![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 6480 |
FusionGeneSummary for CDK11B_DMD |
![]() |
Fusion gene information | Fusion gene name: CDK11B_DMD | Fusion gene ID: 6480 | Hgene | Tgene | Gene symbol | CDK11B | DMD | Gene ID | 984 | 1756 |
Gene name | cyclin dependent kinase 11B | dystrophin | |
Synonyms | CDC2L1|CDK11|CDK11-p110|CDK11-p46|CDK11-p58|CLK-1|PITSLREA|PK58|p58|p58CDC2L1|p58CLK-1 | BMD|CMD3B|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272|MRX85 | |
Cytomap | 1p36.33 | Xp21.2-p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclin-dependent kinase 11BCDC-related protein kinase p58PITSLRE serine/threonine-protein kinase CDC2L1cell division cycle 2-like 1 (PITSLRE proteins)cell division protein kinase 11Bgalactosyltransferase-associated protein kinase p58/GTAp58 CLK-1 | dystrophin | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P11532 | ||
Ensembl transtripts involved in fusion gene | ENST00000341832, ENST00000340677, ENST00000407249, ENST00000317673, | ENST00000378707, ENST00000359836, ENST00000541735, ENST00000343523, ENST00000378677, ENST00000357033, ENST00000474231, ENST00000378723, ENST00000378702, ENST00000361471, ENST00000378680, ENST00000288447, ENST00000445312, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 16 X 18 X 7=2016 |
# samples | 4 | 18 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(18/2016*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDK11B [Title/Abstract] AND DMD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDK11B | GO:0006468 | protein phosphorylation | 12501247 |
Hgene | CDK11B | GO:0050684 | regulation of mRNA processing | 12501247 |
Tgene | DMD | GO:0043043 | peptide biosynthetic process | 16000376 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-22-A5C4-01A | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000341832 | ENST00000378707 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000341832 | ENST00000359836 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000341832 | ENST00000541735 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000341832 | ENST00000343523 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000341832 | ENST00000378677 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000341832 | ENST00000357033 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000341832 | ENST00000474231 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000341832 | ENST00000378723 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000341832 | ENST00000378702 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000341832 | ENST00000361471 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000341832 | ENST00000378680 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000341832 | ENST00000288447 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000341832 | ENST00000445312 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000378707 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000359836 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000541735 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000343523 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000378677 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000357033 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000340677 | ENST00000474231 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000340677 | ENST00000378723 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000340677 | ENST00000378702 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000340677 | ENST00000361471 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000340677 | ENST00000378680 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000340677 | ENST00000288447 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000340677 | ENST00000445312 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000378707 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000359836 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000541735 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000343523 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000378677 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000357033 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000407249 | ENST00000474231 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000407249 | ENST00000378723 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000407249 | ENST00000378702 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000407249 | ENST00000361471 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000407249 | ENST00000378680 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000407249 | ENST00000288447 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000407249 | ENST00000445312 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000378707 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000359836 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000541735 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000343523 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000378677 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000357033 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-5UTR | ENST00000317673 | ENST00000474231 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000317673 | ENST00000378723 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000317673 | ENST00000378702 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000317673 | ENST00000361471 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000317673 | ENST00000378680 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000317673 | ENST00000288447 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
5CDS-intron | ENST00000317673 | ENST00000445312 | CDK11B | chr1 | 1577023 | - | DMD | chrX | 31854936 | - |
Top |
FusionProtFeatures for CDK11B_DMD |
![]() |
Hgene | Tgene |
CDK11B | DMD |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CDK11B_DMD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CDK11B_DMD |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDK11B | RNPS1, CCND3, MEPCE, HSP90AA1, HSPA4, HSPA8, CDC37, KAT7, VDR, POU2F1, ESR1, EIF3F, AP3D1, RBM25, RAP1A, PNKP, AP2M1, MSN, RPS27A, TPPP, YWHAE, YWHAB, YWHAG, YWHAQ, YWHAZ, CDK11B, PIN1, CSNK2A2, RANBP9, ZRSR2, CDK11A, NTRK1, TGM2, KMT2E, JMJD6, RSBN1, ZNF221, FGF8, HIST1H1E, UHRF2 | DMD | DTNA, KCNJ12, KCNJ4, SNTA1, SNTB2, SNTB1, DAG1, ACTA1, MAP3K5, TERF1, TERF2, DISC1, TRAF3IP1, ARRB1, NFX1, MARK2, APP, NEDD4, PTRF, AHNAK, ALB, NOS1, CDC25A, DTNB, CTNNAL1, HAUS1, LPAR6, CTNNA1, XPO1, NUPL1, KIF15, GAN, MCM2, TENC1, TNS1, TNS3, SNTG2, LONRF3, HAUS4, UTRN, OSBPL1A, LRRC8E, KIF23, SIRT2, TRIM41, IFIT5, WDR54, MPP6, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CDK11B_DMD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CDK11B_DMD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DMD | C0013264 | Muscular Dystrophy, Duchenne | 16 | CTD_human;ORPHANET;UNIPROT |
Tgene | DMD | C0026850 | Muscular Dystrophy | 4 | CTD_human;HPO |
Tgene | DMD | C3668940 | Dmd-Associated Dilated Cardiomyopathy | 4 | CTD_human;UNIPROT |
Tgene | DMD | C0878544 | Cardiomyopathies | 3 | CTD_human;HPO |
Tgene | DMD | C0006663 | Calcinosis | 1 | CTD_human |
Tgene | DMD | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human;HPO |
Tgene | DMD | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | DMD | C0023269 | leiomyosarcoma | 1 | CTD_human |
Tgene | DMD | C0026851 | Muscular Dystrophy, Animal | 1 | CTD_human |
Tgene | DMD | C0027540 | Necrosis | 1 | CTD_human |
Tgene | DMD | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | DMD | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | DMD | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | DMD | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | DMD | C0151786 | Muscle Weakness | 1 | CTD_human;HPO |
Tgene | DMD | C0206656 | Rhabdomyosarcoma, Embryonal | 1 | CTD_human |
Tgene | DMD | C0238198 | Gastrointestinal Stromal Tumors | 1 | CTD_human |
Tgene | DMD | C0242973 | Ventricular Dysfunction | 1 | CTD_human |
Tgene | DMD | C0917713 | Becker Muscular Dystrophy | 1 | ORPHANET;UNIPROT |