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FusionGeneSummary

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Fusion gene ID: 6725

FusionGeneSummary for CELF2_GABRR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CELF2_GABRR1
Fusion gene ID: 6725
HgeneTgene
Gene symbol

CELF2

GABRR1

Gene ID

10659

2569

Gene nameCUGBP Elav-like family member 2gamma-aminobutyric acid type A receptor rho1 subunit
SynonymsBRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR-
Cytomap

10p14

6q15

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding protegamma-aminobutyric acid receptor subunit rho-1GABA(A) receptor subunit rho-1GABA(A) receptor, rho 1GABA(C) receptorbA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1)gamma-aminobutyric acid (GABA) A receptor, rho-1gamma-aminobutyric acid (GA
Modification date2018052320180523
UniProtAcc

O95319

P24046

Ensembl transtripts involved in fusion geneENST00000379261, ENST00000416382, 
ENST00000450189, ENST00000542579, 
ENST00000399850, ENST00000417956, 
ENST00000354440, ENST00000427450, 
ENST00000315874, ENST00000608830, 
ENST00000609692, ENST00000354897, 
ENST00000537122, 		ENST00000454853, 
ENST00000435811, ENST00000369451, 
ENST00000481493, 
Fusion gene scores* DoF score11 X 11 X 3=3632 X 2 X 1=4
# samples 121
** MAII scorelog2(12/363*10)=-1.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/4*10)=1.32192809488736
Context

PubMed: CELF2 [Title/Abstract] AND GABRR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF2

GO:0006376

mRNA splice site selection

11158314


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A1KZ-01ACELF2chr10

11060126

+GABRR1chr6

89913204

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000379261ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000379261ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000379261ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000379261ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000416382ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000416382ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000416382ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000416382ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
In-frameENST00000450189ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000450189ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-5UTRENST00000450189ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000450189ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
In-frameENST00000542579ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000542579ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-5UTRENST00000542579ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5CDS-intronENST00000542579ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-3CDSENST00000399850ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000399850ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-5UTRENST00000399850ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000399850ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-3CDSENST00000417956ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000417956ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-5UTRENST00000417956ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
5UTR-intronENST00000417956ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000354440ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354440ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000354440ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354440ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000427450ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000427450ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000427450ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000427450ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000315874ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000315874ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000315874ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000315874ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000608830ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000608830ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000608830ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000608830ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000609692ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000609692ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000609692ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000609692ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000354897ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354897ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000354897ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000354897ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-3CDSENST00000537122ENST00000454853CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000537122ENST00000435811CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-5UTRENST00000537122ENST00000369451CELF2chr10

11060126

+GABRR1chr6

89913204

-
intron-intronENST00000537122ENST00000481493CELF2chr10

11060126

+GABRR1chr6

89913204

-

Top

FusionProtFeatures for CELF2_GABRR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELF2

O95319

GABRR1

P24046

GABA, the major inhibitory neurotransmitter in thevertebrate brain, mediates neuronal inhibition by binding to theGABA/benzodiazepine receptor and opening an integral chloridechannel. Rho-1 GABA receptor could play a role in retinalneurotransmission.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CELF2_GABRR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CELF2_ENST00000450189_chr10_11060126_+_GABRR1_ENST00000454853_chr6_89913204_-_464aa
MTSAFKLDFLPDMMVEGRLLVPDRMPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVE
SLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTA
MCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLL
QTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE
QKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAA

>In-frame_CELF2_ENST00000542579_chr10_11060126_+_GABRR1_ENST00000454853_chr6_89913204_-_464aa
MTSAFKLDFLPDMMVEGRLLVPDRMPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVE
SLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTA
MCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLL
QTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE
QKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CELF2_ENST00000450189_chr10_11060126_+_GABRR1_ENST00000454853_chr6_89913204_-_1392nt
ATGACTTCTGCCTTCAAGCTGGATTTCCTCCCGGACATGATGGTCGAGGGCCGCCTGCTCGTTCCTGACAGAATGCCCCAAAGACAAAGA
CGAGAAGTACATGAAGATGCCCACAAGCAAGTCAGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAA
CAGCTTCTGAGGATAGATGACCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATTCCTGTTGGTGTGGATGTGCAGGTGGAG
AGTTTGGATAGCATCTCAGAGGTTGACATGGACTTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCA
AGCACCAACAACCTCAGCATGACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGACATGTTTTTCGTGCACTCCAAACGCTCC
TTCATCCACGACACCACCACAGACAACGTCATGTTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCA
ATGTGCAACATGGACTTCAGCCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAAAGCTATGCCTATACAGAAGATGACCTC
ATGCTGTACTGGAAAAAGGGCAATGACTCCTTAAAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACC
ACCAAACTGGCTTTCTACAGCAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTGCGTCGCCACATCTTCTTCTTCTTGCTC
CAAACTTATTTCCCCGCTACCCTGATGGTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTA
GGTATCACAACGGTGCTGACCATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGCGTCTCCTACATCAAGGCCGTGGACATC
TACCTCTGGGTCAGCTTTGTGTTCGTGTTCCTCTCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAA
CAGAAGCTGCGGGAGAAGCTTCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTGGACGGCAACTACAGTGATGGGGAGGTG
AATGACCTGGACAACTACATGCCAGAGAATGGAGAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCA
CAGAGGAAAAGTCAGAGAAGCAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAATACTCCAGGATCATCTTTCCAGCAGCA

>In-frame_CELF2_ENST00000542579_chr10_11060126_+_GABRR1_ENST00000454853_chr6_89913204_-_1392nt
ATGACTTCTGCCTTCAAGCTGGATTTCCTCCCGGACATGATGGTCGAGGGCCGCCTGCTCGTTCCTGACAGAATGCCCCAAAGACAAAGA
CGAGAAGTACATGAAGATGCCCACAAGCAAGTCAGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAA
CAGCTTCTGAGGATAGATGACCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATTCCTGTTGGTGTGGATGTGCAGGTGGAG
AGTTTGGATAGCATCTCAGAGGTTGACATGGACTTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCA
AGCACCAACAACCTCAGCATGACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGACATGTTTTTCGTGCACTCCAAACGCTCC
TTCATCCACGACACCACCACAGACAACGTCATGTTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCA
ATGTGCAACATGGACTTCAGCCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAAAGCTATGCCTATACAGAAGATGACCTC
ATGCTGTACTGGAAAAAGGGCAATGACTCCTTAAAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACC
ACCAAACTGGCTTTCTACAGCAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTGCGTCGCCACATCTTCTTCTTCTTGCTC
CAAACTTATTTCCCCGCTACCCTGATGGTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTA
GGTATCACAACGGTGCTGACCATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGCGTCTCCTACATCAAGGCCGTGGACATC
TACCTCTGGGTCAGCTTTGTGTTCGTGTTCCTCTCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAA
CAGAAGCTGCGGGAGAAGCTTCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTGGACGGCAACTACAGTGATGGGGAGGTG
AATGACCTGGACAACTACATGCCAGAGAATGGAGAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCA
CAGAGGAAAAGTCAGAGAAGCAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAATACTCCAGGATCATCTTTCCAGCAGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CELF2_ENST00000450189_chr10_11060126_+_GABRR1_ENST00000454853_chr6_89913204_-_2821nt
GGGGATTGGCGGAGCGCGAGGAGAGAATGTGACAAGTGCCGGCTCGGCGGCCGCCGGGGGAGGCCGCGCGCACCTGTCCCTGCCCGTCTC
GCGCCGCCCGCGGCCGCTCGGACGCGCGCAGAGCCGCCCCCCGCCGCTGCCGCCGCGTGCGCCCGCGAACATGACTTCTGCCTTCAAGCT
GGATTTCCTCCCGGACATGATGGTCGAGGGCCGCCTGCTCGTTCCTGACAGAATGCCCCAAAGACAAAGACGAGAAGTACATGAAGATGC
CCACAAGCAAGTCAGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAACAGCTTCTGAGGATAGATGA
CCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATTCCTGTTGGTGTGGATGTGCAGGTGGAGAGTTTGGATAGCATCTCAGA
GGTTGACATGGACTTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCAAGCACCAACAACCTCAGCAT
GACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGACATGTTTTTCGTGCACTCCAAACGCTCCTTCATCCACGACACCACCAC
AGACAACGTCATGTTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCAATGTGCAACATGGACTTCAG
CCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAAAGCTATGCCTATACAGAAGATGACCTCATGCTGTACTGGAAAAAGGG
CAATGACTCCTTAAAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACCACCAAACTGGCTTTCTACAG
CAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTGCGTCGCCACATCTTCTTCTTCTTGCTCCAAACTTATTTCCCCGCTAC
CCTGATGGTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTAGGTATCACAACGGTGCTGAC
CATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGCGTCTCCTACATCAAGGCCGTGGACATCTACCTCTGGGTCAGCTTTGT
GTTCGTGTTCCTCTCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAACAGAAGCTGCGGGAGAAGCT
TCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTGGACGGCAACTACAGTGATGGGGAGGTGAATGACCTGGACAACTACAT
GCCAGAGAATGGAGAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCACAGAGGAAAAGTCAGAGAAG
CAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAATACTCCAGGATCATCTTTCCAGCAGCATACATTTTATTCAATTTAAT
ATACTGGTCTATTTTCTCCTAGATGCTTGTAATTCTACAAATTTCACATTTCCATGGCATGCACTACAGAAATAACTGTATAATGAAAAA
GTATTTAAGGATATGGTTAAAAAAAAATCCCAGGACCCACCCATGTTTTCACTATCCCTTCTGCAGCTTTCCAAAGCTACATTGACGAGA
CACTTACTGGTTTAATTTGCACTTATTAACCATCTATTGAATACACAGCATTATATTAGGTGCTGCAGGAAATACGACACTGTAGCGACT
GATGTTAGTTGTTACCCAGATCCCCTGGAAAAGCACACTACCAGTGTTGTGGGCACATTTAGTTCCACCCGTTAGACCCTTGATGCTATT
CACATGAATAATTTATTTTCCTCAAGTGTCATTACATTGTTCAGGCTACGTGAACTTGGAAGCACCTACAGGCCATTTGCATGAAATTCA
CATGCACCTAAATCCTCACTTTGACAGAAACTCATGCTTCAGTTTATAACCTATTACCTATTTTGTATGCGACTCCACCTCCGCATGTTT
ATTTTAATAAAAGGCAATGATAACATTCACATTATTTTTCTTTATATGCTGTGGTTCACAGGCTTTACCCCTTCACAAGAAAAGCTCTTT
AGATTGGCGCAATTGCTTCTGATTTTGGTGAAATTTTCCCTGGTAGGGAAACTTTGAAGATAAGAGTACACACATGCATTTTGTCTGTTG
TGTCATAGAGGTAACTAGGCTAGAAAATTTGTGTTTAAATGTTCCCTATTTTATATAATCACCACTTCATGTTTCTTCTTCTTGGAGCAT
GTCCTTGTTCAAAGAGAAGTGCTTTCTCAGTGATGTGATATCTTCACTGAGGAACTTGGGTAGAGAATGATTTCTTCTGCATAAACACTT
CAAGGAAATACATAATTTGGGACTACTTGTAACTCATTAGAATGAGAAATACTCACATGGTTTCTTAAGAGAAAAAGAACATCGGAAAGC
AAAATAAATGGGAAGATATCACTGGACATCTGCATTTATACTCGAAATACCAGCATTTTCTATGGACCAGAAAACTGCCATCACCTAGAC
CACACAGCCCAGATACCAGGCAGACGGATGGCCCAATGGCAACTGATGTCAGGGCATGGGGTAAAGGAGAGGGTTCTAATCTGGTGTATC
ACTTAAAAACAGTTATTTATATTATATATCTGCTATATAGATCAACCTCCACCAAACTTACCCAAACAGCATTTGTTTTATTTGAAACTC

>In-frame_CELF2_ENST00000542579_chr10_11060126_+_GABRR1_ENST00000454853_chr6_89913204_-_2661nt
ATGACTTCTGCCTTCAAGCTGGATTTCCTCCCGGACATGATGGTCGAGGGCCGCCTGCTCGTTCCTGACAGAATGCCCCAAAGACAAAGA
CGAGAAGTACATGAAGATGCCCACAAGCAAGTCAGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAA
CAGCTTCTGAGGATAGATGACCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATTCCTGTTGGTGTGGATGTGCAGGTGGAG
AGTTTGGATAGCATCTCAGAGGTTGACATGGACTTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCA
AGCACCAACAACCTCAGCATGACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGACATGTTTTTCGTGCACTCCAAACGCTCC
TTCATCCACGACACCACCACAGACAACGTCATGTTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCA
ATGTGCAACATGGACTTCAGCCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAAAGCTATGCCTATACAGAAGATGACCTC
ATGCTGTACTGGAAAAAGGGCAATGACTCCTTAAAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACC
ACCAAACTGGCTTTCTACAGCAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTGCGTCGCCACATCTTCTTCTTCTTGCTC
CAAACTTATTTCCCCGCTACCCTGATGGTCATGCTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTA
GGTATCACAACGGTGCTGACCATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGCGTCTCCTACATCAAGGCCGTGGACATC
TACCTCTGGGTCAGCTTTGTGTTCGTGTTCCTCTCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAA
CAGAAGCTGCGGGAGAAGCTTCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTGGACGGCAACTACAGTGATGGGGAGGTG
AATGACCTGGACAACTACATGCCAGAGAATGGAGAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCA
CAGAGGAAAAGTCAGAGAAGCAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAATACTCCAGGATCATCTTTCCAGCAGCA
TACATTTTATTCAATTTAATATACTGGTCTATTTTCTCCTAGATGCTTGTAATTCTACAAATTTCACATTTCCATGGCATGCACTACAGA
AATAACTGTATAATGAAAAAGTATTTAAGGATATGGTTAAAAAAAAATCCCAGGACCCACCCATGTTTTCACTATCCCTTCTGCAGCTTT
CCAAAGCTACATTGACGAGACACTTACTGGTTTAATTTGCACTTATTAACCATCTATTGAATACACAGCATTATATTAGGTGCTGCAGGA
AATACGACACTGTAGCGACTGATGTTAGTTGTTACCCAGATCCCCTGGAAAAGCACACTACCAGTGTTGTGGGCACATTTAGTTCCACCC
GTTAGACCCTTGATGCTATTCACATGAATAATTTATTTTCCTCAAGTGTCATTACATTGTTCAGGCTACGTGAACTTGGAAGCACCTACA
GGCCATTTGCATGAAATTCACATGCACCTAAATCCTCACTTTGACAGAAACTCATGCTTCAGTTTATAACCTATTACCTATTTTGTATGC
GACTCCACCTCCGCATGTTTATTTTAATAAAAGGCAATGATAACATTCACATTATTTTTCTTTATATGCTGTGGTTCACAGGCTTTACCC
CTTCACAAGAAAAGCTCTTTAGATTGGCGCAATTGCTTCTGATTTTGGTGAAATTTTCCCTGGTAGGGAAACTTTGAAGATAAGAGTACA
CACATGCATTTTGTCTGTTGTGTCATAGAGGTAACTAGGCTAGAAAATTTGTGTTTAAATGTTCCCTATTTTATATAATCACCACTTCAT
GTTTCTTCTTCTTGGAGCATGTCCTTGTTCAAAGAGAAGTGCTTTCTCAGTGATGTGATATCTTCACTGAGGAACTTGGGTAGAGAATGA
TTTCTTCTGCATAAACACTTCAAGGAAATACATAATTTGGGACTACTTGTAACTCATTAGAATGAGAAATACTCACATGGTTTCTTAAGA
GAAAAAGAACATCGGAAAGCAAAATAAATGGGAAGATATCACTGGACATCTGCATTTATACTCGAAATACCAGCATTTTCTATGGACCAG
AAAACTGCCATCACCTAGACCACACAGCCCAGATACCAGGCAGACGGATGGCCCAATGGCAACTGATGTCAGGGCATGGGGTAAAGGAGA
GGGTTCTAATCTGGTGTATCACTTAAAAACAGTTATTTATATTATATATCTGCTATATAGATCAACCTCCACCAAACTTACCCAAACAGC


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FusionGenePPI for CELF2_GABRR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CELF2A1CF, PCBP1, APP, FN1, PTGS2, ELAVL1, PDK1, TRAF3GABRR1CSNK2A1, TAX1BP1, GABRR1, BCR, DNM1L, IP6K2, FEZF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CELF2_GABRR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGABRR1P24046DB00546AdinazolamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved
TgeneGABRR1P24046DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved
TgeneGABRR1P24046DB01594CinolazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved
TgeneGABRR1P24046DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved
TgeneGABRR1P24046DB00683MidazolamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit
TgeneGABRR1P24046DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit
TgeneGABRR1P24046DB01559ClotiazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit
TgeneGABRR1P24046DB01567FludiazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit
TgeneGABRR1P24046DB01588PrazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit
TgeneGABRR1P24046DB01589QuazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit
TgeneGABRR1P24046DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit|investigational
TgeneGABRR1P24046DB01558BromazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit|investigational
TgeneGABRR1P24046DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit|investigational|vet_approved
TgeneGABRR1P24046DB00801HalazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|illicit|withdrawn
TgeneGABRR1P24046DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|investigational
TgeneGABRR1P24046DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|investigational
TgeneGABRR1P24046DB00431LindaneGamma-aminobutyric acid receptor subunit rho-1small moleculeapproved|withdrawn

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RelatedDiseases for CELF2_GABRR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCELF2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCELF2C0036341Schizophrenia1CTD_human
HgeneCELF2C0038325Stevens-Johnson Syndrome1CTD_human
TgeneGABRR1C0005586Bipolar Disorder2PSYGENET
TgeneGABRR1C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGABRR1C0036341Schizophrenia1PSYGENET