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Fusion gene ID: 6654 |
FusionGeneSummary for CDR1_ELAVL4 |
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Fusion gene information | Fusion gene name: CDR1_ELAVL4 | Fusion gene ID: 6654 | Hgene | Tgene | Gene symbol | CDR1 | ELAVL4 | Gene ID | 1038 | 1996 |
Gene name | cerebellar degeneration related protein 1 | ELAV like RNA binding protein 4 | |
Synonyms | CDR|CDR34|CDR62A | HUD|PNEM | |
Cytomap | Xq27.1 | 1p33-p32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cerebellar degeneration-related antigen 1cerebellar degeneration-related protein 1, 34kDa | ELAV-like protein 4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)ELAV like neuron-specific RNA binding protein 4Hu antigen Dparaneoplastic encephalomyelitis antigen HuD | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P51861 | P26378 | |
Ensembl transtripts involved in fusion gene | ENST00000370532, | ENST00000448907, ENST00000371827, ENST00000357083, ENST00000371824, ENST00000371823, ENST00000371821, ENST00000371819, ENST00000492299, | |
Fusion gene scores | * DoF score | 4 X 6 X 1=24 | 3 X 3 X 2=18 |
# samples | 25 | 3 | |
** MAII score | log2(25/24*10)=3.38082178394093 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CDR1 [Title/Abstract] AND ELAVL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BY798206 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000370532 | ENST00000448907 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-3CDS | ENST00000370532 | ENST00000371827 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-3CDS | ENST00000370532 | ENST00000357083 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-3CDS | ENST00000370532 | ENST00000371824 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-3CDS | ENST00000370532 | ENST00000371823 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-3CDS | ENST00000370532 | ENST00000371821 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-3CDS | ENST00000370532 | ENST00000371819 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
intron-intron | ENST00000370532 | ENST00000492299 | CDR1 | chrX | 139866259 | + | ELAVL4 | chr1 | 50666827 | + |
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FusionProtFeatures for CDR1_ELAVL4 |
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Hgene | Tgene |
CDR1 | ELAVL4 |
May play a role in neuron-specific RNA processing.Protects CDKN1A mRNA from decay by binding to its 3'-UTR (Bysimilarity). Binds to AU-rich sequences (AREs) of target mRNAs,including VEGF and FOS mRNA. {ECO:0000250,ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:7898713}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDR1_ELAVL4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDR1_ELAVL4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDR1_ELAVL4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDR1_ELAVL4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |