![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 6622 |
FusionGeneSummary for CDKL2_ULK4 |
![]() |
Fusion gene information | Fusion gene name: CDKL2_ULK4 | Fusion gene ID: 6622 | Hgene | Tgene | Gene symbol | CDKL2 | ULK4 | Gene ID | 8999 | 54986 |
Gene name | cyclin dependent kinase like 2 | unc-51 like kinase 4 | |
Synonyms | KKIAMRE|P56 | FAM7C1|REC01035 | |
Cytomap | 4q21.1 | 3p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35 | serine/threonine-protein kinase ULK4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q92772 | Q96C45 | |
Ensembl transtripts involved in fusion gene | ENST00000429927, ENST00000307465, | ENST00000301831, ENST00000420927, ENST00000489118, ENST00000414606, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 9 X 9 X 4=324 |
# samples | 3 | 10 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDKL2 [Title/Abstract] AND ULK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI223964 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000429927 | ENST00000301831 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000429927 | ENST00000420927 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000429927 | ENST00000489118 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000429927 | ENST00000414606 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000307465 | ENST00000301831 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000307465 | ENST00000420927 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000307465 | ENST00000489118 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
intron-intron | ENST00000307465 | ENST00000414606 | CDKL2 | chr4 | 76540566 | + | ULK4 | chr3 | 41704276 | - |
Top |
FusionProtFeatures for CDKL2_ULK4 |
![]() |
Hgene | Tgene |
CDKL2 | ULK4 |
May be involved in the remodeling of cytoskeletalcomponents, such as alpha-tubulin, and in this way regulatesneurite branching and elongation, as well as cell motility.{ECO:0000269|PubMed:24284070}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CDKL2_ULK4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CDKL2_ULK4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CDKL2_ULK4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CDKL2_ULK4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDKL2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | CDKL2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | CDKL2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ULK4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | ULK4 | C0026764 | Multiple Myeloma | 1 | CTD_human |
Tgene | ULK4 | C0036341 | Schizophrenia | 1 | PSYGENET |