![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 6571 |
FusionGeneSummary for CDK5RAP3_NCAPD3 |
![]() |
Fusion gene information | Fusion gene name: CDK5RAP3_NCAPD3 | Fusion gene ID: 6571 | Hgene | Tgene | Gene symbol | CDK5RAP3 | NCAPD3 | Gene ID | 80279 | 23310 |
Gene name | CDK5 regulatory subunit associated protein 3 | non-SMC condensin II complex subunit D3 | |
Synonyms | C53|HSF-27|IC53|LZAP|MST016|OK/SW-cl.114|PP1553 | CAP-D3|CAPD3|MCPH22|hCAP-D3|hHCP-6|hcp-6 | |
Cytomap | 17q21.32 | 11q25 | |
Type of gene | protein-coding | protein-coding | |
Description | CDK5 regulatory subunit-associated protein 3CDK5 regulatory subunit associated protein IC53-2LXXLL/leucine-zipper-containing ARF-binding proteinLXXLL/leucine-zipper-containing ARFbinding proteinischemic heart CDK5 activator-binding protein C53 | condensin-2 complex subunit D3 | |
Modification date | 20180523 | 20180525 | |
UniProtAcc | Q96JB5 | P42695 | |
Ensembl transtripts involved in fusion gene | ENST00000536708, ENST00000338399, ENST00000578663, | ENST00000534548, ENST00000526787, ENST00000526422, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CDK5RAP3 [Title/Abstract] AND NCAPD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDK5RAP3 | GO:0008283 | cell proliferation | 12054757 |
Hgene | CDK5RAP3 | GO:0031398 | positive regulation of protein ubiquitination | 16173922 |
Hgene | CDK5RAP3 | GO:0071569 | protein ufmylation | 23152784 |
Hgene | CDK5RAP3 | GO:1900182 | positive regulation of protein localization to nucleus | 16173922 |
Hgene | CDK5RAP3 | GO:1901798 | positive regulation of signal transduction by p53 class mediator | 16173922 |
Hgene | CDK5RAP3 | GO:1903363 | negative regulation of cellular protein catabolic process | 16173922 |
Hgene | CDK5RAP3 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 16173922 |
Tgene | NCAPD3 | GO:0007076 | mitotic chromosome condensation | 14532007 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW819720 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000536708 | ENST00000534548 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-intron | ENST00000536708 | ENST00000526787 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-intron | ENST00000536708 | ENST00000526422 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-3CDS | ENST00000338399 | ENST00000534548 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-intron | ENST00000338399 | ENST00000526787 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-intron | ENST00000338399 | ENST00000526422 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-3CDS | ENST00000578663 | ENST00000534548 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-intron | ENST00000578663 | ENST00000526787 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
intron-intron | ENST00000578663 | ENST00000526422 | CDK5RAP3 | chr17 | 46053081 | - | NCAPD3 | chr11 | 134037956 | - |
Top |
FusionProtFeatures for CDK5RAP3_NCAPD3 |
![]() |
Hgene | Tgene |
CDK5RAP3 | NCAPD3 |
Regulatory subunit of the condensin-2 complex, a complexwhich establishes mitotic chromosome architecture and is involvedin physical rigidity of the chromatid axis.{ECO:0000269|PubMed:14532007}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CDK5RAP3_NCAPD3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CDK5RAP3_NCAPD3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CDK5RAP3_NCAPD3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CDK5RAP3_NCAPD3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |