![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 6652 |
FusionGeneSummary for CDR1_AIF1L |
![]() |
Fusion gene information | Fusion gene name: CDR1_AIF1L | Fusion gene ID: 6652 | Hgene | Tgene | Gene symbol | CDR1 | AIF1L | Gene ID | 1038 | 83543 |
Gene name | cerebellar degeneration related protein 1 | allograft inflammatory factor 1 like | |
Synonyms | CDR|CDR34|CDR62A | C9orf58|IBA2 | |
Cytomap | Xq27.1 | 9q34.12-q34.13 | |
Type of gene | protein-coding | protein-coding | |
Description | cerebellar degeneration-related antigen 1cerebellar degeneration-related protein 1, 34kDa | allograft inflammatory factor 1-likeionized calcium binding adapter molecule 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P51861 | Q9BQI0 | |
Ensembl transtripts involved in fusion gene | ENST00000370532, | ENST00000372309, ENST00000372302, ENST00000247291, ENST00000372300, ENST00000472942, ENST00000372298, ENST00000372297, ENST00000372312, ENST00000372301, | |
Fusion gene scores | * DoF score | 4 X 6 X 1=24 | 2 X 2 X 2=8 |
# samples | 25 | 2 | |
** MAII score | log2(25/24*10)=3.38082178394093 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CDR1 [Title/Abstract] AND AIF1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA389009 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000370532 | ENST00000372309 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000372302 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000247291 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000372300 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000472942 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000372298 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000372297 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000372312 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
intron-intron | ENST00000370532 | ENST00000372301 | CDR1 | chrX | 139866784 | + | AIF1L | chr9 | 133971918 | + |
Top |
FusionProtFeatures for CDR1_AIF1L |
![]() |
Hgene | Tgene |
CDR1 | AIF1L |
Actin-binding protein that promotes actin bundling. Mayneither bind calcium nor depend on calcium for function.{ECO:0000269|PubMed:18699778}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CDR1_AIF1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CDR1_AIF1L |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CDR1_AIF1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CDR1_AIF1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |