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Fusion gene ID: 6761 |
FusionGeneSummary for CENPF_EGLN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CENPF_EGLN1 | Fusion gene ID: 6761 | Hgene | Tgene | Gene symbol | CENPF | EGLN1 | Gene ID | 1063 | 54583 |
| Gene name | centromere protein F | egl-9 family hypoxia inducible factor 1 | |
| Synonyms | CENF|CILD31|PRO1779|STROMS|hcp-1 | C1orf12|ECYT3|HALAH|HIF-PH2|HIFPH2|HPH-2|HPH2|PHD2|SM20|ZMYND6 | |
| Cytomap | 1q41 | 1q42.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | centromere protein FAH antigenCENP-F kinetochore proteincell-cycle-dependent 350K nuclear proteincentromere protein F, 350/400kDakinetochore protein CENPFmitosin | egl nine homolog 1HIF-prolyl hydroxylase 2egl nine-like protein 1hypoxia-inducible factor prolyl hydroxylase 2prolyl hydroxylase domain-containing protein 2zinc finger MYND domain-containing protein 6 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P49454 | Q9GZT9 | |
| Ensembl transtripts involved in fusion gene | ENST00000366955, ENST00000467765, | ENST00000366641, ENST00000476717, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 5 X 3 X 3=45 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CENPF [Title/Abstract] AND EGLN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CENPF | GO:0015031 | protein transport | 12974617 |
| Hgene | CENPF | GO:0045892 | negative regulation of transcription, DNA-templated | 15677469 |
| Hgene | CENPF | GO:0051310 | metaphase plate congression | 15870278 |
| Tgene | EGLN1 | GO:0001666 | response to hypoxia | 16956324 |
| Tgene | EGLN1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 11598268 |
| Tgene | EGLN1 | GO:0032364 | oxygen homeostasis | 16956324 |
| Tgene | EGLN1 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 16956324 |
| Tgene | EGLN1 | GO:0071731 | response to nitric oxide | 21601578 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-56-7582-01A | CENPF | chr1 | 214795624 | + | EGLN1 | chr1 | 231509845 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000366955 | ENST00000366641 | CENPF | chr1 | 214795624 | + | EGLN1 | chr1 | 231509845 | - |
| 5CDS-5UTR | ENST00000366955 | ENST00000476717 | CENPF | chr1 | 214795624 | + | EGLN1 | chr1 | 231509845 | - |
| intron-3CDS | ENST00000467765 | ENST00000366641 | CENPF | chr1 | 214795624 | + | EGLN1 | chr1 | 231509845 | - |
| intron-5UTR | ENST00000467765 | ENST00000476717 | CENPF | chr1 | 214795624 | + | EGLN1 | chr1 | 231509845 | - |
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FusionProtFeatures for CENPF_EGLN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CENPF | EGLN1 |
| Required for kinetochore function and chromosomesegregation in mitosis. Required for kinetochore localization ofdynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasmamembrane by acting as a link between recycling vesicles and themicrotubule network though its association with STX4 and SNAP25.Acts as a potential inhibitor of pocket protein-mediated cellularprocesses during development by regulating the activity of RBproteins during cell division and proliferation. May play aregulatory or permissive role in the normal embryoniccardiomyocyte cell cycle and in promoting continued mitosis intransformed, abnormally dividing neonatal cardiomyocytes.Interaction with RB directs embryonic stem cells toward a cardiaclineage. Involved in the regulation of DNA synthesis and hencecell cycle progression, via its C-terminus. Has a potential roleregulating skeletal myogenesis and in cell differentiation inembryogenesis. Involved in dendritic cell regulation of T-cellimmunity against chlamydia. {ECO:0000269|PubMed:12974617,ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657,ECO:0000269|PubMed:7651420}. | Cellular oxygen sensor that catalyzes, under normoxicconditions, the post-translational formation of 4-hydroxyprolinein hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates aspecific proline found in each of the oxygen-dependent degradation(ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A.Also hydroxylates HIF2A. Has a preference for the CODD site forboth HIF1A and HIF1B. Hydroxylated HIFs are then targeted forproteasomal degradation via the von Hippel-Lindau ubiquitinationcomplex. Under hypoxic conditions, the hydroxylation reaction isattenuated allowing HIFs to escape degradation resulting in theirtranslocation to the nucleus, heterodimerization with HIF1B, andincreased expression of hypoxy-inducible genes. EGLN1 is the mostimportant isozyme under normoxia and, through regulating thestability of HIF1, involved in various hypoxia-influencedprocesses such as angiogenesis in retinal and cardiacfunctionality. Target proteins are preferentially recognized via aLXXLAP motif. {ECO:0000269|PubMed:11595184,ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:12351678,ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:19339211,ECO:0000269|PubMed:21792862, ECO:0000269|PubMed:25129147}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 14_197 | 356 | 3115 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 1642_1746 | 356 | 3115 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 1862_2987 | 356 | 3115 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 273_769 | 356 | 3115 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 823_1328 | 356 | 3115 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 3015_3032 | 356 | 3115 | Motif | Nuclear localization signal |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 1435_1626 | 356 | 3115 | Region | Note=2 X 96 AA approximate tandem repeats |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2207_2568 | 356 | 3115 | Region | Note=2 X 177 AA tandem repeats |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2488_2925 | 356 | 3115 | Region | Note=Sufficient for self-association |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2488_3113 | 356 | 3115 | Region | Note=Sufficient for centromere localization |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2927_3113 | 356 | 3115 | Region | Note=Sufficient for nuclear localization |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 1435_1530 | 356 | 3115 | Repeat | Note=1-1 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 1531_1626 | 356 | 3115 | Repeat | Note=1-2 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2207_2386 | 356 | 3115 | Repeat | Note=2-1 |
| Hgene | >CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2389_2568 | 356 | 3115 | Repeat | Note=2-2 |
| Tgene | EGLN1 | chr1:214795624 | chr1:231509845 | ENST00000366641 | - | 0 | 5 | 291_392 | 297 | 427 | Domain | Fe2OG dioxygenase |
| Tgene | EGLN1 | chr1:214795624 | chr1:231509845 | ENST00000366641 | - | 0 | 5 | 241_251 | 297 | 427 | Region | Beta(2)beta(3) 'finger-like' loop |
| Tgene | EGLN1 | chr1:214795624 | chr1:231509845 | ENST00000366641 | - | 0 | 5 | 6_20 | 297 | 427 | Region | Note=Required for nuclear export |
| Tgene | EGLN1 | chr1:214795624 | chr1:231509845 | ENST00000366641 | - | 0 | 5 | 21_58 | 297 | 427 | Zinc finger | MYND-type |
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FusionGeneSequence for CENPF_EGLN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CENPF_ENST00000366955_chr1_214795624_+_EGLN1_ENST00000366641_chr1_231509845_-_486aa MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHEL QVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSF FDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKAMVA CYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CENPF_ENST00000366955_chr1_214795624_+_EGLN1_ENST00000366641_chr1_231509845_-_1458nt ATGAGCTGGGCTTTGGAAGAATGGAAAGAAGGGCTGCCTACAAGAGCTCTTCAGAAAATTCAAGAGCTTGAAGGACAGCTTGACAAACTG AAGAAGGAAAAGCAGCAAAGGCAGTTTCAGCTTGACAGTCTCGAGGCTGCGCTGCAGAAGCAAAAACAGAAGGTTGAAAATGAAAAAACC GAGGGTACAAACCTGAAAAGGGAGAATCAAAGATTGATGGAAATATGTGAAAGTCTGGAGAAAACTAAGCAGAAGATTTCTCATGAACTT CAAGTCAAGGAGTCACAAGTGAATTTCCAGGAAGGACAACTGAATTCAGGCAAAAAACAAATAGAAAAACTGGAACAGGAACTTAAAAGG TGTAAATCTGAGCTTGAAAGAAGCCAACAAGCTGCGCAGTCTGCAGATGTCTCTCTGAATCCATGCAATACACCACAAAAAATTTTTACA ACTCCACTAACACCAAGTCAATATTATAGTGGTTCCAAGTATGAAGATCTAAAAGAAAAATATAATAAAGAGGTTGAAGAACGAAAAAGA TTAGAGGCAGAGGTTAAAGCCTTGCAGGCTAAAAAAGCAAGCCAGACTCTTCCACAAGCCACCATGAATCACCGCGACATTGCCCGGCAT CAGGCTTCATCATCTGTGTTCTCATGGCAGCAAGAGAAGACCCCAAGTCATCTTTCATCTAATTCTCAAAGAACTCCAATTAGGAGAGAT TTCTCTGCATCTTACTTTTCTGGGGAACAAGAGGTGACTCCAAGTCGATCAACTTTGCAAATAGGGAAAAGAGATGCTAATAGCAGTTTC TTTGACAATTCTAGCAGTCCTCATCTTTTGGATCAATTAAAAGCGCAGAATCAAGAGCTAAGAAACAAGATTAATGAGTTGGAACTACGC CTGCAAGGACATGAAAAAGAAATGAAAGGCCAAGTGAATAAGTTTCAAGAACTCCAACTCCAACTGGAGAAAGCAAAAGTGGAATTAATT GAAAAAGAGAAAGTTTTGAACAAATGTAGGGATGAACTAGTGAGAACAACAGCACAATACGACCAGGCGTCAACCAAGGCCATGGTTGCT TGTTATCCGGGCAATGGAACGGGTTATGTACGTCATGTTGATAATCCAAATGGAGATGGAAGATGTGTGACATGTATATATTATCTTAAT AAAGACTGGGATGCCAAGGTAAGTGGAGGTATACTTCGAATTTTTCCAGAAGGCAAAGCCCAGTTTGCTGACATTGAACCCAAATTTGAT AGACTGCTGTTTTTCTGGTCTGACCGTCGCAACCCTCATGAAGTACAACCAGCATATGCTACAAGGTACGCAATAACTGTTTGGTATTTT GATGCAGATGAGAGAGCACGAGCTAAAGTAAAATATCTAACAGGTGAAAAAGGTGTGAGGGTTGAACTCAATAAACCTTCAGATTCGGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CENPF_ENST00000366955_chr1_214795624_+_EGLN1_ENST00000366641_chr1_231509845_-_4286nt AGAAGCGGGCGAATTGGGCACCGGTGGCGGCTGCGGGCAGTTTGAATTAGACTCTGGGCTCCAGCCCGCCGAAGCCGCGCCAGAACTGTA CTCTCCGAGAGGTCGTTTTCCCGTCCCCGAGAGCAAGTTTATTTACAAATGTTGGAGTAATAAAGAAGGCAGAACAAAATGAGCTGGGCT TTGGAAGAATGGAAAGAAGGGCTGCCTACAAGAGCTCTTCAGAAAATTCAAGAGCTTGAAGGACAGCTTGACAAACTGAAGAAGGAAAAG CAGCAAAGGCAGTTTCAGCTTGACAGTCTCGAGGCTGCGCTGCAGAAGCAAAAACAGAAGGTTGAAAATGAAAAAACCGAGGGTACAAAC CTGAAAAGGGAGAATCAAAGATTGATGGAAATATGTGAAAGTCTGGAGAAAACTAAGCAGAAGATTTCTCATGAACTTCAAGTCAAGGAG TCACAAGTGAATTTCCAGGAAGGACAACTGAATTCAGGCAAAAAACAAATAGAAAAACTGGAACAGGAACTTAAAAGGTGTAAATCTGAG CTTGAAAGAAGCCAACAAGCTGCGCAGTCTGCAGATGTCTCTCTGAATCCATGCAATACACCACAAAAAATTTTTACAACTCCACTAACA CCAAGTCAATATTATAGTGGTTCCAAGTATGAAGATCTAAAAGAAAAATATAATAAAGAGGTTGAAGAACGAAAAAGATTAGAGGCAGAG GTTAAAGCCTTGCAGGCTAAAAAAGCAAGCCAGACTCTTCCACAAGCCACCATGAATCACCGCGACATTGCCCGGCATCAGGCTTCATCA TCTGTGTTCTCATGGCAGCAAGAGAAGACCCCAAGTCATCTTTCATCTAATTCTCAAAGAACTCCAATTAGGAGAGATTTCTCTGCATCT TACTTTTCTGGGGAACAAGAGGTGACTCCAAGTCGATCAACTTTGCAAATAGGGAAAAGAGATGCTAATAGCAGTTTCTTTGACAATTCT AGCAGTCCTCATCTTTTGGATCAATTAAAAGCGCAGAATCAAGAGCTAAGAAACAAGATTAATGAGTTGGAACTACGCCTGCAAGGACAT GAAAAAGAAATGAAAGGCCAAGTGAATAAGTTTCAAGAACTCCAACTCCAACTGGAGAAAGCAAAAGTGGAATTAATTGAAAAAGAGAAA GTTTTGAACAAATGTAGGGATGAACTAGTGAGAACAACAGCACAATACGACCAGGCGTCAACCAAGGCCATGGTTGCTTGTTATCCGGGC AATGGAACGGGTTATGTACGTCATGTTGATAATCCAAATGGAGATGGAAGATGTGTGACATGTATATATTATCTTAATAAAGACTGGGAT GCCAAGGTAAGTGGAGGTATACTTCGAATTTTTCCAGAAGGCAAAGCCCAGTTTGCTGACATTGAACCCAAATTTGATAGACTGCTGTTT TTCTGGTCTGACCGTCGCAACCCTCATGAAGTACAACCAGCATATGCTACAAGGTACGCAATAACTGTTTGGTATTTTGATGCAGATGAG AGAGCACGAGCTAAAGTAAAATATCTAACAGGTGAAAAAGGTGTGAGGGTTGAACTCAATAAACCTTCAGATTCGGTCGGTAAAGACGTC TTCTAGAGCCTTTGATCCAGCAATACCCCACTTCACCTACAATATTGTTAACTATTTGTTAACTTGTGAATACGAATAAATGGGATAAAG AAAAATAGACAACCAGTTCGCATTTTAATAAGGAAACAGAAACAACTTTTTGTGTTGCATCAAACAGAAGATTTTGACTGCTGTGACTTT GTACTGCATGATCAACTTCAAATCTGTGATTGCTTACAGGAGGAAGATAAGCTACTAATTGAAAATGGTTTTTACATCTGGATATGAAAT AAGTGCCCTGTGTAGAATTTTTTTCATTCTTATATTTTGCCAGATCTGTTATCTAGCTGAGTTCATTTCATCTCTCCCTTTTTTATATCA AGTTTGAATTTGGGATAATTTTTCTATATTAGGTACAATTTATCTAAACTGAATTGAGAAAAAATTACAGTATTATTCCTCAAAATAACA TCAATCTATTTTTGTAAACCTGTTCATACTATTAAATTTTGCCCTAAAAGACCTCTTAATAATGATTGTTGCCAGTGACTGATGATTAAT TTTATTTTACTTAAAATAAGAAAAGGAGCACTTTAATTACAACTGAAAAATCAGATTGTTTTGTAGTCCTTCCTTACACTAATTTGAACT GTTAAAGATTGCTGCTTTTTTTTTGACATTGTCAATAACGAAACCTAATTGTAAAACAGTCACCATTTACTACCAATAACTTTTAGTTAA TGTTTTACAAGGAAAAAGACACAAGAAGAGTTTAAATTTTTTTGTTTTGTTTTGTTTTTTTGAGACAGTCTTGCTCTGTTACCCAGGCTG GAGGGGAGTGGTGCATTCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATCCTCCCACCTCAGCCTCCCAACTAGCTGGGACT GCAGGCACACACCACCATGCCTGACTAATTTTTGTATGTTTAGTAGAGACGGGGTTTTGCCATGTTGCCTAGGCTGGGGTTTAAGTTAAA TTTTTTAAAAAACTAAAGTGACTGGCACTAAGTGAACTTGAGATTATCCTCAGCTTCAAGTTCCTAAGATAAGGGCTTTCTTAAGCTTTC AGGTGTATGTATCCTCTAGATGTAGACAATAATGTCCCATTTCTAAGTCTTTTCCTTTTGCTTCTCCTTAAATTGATTGTACTTCCAAAT TTGCTGTTATGTTTTTTTCCTAATACTGTGATCTATCTGATCTGCAGACAAGAACCTTGTCTCTGTTGAAGAGCATCAAGGGGAGATTAT GTACACATTGAAACTGAAGTGTGGTGTTACTGACGGAATGTGCAGTAACTCCTCAGATATCTGTTAAGGCATTTCCCAGATGTGATGCCA GCCTTCTTACCTGTACTGAAAGATGCTTAGCTTAGAAAAAAACAAAACAGATGCAAAATCAGATAATTTTATTTTGTTTCATGGGTTTTC TTATTTACTTTTTAAACAAGGAAGGAATATTAGAAAATCACACAAGGCCTCACATACATGTTATTTAAAGAATGAATTGGGACGGATGTC TTAGACTTCACTTTCCTAGGCTTTTTAGCAAAACCTAAAGGGTGGTATCCATATTTTGCGTGAATTATGGGTGTAAGACCTTGCCCACTT AGGTTTTCTATCTCTGTCCTTGATCTTCTTTGCCAAAATGTGAGTATACAGAAATTTTCTGTATATTTCAACTTAAGACATTTTTAGCAT CTGTATAGTTTGTATTCAATTTGAGACCTTTTCTATGGGAAGCTCAGTAATTTTTATTAAAAGATTGCCATTGCTATTCATGTAAAACAT GGAAAAAAATTGTGTAGTGAAGCCAACAGTGGACTTAGGATGGGATTGAATGTTCAGTATAGTGATCTCACTTAGGAGAATTTGCAGGAG AAAGTGATAGTTTATTGTTTTTTCCTCGCCCATATTCAGTTTTGTTCTACTTCCTCCCCTTCCTTCCAGATGATAACATCACATCTCTAC AGTAAGTGCCTCTGCCAGCCCAACCCAGGAGCGCAAGTTGTCTTTGCCATCTGGTCTATAGTACAGTGCGCGGCGTTAGGCCACAACTCA AAAGCATTATCTTTTTTAGGGTTAGTAGAAATTGTTTTATGTTGATGGGAGGTTTGTTTGATTGTCAAAATGTACAGCCACAGCCTTTTA ATTTGGGAGCCCCTGTTGTCATTCAAATGTGTACCTCTACAGTTGTAAAAAGTATTAGATTCTACTATCTGTGGGTTGTGCTTGCCAGAC AGGTCTTAAATTGTATATTTTTTGGAAAAGTTTATATACTCTCTTAGGAATCATTGTGAAAAGATCAAGAAATCAGGATGGCCATTTATT TAATATCCATTCATTTCATGTTAGTGGGACTATTAACTTGTCACCAAGCAGGACTCTATTTCAAACAAAATTTAAAACTGTTTGTGGCCT ATATGTGTTTAATCCTGGTTAAAGATAAAGCTTCATAATGCTGTTTTTATTCAACACATTAACCAGCTGTAAAACACAGACCTTTATCAA GAGTAGGCAAAGATTTTCAGGATTCATATACAGATAGACTATAAAGTCATGTAATTTGAAAAGCAGTGTTTCATTATGAAAGAGCTCTCA |
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FusionGenePPI for CENPF_EGLN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CENPF | TOP3B, CENPF, ALK, NPM1, TERF1, TERF2, NDEL1, SVIL, ARRB2, SIRT7, COPS6, NUP107, NUP133, NQO2, HECW2, CUL7, OBSL1, CCDC68, FNTB, RNF166, MYC, NFKBIA, POLH, G3BP1, CDCA5, MZT1, CENPU, NANOG, CCDC33, IKBKG, TCP10L, GOPC, FAM167A, FBXL5, COG6, TMA16, ESAM, WASF3, MAP7D2, BRCA1 | EGLN1 | POLR2A, ING4, OSR1, HIF1A, EPAS1, HIST1H3A, OS9, SIAH2, EGLN1, EGLN3, SPRY2, SRC, FKBP8, LIMD1, VHL, MAGEA11, MAGEA9, PKM, KRAS, ZNF281, FKBP5, PLD1, RFPL4B, PEX19, SNUPN, CBWD1, CBWD2, MKS1, PLD2, GPLD1, RHOBTB3, PTGES3, FKBP4, HSP90AA1, HSP90AB1, N6AMT2, AKT1, AKT2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 2122_2447 | 356 | 3115 | NDE1 and NDEL1 |
| Hgene | CENPF | chr1:214795624 | chr1:231509845 | ENST00000366955 | + | 7 | 20 | 1_481 | 356 | 3115 | SNAP25 and required for localization to the cytoplasm |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CENPF_EGLN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | EGLN1 | Q9GZT9 | DB01592 | Iron | Egl nine homolog 1 | small molecule | approved |
| Tgene | EGLN1 | Q9GZT9 | DB00126 | Vitamin C | Egl nine homolog 1 | small molecule | approved|nutraceutical |
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RelatedDiseases for CENPF_EGLN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CENPF | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | EGLN1 | C1853286 | Erythrocytosis, Familial, 3 | 2 | CTD_human;UNIPROT |
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