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Fusion gene ID: 6661 |
FusionGeneSummary for CDRT4_USP20 |
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Fusion gene information | Fusion gene name: CDRT4_USP20 | Fusion gene ID: 6661 | Hgene | Tgene | Gene symbol | CDRT4 | USP20 | Gene ID | 284040 | 10868 |
Gene name | CMT1A duplicated region transcript 4 | ubiquitin specific peptidase 20 | |
Synonyms | - | LSFR3A|VDU2|hVDU2 | |
Cytomap | 17p12 | 9q34.11 | |
Type of gene | protein-coding | protein-coding | |
Description | CMT1A duplicated region transcript 4 protein | ubiquitin carboxyl-terminal hydrolase 20deubiquitinating enzyme 20pVHL-interacting deubiquitinating enzyme 2ubiquitin thioesterase 20ubiquitin thiolesterase 20ubiquitin-specific-processing protease 20 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8N9R6 | Q9Y2K6 | |
Ensembl transtripts involved in fusion gene | ENST00000312177, ENST00000519354, | ENST00000372429, ENST00000315480, ENST00000358355, ENST00000472108, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 3=90 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDRT4 [Title/Abstract] AND USP20 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | USP20 | GO:0016579 | protein deubiquitination | 19424180 |
Tgene | USP20 | GO:0070536 | protein K63-linked deubiquitination | 19424180 |
Tgene | USP20 | GO:0071108 | protein K48-linked deubiquitination | 19424180 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-IW-A3M4-01A | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000312177 | ENST00000372429 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-3CDS | ENST00000312177 | ENST00000315480 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-3CDS | ENST00000312177 | ENST00000358355 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-intron | ENST00000312177 | ENST00000472108 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-3CDS | ENST00000519354 | ENST00000372429 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-3CDS | ENST00000519354 | ENST00000315480 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-3CDS | ENST00000519354 | ENST00000358355 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
intron-intron | ENST00000519354 | ENST00000472108 | CDRT4 | chr17 | 15406412 | - | USP20 | chr9 | 132620329 | + |
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FusionProtFeatures for CDRT4_USP20 |
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Hgene | Tgene |
CDRT4 | USP20 |
Deubiquitinating enzyme involved in beta-2 adrenergicreceptor (ADRB2) recycling. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating thedeubiquitination beta-2 adrenergic receptor (ADRB2). Plays acentral role in ADRB2 recycling and resensitization afterprolonged agonist stimulation by constitutively binding ADRB2,mediating deubiquitination of ADRB2 and inhibiting lysosomaltrafficking of ADRB2. Upon dissociation, it is probablytransferred to the translocated beta-arrestins, possibly leadingto beta-arrestins deubiquitination and disengagement from ADRB2.This suggests the existence of a dynamic exchange between theADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulatingthyroid hormone regulation. Deubiquitinates HIF1A, leading tostabilize HIF1A and enhance HIF1A-mediated activity. Mediatesdeubiquitination of both 'Lys-48'- and 'Lys-63'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:12056827,ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016,ECO:0000269|PubMed:19424180}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDRT4_USP20 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDRT4_USP20 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDRT4 | VAC14, SORT1 | USP20 | DIO2, ACADM, APBA2, CALM1, FECH, EIF3E, MYO1A, MYO1C, PLEC, PLK1, PSMD7, PSMD11, PSMD12, RAD17, RFC2, RFC3, RFC4, UCHL3, EIF3C, HERC2, VAPB, VAPA, PSMD6, NUP153, ATP6AP2, ECI2, USP21, N4BP3, SUN2, ZNF770, LRRC59, MAP7D1, ATAD3B, RGPD5, POLDIP3, NEURL4, GPT2, SYTL4, PLEKHA7, HERC2P2, HIF1A, VHL, PJA1, USP15, USP28, ADRB2, CCP110, USP33, USP20, PLA2G2A, ALAS1, TRIM23, MAGEA11, MDFI, SPRY2, BEND5, FATE1, BEND7, CCDC36, CBX7, VSX2, DBNL, PRKACA, TRAF6, CLSPN, ATR, TMEM173, MAPK6, CRAMP1L, MAP7D2, LMNA, GTF2IRD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDRT4_USP20 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDRT4_USP20 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |