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Fusion gene ID: 6621 |
FusionGeneSummary for CDKL2_G3BP2 |
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Fusion gene information | Fusion gene name: CDKL2_G3BP2 | Fusion gene ID: 6621 | Hgene | Tgene | Gene symbol | CDKL2 | G3BP2 | Gene ID | 8999 | 9908 |
Gene name | cyclin dependent kinase like 2 | G3BP stress granule assembly factor 2 | |
Synonyms | KKIAMRE|P56 | - | |
Cytomap | 4q21.1 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35 | ras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92772 | Q9UN86 | |
Ensembl transtripts involved in fusion gene | ENST00000429927, ENST00000307465, | ENST00000395719, ENST00000359707, ENST00000357854, ENST00000502654, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 3 X 2 X 2=12 |
# samples | 3 | 3 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CDKL2 [Title/Abstract] AND G3BP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-38-4632-01A | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000429927 | ENST00000395719 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
In-frame | ENST00000429927 | ENST00000359707 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
In-frame | ENST00000429927 | ENST00000357854 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
5CDS-intron | ENST00000429927 | ENST00000502654 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
In-frame | ENST00000307465 | ENST00000395719 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
In-frame | ENST00000307465 | ENST00000359707 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
In-frame | ENST00000307465 | ENST00000357854 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
5CDS-intron | ENST00000307465 | ENST00000502654 | CDKL2 | chr4 | 76551005 | - | G3BP2 | chr4 | 76573925 | - |
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FusionProtFeatures for CDKL2_G3BP2 |
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Hgene | Tgene |
CDKL2 | G3BP2 |
Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CDKL2 | chr4:76551005 | chr4:76573925 | ENST00000429927 | - | 2 | 12 | 45_51 | 56 | 624 | Motif | Note=[NKR]KIAxRE |
Hgene | CDKL2 | chr4:76551005 | chr4:76573925 | ENST00000429927 | - | 2 | 12 | 10_18 | 56 | 624 | Nucleotide binding | ATP |
Tgene | >G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000357854 | - | 6 | 11 | 419_479 | 242 | 450 | Compositional bias | Note=Gly-rich |
Tgene | >G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000359707 | - | 7 | 12 | 419_479 | 275 | 483 | Compositional bias | Note=Gly-rich |
Tgene | >G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000395719 | - | 7 | 12 | 419_479 | 275 | 483 | Compositional bias | Note=Gly-rich |
Tgene | >G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000357854 | - | 6 | 11 | 331_409 | 242 | 450 | Domain | RRM |
Tgene | >G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000359707 | - | 7 | 12 | 331_409 | 275 | 483 | Domain | RRM |
Tgene | >G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000395719 | - | 7 | 12 | 331_409 | 275 | 483 | Domain | RRM |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CDKL2 | chr4:76551005 | chr4:76573925 | ENST00000429927 | - | 2 | 12 | 4_287 | 56 | 624 | Domain | Protein kinase |
Tgene | G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000357854 | - | 6 | 11 | 134_223 | 242 | 450 | Compositional bias | Note=Glu-rich |
Tgene | G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000359707 | - | 7 | 12 | 134_223 | 275 | 483 | Compositional bias | Note=Glu-rich |
Tgene | G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000395719 | - | 7 | 12 | 134_223 | 275 | 483 | Compositional bias | Note=Glu-rich |
Tgene | G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000357854 | - | 6 | 11 | 11_133 | 242 | 450 | Domain | NTF2 |
Tgene | G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000359707 | - | 7 | 12 | 11_133 | 275 | 483 | Domain | NTF2 |
Tgene | G3BP2 | chr4:76551005 | chr4:76573925 | ENST00000395719 | - | 7 | 12 | 11_133 | 275 | 483 | Domain | NTF2 |
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FusionGeneSequence for CDKL2_G3BP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDKL2_G3BP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDKL2 | APP, FRY, HSP90AA1, HSP90AA5P, HSP90AA4P, CDC37, CDK14 | G3BP2 | STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDKL2_G3BP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDKL2_G3BP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDKL2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | CDKL2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | CDKL2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |