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Fusion gene ID: 6749 |
FusionGeneSummary for CELSR2_SARS |
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Fusion gene information | Fusion gene name: CELSR2_SARS | Fusion gene ID: 6749 | Hgene | Tgene | Gene symbol | CELSR2 | SARS | Gene ID | 1952 | 54938 |
Gene name | cadherin EGF LAG seven-pass G-type receptor 2 | seryl-tRNA synthetase 2, mitochondrial | |
Synonyms | ADGRC2|CDHF10|EGFL2|Flamingo1|MEGF3 | SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS | |
Cytomap | 1p13.3 | 19q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cadherin EGF LAG seven-pass G-type receptor 2EGF-like protein 2EGF-like-domain, multiple 2adhesion G protein-coupled receptor C2cadherin family member 10cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)epidermal growth fa | serine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9HCU4 | P49591 | |
Ensembl transtripts involved in fusion gene | ENST00000271332, ENST00000498157, | ENST00000234677, ENST00000369923, ENST00000468588, | |
Fusion gene scores | * DoF score | 6 X 7 X 7=294 | 6 X 5 X 4=120 |
# samples | 11 | 7 | |
** MAII score | log2(11/294*10)=-1.4183126313117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CELSR2 [Title/Abstract] AND SARS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A208-01A | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
TCGA | RV | UCEC | TCGA-A5-A2K4-01A | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000271332 | ENST00000234677 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
Frame-shift | ENST00000271332 | ENST00000369923 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
5CDS-3UTR | ENST00000271332 | ENST00000468588 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
3UTR-3CDS | ENST00000498157 | ENST00000234677 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
3UTR-3CDS | ENST00000498157 | ENST00000369923 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
3UTR-3UTR | ENST00000498157 | ENST00000468588 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109780353 | + |
Frame-shift | ENST00000271332 | ENST00000234677 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
Frame-shift | ENST00000271332 | ENST00000369923 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
5CDS-intron | ENST00000271332 | ENST00000468588 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
3UTR-3CDS | ENST00000498157 | ENST00000234677 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
3UTR-3CDS | ENST00000498157 | ENST00000369923 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
3UTR-intron | ENST00000498157 | ENST00000468588 | CELSR2 | chr1 | 109816292 | + | SARS | chr1 | 109773500 | + |
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FusionProtFeatures for CELSR2_SARS |
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Hgene | Tgene |
CELSR2 | SARS |
Receptor that may have an important role in cell/cellsignaling during nervous system formation. | Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2743_2752 | 2914 | 2924 | Compositional bias | Note=Poly-Glu |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1028_1146 | 2914 | 2924 | Domain | Cadherin 9 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1228_1286 | 2914 | 2924 | Domain | EGF-like 1%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1288_1324 | 2914 | 2924 | Domain | EGF-like 2%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1328_1366 | 2914 | 2924 | Domain | EGF-like 3%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1367_1571 | 2914 | 2924 | Domain | Laminin G-like 1 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1574_1610 | 2914 | 2924 | Domain | EGF-like 4%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1614_1791 | 2914 | 2924 | Domain | Laminin G-like 2 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1793_1828 | 2914 | 2924 | Domain | EGF-like 5%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1829_1867 | 2914 | 2924 | Domain | EGF-like 6%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 182_289 | 2914 | 2924 | Domain | Cadherin 1 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1883_1922 | 2914 | 2924 | Domain | EGF-like 7%3B calcium-binding |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 1924_1971 | 2914 | 2924 | Domain | Laminin EGF-like |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2316_2368 | 2914 | 2924 | Domain | GPS |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 290_399 | 2914 | 2924 | Domain | Cadherin 2 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 400_505 | 2914 | 2924 | Domain | Cadherin 3 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 506_610 | 2914 | 2924 | Domain | Cadherin 4 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 611_712 | 2914 | 2924 | Domain | Cadherin 5 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 713_815 | 2914 | 2924 | Domain | Cadherin 6 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 816_921 | 2914 | 2924 | Domain | Cadherin 7 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 922_1023 | 2914 | 2924 | Domain | Cadherin 8 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2402_2416 | 2914 | 2924 | Topological domain | Cytoplasmic |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2438_2438 | 2914 | 2924 | Topological domain | Extracellular |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2460_2480 | 2914 | 2924 | Topological domain | Cytoplasmic |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2502_2519 | 2914 | 2924 | Topological domain | Extracellular |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2541_2560 | 2914 | 2924 | Topological domain | Cytoplasmic |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2582_2591 | 2914 | 2924 | Topological domain | Extracellular |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 32_2380 | 2914 | 2924 | Topological domain | Extracellular |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2381_2401 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D1 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2417_2437 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D2 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2439_2459 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D3 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2481_2501 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D4 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2520_2540 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D5 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2561_2581 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D6 |
Hgene | CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2592_2612 | 2914 | 2924 | Transmembrane | Helical%3B Name%3D7 |
Tgene | >SARS | chr1:109816292 | chr1:109780353 | ENST00000234677 | + | 9 | 11 | 482_494 | 462 | 515 | Motif | Nuclear localization signal |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CELSR2 | chr1:109816292 | chr1:109780353 | ENST00000271332 | + | 33 | 34 | 2613_2923 | 2914 | 2924 | Topological domain | Cytoplasmic |
Tgene | SARS | chr1:109816292 | chr1:109780353 | ENST00000234677 | + | 9 | 11 | 302_304 | 462 | 515 | Nucleotide binding | ATP |
Tgene | SARS | chr1:109816292 | chr1:109780353 | ENST00000234677 | + | 9 | 11 | 318_321 | 462 | 515 | Nucleotide binding | ATP |
Tgene | SARS | chr1:109816292 | chr1:109780353 | ENST00000234677 | + | 9 | 11 | 391_394 | 462 | 515 | Nucleotide binding | ATP |
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FusionGeneSequence for CELSR2_SARS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CELSR2_SARS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CELSR2 | RYK, NXPH2, USP36, KLK5, DTWD2, NAALADL2, DDX39A, TNF, LYPD6, LCA5, XAGE1B, SIRT6, TMEM30B, DKKL1, PCDH12, PCDHGB1, RPL28, PSG8, ZBBX, FGFRL1, VAPB, ST8SIA4, PCDH20, IL27RA | SARS | SIRT2, TRS-AGA2-4, UBA5, MYC, TERF1, TINF2, POT1, CDK2, PALLD, TARS, GATC, ANP32E, EFTUD2, GTF2A1, ACBD3, ASF1A, ATG7, ATP6V1C1, CTTN, DUS3L, ELAC2, GTF2E1, STAT1, TTC1, XPO5, SNX5, TBCD, FRMPD2, R3HCC1L, C12orf45, ARFIP1, ARFIP2, C9orf78, CAD, CCDC6, GFPT2, HARS, HARS2, HIP1R, HSPB1, NUP210, PAPOLA, PFDN2, PFKM, PPM1G, PRRC1, PTGES3, MESDC2, TSG101, SEC13, SNW1, TRIM25, WARS, NTRK1, XPO1, MCM2, DUSP21, SOD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | SARS | chr1:109816292 | chr1:109780353 | ENST00000234677 | + | 9 | 11 | 9_61 | 462 | 515 | tRNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CELSR2_SARS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CELSR2_SARS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CELSR2 | C0014173 | Endometrial Hyperplasia | 1 | CTD_human |