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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6721

FusionGeneSummary for CELF2_AARSD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CELF2_AARSD1
Fusion gene ID: 6721
HgeneTgene
Gene symbol

CELF2

AARSD1

Gene ID

10659

80755

Gene nameCUGBP Elav-like family member 2alanyl-tRNA synthetase domain containing 1
SynonymsBRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR-
Cytomap

10p14

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding protealanyl-tRNA editing protein Aarsd1alanyl-tRNA synthetase domain-containing protein 1
Modification date2018052320180523
UniProtAcc

O95319

Q9BTE6

Ensembl transtripts involved in fusion geneENST00000379261, ENST00000416382, 
ENST00000450189, ENST00000542579, 
ENST00000399850, ENST00000417956, 
ENST00000354440, ENST00000427450, 
ENST00000315874, ENST00000608830, 
ENST00000609692, ENST00000354897, 
ENST00000537122, 
ENST00000427569, 
ENST00000416949, 
Fusion gene scores* DoF score11 X 11 X 3=3633 X 3 X 3=27
# samples 123
** MAII scorelog2(12/363*10)=-1.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CELF2 [Title/Abstract] AND AARSD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF2

GO:0006376

mRNA splice site selection

11158314


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI916936CELF2chr10

11375428

-AARSD1chr17

41108518

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000379261ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-5UTRENST00000379261ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000416382ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000416382ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-3CDSENST00000450189ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-5UTRENST00000450189ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000542579ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000542579ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000399850ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000399850ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000417956ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000417956ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-3CDSENST00000354440ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-5UTRENST00000354440ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-3CDSENST00000427450ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-5UTRENST00000427450ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-3CDSENST00000315874ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
3UTR-5UTRENST00000315874ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000608830ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000608830ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000609692ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000609692ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000354897ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000354897ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-3CDSENST00000537122ENST00000427569CELF2chr10

11375428

-AARSD1chr17

41108518

+
intron-5UTRENST00000537122ENST00000416949CELF2chr10

11375428

-AARSD1chr17

41108518

+

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FusionProtFeatures for CELF2_AARSD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELF2

O95319

AARSD1

Q9BTE6

Functions in trans to edit the amino acid moiety fromincorrectly charged tRNA(Ala). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CELF2_AARSD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CELF2_AARSD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CELF2_AARSD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CELF2_AARSD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCELF2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCELF2C0036341Schizophrenia1CTD_human
HgeneCELF2C0038325Stevens-Johnson Syndrome1CTD_human