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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6749

FusionGeneSummary for CELSR2_SARS

check button Fusion gene summary
Fusion gene informationFusion gene name: CELSR2_SARS
Fusion gene ID: 6749
HgeneTgene
Gene symbol

CELSR2

SARS

Gene ID

1952

54938

Gene namecadherin EGF LAG seven-pass G-type receptor 2seryl-tRNA synthetase 2, mitochondrial
SynonymsADGRC2|CDHF10|EGFL2|Flamingo1|MEGF3SARS|SARSM|SERS|SYS|SerRS|SerRSmt|mtSerRS
Cytomap

1p13.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptioncadherin EGF LAG seven-pass G-type receptor 2EGF-like protein 2EGF-like-domain, multiple 2adhesion G protein-coupled receptor C2cadherin family member 10cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)epidermal growth faserine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase
Modification date2018051920180523
UniProtAcc

Q9HCU4

P49591

Ensembl transtripts involved in fusion geneENST00000271332, ENST00000498157, 
ENST00000234677, ENST00000369923, 
ENST00000468588, 
Fusion gene scores* DoF score6 X 7 X 7=2946 X 5 X 4=120
# samples 117
** MAII scorelog2(11/294*10)=-1.4183126313117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CELSR2 [Title/Abstract] AND SARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A208-01ACELSR2chr1

109816292

+SARSchr1

109780353

+
TCGARVUCECTCGA-A5-A2K4-01ACELSR2chr1

109816292

+SARSchr1

109773500

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000271332ENST00000234677CELSR2chr1

109816292

+SARSchr1

109780353

+
Frame-shiftENST00000271332ENST00000369923CELSR2chr1

109816292

+SARSchr1

109780353

+
5CDS-3UTRENST00000271332ENST00000468588CELSR2chr1

109816292

+SARSchr1

109780353

+
3UTR-3CDSENST00000498157ENST00000234677CELSR2chr1

109816292

+SARSchr1

109780353

+
3UTR-3CDSENST00000498157ENST00000369923CELSR2chr1

109816292

+SARSchr1

109780353

+
3UTR-3UTRENST00000498157ENST00000468588CELSR2chr1

109816292

+SARSchr1

109780353

+
Frame-shiftENST00000271332ENST00000234677CELSR2chr1

109816292

+SARSchr1

109773500

+
Frame-shiftENST00000271332ENST00000369923CELSR2chr1

109816292

+SARSchr1

109773500

+
5CDS-intronENST00000271332ENST00000468588CELSR2chr1

109816292

+SARSchr1

109773500

+
3UTR-3CDSENST00000498157ENST00000234677CELSR2chr1

109816292

+SARSchr1

109773500

+
3UTR-3CDSENST00000498157ENST00000369923CELSR2chr1

109816292

+SARSchr1

109773500

+
3UTR-intronENST00000498157ENST00000468588CELSR2chr1

109816292

+SARSchr1

109773500

+

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FusionProtFeatures for CELSR2_SARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELSR2

Q9HCU4

SARS

P49591

Receptor that may have an important role in cell/cellsignaling during nervous system formation. Catalyzes the attachment of serine to tRNA(Ser) in atwo-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)(PubMed:22353712, PubMed:24095058, PubMed:9431993,PubMed:26433229, PubMed:28236339). Is probably also able toaminoacylate tRNA(Sec) with serine, to form the misacylated tRNAL-seryl-tRNA(Sec), which will be further converted intoselenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229,PubMed:28236339). In the nucleus, binds to the VEGFA core promoterand prevents MYC binding and transcriptional activation by MYC(PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promotingdeacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibitsthe production of VEGFA and sprouting angiogenesis mediated byVEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).{ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848,ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058,ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229,ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:9431993}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342743_275229142924Compositional biasNote=Poly-Glu
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341028_114629142924DomainCadherin 9
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341228_128629142924DomainEGF-like 1%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341288_132429142924DomainEGF-like 2%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341328_136629142924DomainEGF-like 3%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341367_157129142924DomainLaminin G-like 1
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341574_161029142924DomainEGF-like 4%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341614_179129142924DomainLaminin G-like 2
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341793_182829142924DomainEGF-like 5%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341829_186729142924DomainEGF-like 6%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334182_28929142924DomainCadherin 1
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341883_192229142924DomainEGF-like 7%3B calcium-binding
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33341924_197129142924DomainLaminin EGF-like
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342316_236829142924DomainGPS
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334290_39929142924DomainCadherin 2
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334400_50529142924DomainCadherin 3
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334506_61029142924DomainCadherin 4
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334611_71229142924DomainCadherin 5
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334713_81529142924DomainCadherin 6
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334816_92129142924DomainCadherin 7
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+3334922_102329142924DomainCadherin 8
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342402_241629142924Topological domainCytoplasmic
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342438_243829142924Topological domainExtracellular
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342460_248029142924Topological domainCytoplasmic
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342502_251929142924Topological domainExtracellular
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342541_256029142924Topological domainCytoplasmic
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342582_259129142924Topological domainExtracellular
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+333432_238029142924Topological domainExtracellular
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342381_240129142924TransmembraneHelical%3B Name%3D1
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342417_243729142924TransmembraneHelical%3B Name%3D2
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342439_245929142924TransmembraneHelical%3B Name%3D3
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342481_250129142924TransmembraneHelical%3B Name%3D4
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342520_254029142924TransmembraneHelical%3B Name%3D5
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342561_258129142924TransmembraneHelical%3B Name%3D6
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342592_261229142924TransmembraneHelical%3B Name%3D7
TgeneSARSchr1:109816292chr1:109780353ENST00000234677+911482_494462515MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELSR2chr1:109816292chr1:109780353ENST00000271332+33342613_292329142924Topological domainCytoplasmic
TgeneSARSchr1:109816292chr1:109780353ENST00000234677+911302_304462515Nucleotide bindingATP
TgeneSARSchr1:109816292chr1:109780353ENST00000234677+911318_321462515Nucleotide bindingATP
TgeneSARSchr1:109816292chr1:109780353ENST00000234677+911391_394462515Nucleotide bindingATP


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FusionGeneSequence for CELSR2_SARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CELSR2_SARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CELSR2RYK, NXPH2, USP36, KLK5, DTWD2, NAALADL2, DDX39A, TNF, LYPD6, LCA5, XAGE1B, SIRT6, TMEM30B, DKKL1, PCDH12, PCDHGB1, RPL28, PSG8, ZBBX, FGFRL1, VAPB, ST8SIA4, PCDH20, IL27RASARSSIRT2, TRS-AGA2-4, UBA5, MYC, TERF1, TINF2, POT1, CDK2, PALLD, TARS, GATC, ANP32E, EFTUD2, GTF2A1, ACBD3, ASF1A, ATG7, ATP6V1C1, CTTN, DUS3L, ELAC2, GTF2E1, STAT1, TTC1, XPO5, SNX5, TBCD, FRMPD2, R3HCC1L, C12orf45, ARFIP1, ARFIP2, C9orf78, CAD, CCDC6, GFPT2, HARS, HARS2, HIP1R, HSPB1, NUP210, PAPOLA, PFDN2, PFKM, PPM1G, PRRC1, PTGES3, MESDC2, TSG101, SEC13, SNW1, TRIM25, WARS, NTRK1, XPO1, MCM2, DUSP21, SOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSARSchr1:109816292chr1:109780353ENST00000234677+9119_61462515tRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CELSR2_SARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CELSR2_SARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCELSR2C0014173Endometrial Hyperplasia1CTD_human