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Fusion gene ID: 6487 |
FusionGeneSummary for CDK12_CDC6 |
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Fusion gene information | Fusion gene name: CDK12_CDC6 | Fusion gene ID: 6487 | Hgene | Tgene | Gene symbol | CDK12 | CDC6 | Gene ID | 51755 | 990 |
Gene name | cyclin dependent kinase 12 | cell division cycle 6 | |
Synonyms | CRK7|CRKR|CRKRS | CDC18L|HsCDC18|HsCDC6|MGORS5 | |
Cytomap | 17q12 | 17q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12 | cell division control protein 6 homologCDC6 cell division cycle 6 homologCDC6-related proteincdc18-related proteincell division cycle 6 homologp62(cdc6) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NYV4 | Q99741 | |
Ensembl transtripts involved in fusion gene | ENST00000430627, ENST00000447079, ENST00000559545, | ENST00000209728, | |
Fusion gene scores | * DoF score | 20 X 10 X 12=2400 | 8 X 4 X 7=224 |
# samples | 22 | 9 | |
** MAII score | log2(22/2400*10)=-3.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDK12 [Title/Abstract] AND CDC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDK12 | GO:0046777 | protein autophosphorylation | 11683387 |
Tgene | CDC6 | GO:0051984 | positive regulation of chromosome segregation | 21041660 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-06-0130-01A | CDK12 | chr17 | 37619370 | + | CDC6 | chr17 | 38445660 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000430627 | ENST00000209728 | CDK12 | chr17 | 37619370 | + | CDC6 | chr17 | 38445660 | + |
5CDS-5UTR | ENST00000447079 | ENST00000209728 | CDK12 | chr17 | 37619370 | + | CDC6 | chr17 | 38445660 | + |
intron-5UTR | ENST00000559545 | ENST00000209728 | CDK12 | chr17 | 37619370 | + | CDC6 | chr17 | 38445660 | + |
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FusionProtFeatures for CDK12_CDC6 |
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Hgene | Tgene |
CDK12 | CDC6 |
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}. | Involved in the initiation of DNA replication. Alsoparticipates in checkpoint controls that ensure DNA replication iscompleted before mitosis is initiated. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDK12_CDC6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDK12_CDC6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDK12 | MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1 | CDC6 | PPP2R3B, ORC2, ORC1, MCM7, PSKH1, CCNA2, MYC, CDK2, PCNA, MCM3, AKAP8L, PPP2R3A, CDT1, MCM8, HUWE1, TERF1, ATR, ATM, ATRIP, BMI1, KAT7, CCL2, FZR1, CDC20, CDK4, CDK6, MCM10, MCM2, ORC5, ORC3, ORC6, CDKN2A, CDKN1A, CCNE1, CCNB1, CDK1, B3GALNT1, UBE2K, CDC14A, UBR1, TSPAN3, COLEC11, TGFBR2, ISLR, PON2, POLA1, NOP56, CCNF, LAMP2, IL20RA, TNFRSF1A, FAM131B, PROZ, MANSC1, PCDHB11, TNFRSF10A, LAMP3, BPNT1, C1orf85, TNFRSF8, MAGEA10, PCDHGA5, CHEK2, CHEK1, TOP1, TOP2A, TOP3A, WEE1, HEY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDK12_CDC6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDK12_CDC6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CDC6 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | CDC6 | C1868684 | EAR, PATELLA, SHORT STATURE SYNDROME | 1 | CTD_human;ORPHANET |
Tgene | CDC6 | C3151126 | MEIER-GORLIN SYNDROME 5 | 1 | UNIPROT |