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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6620

FusionGeneSummary for CDKL2_CXCL11

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKL2_CXCL11
Fusion gene ID: 6620
HgeneTgene
Gene symbol

CDKL2

CXCL11

Gene ID

8999

6373

Gene namecyclin dependent kinase like 2C-X-C motif chemokine ligand 11
SynonymsKKIAMRE|P56H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1
Cytomap

4q21.1

4q21.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35C-X-C motif chemokine 11beta-R1chemokine (C-X-C motif) ligand 11interferon gamma-inducible protein 9interferon-inducible T-cell alpha chemoattractantsmall inducible cytokine B11small inducible cytokine subfamily B (Cys-X-Cys), member 11small induci
Modification date2018052320180523
UniProtAcc

Q92772

O14625

Ensembl transtripts involved in fusion geneENST00000429927, ENST00000307465, 
ENST00000306621, ENST00000503860, 
Fusion gene scores* DoF score3 X 2 X 2=124 X 1 X 4=16
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDKL2 [Title/Abstract] AND CXCL11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCXCL11

GO:0006935

chemotaxis

12782716

TgeneCXCL11

GO:0030816

positive regulation of cAMP metabolic process

12782716

TgeneCXCL11

GO:0043950

positive regulation of cAMP-mediated signaling

12782716

TgeneCXCL11

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

12782716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-7914-01ACDKL2chr4

76551005

-CXCL11chr4

76957217

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000429927ENST00000306621CDKL2chr4

76551005

-CXCL11chr4

76957217

-
5CDS-5UTRENST00000429927ENST00000503860CDKL2chr4

76551005

-CXCL11chr4

76957217

-
5CDS-5UTRENST00000307465ENST00000306621CDKL2chr4

76551005

-CXCL11chr4

76957217

-
5CDS-5UTRENST00000307465ENST00000503860CDKL2chr4

76551005

-CXCL11chr4

76957217

-

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FusionProtFeatures for CDKL2_CXCL11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKL2

Q92772

CXCL11

O14625

Chemotactic for interleukin-activated T-cells but notunstimulated T-cells, neutrophils or monocytes. Induces calciumrelease in activated T-cells. Binds to CXCR3. May play animportant role in CNS diseases which involve T-cell recruitment.May play a role in skin immune responses.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDKL2_CXCL11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDKL2_CXCL11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDKL2APP, FRY, HSP90AA1, HSP90AA5P, HSP90AA4P, CDC37, CDK14CXCL11CXCR3, MTUS2, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDKL2_CXCL11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDKL2_CXCL11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKL2C0007621Neoplastic Cell Transformation1CTD_human
HgeneCDKL2C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDKL2C0027627Neoplasm Metastasis1CTD_human
TgeneCXCL11C0282488Interstitial Cystitis1CTD_human