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Fusion gene ID: 6471 |
FusionGeneSummary for CDHR3_DMP1 |
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Fusion gene information | Fusion gene name: CDHR3_DMP1 | Fusion gene ID: 6471 | Hgene | Tgene | Gene symbol | CDHR3 | DMP1 | Gene ID | 222256 | 9988 |
Gene name | cadherin related family member 3 | cyclin D binding myb like transcription factor 1 | |
Synonyms | CDH28 | DMP1|DMTF|MRUL|hDMP1 | |
Cytomap | 7q22.3 | 7q21.12 | |
Type of gene | protein-coding | protein-coding | |
Description | cadherin-related family member 3cadherin-like protein 28 | cyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q6ZTQ4 | Q13316 | |
Ensembl transtripts involved in fusion gene | ENST00000470188, ENST00000542731, ENST00000343407, ENST00000317716, ENST00000478080, ENST00000541203, | ENST00000282479, ENST00000339673, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CDHR3 [Title/Abstract] AND DMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CR745188 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000470188 | ENST00000282479 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
3UTR-intron | ENST00000470188 | ENST00000339673 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000542731 | ENST00000282479 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000542731 | ENST00000339673 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000343407 | ENST00000282479 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000343407 | ENST00000339673 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000317716 | ENST00000282479 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000317716 | ENST00000339673 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000478080 | ENST00000282479 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000478080 | ENST00000339673 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000541203 | ENST00000282479 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
intron-intron | ENST00000541203 | ENST00000339673 | CDHR3 | chr7 | 105553084 | + | DMP1 | chr4 | 88581950 | - |
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FusionProtFeatures for CDHR3_DMP1 |
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Hgene | Tgene |
CDHR3 | DMP1 |
Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. (Microbial infection) Acts as a receptor for rhinovirusC. {ECO:0000269|PubMed:25848009}. | May have a dual function during osteoblastdifferentiation. In the nucleus of undifferentiated osteoblasts,unphosphorylated form acts as a transcriptional component foractivation of osteoblast-specific genes like osteocalcin. Duringthe osteoblast to osteocyte transition phase it is phosphorylatedand exported into the extracellular matrix, where it regulatesnucleation of hydroxyapatite. {ECO:0000269|PubMed:12615915}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDHR3_DMP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDHR3_DMP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDHR3_DMP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDHR3_DMP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDHR3 | C0004096 | Asthma | 1 | CTD_human |