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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6584

FusionGeneSummary for CDK6_STXBP6

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK6_STXBP6
Fusion gene ID: 6584
HgeneTgene
Gene symbol

CDK6

STXBP6

Gene ID

1021

29091

Gene namecyclin dependent kinase 6syntaxin binding protein 6
SynonymsMCPH12|PLSTIREHSPC156|amisyn
Cytomap

7q21.2

14q12

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIREsyntaxin-binding protein 6
Modification date2018052720180523
UniProtAcc

Q00534

Q8NFX7

Ensembl transtripts involved in fusion geneENST00000265734, ENST00000424848, 
ENST00000491250, 
ENST00000548724, 
ENST00000396700, ENST00000323944, 
ENST00000419632, ENST00000546511, 
ENST00000550887, ENST00000358326, 
ENST00000548369, 
Fusion gene scores* DoF score9 X 6 X 5=2703 X 2 X 3=18
# samples 103
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDK6 [Title/Abstract] AND STXBP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK6

GO:0001954

positive regulation of cell-matrix adhesion

10205165

HgeneCDK6

GO:0003323

type B pancreatic cell development

20668294

HgeneCDK6

GO:0006468

protein phosphorylation

8114739

HgeneCDK6

GO:0010468

regulation of gene expression

15254224

HgeneCDK6

GO:0045638

negative regulation of myeloid cell differentiation

17431401

HgeneCDK6

GO:0045656

negative regulation of monocyte differentiation

26542173

HgeneCDK6

GO:0045668

negative regulation of osteoblast differentiation

15254224

HgeneCDK6

GO:0045786

negative regulation of cell cycle

14985467

HgeneCDK6

GO:2000773

negative regulation of cellular senescence

17420273

TgeneSTXBP6

GO:0035542

regulation of SNARE complex assembly

12145319


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7670-01ACDK6chr7

92462405

-STXBP6chr14

25281938

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265734ENST00000548724CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000265734ENST00000396700CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000265734ENST00000323944CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000265734ENST00000419632CDK6chr7

92462405

-STXBP6chr14

25281938

-
In-frameENST00000265734ENST00000546511CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000265734ENST00000550887CDK6chr7

92462405

-STXBP6chr14

25281938

-
5CDS-intronENST00000265734ENST00000358326CDK6chr7

92462405

-STXBP6chr14

25281938

-
5CDS-intronENST00000265734ENST00000548369CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000424848ENST00000548724CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000424848ENST00000396700CDK6chr7

92462405

-STXBP6chr14

25281938

-
In-frameENST00000424848ENST00000323944CDK6chr7

92462405

-STXBP6chr14

25281938

-
In-frameENST00000424848ENST00000419632CDK6chr7

92462405

-STXBP6chr14

25281938

-
Frame-shiftENST00000424848ENST00000546511CDK6chr7

92462405

-STXBP6chr14

25281938

-
In-frameENST00000424848ENST00000550887CDK6chr7

92462405

-STXBP6chr14

25281938

-
5CDS-intronENST00000424848ENST00000358326CDK6chr7

92462405

-STXBP6chr14

25281938

-
5CDS-intronENST00000424848ENST00000548369CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-3CDSENST00000491250ENST00000548724CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-3CDSENST00000491250ENST00000396700CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-3CDSENST00000491250ENST00000323944CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-3CDSENST00000491250ENST00000419632CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-3CDSENST00000491250ENST00000546511CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-3CDSENST00000491250ENST00000550887CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-intronENST00000491250ENST00000358326CDK6chr7

92462405

-STXBP6chr14

25281938

-
intron-intronENST00000491250ENST00000548369CDK6chr7

92462405

-STXBP6chr14

25281938

-

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FusionProtFeatures for CDK6_STXBP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK6

Q00534

STXBP6

Q8NFX7

Serine/threonine-protein kinase involved in the controlof the cell cycle and differentiation; promotes G1/S transition.Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclinsduring interphase at G1 to form a pRB/RB1 kinase and controls theentrance into the cell cycle. Involved in initiation andmaintenance of cell cycle exit during cell differentiation;prevents cell proliferation and regulates negatively celldifferentiation, but is required for the proliferation of specificcell types (e.g. erythroid and hematopoietic cells). Essential forcell proliferation within the dentate gyrus of the hippocampus andthe subventricular zone of the lateral ventricles. Required duringthymocyte development. Promotes the production of newborn neurons,probably by modulating G1 length. Promotes, at least inastrocytes, changes in patterns of gene expression, changes in theactin cytoskeleton including loss of stress fibers, and enhancedmotility during cell differentiation. Prevents myeloiddifferentiation by interfering with RUNX1 and reducing itstranscription transactivation activity, but promotes proliferationof normal myeloid progenitors. Delays senescence. Promotes theproliferation of beta-cells in pancreatic islets of Langerhans.May play a role in the centrosome organization during the cellcycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137,ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224,ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273,ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249,ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663,ECO:0000269|PubMed:8114739}. Forms non-fusogenic complexes with SNAP25 and STX1A andmay thereby modulate the formation of functional SNARE complexesand exocytosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK6_STXBP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDK6_ENST00000265734_chr7_92462405_-_STXBP6_ENST00000546511_chr14_25281938_-_85aa

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000323944_chr14_25281938_-_85aa

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000419632_chr14_25281938_-_85aa

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000550887_chr14_25281938_-_85aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDK6_ENST00000265734_chr7_92462405_-_STXBP6_ENST00000546511_chr14_25281938_-_257nt
ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCC
CGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGC

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000323944_chr14_25281938_-_257nt
ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCC
CGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGC

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000419632_chr14_25281938_-_257nt
ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCC
CGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGC

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000550887_chr14_25281938_-_257nt
ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCC
CGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDK6_ENST00000265734_chr7_92462405_-_STXBP6_ENST00000546511_chr14_25281938_-_1186nt
AACCTCTCCGCGCGAAGACGGCTTCAGCCCTGCAGGGAAAGAAAAGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTA
ATCGTGTCTGTGTTGAGGACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAG
GCGGAGTTTCGCGGCGGCGGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGC
CCGAGCGCCTGAGCCGGCGGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGA
GCGCACCCCCCGCCCGCCCCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTA
CGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAA
GCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCA
CCCCAACGTGGTCAGCTTGCCATGAAGCACAAATGTTGAGAAACTGCCTATCCTGGTGACTCTTCTTAAGAGAAACTGAAGAGTTTGTTC
AGCAGTTTTTACAAGAATTCGGGACCTCCGCTTGCTTCTTTTTTTCCAATATTTGGACACTTAGAGTGGTTTTTGTTTTTTCTTTTCAGA
TGTTAATGTGAAAGAAAGGGTGTTGCATTTTTACATTTCCCTAATGATCTTGCTAATAAATGCTACAATAGCATCAGCTTCATTTTGGGT
TTTTGCCTCCTCCCACTGTGTGTATGTGTGTATATGTATGTTTTGAATATGTTTTCTTTATTAAAAAATATTTTTTGTAGTTTGAATATG
AAATTTGGACCAAATGATAAACTGCGCTGAGTCTAAACTGGCAACATGTATTTTTTTCTCTGATATTAAGCAGGAAGGCATTTTAATGTG
GTGACATCAGATGTTATTTTTCCTAGATGAAAATAAAAGTCAAGCAGTGATTAGTTTCACTCACTGTCCTAGCTACACTTAATTTGAAGA

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000323944_chr14_25281938_-_3788nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGCTT
GCCATGAAGCACAAATGTTGAGAAACTGCCTATCCTGGTGACTCTTCTTAAGAGAAACTGAAGAGTTTGTTCAGCAGTTTTTACAAGAAT
TCGGGACCTCCGCTTGCTTCTTTTTTTCCAATATTTGGACACTTAGAGTGGTTTTTGTTTTTTCTTTTCAGATGTTAATGTGAAAGAAAG
GGTGTTGCATTTTTACATTTCCCTAATGATCTTGCTAATAAATGCTACAATAGCATCAGCTTCATTTTGGGTTTTTGCCTCCTCCCACTG
TGTGTATGTGTGTATATGTATGTTTTGAATATGTTTTCTTTATTAAAAAATATTTTTTGTAGTTTGAATATGAAATTTGGACCAAATGAT
AAACTGCGCTGAGTCTAAACTGGCAACATGTATTTTTTTCTCTGATATTAAGCAGGAAGGCATTTTAATGTGGTGACATCAGATGTTATT
TTTCCTAGATGAAAATAAAAGTCAAGCAGTGATTAGTTTCACTCACTGTCCTAGCTACACTTAATTTGAAGATTAAAATTCTACATTGTG
GAAAACAATTGAATTTATTGGGAAAAACAGCAGTCTTAGATTTTGCTCCTTGCATAGTAATCTTTTGCATGAACCATCACCAGCGTTCAA
AAAAAAAAAAAAATCAGAATCGCAGATAGAAATCTCTTTCCTGAGTTACAGTTTAAATACTCTTGCTACTTGTATCCAGGGTGTTTACTT
GGAATTATCATATGAAGGGTAAAAATTTGAGAGTAAAGCCCTAAAGAAAAGCCTACCTAAAACCCTCTGTGTACTCACAGATGTTTCTCT
TGTCACTGTCATAGTGATGGTCGCTGGTATGGAAAAGTGCTTATATTTTTATCAAAAAATTGATTTGTCCAGGTAAAGGTCTGTGTCAAT
GATAATGTGAACAAGTAGTACATTTAAAATGTTTGTCTTGTCTTTTTACAGTCATGCCTATTTTAGAGACACCTTCATAATGTCCTTGGG
AGAGGGCCTTTAGTTTCTTGGTATCTGGATTTTGGAGGTTTTGATGTTGTTTTTGCTATCTATTTATTTAATGTAATTTAATATGTGAGT
TTCTTGACAAATTGCATTTCATGGCAATTGCACCTTGCCTGGTCTGATATAAAACACCACAATCACAAACCTTTACATTGCAGTCAGTTT
CAATACAGTTGGTCACACACCTCGTGATTTTCTATTACTCAAGATAATAAGGGGCTTAGGGTCTAGAAGTTCTGTTTCCTAGAGGGTTAA
AATGCTAAACATAAAAAAAGCTGTGCTTTTTTTGTGAAACTAGGAGACAAGCTGCACATCTCAGACACATTGTAAGCCTACCACTGCAGC
GCATTGATTTTTAAGCTGCCTGAATCTTCAGGACCCCTATCTATTCCATCCTATCCATTTTGCTGATTGAGTCGATATGTATTGCAGCCT
CTTACATAGGAGCATAAGATGACTTTTGGATTGTTAATACTGATTTAAATAGCTGAAGTTCTCCTAATAAAGCATTCCCAAGGAGAGAGA
AAGTTTGTCTACTGGGGGTAAAAATATCAGATGGTGCACATTAAAAGGGAGATGAGATTTGTCGGAGACAGATTTCAGAATCCTTTTAGA
TGATCCAATTCAAGAAAACCCTCTATAAAATTTAATAAACTGTATAAGTTAACTATAATATTTTATACTTTCTTTTTGGTGTCTTAAAAA
TTTAAAGAAGCGAGGAACATGCCATTTGGTGAGTACCGTTGGAAGCTATTTTAATTTCTAGGAAAAGCCCCAAATATCACTCCAAATAGA
TTTTGTTTGCAGATCTCAGTTCAGAATGCACACACACACACACACACACACACACACACACACAGAGATGTATTTATCTTTCCAAATTGG
ATTCTGGTTTCAGAGATAGAGAGTTGGTATAAATAATTGAAAGGATAAATCTAAAACCCCCTGACAGTCCGCCAAATTCAAGAACAGAAG
TGGTTGCCAACTCTCTAACAACAATGTTTGGGAAGCTGATTCCAAAGTAGCTGAGGATGAGGTCATAAGCATACTGTGAAACCCAAGATT
CTTCTTCCCTGGTAGAATTACAATAGTTACTCTTGATAAATATAAGTATTCCATGTCTTGCCCTCTTTCCTCACTCTCTGCTTATCCTTT
TAGACCTAAGTTTCATTGGAAATAGCCTGAATTAGAAGAAAGCCCATCCGAATCTTTATTAGCCCCCTCTAATGATTAGTTTCCAGGCTG
CGTTCATACCTTTGACCTCTCAGTGTCAAAGTCCTACCTAGGCCTCCCCACAACAGAGAGGGCCGTAACAGCAATCCCTGCCCCTCCTTT
ACCTCCCAGCCTCTTGCAGAGGAGCCCAGTGATAACACATGTGAAGTTCTTTGCTGTCCTCTTGTAGAAGGTGCTGCAGTGCAAAGTATT
AATACGGTCTTAGACAAAATAACTGTCATGATTTGGGACCAGTTTGGTTGAGCTTGTCAGAAGACATTTCATTTGTTTCATTTCTGCACT
TCTCTATGAATTTTGGGATACTATATTTCTGTGAAGGACTTATTGTATAGACAACTCAAAAAGGAAAGAAACTTTCCAGTATTACCACTT
CTTCCTGGAATATAGCTGTAGTATTTCTCACTAGTATTATTAGATACCTGTGTACAGAAAGTATGCAGTTATTCAGGTTAATGTTTCATA
TTAAAGAATGTATTTGTAAAATGTAACATGATCAGTAGTTACCTTTTTTCAAGCTCTGAAGAAGTTCAGATTACGTGTTAGACTTAAGTT
ACAGTGAAAACTGTTTTAATACTACTTTTGTGGCTAGCAAAGGTTGTGCATCTATTTAAAATTATTTACAGGATGCTCTAAATAAGGGGC
ATTAAAGATAGGTTTAGCTCTTAATTTTAGAAATTGTGACACTACTGATGTCTGTCATACAGTTATTCTTCAGAAGTTCTCTGAGATGTC
AAATATAATTTTTGTTTAATTCAGAGATAAGTAACACCTGCTCTATTGATTCACTATTACAACAAACCCTAATTTTGTCATTAAATATTT

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000419632_chr14_25281938_-_1363nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGCTT
GCCATGAAGCACAAATGTTGAGAAACTGCCTATCCTGGTGACTCTTCTTAAGAGAAACTGAAGAGTTTGTTCAGCAGTTTTTACAAGAAT
TCGGGACCTCCGCTTGCTTCTTTTTTTCCAATATTTGGACACTTAGAGTGGTTTTTGTTTTTTCTTTTCAGATGTTAATGTGAAAGAAAG
GGTGTTGCATTTTTACATTTCCCTAATGATCTTGCTAATAAATGCTACAATAGCATCAGCTTCATTTTGGGTTTTTGCCTCCTCCCACTG
TGTGTATGTGTGTATATGTATGTTTTGAATATGTTTTCTTTATTAAAAAATATTTTTTGTAGTTTGAATATGAAATTTGGACCAAATGAT
AAACTGCGCTGAGTCTAAACTGGCAACATGTATTTTTTTCTCTGATATTAAGCAGGAAGGCATTTTAATGTGGTGACATCAGATGTTATT
TTTCCTAGATGAAAATAAAAGTCAAGCAGTGATTAGTTTCACTCACTGTCCTAGCTACACTTAATTTGAAGATTAAAATTCTACATTGTG
GAAAACAATTGAATTTATTGGGAAAAACAGCAGTCTTAGATTTTGCTCCTTGCATAGTAATCTTTTGCATGAACCATCACCAGCGTTCAA

>In-frame_CDK6_ENST00000424848_chr7_92462405_-_STXBP6_ENST00000550887_chr14_25281938_-_1150nt
GCTGGTAACTCCTTCCCCAGAGTCTGATTACCTGCTCCGCGAGGCCGCGGACACGTGCGGAGAGCCGACTGACACTCGCAGCCCCCTCGG
GAGGCCCGACGCGACTGGGCCCCTCAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGG
ACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGC
GGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGC
GGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCC
CCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGAT
CGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGAC
CGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGCTT
GCCATGAAGCACAAATGTTGAGAAACTGCCTATCCTGGTGACTCTTCTTAAGAGAAACTGAAGAGTTTGTTCAGCAGTTTTTACAAGAAT
TCGGGACCTCCGCTTGCTTCTTTTTTTCCAATATTTGGACACTTAGAGTGGTTTTTGTTTTTTCTTTTCAGATGTTAATGTGAAAGAAAG
GGTGTTGCATTTTTACATTTCCCTAATGATCTTGCTAATAAATGCTACAATAGCATCAGCTTCATTTTGGGTTTTTGCCTCCTCCCACTG
TGTGTATGTGTGTATATGTATGTTTTGAATATGTTTTCTTTATTAAAAAATATTTTTTGTAGTTTGAATATGAAATTTGGACCAAATGAT


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FusionGenePPI for CDK6_STXBP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDK6CDKN2C, CDKN2A, CCND1, CDKN2D, PPP2CA, PPM1B, CDK2, CCND2, CCND3, CDKN1B, CDC37, FBXO7, CDKN1A, UHRF2, CDK5R1, ELAVL1, CCNE1, CCNA2, KIF26B, RB1, CDK7, ATXN1, HIST1H1A, PML, HSP90AA1, FOXM1, ZSCAN1, SYNPO2, DEDD2, SRSF12, ZNF101, SNIP1, ZNF335, PRX, EBF4, EIF4ENIF1, RBM23, BCL11A, TCEB3B, PPHLN1, TRA2A, SENP3, NIPBL, CBY1, SSBP2, SIRT1, POGZ, LPIN1, ANKRD12, TPX2, TRAK1, CASC3, CLASRP, PPARGC1A, MSL3, SORBS1, ABI2, N4BP1, VGLL4, TJP2, SRSF11, ZMYM3, ZNF174, SLBP, ZFP36, MZF1, KLF10, TFDP1, ZEB1, SOX5, SOX10, SRSF1, SRSF2, SRSF7, TRA2B, RBL1, RBL2, NUMA1, NFATC3, MYC, MEF2D, MLLT3, ISL1, HSF1, EZH2, FOXO3, ELK1, ATF6B, DDIT3, CDC6, MCM2, MCM10, UCHL1, CDKN2B, WDR33, CDKL3, CDK6, DMBT1, AMY2A, PIGR, CDK4, DAB1, PSMA3, RTFDC1, HSP90AA5P, UBE2W, CCNT2, CCNT1, RCHY1, EIF2AK1, CDKN1C, NTRK1, RUNX1, CTNNB1, AR, VHL, FGFR3, USP17L2, MCF2L2, PAK4, FKBP5, FAM26E, TRIM25STXBP6CDH1, ALS2, STX7, STX1A, STX3, STX4, NAPG, STX8, VTI1B, STX12, ATG7, STX6, NAPA, SNAP23


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK6_STXBP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCDK6Q00534DB09073PalbociclibCyclin-dependent kinase 6small moleculeapproved|investigational

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RelatedDiseases for CDK6_STXBP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDK6C0025149Medulloblastoma2CTD_human
HgeneCDK6C0003873Rheumatoid Arthritis1CTD_human
HgeneCDK6C0008625Chromosome Aberrations1CTD_human
HgeneCDK6C0017636Glioblastoma1CTD_human
HgeneCDK6C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCDK6C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDK6C0263454Chloracne1CTD_human
HgeneCDK6C0345967Malignant mesothelioma1CTD_human
HgeneCDK6C0677866Brain Stem Neoplasms1CTD_human
HgeneCDK6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneCDK6C4015156MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE1UNIPROT
TgeneSTXBP6C0004352Autistic Disorder1CTD_human