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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6571

FusionGeneSummary for CDK5RAP3_NCAPD3

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK5RAP3_NCAPD3
Fusion gene ID: 6571
HgeneTgene
Gene symbol

CDK5RAP3

NCAPD3

Gene ID

80279

23310

Gene nameCDK5 regulatory subunit associated protein 3non-SMC condensin II complex subunit D3
SynonymsC53|HSF-27|IC53|LZAP|MST016|OK/SW-cl.114|PP1553CAP-D3|CAPD3|MCPH22|hCAP-D3|hHCP-6|hcp-6
Cytomap

17q21.32

11q25

Type of geneprotein-codingprotein-coding
DescriptionCDK5 regulatory subunit-associated protein 3CDK5 regulatory subunit associated protein IC53-2LXXLL/leucine-zipper-containing ARF-binding proteinLXXLL/leucine-zipper-containing ARFbinding proteinischemic heart CDK5 activator-binding protein C53condensin-2 complex subunit D3
Modification date2018052320180525
UniProtAcc

Q96JB5

P42695

Ensembl transtripts involved in fusion geneENST00000536708, ENST00000338399, 
ENST00000578663, 
ENST00000534548, 
ENST00000526787, ENST00000526422, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CDK5RAP3 [Title/Abstract] AND NCAPD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK5RAP3

GO:0008283

cell proliferation

12054757

HgeneCDK5RAP3

GO:0031398

positive regulation of protein ubiquitination

16173922

HgeneCDK5RAP3

GO:0071569

protein ufmylation

23152784

HgeneCDK5RAP3

GO:1900182

positive regulation of protein localization to nucleus

16173922

HgeneCDK5RAP3

GO:1901798

positive regulation of signal transduction by p53 class mediator

16173922

HgeneCDK5RAP3

GO:1903363

negative regulation of cellular protein catabolic process

16173922

HgeneCDK5RAP3

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

16173922

TgeneNCAPD3

GO:0007076

mitotic chromosome condensation

14532007


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW819720CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000536708ENST00000534548CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-intronENST00000536708ENST00000526787CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-intronENST00000536708ENST00000526422CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-3CDSENST00000338399ENST00000534548CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-intronENST00000338399ENST00000526787CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-intronENST00000338399ENST00000526422CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-3CDSENST00000578663ENST00000534548CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-intronENST00000578663ENST00000526787CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-
intron-intronENST00000578663ENST00000526422CDK5RAP3chr17

46053081

-NCAPD3chr11

134037956

-

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FusionProtFeatures for CDK5RAP3_NCAPD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK5RAP3

Q96JB5

NCAPD3

P42695

Regulatory subunit of the condensin-2 complex, a complexwhich establishes mitotic chromosome architecture and is involvedin physical rigidity of the chromatid axis.{ECO:0000269|PubMed:14532007}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDK5RAP3_NCAPD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDK5RAP3_NCAPD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDK5RAP3_NCAPD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDK5RAP3_NCAPD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource