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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6621

FusionGeneSummary for CDKL2_G3BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKL2_G3BP2
Fusion gene ID: 6621
HgeneTgene
Gene symbol

CDKL2

G3BP2

Gene ID

8999

9908

Gene namecyclin dependent kinase like 2G3BP stress granule assembly factor 2
SynonymsKKIAMRE|P56-
Cytomap

4q21.1

4q21.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35ras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2
Modification date2018052320180523
UniProtAcc

Q92772

Q9UN86

Ensembl transtripts involved in fusion geneENST00000429927, ENST00000307465, 
ENST00000395719, ENST00000359707, 
ENST00000357854, ENST00000502654, 
Fusion gene scores* DoF score3 X 2 X 2=123 X 2 X 2=12
# samples 33
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDKL2 [Title/Abstract] AND G3BP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-38-4632-01ACDKL2chr4

76551005

-G3BP2chr4

76573925

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000429927ENST00000395719CDKL2chr4

76551005

-G3BP2chr4

76573925

-
In-frameENST00000429927ENST00000359707CDKL2chr4

76551005

-G3BP2chr4

76573925

-
In-frameENST00000429927ENST00000357854CDKL2chr4

76551005

-G3BP2chr4

76573925

-
5CDS-intronENST00000429927ENST00000502654CDKL2chr4

76551005

-G3BP2chr4

76573925

-
In-frameENST00000307465ENST00000395719CDKL2chr4

76551005

-G3BP2chr4

76573925

-
In-frameENST00000307465ENST00000359707CDKL2chr4

76551005

-G3BP2chr4

76573925

-
In-frameENST00000307465ENST00000357854CDKL2chr4

76551005

-G3BP2chr4

76573925

-
5CDS-intronENST00000307465ENST00000502654CDKL2chr4

76551005

-G3BP2chr4

76573925

-

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FusionProtFeatures for CDKL2_G3BP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKL2

Q92772

G3BP2

Q9UN86

Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKL2chr4:76551005chr4:76573925ENST00000429927-21245_5156624MotifNote=[NKR]KIAxRE
HgeneCDKL2chr4:76551005chr4:76573925ENST00000429927-21210_1856624Nucleotide bindingATP
TgeneG3BP2chr4:76551005chr4:76573925ENST00000357854-611419_479242450Compositional biasNote=Gly-rich
TgeneG3BP2chr4:76551005chr4:76573925ENST00000359707-712419_479275483Compositional biasNote=Gly-rich
TgeneG3BP2chr4:76551005chr4:76573925ENST00000395719-712419_479275483Compositional biasNote=Gly-rich
TgeneG3BP2chr4:76551005chr4:76573925ENST00000357854-611331_409242450DomainRRM
TgeneG3BP2chr4:76551005chr4:76573925ENST00000359707-712331_409275483DomainRRM
TgeneG3BP2chr4:76551005chr4:76573925ENST00000395719-712331_409275483DomainRRM

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKL2chr4:76551005chr4:76573925ENST00000429927-2124_28756624DomainProtein kinase
TgeneG3BP2chr4:76551005chr4:76573925ENST00000357854-611134_223242450Compositional biasNote=Glu-rich
TgeneG3BP2chr4:76551005chr4:76573925ENST00000359707-712134_223275483Compositional biasNote=Glu-rich
TgeneG3BP2chr4:76551005chr4:76573925ENST00000395719-712134_223275483Compositional biasNote=Glu-rich
TgeneG3BP2chr4:76551005chr4:76573925ENST00000357854-61111_133242450DomainNTF2
TgeneG3BP2chr4:76551005chr4:76573925ENST00000359707-71211_133275483DomainNTF2
TgeneG3BP2chr4:76551005chr4:76573925ENST00000395719-71211_133275483DomainNTF2


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FusionGeneSequence for CDKL2_G3BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDKL2_G3BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDKL2APP, FRY, HSP90AA1, HSP90AA5P, HSP90AA4P, CDC37, CDK14G3BP2STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDKL2_G3BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDKL2_G3BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKL2C0007621Neoplastic Cell Transformation1CTD_human
HgeneCDKL2C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDKL2C0027627Neoplasm Metastasis1CTD_human