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Fusion gene ID: 6758 |
FusionGeneSummary for CENPC_PAICS |
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Fusion gene information | Fusion gene name: CENPC_PAICS | Fusion gene ID: 6758 | Hgene | Tgene | Gene symbol | CENPC | PAICS | Gene ID | 1060 | 10606 |
Gene name | centromere protein C | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase | |
Synonyms | CENP-C|CENPC1|MIF2|hcp-4 | ADE2|ADE2H1|AIRC|PAIS | |
Cytomap | 4q13.2 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | centromere protein CCENP-C 1centromere autoantigen Ccentromere autoantigen C1centromere protein C 1interphase centromere complex protein 7 | multifunctional protein ADE2AIR carboxylaseSAICAR synthetasemultifunctional protein ADE2H1phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetasephosphoribosylaminoimidazole carboxylase; phosphoribosylamin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q03188 | P22234 | |
Ensembl transtripts involved in fusion gene | ENST00000273853, | ENST00000514888, ENST00000264221, ENST00000399688, ENST00000512576, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CENPC [Title/Abstract] AND PAICS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DC389672 | CENPC | chr4 | 68405556 | - | PAICS | chr4 | 57325536 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000273853 | ENST00000514888 | CENPC | chr4 | 68405556 | - | PAICS | chr4 | 57325536 | + |
In-frame | ENST00000273853 | ENST00000264221 | CENPC | chr4 | 68405556 | - | PAICS | chr4 | 57325536 | + |
Frame-shift | ENST00000273853 | ENST00000399688 | CENPC | chr4 | 68405556 | - | PAICS | chr4 | 57325536 | + |
In-frame | ENST00000273853 | ENST00000512576 | CENPC | chr4 | 68405556 | - | PAICS | chr4 | 57325536 | + |
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FusionProtFeatures for CENPC_PAICS |
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Hgene | Tgene |
CENPC | PAICS |
Component of the CENPA-NAC (nucleosome-associated)complex, a complex that plays a central role in assembly ofkinetochore proteins, mitotic progression and chromosomesegregation. The CENPA-NAC complex recruits the CENPA-CAD(nucleosome distal) complex and may be involved in incorporationof newly synthesized CENPA into centromeres. CENPC recruits DNAmethylation and DNMT3B to both centromeric and pericentromericsatellite repeats and regulates the histone code in these regions.{ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CENPC_PAICS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CENPC_ENST00000273853_chr4_68405556_-_PAICS_ENST00000264221_chr4_57325536_+_2479nt ATGTGTCTCCGGGTTCAAACCCAGGCACAGGCCAAGCGTTCTTGTTTGTTGAGGGCGGAGCCAATGGCGGGGGAGTGTTGTTAGCGCGCG CCTTCCGGATCGCAGCTCTCGCGGCAGTCGCCTGAGACTTAAGGTTATTGCTTGGCCGCGGCCTGGTATTCCGGCGATTCGTTTCTTGCT CGGCTTCCTGGAGCTGTGGTCCGTGTGGGCTTCCACCTCAGACAGTTGCGCTGGCTCAGCGGGGCCGGAACATGGCTGCGTCCGGTCTGG ATCATCTCAAAAATGGCTACAGAAGAAGATTTTGTCGACCTTCCAGGGCACGTGACATTAACACAGAGCAAGGCCAGAATGTTCTGGAAA TCTTACAAGACTGTTTTGAAGAAAAAAGTCTTGCCAATGATTTTAGTACAAATTCTACAAAATCAGTGCCTAATTCAACACGCAAAATAA AAGACACTTGTATTCAGTCACCAAGCAAAGAGGTCTTGGCTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGAT ATTTGGGTTAAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAAT CAGAGAATGTAATTTATAAGAAAGAATGCCATTGAATTTTTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAA GATGAAAAGGTAATTTTAAATTAGAGAACACAAATAAAATGTATTAGTGAATAAATGCTTCTCTAGATCCATATTAATAAACATGAGCAT CTAACCCCTCCTTTCTTAGGCTAGACACCAAGATATTTCAGCCAGCCTTTATCATTCCTCTTACTTTATCCTTTTTCCTTAAGTATTGGT GGTCACTACTATTGAGTTTCTTCCTTAACACTGATTAAATGATCTTAACTCCCTCAGCTAAAACTGGCATTACTGACTCCCAGCTATATT TCTCCAGACTTGCATTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGTTCACTGC TGCTTTCCCTCCTGGGCTCAAGCAGTTCTCCCACCTCAGCCTCTCGACTAACAGGGACTATAATCTTGCAGCACCATGCCGAGCTAATTT TATTTTTTGTAGAGATGAGCTCTCACTATGTCACCCAGGTTCGTCTCAAACTCCTGAACCCTAGTAATTCTCCTATCTCAGCCTCCCAAA GTGCTAGGGTTACAGACATGAGCCACTGTGCCTGTCTAGACTTGTACTTTCAACTGTCCATTTCTCCCTGTCTGTCCCATGGGCACTCAT GAAAAAACAGAATGCTCCCAACTTTATTCATCTTCCAAGCCTGTAGCTCTTGGTATACTCACTGTTGCAAGTCAGAAGCTTGATTTCATC ATTGATGTTTTTCTCACGTTTCACATCTCACTCATCACCAAGTCATGTTGGTGTTAATTTCTGATTAACCCTTGAATTTACCGTCTTCTC ATCCTCTGTACAAAAGCCTCAAGTGAGGGTCAAATTCAACATTATCCTGATCTAGACAGCCCCCATTCTCAATCCACCCTTTTCCAAGTT GATTGCCCAAGGACTTCTAACAATAAACTCTCTTTTGCACCACAGACTTCTTTGAAAATATACATGCTGTTGACCCTCTCTGTAGAAAAC CGCACACATAAAACTTACCAACAGATTTCATTGGTTCTTGGGTTCTCCCGAAGCCTATCCATGGTTTATAGATTAAGAATTGATGAGGTA GCTGGGCACAGTGGCTCACACCTACGATCACAGCACTTCGGGAGGCTGAAGCAAGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCT GGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAGTAGCCAGCCGTGATGACAGGCACCTGTAATCCCAGCTACTCGGGAGG CTGAGGCATGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCTAGATCATGCCACTGCACTCCAACCTGGGCAGCAGAGCAA GACTCTGTCTCAAAAGGGGAAAAAAAAAATTGCTGATGTGACCCATGAAGGGAACTCATTTTCCTCGTAATTTTGGACTGCCACACATTG GTACCTTTAGTTCTCTGAAGGCCCACGTTTTTATCATTAAGACCTATTTGTTAGCTAGTAGAGCTTTATGTTCGCTGTCCATGAAACCTT CTGTAACCACAGTGACTACAAGTAGTTCTTTCTCTATTGAATTATTAGGTCCAGAATAGAAGATGTCATTGTACACTTTATTTCCCTCAC ACTGTGTTATGCTCTGATGTGCTATGCTTAGCTATCTGTCAGAGATTAGTAAATTATAAAACTCATGTGTACTACTTAAGTTTATATCTT >In-frame_CENPC_ENST00000273853_chr4_68405556_-_PAICS_ENST00000512576_chr4_57325536_+_775nt ATGTGTCTCCGGGTTCAAACCCAGGCACAGGCCAAGCGTTCTTGTTTGTTGAGGGCGGAGCCAATGGCGGGGGAGTGTTGTTAGCGCGCG CCTTCCGGATCGCAGCTCTCGCGGCAGTCGCCTGAGACTTAAGGTTATTGCTTGGCCGCGGCCTGGTATTCCGGCGATTCGTTTCTTGCT CGGCTTCCTGGAGCTGTGGTCCGTGTGGGCTTCCACCTCAGACAGTTGCGCTGGCTCAGCGGGGCCGGAACATGGCTGCGTCCGGTCTGG ATCATCTCAAAAATGGCTACAGAAGAAGATTTTGTCGACCTTCCAGGGCACGTGACATTAACACAGAGCAAGGCCAGAATGTTCTGGAAA TCTTACAAGACTGTTTTGAAGAAAAAAGTCTTGCCAATGATTTTAGTACAAATTCTACAAAATCAGTGCCTAATTCAACACGCAAAATAA AAGACACTTGTATTCAGTCACCAAGCAAAGAGGTCTTGGCTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGAT ATTTGGGTTAAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAAT CAGAGAATGTAATTTATAAGAAAGAATGCCATTGAATTTTTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAA |
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FusionGenePPI for CENPC_PAICS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CENPC | MDC1, DAXX, UBTF, RPAP1, HNRNPA1, ZWINT, MIS12, PTEN, MAPK14, CENPA, CENPM, TCEB1, NIFK, NPM1, FGL1, HIST1H2BG, JAK3, NUP153, CENPQ, CENPO, CDC14B, RBM34, DSN1, DGCR8, RBM4, H2AFY2, CENPU, NDC80, RPL18, RRP8, PMF1, ACTA2, NUF2 | PAICS | CEP76, FXR2, PAICS, NUDT18, LNX1, PSMC4, DGKE, HLA-B, GNAS, EPB41, TRAF6, MCC, EIF6, CHD3, MOB4, SIRT7, TERF1, CUL3, CDK2, GART, ZPR1, TTC1, UNK, PUM1, GINS4, STUB1, UBE2B, RPAP1, SSSCA1, TACC3, TMEM177, NDUFV1, TP53BP1, FN1, NIF3L1, PRKAG1, SMARCD1, FARSB, PRKCSH, SET, QRICH1, SUPT5H, SWAP70, WWOX, HUWE1, FUS, L3MBTL2, ABCC1, ASNS, ASS1, ATIC, ETFA, GLOD4, GLRX5, HSPB1, HSPE1, IMPA2, MIF, ADSL, ARF1, DAZAP1, UFM1, PCBP1, PFAS, PKLR, PKM, PRDX2, RPIA, SHMT1, TKT, UGP2, NTRK1, HIST1H2BG, MED4, POLR2G, HNRNPA1L2, CRY1, CRY2, MCM2, U2AF2, CDC73, CDH1, DLD, DLST, DNM1L, TRIM25, BRCA1, YAP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CENPC_PAICS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CENPC_PAICS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |