWOX, RABEP2, ILK, XRN2, ESR1, SRC, PSMB9, TCEB3, OBSL1, SUZ12, RNF2, SNAR-B2, RPRD1B, GPN2, POLR2M, EEF1A1, EEFSEC, POLR1A, POLR1B, SUPT5H, POLR2F, POLR3A, RPS5, TUBB, NTRK1, IFI16, MED4, XPO1, DNAJC7, CTR9, CEP170P1, BRD2, NELFA, RNGTT, LMO2, GPN3, PIH1D1, ASB6, CPNE2, NCL, AAR2, INO80B, RUVBL1, URI1, WDR92, ZNHIT2, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CEP135_POLR2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CEP135_POLR2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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