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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6758

FusionGeneSummary for CENPC_PAICS

check button Fusion gene summary
Fusion gene informationFusion gene name: CENPC_PAICS
Fusion gene ID: 6758
HgeneTgene
Gene symbol

CENPC

PAICS

Gene ID

1060

10606

Gene namecentromere protein Cphosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
SynonymsCENP-C|CENPC1|MIF2|hcp-4ADE2|ADE2H1|AIRC|PAIS
Cytomap

4q13.2

4q12

Type of geneprotein-codingprotein-coding
Descriptioncentromere protein CCENP-C 1centromere autoantigen Ccentromere autoantigen C1centromere protein C 1interphase centromere complex protein 7multifunctional protein ADE2AIR carboxylaseSAICAR synthetasemultifunctional protein ADE2H1phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetasephosphoribosylaminoimidazole carboxylase; phosphoribosylamin
Modification date2018052320180523
UniProtAcc

Q03188

P22234

Ensembl transtripts involved in fusion geneENST00000273853, ENST00000514888, 
ENST00000264221, ENST00000399688, 
ENST00000512576, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CENPC [Title/Abstract] AND PAICS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DC389672CENPCchr4

68405556

-PAICSchr4

57325536

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000273853ENST00000514888CENPCchr4

68405556

-PAICSchr4

57325536

+
In-frameENST00000273853ENST00000264221CENPCchr4

68405556

-PAICSchr4

57325536

+
Frame-shiftENST00000273853ENST00000399688CENPCchr4

68405556

-PAICSchr4

57325536

+
In-frameENST00000273853ENST00000512576CENPCchr4

68405556

-PAICSchr4

57325536

+

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FusionProtFeatures for CENPC_PAICS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CENPC

Q03188

PAICS

P22234

Component of the CENPA-NAC (nucleosome-associated)complex, a complex that plays a central role in assembly ofkinetochore proteins, mitotic progression and chromosomesegregation. The CENPA-NAC complex recruits the CENPA-CAD(nucleosome distal) complex and may be involved in incorporationof newly synthesized CENPA into centromeres. CENPC recruits DNAmethylation and DNMT3B to both centromeric and pericentromericsatellite repeats and regulates the histone code in these regions.{ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CENPC_PAICS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_CENPC_ENST00000273853_chr4_68405556_-_PAICS_ENST00000264221_chr4_57325536_+_2479nt
ATGTGTCTCCGGGTTCAAACCCAGGCACAGGCCAAGCGTTCTTGTTTGTTGAGGGCGGAGCCAATGGCGGGGGAGTGTTGTTAGCGCGCG
CCTTCCGGATCGCAGCTCTCGCGGCAGTCGCCTGAGACTTAAGGTTATTGCTTGGCCGCGGCCTGGTATTCCGGCGATTCGTTTCTTGCT
CGGCTTCCTGGAGCTGTGGTCCGTGTGGGCTTCCACCTCAGACAGTTGCGCTGGCTCAGCGGGGCCGGAACATGGCTGCGTCCGGTCTGG
ATCATCTCAAAAATGGCTACAGAAGAAGATTTTGTCGACCTTCCAGGGCACGTGACATTAACACAGAGCAAGGCCAGAATGTTCTGGAAA
TCTTACAAGACTGTTTTGAAGAAAAAAGTCTTGCCAATGATTTTAGTACAAATTCTACAAAATCAGTGCCTAATTCAACACGCAAAATAA
AAGACACTTGTATTCAGTCACCAAGCAAAGAGGTCTTGGCTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGAT
ATTTGGGTTAAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAAT
CAGAGAATGTAATTTATAAGAAAGAATGCCATTGAATTTTTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAA
GATGAAAAGGTAATTTTAAATTAGAGAACACAAATAAAATGTATTAGTGAATAAATGCTTCTCTAGATCCATATTAATAAACATGAGCAT
CTAACCCCTCCTTTCTTAGGCTAGACACCAAGATATTTCAGCCAGCCTTTATCATTCCTCTTACTTTATCCTTTTTCCTTAAGTATTGGT
GGTCACTACTATTGAGTTTCTTCCTTAACACTGATTAAATGATCTTAACTCCCTCAGCTAAAACTGGCATTACTGACTCCCAGCTATATT
TCTCCAGACTTGCATTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGTTCACTGC
TGCTTTCCCTCCTGGGCTCAAGCAGTTCTCCCACCTCAGCCTCTCGACTAACAGGGACTATAATCTTGCAGCACCATGCCGAGCTAATTT
TATTTTTTGTAGAGATGAGCTCTCACTATGTCACCCAGGTTCGTCTCAAACTCCTGAACCCTAGTAATTCTCCTATCTCAGCCTCCCAAA
GTGCTAGGGTTACAGACATGAGCCACTGTGCCTGTCTAGACTTGTACTTTCAACTGTCCATTTCTCCCTGTCTGTCCCATGGGCACTCAT
GAAAAAACAGAATGCTCCCAACTTTATTCATCTTCCAAGCCTGTAGCTCTTGGTATACTCACTGTTGCAAGTCAGAAGCTTGATTTCATC
ATTGATGTTTTTCTCACGTTTCACATCTCACTCATCACCAAGTCATGTTGGTGTTAATTTCTGATTAACCCTTGAATTTACCGTCTTCTC
ATCCTCTGTACAAAAGCCTCAAGTGAGGGTCAAATTCAACATTATCCTGATCTAGACAGCCCCCATTCTCAATCCACCCTTTTCCAAGTT
GATTGCCCAAGGACTTCTAACAATAAACTCTCTTTTGCACCACAGACTTCTTTGAAAATATACATGCTGTTGACCCTCTCTGTAGAAAAC
CGCACACATAAAACTTACCAACAGATTTCATTGGTTCTTGGGTTCTCCCGAAGCCTATCCATGGTTTATAGATTAAGAATTGATGAGGTA
GCTGGGCACAGTGGCTCACACCTACGATCACAGCACTTCGGGAGGCTGAAGCAAGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCT
GGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAGTAGCCAGCCGTGATGACAGGCACCTGTAATCCCAGCTACTCGGGAGG
CTGAGGCATGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCTAGATCATGCCACTGCACTCCAACCTGGGCAGCAGAGCAA
GACTCTGTCTCAAAAGGGGAAAAAAAAAATTGCTGATGTGACCCATGAAGGGAACTCATTTTCCTCGTAATTTTGGACTGCCACACATTG
GTACCTTTAGTTCTCTGAAGGCCCACGTTTTTATCATTAAGACCTATTTGTTAGCTAGTAGAGCTTTATGTTCGCTGTCCATGAAACCTT
CTGTAACCACAGTGACTACAAGTAGTTCTTTCTCTATTGAATTATTAGGTCCAGAATAGAAGATGTCATTGTACACTTTATTTCCCTCAC
ACTGTGTTATGCTCTGATGTGCTATGCTTAGCTATCTGTCAGAGATTAGTAAATTATAAAACTCATGTGTACTACTTAAGTTTATATCTT

>In-frame_CENPC_ENST00000273853_chr4_68405556_-_PAICS_ENST00000512576_chr4_57325536_+_775nt
ATGTGTCTCCGGGTTCAAACCCAGGCACAGGCCAAGCGTTCTTGTTTGTTGAGGGCGGAGCCAATGGCGGGGGAGTGTTGTTAGCGCGCG
CCTTCCGGATCGCAGCTCTCGCGGCAGTCGCCTGAGACTTAAGGTTATTGCTTGGCCGCGGCCTGGTATTCCGGCGATTCGTTTCTTGCT
CGGCTTCCTGGAGCTGTGGTCCGTGTGGGCTTCCACCTCAGACAGTTGCGCTGGCTCAGCGGGGCCGGAACATGGCTGCGTCCGGTCTGG
ATCATCTCAAAAATGGCTACAGAAGAAGATTTTGTCGACCTTCCAGGGCACGTGACATTAACACAGAGCAAGGCCAGAATGTTCTGGAAA
TCTTACAAGACTGTTTTGAAGAAAAAAGTCTTGCCAATGATTTTAGTACAAATTCTACAAAATCAGTGCCTAATTCAACACGCAAAATAA
AAGACACTTGTATTCAGTCACCAAGCAAAGAGGTCTTGGCTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGAT
ATTTGGGTTAAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAAT
CAGAGAATGTAATTTATAAGAAAGAATGCCATTGAATTTTTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAA


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FusionGenePPI for CENPC_PAICS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CENPCMDC1, DAXX, UBTF, RPAP1, HNRNPA1, ZWINT, MIS12, PTEN, MAPK14, CENPA, CENPM, TCEB1, NIFK, NPM1, FGL1, HIST1H2BG, JAK3, NUP153, CENPQ, CENPO, CDC14B, RBM34, DSN1, DGCR8, RBM4, H2AFY2, CENPU, NDC80, RPL18, RRP8, PMF1, ACTA2, NUF2PAICSCEP76, FXR2, PAICS, NUDT18, LNX1, PSMC4, DGKE, HLA-B, GNAS, EPB41, TRAF6, MCC, EIF6, CHD3, MOB4, SIRT7, TERF1, CUL3, CDK2, GART, ZPR1, TTC1, UNK, PUM1, GINS4, STUB1, UBE2B, RPAP1, SSSCA1, TACC3, TMEM177, NDUFV1, TP53BP1, FN1, NIF3L1, PRKAG1, SMARCD1, FARSB, PRKCSH, SET, QRICH1, SUPT5H, SWAP70, WWOX, HUWE1, FUS, L3MBTL2, ABCC1, ASNS, ASS1, ATIC, ETFA, GLOD4, GLRX5, HSPB1, HSPE1, IMPA2, MIF, ADSL, ARF1, DAZAP1, UFM1, PCBP1, PFAS, PKLR, PKM, PRDX2, RPIA, SHMT1, TKT, UGP2, NTRK1, HIST1H2BG, MED4, POLR2G, HNRNPA1L2, CRY1, CRY2, MCM2, U2AF2, CDC73, CDH1, DLD, DLST, DNM1L, TRIM25, BRCA1, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CENPC_PAICS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CENPC_PAICS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource