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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6676

FusionGeneSummary for CDV3_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: CDV3_MBP
Fusion gene ID: 6676
HgeneTgene
Gene symbol

CDV3

MBP

Gene ID

55573

5553

Gene nameCDV3 homologproteoglycan 2, pro eosinophil major basic protein
SynonymsH41BMPG|MBP|MBP1|proMBP
Cytomap

3q22.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein CDV3 homologcarnitine deficiency-associated gene expressed in ventricle 3bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018051920180519
UniProtAcc

Q9UKY7

P02686

Ensembl transtripts involved in fusion geneENST00000264993, ENST00000431519, 
ENST00000508481, ENST00000420115, 
ENST00000511392, ENST00000515421, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score4 X 3 X 3=3626 X 20 X 3=1560
# samples 427
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDV3 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA349409CDV3chr3

133297269

+MBPchr18

74729011

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000264993ENST00000382582CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000355994CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000397875CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000397866CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000397865CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000527041CDV3chr3

133297269

+MBPchr18

74729011

-
intron-intronENST00000264993ENST00000359645CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000528160CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000397869CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000354542CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000526111CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000580402CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000579129CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000578193CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000397863CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000397860CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000264993ENST00000487778CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000382582CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000355994CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000397875CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000397866CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000397865CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000527041CDV3chr3

133297269

+MBPchr18

74729011

-
intron-intronENST00000431519ENST00000359645CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000528160CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000397869CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000354542CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000526111CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000580402CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000579129CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000578193CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000397863CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000397860CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000431519ENST00000487778CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000382582CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000355994CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000397875CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000397866CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000397865CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000527041CDV3chr3

133297269

+MBPchr18

74729011

-
intron-intronENST00000508481ENST00000359645CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000528160CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000397869CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000354542CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000526111CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000580402CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000579129CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000578193CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000397863CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000397860CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000508481ENST00000487778CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000382582CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000355994CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000397875CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000397866CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000397865CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000527041CDV3chr3

133297269

+MBPchr18

74729011

-
intron-intronENST00000420115ENST00000359645CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000528160CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000397869CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000354542CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000526111CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000580402CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000579129CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000578193CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000397863CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000397860CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000420115ENST00000487778CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000382582CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000355994CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000397875CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000397866CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000397865CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000527041CDV3chr3

133297269

+MBPchr18

74729011

-
intron-intronENST00000511392ENST00000359645CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000528160CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000397869CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000354542CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000526111CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000580402CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000579129CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000578193CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000397863CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000397860CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000511392ENST00000487778CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000382582CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000355994CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000397875CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000397866CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000397865CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000527041CDV3chr3

133297269

+MBPchr18

74729011

-
intron-intronENST00000515421ENST00000359645CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000528160CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000397869CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000354542CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000526111CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000580402CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000579129CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000578193CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000397863CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000397860CDV3chr3

133297269

+MBPchr18

74729011

-
intron-5UTRENST00000515421ENST00000487778CDV3chr3

133297269

+MBPchr18

74729011

-

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FusionProtFeatures for CDV3_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDV3

Q9UKY7

MBP

P02686


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDV3_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDV3_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CDV3_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CDV3_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human