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Fusion gene ID: 677 |
FusionGeneSummary for ADAM10_ZNF770 |
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Fusion gene information | Fusion gene name: ADAM10_ZNF770 | Fusion gene ID: 677 | Hgene | Tgene | Gene symbol | ADAM10 | ZNF770 | Gene ID | 102 | 54989 |
Gene name | ADAM metallopeptidase domain 10 | zinc finger protein 770 | |
Synonyms | AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz | PRO1914 | |
Cytomap | 15q21.3 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease | zinc finger protein 770 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O14672 | Q6IQ21 | |
Ensembl transtripts involved in fusion gene | ENST00000260408, ENST00000402627, ENST00000561288, ENST00000396140, ENST00000558733, | ENST00000356321, | |
Fusion gene scores | * DoF score | 9 X 4 X 6=216 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ADAM10 [Title/Abstract] AND ZNF770 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAM10 | GO:0006509 | membrane protein ectodomain proteolysis | 12714508|17557115|18355449|18419754|18676862|19114711 |
Hgene | ADAM10 | GO:0007162 | negative regulation of cell adhesion | 12714508 |
Hgene | ADAM10 | GO:0034612 | response to tumor necrosis factor | 11831872 |
Hgene | ADAM10 | GO:0051089 | constitutive protein ectodomain proteolysis | 12714508 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-HT-8011-01A | ADAM10 | chr15 | 59041679 | - | ZNF770 | chr15 | 35279874 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000260408 | ENST00000356321 | ADAM10 | chr15 | 59041679 | - | ZNF770 | chr15 | 35279874 | - |
5CDS-5UTR | ENST00000402627 | ENST00000356321 | ADAM10 | chr15 | 59041679 | - | ZNF770 | chr15 | 35279874 | - |
5CDS-5UTR | ENST00000561288 | ENST00000356321 | ADAM10 | chr15 | 59041679 | - | ZNF770 | chr15 | 35279874 | - |
5CDS-5UTR | ENST00000396140 | ENST00000356321 | ADAM10 | chr15 | 59041679 | - | ZNF770 | chr15 | 35279874 | - |
5UTR-5UTR | ENST00000558733 | ENST00000356321 | ADAM10 | chr15 | 59041679 | - | ZNF770 | chr15 | 35279874 | - |
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FusionProtFeatures for ADAM10_ZNF770 |
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Hgene | Tgene |
ADAM10 | ZNF770 |
Cleaves the membrane-bound precursor of TNF-alpha at'76-Ala-|-Val-77' to its mature soluble form. Responsible for theproteolytical release of soluble JAM3 from endothelial cellssurface (PubMed:20592283). Responsible for the proteolytic releaseof several other cell-surface proteins, including heparin-bindingepidermal growth-like factor, ephrin-A2, CD44, CDH2 and forconstitutive and regulated alpha-secretase cleavage of amyloidprecursor protein (APP) (PubMed:26686862, PubMed:11786905,PubMed:29224781). Contributes to the normal cleavage of thecellular prion protein (PubMed:11477090). Involved in the cleavageof the adhesion molecule L1 at the cell surface and in releasedmembrane vesicles, suggesting a vesicle-based protease activity(PubMed:12475894). Controls also the proteolytic processing ofNotch and mediates lateral inhibition during neurogenesis (Bysimilarity). Responsible for the FasL ectodomain shedding and forthe generation of the remnant ADAM10-processed FasL (FasL APL)transmembrane form (PubMed:17557115). Also cleaves the ectodomainof the integral membrane proteins CORIN and ITM2B(PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3signaling (PubMed:16239146). {ECO:0000250|UniProtKB:O35598,ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905,ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146,ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711,ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900,ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29224781}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAM10_ZNF770 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAM10_ZNF770 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADAM10 | EFNA2, MAD2L1, GRB2, LCK, OR4S2, MSRB2, PDIA3, FBXO6, PXN, DLG1, TSPAN5, TSPAN14, TSPAN15, TSPAN17, TSPAN33, TSPAN10, TAZ, B3GNT2, KRAS, MPPE1, TRIM25, NOTCH1 | ZNF770 | USP20, ELAVL1, NOL12, RPL14, RPL8, NIFK, MPHOSPH8, ZNF2, PPAN, CACNG5, WDR46, E4F1, H2AFY2, MRPS34 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAM10_ZNF770 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAM10_ZNF770 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADAM10 | C3810041 | ALZHEIMER DISEASE 18 | 2 | UNIPROT |
Hgene | ADAM10 | C0406811 | Reticulate acropigmentation of Kitamura | 1 | ORPHANET;UNIPROT |
Hgene | ADAM10 | C1458155 | Mammary Neoplasms | 1 | CTD_human |