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Fusion gene ID: 6645 |
FusionGeneSummary for CDKN2B_DGKD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDKN2B_DGKD | Fusion gene ID: 6645 | Hgene | Tgene | Gene symbol | CDKN2B | DGKD | Gene ID | 1030 | 8527 |
| Gene name | cyclin dependent kinase inhibitor 2B | diacylglycerol kinase delta | |
| Synonyms | CDK4I|INK4B|MTS2|P15|TP15|p15INK4b | DGKdelta|dgkd-2 | |
| Cytomap | 9p21.3 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclin-dependent kinase 4 inhibitor BCDK inhibitory proteinCDK4B inhibitorMTS-2cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)cyclin-dependent kinases 4 and 6 binding proteinmultiple tumor suppressor 2p14-INK4bp14_CDK inhibitorp14_INK4B | diacylglycerol kinase deltaDAG kinase deltaDGK-deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P42772 | Q16760 | |
| Ensembl transtripts involved in fusion gene | ENST00000276925, ENST00000380142, ENST00000539462, | ENST00000264057, ENST00000409813, ENST00000489613, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/27*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CDKN2B [Title/Abstract] AND DGKD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDKN2B | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 8078588 |
| Hgene | CDKN2B | GO:0042326 | negative regulation of phosphorylation | 8078588 |
| Tgene | DGKD | GO:0010033 | response to organic substance | 12200442 |
| Tgene | DGKD | GO:0051260 | protein homooligomerization | 12200442 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0155-01B | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000276925 | ENST00000264057 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| Frame-shift | ENST00000276925 | ENST00000409813 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| 5CDS-3UTR | ENST00000276925 | ENST00000489613 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| intron-3CDS | ENST00000380142 | ENST00000264057 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| intron-3CDS | ENST00000380142 | ENST00000409813 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| intron-3UTR | ENST00000380142 | ENST00000489613 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| intron-3CDS | ENST00000539462 | ENST00000264057 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| intron-3CDS | ENST00000539462 | ENST00000409813 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
| intron-3UTR | ENST00000539462 | ENST00000489613 | CDKN2B | chr9 | 22008797 | - | DGKD | chr2 | 234296903 | + |
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FusionProtFeatures for CDKN2B_DGKD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDKN2B | DGKD |
| Interacts strongly with CDK4 and CDK6. Potent inhibitor.Potential effector of TGF-beta induced cell cycle arrest. | May function as signaling molecule.{ECO:0000269|PubMed:17880279}. Isoform 2 may be involved in cell growth andtumorigenesis. Involved in clathrin-dependent endocytosis.{ECO:0000269|PubMed:17880279}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000276925 | - | 1 | 2 | 13_39 | 52 | 139 | Repeat | Note=ANK 1%3B truncated |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000409813 | + | 0 | 29 | 8_36 | -27 | 1171 | Compositional bias | Note=Pro-rich |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000264057 | + | 0 | 30 | 1145_1208 | 52 | 1215 | Domain | SAM |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000264057 | + | 0 | 30 | 317_451 | 52 | 1215 | Domain | DAGKc |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000264057 | + | 0 | 30 | 53_146 | 52 | 1215 | Domain | PH |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000409813 | + | 0 | 29 | 1145_1208 | -27 | 1171 | Domain | SAM |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000409813 | + | 0 | 29 | 317_451 | -27 | 1171 | Domain | DAGKc |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000409813 | + | 0 | 29 | 53_146 | -27 | 1171 | Domain | PH |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000264057 | + | 0 | 30 | 163_213 | 52 | 1215 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000264057 | + | 0 | 30 | 235_286 | 52 | 1215 | Zinc finger | Phorbol-ester/DAG-type 2 |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000409813 | + | 0 | 29 | 163_213 | -27 | 1171 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Tgene | >DGKD | chr9:22008797 | chr2:234296903 | ENST00000409813 | + | 0 | 29 | 235_286 | -27 | 1171 | Zinc finger | Phorbol-ester/DAG-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000276925 | - | 1 | 2 | 112_138 | 52 | 139 | Repeat | Note=ANK 4 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000276925 | - | 1 | 2 | 46_74 | 52 | 139 | Repeat | Note=ANK 2 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000276925 | - | 1 | 2 | 79_108 | 52 | 139 | Repeat | Note=ANK 3 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000380142 | - | 1 | 2 | 112_138 | -107 | 79 | Repeat | Note=ANK 4 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000380142 | - | 1 | 2 | 13_39 | -107 | 79 | Repeat | Note=ANK 1%3B truncated |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000380142 | - | 1 | 2 | 46_74 | -107 | 79 | Repeat | Note=ANK 2 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000380142 | - | 1 | 2 | 79_108 | -107 | 79 | Repeat | Note=ANK 3 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000539462 | - | 1 | 1 | 112_138 | 0 | 79 | Repeat | Note=ANK 4 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000539462 | - | 1 | 1 | 13_39 | 0 | 79 | Repeat | Note=ANK 1%3B truncated |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000539462 | - | 1 | 1 | 46_74 | 0 | 79 | Repeat | Note=ANK 2 |
| Hgene | >CDKN2B | chr9:22008797 | chr2:234296903 | ENST00000539462 | - | 1 | 1 | 79_108 | 0 | 79 | Repeat | Note=ANK 3 |
| Tgene | DGKD | chr9:22008797 | chr2:234296903 | ENST00000264057 | + | 0 | 30 | 8_36 | 52 | 1215 | Compositional bias | Note=Pro-rich |
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FusionGeneSequence for CDKN2B_DGKD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDKN2B_ENST00000276925_chr9_22008797_-_DGKD_ENST00000264057_chr2_234296903_+_1215aa MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS IIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVC REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWC KAMVHTSCKESLLTKCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA YEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS VLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKA VDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKIL YPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELL HRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCR TVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGV LIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMD RQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDKN2B_ENST00000276925_chr9_22008797_-_DGKD_ENST00000264057_chr2_234296903_+_3645nt ATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCAGCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACTAGTGGAGAAGGTG CGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCAACCGTTTCGGGAGGCGCGCGATCCAGACCATCATCAAAGAGGGGATGCTG ACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCA ATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTCATAACTCCA TGCAGGAAGCTCATCTTGTGTGCTGATAACAGAAAAGAAATGGAAGATTGGATTGCAGCATTAAAGACTGTGCAGAACAGGGAGCACTTT GAGCCCACCCAGTACAGCATGGACCACTTCTCAGGGATGCACAATTGGTACGCCTGTTCCCACGCGAGGCCGACCTACTGCAATGTGTGC CGTGAGGCTCTGTCTGGGGTCACGTCGCACGGGCTGTCCTGCGAGGTGTGCAAATTTAAGGCCCACAAGCGCTGTGCTGTGCGTGCAACC AATAACTGCAAGTGGACCACACTGGCCTCGATCGGGAAGGACATCATTGAAGATGCAGATGGGATTGCAATGCCCCACCAGTGGTTGGAA GGAAACCTACCTGTGAGCGCCAAGTGCACTGTGTGCGACAAGACCTGTGGCAGTGTGCTGCGCCTGCAGGACTGGCGCTGCCTCTGGTGC AAGGCCATGGTTCACACATCGTGTAAAGAATCCTTGCTGACCAAGTGCCCACTTGGCCTGTGCAAAGTGTCAGTCATCCCACCCACGGCT CTCAACAGCATCGACTCCGATGGGTTCTGGAAGGCCAGCTGTCCTCCTTCTTGCACAAGCCCACTGTTGGTCTTCGTCAATTCAAAAAGT GGGGACAACCAGGGTGTGAAGTTCCTCAGAAGATTCAAACAGCTACTAAACCCCGCCCAGGTCTTCGACCTCATGAACGGAGGCCCACAC CTCGGCTTACGGTTATTCCAGAAGTTTGACACATTCCGGATTCTGGTTTGTGGCGGGGATGGAAGTGTTGGCTGGGTCCTCTCCGAAATC GACAGCCTCAACCTTCATAAACAGTGTCAGCTGGGAGTGCTGCCGCTCGGCACAGGGAACGACTTGGCCCGAGTACTGGGCTGGGGCTCA GCCTGCGATGACGACACCCAGCTCCCCCAGATCTTGGAGAAGTTGGAGAGAGCCAGCACCAAGATGCTGGACAGGTGGAGCGTCATGGCA TACGAGGCCAAGCTCCCCCGGCAGGCCTCCTCCTCTACCGTCACCGAAGACTTCAGCGAGGATTCCGAGGTACAGCAGATTCTCTTCTAT GAAGACTCGGTTGCAGCCCACCTTTCTAAAATCCTCACCTCGGACCAGCACTCGGTGGTCATCTCCTCGGCCAAAGTGCTCTGTGAGACG GTGAAGGACTTCGTGGCACGGGTGGGGAAGGCCTATGAGAAGACGACCGAGAGCTCGGAGGAGTCAGAGGTCATGGCCAAGAAGTGCTCT GTCCTGAAAGAGAAGCTGGATTCCCTTCTCAAGACCTTGGACGATGAGTCCCAGGCCTCGTCCTCTCTGCCCAACCCGCCCCCCACCATT GCCGAGGAGGCTGAAGATGGAGATGGGTCGGGCAGCATCTGCGGTTCCACCGGAGACCGCTTGGTGGCATCAGCTTGCCCGGCCCGGCCG CAGATATTCCGGCCTCGAGAACAGCTCATGCTGAGAGCCAACAGCCTGAAGAAAGCAATTCGTCAGATCATAGAACACACAGAAAAAGCT GTCGATGAGCAGAATGCCCAGACCCAGGAGCAGGAGGGCTTCGTCCTGGGCCTCTCTGAGTCAGAGGAGAAGATGGACCACAGAGTGTGC CCACCACTGTCCCACAGCGAGAGCTTCGGGGTCCCCAAGGGGAGGAGCCAGCGCAAAGTGTCGAAATCTCCGTGTGAAAAGCTGATCAGC AAAGGGAGTCTGTCCCTAGGCAGTTCTGCTTCCCTTCCGCCCCAGCCGGGAAGCCGGGACGGCCTGCCTGCGCTCAACACCAAGATCCTG TACCCAAATGTCCGGGCTGGAATGTCTGGTTCCTTACCCGGTGGCTCAGTCATCAGTCGCCTGTTAATTAATGCTGATCCCTTCAACTCT GAACCAGAAACCCTAGAGTATTACACGGAGAAATGTGTCATGAACAACTATTTTGGCATTGGCCTGGATGCGAAGATATCCCTGGACTTT AACAACAAGCGCGATGAGCACCCAGAGAAGTGCAGGAGCCGAACCAAGAACATGATGTGGTATGGAGTTCTTGGAACCAAAGAGTTGCTG CACAGAACCTACAAGAACCTGGAGCAAAAGGTCTTGCTGGAGTGTGACGGGCGACCCATCCCACTCCCCAGTCTTCAGGGAATTGCTGTC CTTAACATTCCCAGCTATGCCGGAGGAACCAACTTCTGGGGGGGTACCAAGGAAGATGATACTTTCGCAGCTCCATCATTCGATGACAAG ATTCTGGAGGTGGTCGCCGTGTTCGGCAGCATGCAGATGGCCGTCTCTCGAGTCATCAGGCTACAGCATCATCGGATCGCCCAGTGTCGC ACGGTGAAGATCTCCATCCTTGGGGATGAGGGCGTGCCTGTGCAGGTGGACGGAGAGGCCTGGGTCCAGCCGCCAGGGTACATTCGGATT GTCCACAAGAACCGGGCACAGACACTGACCAGAGACAGGGCATTTGAGAGCACCCTGAAGTCCTGGGAAGACAAGCAGAAGTGCGAGCTG CCCCGCCCTCCATCCTGTTCCCTGCACCCGGAGATGCTGTCCGAGGAGGAGGCCACCCAGATGGACCAGTTTGGGCAGGCAGCAGGGGTC CTCATTCACAGTATCCGAGAAATAGCTCAGTCTCACCGGGACATGGAGCAGGAACTGGCCCACGCCGTCAATGCCAGCTCCAAGTCCATG GACCGTGTGTATGGCAAGCCCAGAACCACAGAGGGGCTCAACTGCAGCTTCGTCCTGGAAATGGTGAATAACTTCAGAGCTCTGCGCAGT GAGACGGAGCTGCTGCTGTCTGGGAAGATGGCCCTGCAGCTGGATCCGCCTCAGAAGGAGCAGCTGGGGAGTGCTCTTGCCGAGATGGAC CGACAGCTCAGGAGGCTGGCAGACACCCCGTGGCTCTGCCAGTCCGCAGAGCCCGGCGACGAAGAGAGTGTGATGCTGGATCTTGCCAAG CGCAGTCGCAGTGGTAAATTCCGCCTCGTGACCAAGTTTAAAAAGGAGAAAAACAACAAGAACAAAGAAGCTCACAGTAGCCTGGGAGCC CCGGTTCACCTCTGGGGGACAGAGGAGGTTGCTGCCTGGCTGGAGCACCTCAGTCTCTGTGAGTATAAGGACATCTTCACACGGCACGAC ATCCGGGGCTCTGAGCTCCTGCACCTGGAGCGGAGGGACCTCAAGGACCTGGGCGTGACCAAGGTGGGCCACATGAAGAGGATCCTGTGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDKN2B_ENST00000276925_chr9_22008797_-_DGKD_ENST00000264057_chr2_234296903_+_6695nt GGGAGACGCCGGCCCCTTGGCCCAGCTGAAAACGGAATTCTTTGCCGGCTGGCTCCCCACTCTGCCAGAGCGAGGCGGGGCAGTGAGGAC TCCGCGACGCGTCCGCACCCTGCGGCCAGAGCGGCTTTGAGCTCGGCTGCGTCCGCGCTAGGCGCTTTTTCCCAGAAGCAATCCAGGCGC GCCCGCTGGTTCTTGAGCGCCAGGAAAAGCCCGGAGCTAACGACCGGCCGCTCGGCCACTGCACGGGGCCCCAAGCCGCAGAAGGACGAC GGGAGGGTAATGAAGCTGAGCCCAGGTCTCCTAGGAAGGAGAGAGTGCGCCGGAGCAGCGTGGGAAAGAAGGGAAGAGTGTCGTTAAGTT TACGGCCAACGGTGGATTATCCGGGCCGCTGCGCGTCTGGGGGCTGCGGAATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCA GCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCA ACCGTTTCGGGAGGCGCGCGATCCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGAT ACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAG CTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTCATAACTCCATGCAGGAAGCTCATCTTGTGTGCTGATAACAGAAAAGAAA TGGAAGATTGGATTGCAGCATTAAAGACTGTGCAGAACAGGGAGCACTTTGAGCCCACCCAGTACAGCATGGACCACTTCTCAGGGATGC ACAATTGGTACGCCTGTTCCCACGCGAGGCCGACCTACTGCAATGTGTGCCGTGAGGCTCTGTCTGGGGTCACGTCGCACGGGCTGTCCT GCGAGGTGTGCAAATTTAAGGCCCACAAGCGCTGTGCTGTGCGTGCAACCAATAACTGCAAGTGGACCACACTGGCCTCGATCGGGAAGG ACATCATTGAAGATGCAGATGGGATTGCAATGCCCCACCAGTGGTTGGAAGGAAACCTACCTGTGAGCGCCAAGTGCACTGTGTGCGACA AGACCTGTGGCAGTGTGCTGCGCCTGCAGGACTGGCGCTGCCTCTGGTGCAAGGCCATGGTTCACACATCGTGTAAAGAATCCTTGCTGA CCAAGTGCCCACTTGGCCTGTGCAAAGTGTCAGTCATCCCACCCACGGCTCTCAACAGCATCGACTCCGATGGGTTCTGGAAGGCCAGCT GTCCTCCTTCTTGCACAAGCCCACTGTTGGTCTTCGTCAATTCAAAAAGTGGGGACAACCAGGGTGTGAAGTTCCTCAGAAGATTCAAAC AGCTACTAAACCCCGCCCAGGTCTTCGACCTCATGAACGGAGGCCCACACCTCGGCTTACGGTTATTCCAGAAGTTTGACACATTCCGGA TTCTGGTTTGTGGCGGGGATGGAAGTGTTGGCTGGGTCCTCTCCGAAATCGACAGCCTCAACCTTCATAAACAGTGTCAGCTGGGAGTGC TGCCGCTCGGCACAGGGAACGACTTGGCCCGAGTACTGGGCTGGGGCTCAGCCTGCGATGACGACACCCAGCTCCCCCAGATCTTGGAGA AGTTGGAGAGAGCCAGCACCAAGATGCTGGACAGGTGGAGCGTCATGGCATACGAGGCCAAGCTCCCCCGGCAGGCCTCCTCCTCTACCG TCACCGAAGACTTCAGCGAGGATTCCGAGGTACAGCAGATTCTCTTCTATGAAGACTCGGTTGCAGCCCACCTTTCTAAAATCCTCACCT CGGACCAGCACTCGGTGGTCATCTCCTCGGCCAAAGTGCTCTGTGAGACGGTGAAGGACTTCGTGGCACGGGTGGGGAAGGCCTATGAGA AGACGACCGAGAGCTCGGAGGAGTCAGAGGTCATGGCCAAGAAGTGCTCTGTCCTGAAAGAGAAGCTGGATTCCCTTCTCAAGACCTTGG ACGATGAGTCCCAGGCCTCGTCCTCTCTGCCCAACCCGCCCCCCACCATTGCCGAGGAGGCTGAAGATGGAGATGGGTCGGGCAGCATCT GCGGTTCCACCGGAGACCGCTTGGTGGCATCAGCTTGCCCGGCCCGGCCGCAGATATTCCGGCCTCGAGAACAGCTCATGCTGAGAGCCA ACAGCCTGAAGAAAGCAATTCGTCAGATCATAGAACACACAGAAAAAGCTGTCGATGAGCAGAATGCCCAGACCCAGGAGCAGGAGGGCT TCGTCCTGGGCCTCTCTGAGTCAGAGGAGAAGATGGACCACAGAGTGTGCCCACCACTGTCCCACAGCGAGAGCTTCGGGGTCCCCAAGG GGAGGAGCCAGCGCAAAGTGTCGAAATCTCCGTGTGAAAAGCTGATCAGCAAAGGGAGTCTGTCCCTAGGCAGTTCTGCTTCCCTTCCGC CCCAGCCGGGAAGCCGGGACGGCCTGCCTGCGCTCAACACCAAGATCCTGTACCCAAATGTCCGGGCTGGAATGTCTGGTTCCTTACCCG GTGGCTCAGTCATCAGTCGCCTGTTAATTAATGCTGATCCCTTCAACTCTGAACCAGAAACCCTAGAGTATTACACGGAGAAATGTGTCA TGAACAACTATTTTGGCATTGGCCTGGATGCGAAGATATCCCTGGACTTTAACAACAAGCGCGATGAGCACCCAGAGAAGTGCAGGAGCC GAACCAAGAACATGATGTGGTATGGAGTTCTTGGAACCAAAGAGTTGCTGCACAGAACCTACAAGAACCTGGAGCAAAAGGTCTTGCTGG AGTGTGACGGGCGACCCATCCCACTCCCCAGTCTTCAGGGAATTGCTGTCCTTAACATTCCCAGCTATGCCGGAGGAACCAACTTCTGGG GGGGTACCAAGGAAGATGATACTTTCGCAGCTCCATCATTCGATGACAAGATTCTGGAGGTGGTCGCCGTGTTCGGCAGCATGCAGATGG CCGTCTCTCGAGTCATCAGGCTACAGCATCATCGGATCGCCCAGTGTCGCACGGTGAAGATCTCCATCCTTGGGGATGAGGGCGTGCCTG TGCAGGTGGACGGAGAGGCCTGGGTCCAGCCGCCAGGGTACATTCGGATTGTCCACAAGAACCGGGCACAGACACTGACCAGAGACAGGG CATTTGAGAGCACCCTGAAGTCCTGGGAAGACAAGCAGAAGTGCGAGCTGCCCCGCCCTCCATCCTGTTCCCTGCACCCGGAGATGCTGT CCGAGGAGGAGGCCACCCAGATGGACCAGTTTGGGCAGGCAGCAGGGGTCCTCATTCACAGTATCCGAGAAATAGCTCAGTCTCACCGGG ACATGGAGCAGGAACTGGCCCACGCCGTCAATGCCAGCTCCAAGTCCATGGACCGTGTGTATGGCAAGCCCAGAACCACAGAGGGGCTCA ACTGCAGCTTCGTCCTGGAAATGGTGAATAACTTCAGAGCTCTGCGCAGTGAGACGGAGCTGCTGCTGTCTGGGAAGATGGCCCTGCAGC TGGATCCGCCTCAGAAGGAGCAGCTGGGGAGTGCTCTTGCCGAGATGGACCGACAGCTCAGGAGGCTGGCAGACACCCCGTGGCTCTGCC AGTCCGCAGAGCCCGGCGACGAAGAGAGTGTGATGCTGGATCTTGCCAAGCGCAGTCGCAGTGGTAAATTCCGCCTCGTGACCAAGTTTA AAAAGGAGAAAAACAACAAGAACAAAGAAGCTCACAGTAGCCTGGGAGCCCCGGTTCACCTCTGGGGGACAGAGGAGGTTGCTGCCTGGC TGGAGCACCTCAGTCTCTGTGAGTATAAGGACATCTTCACACGGCACGACATCCGGGGCTCTGAGCTCCTGCACCTGGAGCGGAGGGACC TCAAGGACCTGGGCGTGACCAAGGTGGGCCACATGAAGAGGATCCTGTGTGGCATCAAGGAGCTGAGCCGCAGCGCCCCCGCCGTCGAGG CCTAGCCTCTGTCCTCTCAGCCTGTGGCCTCCACATCCCCGCCGCCGAGGCCTAGCCTCCGCCCTCTCAGCCTGTGGCCTCTGCGCCTCC TGCCACTGAGGCCCTGGGCAGATGCTGCAGCCCGCCCCCTTCTCATGGTGCTACTTCCTCTGTCAGCTACAGAAAGCCTCCGTGACACCG TCCACCAGAGCTCTGGGGTCTCGAACATAACAACACAGCTACCTTTGAAACAACACTTTCTCCAGCTCAGAGTCACCTGGGGCACATGTG TCACGGCCACTCAGCTCTCGCCCGCCTGTGCTGTGGGCCAGGGAATCCAGCGGCGTCTGGCCTCCTGGGCACTGCTTGCCTGGCCTCGTG CTTGGATTGTCCCGGGGGCTCCTCTCCGTGTGTCCTTCTGTGGCCGCACCGTGTGGCTCCGCCTCCTGGCCCCCAGCCAGTTCTCAGAAA CGTGGCTGGGGCCCAGCACAGCAGCCTGCAAGGGCCCCTGTTTGTTGATGCAGCTTTTGTTGAACAAAAATCGTGCTCTTTCCTGGTTTG AAAGTAGCATGGATGTTTCCAGTCTTGTTGATTGTAATTTGACGTGAAGAGAAAAAAAAATTCCTCCTGCGTGAGCCAAGGCAGCGGGTG CTGTTTCCCAGGCGGGGAGCCCCTCCCTGGGTGTCACAGGGCCTGTGCTCCTCCCTCCTCCATCCTCTCTCCTCCCGCTCCTCCCTCCCC CCACTGTGGGCTGGGGACGCCTGCCCTTCTGTCTCCGGACGCTCTAGGCGAGTTCAGCTTGGGGTGTGAGTGAGACAGCTTGCCAGCTGC ATCCCTGCAGACAGAGGATGTGTGTCCACATGAGTGTTTCTGTGTGGGAAATGCTTCCTGGCTCTGGGAAACTTTTTCTGCCCATTCTGT GGTTCCCAGGGAGCGTGGCCCTGGTGGGCCAGGGGTGGTTTGACCTCTTCAGCCCGTCCGGTGGCCTGGAGGCCGGAGGCTCTCCTGAGT GTCTGCCCCTGCAGTGGCTTCTTGTCGCCTGCTGCTGGGCGTGATGTCGCTGGAGGTGCTGGCAGGGACTCTGATTTGGTGGTCCGCGCT GCCCCTGCCCTGCCTCTGTCCTGGCTCTGAACTAGTAGATGATGGTGCCAGAGGGCAGGGAGCTCGCCTGGGGAGAGGGCTGTGCCCCGT AGGGACAGTGCCCAGGTGAAGGATGCCCCTGGTCCTCCAGGGCACTGACTTTGCCCTTTTTTCCCGTTGATAGTCATGGCTCAGAGGTGC TTGTAAATGTCTTGGGAAGAGGTTTCTGTAACCCCTGCCCTGGTGTGAGGAGGAAATGGCTCTGGCCTGGCTGCCTGGCCGTGGCTTCTC TTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTGCCGTGGCTTCTCTTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTG CCGGCGCTGTCCAGGTCCTTTAGTCAGCGTCACTCCATCTGATGTGCAGAAGCTGGGCTGCACCTGCGGGGGTGGGCATAGACCGGGCTG GGTCTGCAGCAGCCCCTGGTCCTGAGCAGGCGGCAGTGAACAGCACTGGCCCACCTCCCACTCACAGCCCCTCTGTCCCCTCTGCAGTGC ACCCAGGTGGGCCCCTCTGCGTGCCTTTGGGTGCTCCCCTCTCGTGGTCGTTCTGGCCCGAGGCCCTTAGAGTATGGAGGCTGAGCCAGG CCTTGGGTTTCCCCAGCACAGCCTCCTGTCGCTGCATGCGACGTGTTGGGATTTTTGGATGAAAGACTCTCCCACGCTCTGTTGGTGGAC TTAGCTGCCTCACTGGAAGTGATGTGGGTGGAAGGTGGTTGTATGTTACCTTTTCCACCTCTCATTGTTTTCCCCAGAACATTGTAGATG GGGGTTGGCAGAGGGAGAAATAAGCCAGCCACGGCAGTCGCTTGGTTTCCCAGGTGGAATGGGCTAACACAGGAGATGATGGGAACCTGT CCCGCAGTCCCTGCATGACCATTGGCCCTGCTGGCCTGGCGATGTGGGCATCCTGGGGTTCTTAGGGTCCCAGAACAAGCCCCAGGCAAG CTGGAACTTGGGTGGGGAGGGGACATGAGGAGGATAAACAGCTGACTGTGGCTTCAAGGACATCAGGGCCACCCCAAGTCCTCAGTGTCC TACTCCTGGCAAGGAGTTGGGTTTGGATCAAAAGTGTTTAAAATTAATATGTTGTCAGTGATTAGAACAACACTGTTTACATAAAAACCA TTTTTCTAATTCTAACAAGTTAGAATGTGAGGAAGGAATGAACATGAGTGTTTAGGAACCTGCCCTTTGGTGCTGGGCTGGCGTCCCGCA CTGGGGTGTCCTCGCTGTCTGGGGGCTGCTCTGCTGCCCCGGCCCAGGTCCCCTTGTGGTGTTGCCAGACGGGCCTCATGGTCTGCTGTG CAGAGAGAGGCAGGAAGGATCCCTGAAGAGTCTTGGAGAAAAGGTTCTGTGCCCTCAGGTGGGGCTTACCCCCTCGTATTTATAATCTTA ATTTATATAGTGACCACCGTGGAAACAAACGCCTCTTGTATTGTCATGTACATAGTCCATACCTGAGTGCTGTACATAAGTTGTTCTGTG |
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FusionGenePPI for CDKN2B_DGKD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDKN2B | MAGEA11, CDK4, ARPC3, IKBKAP, CCDC90B, KIAA1377, APP, PYCRL, RNF20, ISL1, TGFB1I1, CDK6, TRAF1, NIF3L1, CCDC33, PIAS2 | DGKD | DGKH, HAX1, IGSF21, DGKD, TNFRSF14, SREK1, FEZ1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDKN2B_DGKD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDKN2B_DGKD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDKN2B | C0017638 | Glioma | 2 | CTD_human |
| Hgene | CDKN2B | C0017601 | Glaucoma | 1 | CTD_human |
| Hgene | CDKN2B | C0024299 | Lymphoma | 1 | CTD_human |
| Hgene | CDKN2B | C1956346 | Coronary Artery Disease | 1 | CTD_human |
| Hgene | CDKN2B | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |
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