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Fusion gene ID: 6754 |
FusionGeneSummary for CEL_CPA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CEL_CPA1 | Fusion gene ID: 6754 | Hgene | Tgene | Gene symbol | CEL | CPA1 | Gene ID | 1056 | 1357 |
| Gene name | carboxyl ester lipase | carboxypeptidase A1 | |
| Synonyms | BAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8 | CPA | |
| Cytomap | 9q34.13 | 7q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera | carboxypeptidase A1carboxypeptidase A1 (pancreatic)pancreatic carboxypeptidase A | |
| Modification date | 20180528 | 20180523 | |
| UniProtAcc | P19835 | P15085 | |
| Ensembl transtripts involved in fusion gene | ENST00000351304, ENST00000372080, | ENST00000011292, ENST00000484324, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 5 X 6 X 2=60 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CEL [Title/Abstract] AND CPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CEL | GO:0006707 | cholesterol catabolic process | 12031288 |
| Hgene | CEL | GO:0030157 | pancreatic juice secretion | 1854805 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-F2-6880-01A | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| TCGA | LD | PAAD | TCGA-IB-7652-01A | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000351304 | ENST00000011292 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| Frame-shift | ENST00000351304 | ENST00000484324 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| Frame-shift | ENST00000372080 | ENST00000011292 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| Frame-shift | ENST00000372080 | ENST00000484324 | CEL | chr9 | 135937455 | + | CPA1 | chr7 | 130027665 | + |
| In-frame | ENST00000351304 | ENST00000011292 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| In-frame | ENST00000351304 | ENST00000484324 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| In-frame | ENST00000372080 | ENST00000011292 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
| In-frame | ENST00000372080 | ENST00000484324 | CEL | chr9 | 135940149 | + | CPA1 | chr7 | 130024987 | + |
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FusionProtFeatures for CEL_CPA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CEL | CPA1 |
| Catalyzes fat and vitamin absorption. Acts in concertwith pancreatic lipase and colipase for the complete digestion ofdietary triglycerides. | Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu,-Arg, -Lys or -Pro. {ECO:0000269|PubMed:8806703}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CPA1 | chr9:135940149 | chr7:130024987 | ENST00000011292 | + | 6 | 10 | 307_308 | 262 | 420 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 21_121 | 113 | 688 | Region | Note=Heparin-binding |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 559_745 | 113 | 688 | Region | Note=17 X 11 AA tandem repeats%2C glycodomain%2C O-linked (mucin type) |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 559_569 | 113 | 688 | Repeat | Note=1 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 570_580 | 113 | 688 | Repeat | Note=2 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 581_591 | 113 | 688 | Repeat | Note=3 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 592_602 | 113 | 688 | Repeat | Note=4 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 603_613 | 113 | 688 | Repeat | Note=5 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 614_624 | 113 | 688 | Repeat | Note=6 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 625_635 | 113 | 688 | Repeat | Note=7 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 636_646 | 113 | 688 | Repeat | Note=8 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 647_657 | 113 | 688 | Repeat | Note=9 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 658_668 | 113 | 688 | Repeat | Note=10 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 669_679 | 113 | 688 | Repeat | Note=11 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 680_690 | 113 | 688 | Repeat | Note=12 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 691_701 | 113 | 688 | Repeat | Note=13 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 702_712 | 113 | 688 | Repeat | Note=14 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 713_723 | 113 | 688 | Repeat | Note=15 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 724_734 | 113 | 688 | Repeat | Note=16 |
| Hgene | >CEL | chr9:135940149 | chr7:130024987 | ENST00000351304 | + | 3 | 10 | 735_745 | 113 | 688 | Repeat | Note=17 |
| Tgene | CPA1 | chr9:135940149 | chr7:130024987 | ENST00000011292 | + | 6 | 10 | 179_182 | 262 | 420 | Region | Substrate binding |
| Tgene | CPA1 | chr9:135940149 | chr7:130024987 | ENST00000011292 | + | 6 | 10 | 254_255 | 262 | 420 | Region | Substrate binding |
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FusionGeneSequence for CEL_CPA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CEL_ENST00000351304_chr9_135940149_+_CPA1_ENST00000011292_chr7_130024987_+_271aa MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATIT QDSTYGDEDCLYLNIWVPQGRKQVSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDEL DQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY >In-frame_CEL_ENST00000351304_chr9_135940149_+_CPA1_ENST00000484324_chr7_130024987_+_271aa MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATIT QDSTYGDEDCLYLNIWVPQGRKQVSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDEL DQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY >In-frame_CEL_ENST00000372080_chr9_135940149_+_CPA1_ENST00000011292_chr7_130024987_+_274aa MLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQA TITQDSTYGDEDCLYLNIWVPQGRKQVSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQ DELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLN >In-frame_CEL_ENST00000372080_chr9_135940149_+_CPA1_ENST00000484324_chr7_130024987_+_274aa MLTMGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQA TITQDSTYGDEDCLYLNIWVPQGRKQVSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQ DELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CEL_ENST00000351304_chr9_135940149_+_CPA1_ENST00000011292_chr7_130024987_+_813nt ATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAAGCTGGGCGCCGTGTACACAGAAGGT GGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCTCCCACCAAG GCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAAGAGATGCCTGCAGGCCACCATCACC CAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTGTCCGGAGCCAGCAGTAAC CCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGACTTTGTGAAGGACCATGGGAACATC AAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGAACCAGTCCCTGACCAGGATGAGCTG GATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGGCAGCATCATCAAGGCAATTTATCAA GCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCTCCGGGACACTGGGCGCTATGGCTTC CTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCATGGAGCACACCCTGAATCACCCCTAC >In-frame_CEL_ENST00000351304_chr9_135940149_+_CPA1_ENST00000484324_chr7_130024987_+_813nt ATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAAGCTGGGCGCCGTGTACACAGAAGGT GGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCTCCCACCAAG GCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAAGAGATGCCTGCAGGCCACCATCACC CAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTGTCCGGAGCCAGCAGTAAC CCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGACTTTGTGAAGGACCATGGGAACATC AAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGAACCAGTCCCTGACCAGGATGAGCTG GATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGGCAGCATCATCAAGGCAATTTATCAA GCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCTCCGGGACACTGGGCGCTATGGCTTC CTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCATGGAGCACACCCTGAATCACCCCTAC >In-frame_CEL_ENST00000372080_chr9_135940149_+_CPA1_ENST00000011292_chr7_130024987_+_822nt ATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAAGCTGGGCGCCGTGTAC ACAGAAGGTGGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCT CCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAAGAGATGCCTGCAGGCC ACCATCACCCAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTGTCCGGAGCC AGCAGTAACCCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGACTTTGTGAAGGACCAT GGGAACATCAAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGAACCAGTCCCTGACCAG GATGAGCTGGATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGGCAGCATCATCAAGGCA ATTTATCAAGCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCTCCGGGACACTGGGCGC TATGGCTTCCTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCATGGAGCACACCCTGAAT >In-frame_CEL_ENST00000372080_chr9_135940149_+_CPA1_ENST00000484324_chr7_130024987_+_822nt ATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAAGCTGGGCGCCGTGTAC ACAGAAGGTGGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCT CCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAAGAGATGCCTGCAGGCC ACCATCACCCAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTGTCCGGAGCC AGCAGTAACCCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGACTTTGTGAAGGACCAT GGGAACATCAAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGAACCAGTCCCTGACCAG GATGAGCTGGATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGGCAGCATCATCAAGGCA ATTTATCAAGCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCTCCGGGACACTGGGCGC TATGGCTTCCTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCATGGAGCACACCCTGAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CEL_ENST00000351304_chr9_135940149_+_CPA1_ENST00000011292_chr7_130024987_+_915nt GGCCACCCAGAGGCTGATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAA GCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGG CATCCCCTTCGCAGCTCCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAA GAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAA GCAAGTGTCCGGAGCCAGCAGTAACCCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGA CTTTGTGAAGGACCATGGGAACATCAAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGA ACCAGTCCCTGACCAGGATGAGCTGGATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGG CAGCATCATCAAGGCAATTTATCAAGCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCT CCGGGACACTGGGCGCTATGGCTTCCTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCAT GGAGCACACCCTGAATCACCCCTACTGAGCTGACCCTTTGACACCCTTCTTGTCCTCCTCTCTGGCCCCATCCAGGCAACCAAATAAAGT >In-frame_CEL_ENST00000351304_chr9_135940149_+_CPA1_ENST00000484324_chr7_130024987_+_941nt GGCCACCCAGAGGCTGATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAA GCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGG CATCCCCTTCGCAGCTCCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAA GAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAA GCAAGTGTCCGGAGCCAGCAGTAACCCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGA CTTTGTGAAGGACCATGGGAACATCAAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGA ACCAGTCCCTGACCAGGATGAGCTGGATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGG CAGCATCATCAAGGCAATTTATCAAGCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCT CCGGGACACTGGGCGCTATGGCTTCCTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCAT GGAGCACACCCTGAATCACCCCTACTGAGCTGACCCTTTGACACCCTTCTTGTCCTCCTCTCTGGCCCCATCCAGGCAACCAAATAAAGT >In-frame_CEL_ENST00000372080_chr9_135940149_+_CPA1_ENST00000011292_chr7_130024987_+_915nt GGCCACCCAGAGGCTGATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAA GCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGG CATCCCCTTCGCAGCTCCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAA GAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAA GCAAGTGTCCGGAGCCAGCAGTAACCCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGA CTTTGTGAAGGACCATGGGAACATCAAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGA ACCAGTCCCTGACCAGGATGAGCTGGATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGG CAGCATCATCAAGGCAATTTATCAAGCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCT CCGGGACACTGGGCGCTATGGCTTCCTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCAT GGAGCACACCCTGAATCACCCCTACTGAGCTGACCCTTTGACACCCTTCTTGTCCTCCTCTCTGGCCCCATCCAGGCAACCAAATAAAGT >In-frame_CEL_ENST00000372080_chr9_135940149_+_CPA1_ENST00000484324_chr7_130024987_+_941nt GGCCACCCAGAGGCTGATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTGGCGAGTGCCGCGAA GCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAATAAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGG CATCCCCTTCGCAGCTCCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCCAAGAACTTCAAGAA GAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGATGAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAA GCAAGTGTCCGGAGCCAGCAGTAACCCCTGCTCGGAGACTTACCACGGCAAGTTTGCCAATTCCGAAGTGGAGGTCAAGTCCATTGTAGA CTTTGTGAAGGACCATGGGAACATCAAGGCCTTCATCTCCATCCACAGCTACTCCCAGCTCCTCATGTATCCCTATGGCTACAAAACAGA ACCAGTCCCTGACCAGGATGAGCTGGATCAGCTTTCCAAGGCTGCTGTGACAGCCCTGGCCTCTCTCTACGGGACCAAGTTCAACTATGG CAGCATCATCAAGGCAATTTATCAAGCCAGTGGAAGCACTATTGACTGGACCTACAGCCAGGGCATCAAGTACTCCTTCACCTTCGAGCT CCGGGACACTGGGCGCTATGGCTTCCTGCTGCCAGCCTCCCAGATCATCCCCACAGCCAAGGAGACGTGGCTGGCGCTTCTGACCATCAT GGAGCACACCCTGAATCACCCCTACTGAGCTGACCCTTTGACACCCTTCTTGTCCTCCTCTCTGGCCCCATCCAGGCAACCAAATAAAGT |
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FusionGenePPI for CEL_CPA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CEL | BPGM, OLR1 | CPA1 | ARRB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CEL_CPA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CEL_CPA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CEL | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |
| Tgene | CPA1 | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |
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