FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6763

FusionGeneSummary for CENPF_LAMC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CENPF_LAMC1
Fusion gene ID: 6763
HgeneTgene
Gene symbol

CENPF

LAMC1

Gene ID

1063

3915

Gene namecentromere protein Flaminin subunit gamma 1
SynonymsCENF|CILD31|PRO1779|STROMS|hcp-1LAMB2
Cytomap

1q41

1q25.3

Type of geneprotein-codingprotein-coding
Descriptioncentromere protein FAH antigenCENP-F kinetochore proteincell-cycle-dependent 350K nuclear proteincentromere protein F, 350/400kDakinetochore protein CENPFmitosinlaminin subunit gamma-1S-LAM gammaS-laminin subunit gammalaminin B2 chainlaminin, gamma 1 (formerly LAMB2)laminin-10 subunit gammalaminin-11 subunit gammalaminin-2 subunit gammalaminin-3 subunit gammalaminin-4 subunit gammalaminin-6 subunit gamm
Modification date2018052220180522
UniProtAcc

P49454

P11047

Ensembl transtripts involved in fusion geneENST00000366955, ENST00000467765, 
ENST00000258341, ENST00000466964, 
Fusion gene scores* DoF score5 X 4 X 3=605 X 6 X 5=150
# samples 411
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/150*10)=-0.447458976971221
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CENPF [Title/Abstract] AND LAMC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCENPF

GO:0015031

protein transport

12974617

HgeneCENPF

GO:0045892

negative regulation of transcription, DNA-templated

15677469

HgeneCENPF

GO:0051310

metaphase plate congression

15870278

TgeneLAMC1

GO:0007155

cell adhesion

15159456

TgeneLAMC1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneLAMC1

GO:0065003

protein-containing complex assembly

15159456


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24Z-01ACENPFchr1

214776664

+LAMC1chr1

183105521

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000366955ENST00000258341CENPFchr1

214776664

+LAMC1chr1

183105521

+
5UTR-intronENST00000366955ENST00000466964CENPFchr1

214776664

+LAMC1chr1

183105521

+
intron-3CDSENST00000467765ENST00000258341CENPFchr1

214776664

+LAMC1chr1

183105521

+
intron-intronENST00000467765ENST00000466964CENPFchr1

214776664

+LAMC1chr1

183105521

+

Top

FusionProtFeatures for CENPF_LAMC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CENPF

P49454

LAMC1

P11047

Required for kinetochore function and chromosomesegregation in mitosis. Required for kinetochore localization ofdynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasmamembrane by acting as a link between recycling vesicles and themicrotubule network though its association with STX4 and SNAP25.Acts as a potential inhibitor of pocket protein-mediated cellularprocesses during development by regulating the activity of RBproteins during cell division and proliferation. May play aregulatory or permissive role in the normal embryoniccardiomyocyte cell cycle and in promoting continued mitosis intransformed, abnormally dividing neonatal cardiomyocytes.Interaction with RB directs embryonic stem cells toward a cardiaclineage. Involved in the regulation of DNA synthesis and hencecell cycle progression, via its C-terminus. Has a potential roleregulating skeletal myogenesis and in cell differentiation inembryogenesis. Involved in dendritic cell regulation of T-cellimmunity against chlamydia. {ECO:0000269|PubMed:12974617,ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657,ECO:0000269|PubMed:7651420}. Binding to cells via a high affinity receptor, lamininis thought to mediate the attachment, migration and organizationof cells into tissues during embryonic development by interactingwith other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CENPF_LAMC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CENPF_LAMC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CENPFTOP3B, CENPF, ALK, NPM1, TERF1, TERF2, NDEL1, SVIL, ARRB2, SIRT7, COPS6, NUP107, NUP133, NQO2, HECW2, CUL7, OBSL1, CCDC68, FNTB, RNF166, MYC, NFKBIA, POLH, G3BP1, CDCA5, MZT1, CENPU, NANOG, CCDC33, IKBKG, TCP10L, GOPC, FAM167A, FBXL5, COG6, TMA16, ESAM, WASF3, MAP7D2, BRCA1LAMC1SNAPIN, CCDC53, NID1, NID2, CENPU, LAMB1, ELAVL1, FBXO6, APP, PDIA3, SNX2, TANK, SRPK1, HECW2, ANTXR2, LGR4, TUBG1, CCDC8, FAM175B, FAM175A, TGFB1, CLEC11A, LGALS3, LAMA5, PSMD5, PSMC5, PHKG2, C15orf48, OPA3, TXLNB, PNLIP, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CENPF_LAMC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CENPF_LAMC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCENPFC1458155Mammary Neoplasms1CTD_human
TgeneLAMC1C0003493Aortic Diseases1CTD_human
TgeneLAMC1C0024796Marfan Syndrome1CTD_human
TgeneLAMC1C0033578Prostatic Neoplasms1CTD_human