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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6661

FusionGeneSummary for CDRT4_USP20

check button Fusion gene summary
Fusion gene informationFusion gene name: CDRT4_USP20
Fusion gene ID: 6661
HgeneTgene
Gene symbol

CDRT4

USP20

Gene ID

284040

10868

Gene nameCMT1A duplicated region transcript 4ubiquitin specific peptidase 20
Synonyms-LSFR3A|VDU2|hVDU2
Cytomap

17p12

9q34.11

Type of geneprotein-codingprotein-coding
DescriptionCMT1A duplicated region transcript 4 proteinubiquitin carboxyl-terminal hydrolase 20deubiquitinating enzyme 20pVHL-interacting deubiquitinating enzyme 2ubiquitin thioesterase 20ubiquitin thiolesterase 20ubiquitin-specific-processing protease 20
Modification date2018051920180523
UniProtAcc

Q8N9R6

Q9Y2K6

Ensembl transtripts involved in fusion geneENST00000312177, ENST00000519354, 
ENST00000372429, ENST00000315480, 
ENST00000358355, ENST00000472108, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 3=90
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDRT4 [Title/Abstract] AND USP20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP20

GO:0016579

protein deubiquitination

19424180

TgeneUSP20

GO:0070536

protein K63-linked deubiquitination

19424180

TgeneUSP20

GO:0071108

protein K48-linked deubiquitination

19424180


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-IW-A3M4-01ACDRT4chr17

15406412

-USP20chr9

132620329

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000312177ENST00000372429CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-3CDSENST00000312177ENST00000315480CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-3CDSENST00000312177ENST00000358355CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-intronENST00000312177ENST00000472108CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-3CDSENST00000519354ENST00000372429CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-3CDSENST00000519354ENST00000315480CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-3CDSENST00000519354ENST00000358355CDRT4chr17

15406412

-USP20chr9

132620329

+
intron-intronENST00000519354ENST00000472108CDRT4chr17

15406412

-USP20chr9

132620329

+

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FusionProtFeatures for CDRT4_USP20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDRT4

Q8N9R6

USP20

Q9Y2K6

Deubiquitinating enzyme involved in beta-2 adrenergicreceptor (ADRB2) recycling. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating thedeubiquitination beta-2 adrenergic receptor (ADRB2). Plays acentral role in ADRB2 recycling and resensitization afterprolonged agonist stimulation by constitutively binding ADRB2,mediating deubiquitination of ADRB2 and inhibiting lysosomaltrafficking of ADRB2. Upon dissociation, it is probablytransferred to the translocated beta-arrestins, possibly leadingto beta-arrestins deubiquitination and disengagement from ADRB2.This suggests the existence of a dynamic exchange between theADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulatingthyroid hormone regulation. Deubiquitinates HIF1A, leading tostabilize HIF1A and enhance HIF1A-mediated activity. Mediatesdeubiquitination of both 'Lys-48'- and 'Lys-63'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:12056827,ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016,ECO:0000269|PubMed:19424180}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDRT4_USP20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDRT4_USP20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDRT4VAC14, SORT1USP20DIO2, ACADM, APBA2, CALM1, FECH, EIF3E, MYO1A, MYO1C, PLEC, PLK1, PSMD7, PSMD11, PSMD12, RAD17, RFC2, RFC3, RFC4, UCHL3, EIF3C, HERC2, VAPB, VAPA, PSMD6, NUP153, ATP6AP2, ECI2, USP21, N4BP3, SUN2, ZNF770, LRRC59, MAP7D1, ATAD3B, RGPD5, POLDIP3, NEURL4, GPT2, SYTL4, PLEKHA7, HERC2P2, HIF1A, VHL, PJA1, USP15, USP28, ADRB2, CCP110, USP33, USP20, PLA2G2A, ALAS1, TRIM23, MAGEA11, MDFI, SPRY2, BEND5, FATE1, BEND7, CCDC36, CBX7, VSX2, DBNL, PRKACA, TRAF6, CLSPN, ATR, TMEM173, MAPK6, CRAMP1L, MAP7D2, LMNA, GTF2IRD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDRT4_USP20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDRT4_USP20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource