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Fusion gene ID: 6447 |
FusionGeneSummary for CDH1_TRHDE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDH1_TRHDE | Fusion gene ID: 6447 | Hgene | Tgene | Gene symbol | CDH1 | TRHDE | Gene ID | 51343 | 29953 |
| Gene name | fizzy and cell division cycle 20 related 1 | thyrotropin releasing hormone degrading enzyme | |
| Synonyms | CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1 | PAP-II|PGPEP2|TRH-DE | |
| Cytomap | 19p13.3 | 12q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1 | thyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P12830 | Q9UKU6 | |
| Ensembl transtripts involved in fusion gene | ENST00000261769, ENST00000422392, ENST00000562836, | ENST00000261180, ENST00000549138, | |
| Fusion gene scores | * DoF score | 11 X 10 X 4=440 | 14 X 6 X 5=420 |
| # samples | 13 | 13 | |
| ** MAII score | log2(13/440*10)=-1.7589919004962 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/420*10)=-1.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDH1 [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDH1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 18662541|21596315 |
| Hgene | CDH1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
| Hgene | CDH1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-VP-A879-01A | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261769 | ENST00000261180 | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
| 5CDS-intron | ENST00000261769 | ENST00000549138 | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
| In-frame | ENST00000422392 | ENST00000261180 | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
| 5CDS-intron | ENST00000422392 | ENST00000549138 | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
| 3UTR-3CDS | ENST00000562836 | ENST00000261180 | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
| 3UTR-intron | ENST00000562836 | ENST00000549138 | CDH1 | chr16 | 68835796 | + | TRHDE | chr12 | 72771775 | + |
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FusionProtFeatures for CDH1_TRHDE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDH1 | TRHDE |
| Cadherins are calcium-dependent cell adhesion proteins(PubMed:11976333). They preferentially interact with themselves ina homophilic manner in connecting cells; cadherins may thuscontribute to the sorting of heterogeneous cell types. CDH1 isinvolved in mechanisms regulating cell-cell adhesions, mobilityand proliferation of epithelial cells (PubMed:11976333). Has apotent invasive suppressor role. It is a ligand for integrinalpha-E/beta-7. {ECO:0000269|PubMed:11976333,ECO:0000269|PubMed:16417575}. E-Cad/CTF2 promotes non-amyloidogenic degradation ofAbeta precursors. Has a strong inhibitory effect on APP C99 andC83 production. {ECO:0000269|PubMed:16417575}. | Specific inactivation of TRH after its release. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TRHDE | chr16:68835796 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 404_408 | 351 | 1025 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 838_851 | 129 | 883 | Compositional bias | Note=Ser-rich |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 155_262 | 129 | 883 | Domain | Cadherin 1 |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 263_375 | 129 | 883 | Domain | Cadherin 2 |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 376_486 | 129 | 883 | Domain | Cadherin 3 |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 487_593 | 129 | 883 | Domain | Cadherin 4 |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 594_697 | 129 | 883 | Domain | Cadherin 5 |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 758_769 | 129 | 883 | Region | Note=Required for binding CTNND1 and PSEN1 |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 811_882 | 129 | 883 | Region | Note=Required for binding alpha%2C beta and gamma catenins |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 155_709 | 129 | 883 | Topological domain | Extracellular |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 731_882 | 129 | 883 | Topological domain | Cytoplasmic |
| Hgene | >CDH1 | chr16:68835796 | chr12:72771775 | ENST00000261769 | + | 3 | 16 | 710_730 | 129 | 883 | Transmembrane | Helical |
| Tgene | TRHDE | chr16:68835796 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 1_40 | 351 | 1025 | Topological domain | Cytoplasmic |
| Tgene | TRHDE | chr16:68835796 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 62_1024 | 351 | 1025 | Topological domain | Extracellular |
| Tgene | TRHDE | chr16:68835796 | chr12:72771775 | ENST00000261180 | + | 1 | 19 | 41_61 | 351 | 1025 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for CDH1_TRHDE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDH1_ENST00000261769_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_803aa MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHP YAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDV LHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY LDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY PLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNV RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRD >In-frame_CDH1_ENST00000422392_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_803aa MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHP YAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDV LHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY LDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY PLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNV RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDH1_ENST00000261769_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_2409nt ATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCT GGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGC ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG CACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATA ACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCG TATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTG GATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAG GAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTT CTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTT GACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGAT TATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTA AATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATA ATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCA TTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTAT TTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATT GATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTAT TTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTAT CCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTT GGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGC AGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTT AGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTT TCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAG GTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGAT AAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAA GGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCC >In-frame_CDH1_ENST00000422392_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_2409nt ATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCT GGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGC ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG CACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATA ACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCG TATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTG GATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAG GAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTT CTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTT GACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGAT TATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTA AATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATA ATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCA TTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTAT TTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATT GATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTAT TTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTAT CCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTT GGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGC AGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTT AGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTT TCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAG GTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGAT AAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAA GGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDH1_ENST00000261769_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_5047nt AGCCAATCAGCGGTACGGGGGGCGGTGCCTCCGGGGCTCACCTGGCTGCAGCCACGCACCCCCTCTCAGTGGCGTCGGAACTGCAAAGCA CCTGTGAGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTC CCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGC CCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATT TTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAA GGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGA ATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATG CTCTCCATATAACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGC CTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTT CTTATTTGCTGGATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACG TGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTC TGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTG ACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGG GTTTGCAAGATTATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATG GGAAATATGTAAATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAG AAAATAGAATAATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGT GGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACA GAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGA GATTATTAATTGATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCA GGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCC GAGCTCTTTATCCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACAT ATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAA TGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATAC CACTAAATGTTAGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCA CCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCAC TGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGT TTTTCAGGGATAAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTC TTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAA CTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCAAGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATC TTATAAACAAACAATTCAACTCAGAAGTTTATGAGAAGACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATT TTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGTTTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTC TGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCTTGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGG ACCAAATATGATAGTGATGCATGTTGATGTTACAGTCAATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTG TGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTGTGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTAT ATATGACAATCAGTATTGCAATGAAAGAAAAACTAAAAACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTG ACATGATGAACATCACTTATTTCAGCACTTGGATTGTCTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTA TACATTTTAAAAGGCATATAGATAGTGTATGCATATGTATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACAT GTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCTCTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAAC ATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTGTTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGA TGAATACAAACAAAATTTTTGTATAAACTACTATTCCAGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAG TTCCTTTTGCATGAAACAATTATGCAAACTTATAATTATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATG CTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATGTTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCA AGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAGTTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGC TTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGAATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAA ATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGTTGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCA ATGCAACTACTCTACATAGCCAAATGTTTGTAAATCACGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAA GAAATATATTCTAACAGTACGCACTGAATAGTGAAAATAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAA AGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCACCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAA ATTTTTCAGCACTTCATTCAATTAAAATACATGAATTTTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATC TAAACTTTTTCCATTTATCAGAAATGATAAAATCCAGTTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAAT ATAACAATACTAAATATCACACTGCGATGGAGGTCCCAAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAG AGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAATCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGA GTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCACTGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTT TATCTACAATCTCAAATCCTAAGTGTATAATTATGTGCAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGG CATTAAGATGGTGTTTTTGTTCTACATATTTTTCAATAATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGT TGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAACCAATGATATCTCTTGGAATAATCTGTAAAACGTAGTTATAAAATTCTATTTT >In-frame_CDH1_ENST00000422392_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_4920nt GCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTC GGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTT CACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTT TTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTT GGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCA GGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTATGA AGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACT AAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCATGA GATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATT TGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGG TTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGC TGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGTAA TGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAGTG GACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATCTA TGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAG CCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGG GAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAGGT TCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGAT TATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGCAT GGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGG ATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCA ACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGAGT GTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGC CTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGA TGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGGTA TGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTT CATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCA AGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATCTTATAAACAAACAATTCAACTCAGAAGTTTATGAGAA GACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATTTTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGT TTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTCTGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCT TGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGGACCAAATATGATAGTGATGCATGTTGATGTTACAGTC AATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTGTGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTG TGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTATATATGACAATCAGTATTGCAATGAAAGAAAAACTAAA AACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTGACATGATGAACATCACTTATTTCAGCACTTGGATTGT CTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTATACATTTTAAAAGGCATATAGATAGTGTATGCATATG TATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACATGTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCT CTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAACATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTG TTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGATGAATACAAACAAAATTTTTGTATAAACTACTATTCC AGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAGTTCCTTTTGCATGAAACAATTATGCAAACTTATAATT ATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATGCTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATG TTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCAAGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAG TTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGCTTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGA ATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAAATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGT TGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCAATGCAACTACTCTACATAGCCAAATGTTTGTAAATCA CGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAAGAAATATATTCTAACAGTACGCACTGAATAGTGAAAA TAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAAAGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCA CCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAAATTTTTCAGCACTTCATTCAATTAAAATACATGAATT TTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATCTAAACTTTTTCCATTTATCAGAAATGATAAAATCCAG TTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAATATAACAATACTAAATATCACACTGCGATGGAGGTCCC AAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAGAGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAA TCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGAGTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCAC TGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTTTATCTACAATCTCAAATCCTAAGTGTATAATTATGTG CAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGGCATTAAGATGGTGTTTTTGTTCTACATATTTTTCAAT AATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGTTGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAA |
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FusionGenePPI for CDH1_TRHDE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDH1 | CTNND1, CBLL1, HDAC1, HDAC2, CTNNB1, MET, SRC, VCL, ITGAE, CTNNA1, JUP, CSE1L, ACTG1, ACTN1, GNA13, CDH1, CDH3, GNA12, AJAP1, CA9, FYN, FER, YES1, RAB8B, PKP4, EGFR, MYO7A, VEZT, MAGI1, ARPC2, PSEN1, EZR, IQGAP1, MDM2, ADAM9, CREBBP, EP300, USP9X, NKD2, CDC42, NDRG1, PPP1CA, SMAD7, RAD17, ACTN4, HSP90AA1, HSPD1, HSPA8, POLR2E, XRCC5, KRT1, KRT9, LMNA, ACADVL, IGHA1, TGM2, HSPA5, HSPA9, KRT18, KRT8, SET, ANP32B, C1QBP, NIPSNAP1, GBAS, CRYAB, CFTR, GMNN, AP2M1, PIP5K1C, UCHL3, PTEN, CDC27, RNF2, ECT2, KLF4, E2F1, SKP2, DDR1, DDR2, ILK, MYO6, CASP3, FGFR1, GSK3B, NFE2L2, KEAP1, BRCA1, ADCY9, ADD1, ADD3, AIM1, ALDOA, ANK3, ANXA1, ANXA2, ANXA4, ARHGAP1, ARHGAP5, ARHGDIB, ARVCF, ATIC, ATP2B1, ATP2B4, BCL2L2, BMPR2, DST, BSG, CALD1, CAPG, CAPS, CAPZA1, CAST, CAPZB, CBL, SCARB1, SEPT7, CLIC1, CNN2, CNN3, COL17A1, CRK, CRKL, CSNK1A1, CSNK1D, CTNNA2, CTSB, CXADR, DAG1, DBN1, DDX3X, DDX6, DLG1, DSC3, DSG2, DVL3, EEF1A1, EEF1D, EEF1G, EEF2, EIF2S3, EPHA2, EIF4B, EIF4G1, EIF4G2, EIF5, EIF5A, EMD, MARK2, CTTN, ENO1, EPB41, EPB41L1, EPS15, ERBB2, ERBB3, EVPL, FASN, FLNA, FLNB, FTH1, GAB1, GM2A, GOLGA2, GOLGA3, GOLGB1, SFN, GSPT1, HCFC1, HDLBP, HLA-C, HNRNPK, AGFG1, HSPA1A, HSP90AB1, DNAJB1, IDH1, IGBP1, IGF2R, IL6ST, INPPL1, EIF3E, IRAK1, ITGA6, ITGB1, IVL, KCNN4, KIF5B, KTN1, LAD1, LASP1, LBR, LDHA, ABLIM1, LLGL1, LMO7, LPP, MARCKS, MAP4, MARK3, CD99, MLLT4, MRE11A, MYO1B, MYH9, NCK1, SEPT2, NF2, NFKBIE, NHS, NOTCH1, NOTCH2, NOTCH3, PRDX1, PAK2, PCBP1, PCBP2, PCDH1, PCMT1, PFKP, PFN1, PI4KA, PKM, PKP2, PLCB3, PLEC, PLSCR1, PPL, PKN2, PSMB6, TWF1, PTPN1, PTPRJ, PVRL1, PVRL2, PXN, RAB1A, RAN, RANBP1, RANGAP1, RARS, RDX, RPL6, RPL7A, RPL15, RPL23A, RPL24, RPL29, RPL34, RPL36AL, RPL37, RPL36A, RPS2, RPS26, S100A11, S100P, SDCBP, SH3GL1, SHB, SLC1A5, SLC3A2, SLC9A1, SLC12A2, SNAP25, FSCN1, SNX1, SNX2, SPAG1, SPRR3, SPTAN1, SPTBN1, SPTBN2, SSFA2, STAT1, STAT2, STIM1, CDKL5, STX4, SVIL, ADAM17, TJP1, TLN1, TMPO, TP53BP2, TPD52, TPD52L2, TRIP6, TTK, TTN, UBC, UTRN, VASP, EIF4H, YWHAB, YWHAE, YWHAZ, TRIM25, ZNF185, SLC30A1, ZYX, LUZP1, DDX39B, NUP214, PICALM, HIST1H3A, TAGLN2, STK24, NCK2, PPFIBP1, RUVBL1, USO1, NUMB, SNAP23, SCEL, SYNJ1, SYNJ2, H1FX, MPZL1, RPL14, GPRC5A, SYT7, USP8, SLC16A3, PDLIM1, CCNB2, LRRFIP1, VAPB, VAPA, RAB11B, DLG5, NUMBL, PDLIM7, TRIP11, VAMP3, SNAP29, SLC9A3R2, SLC9A3R1, ARHGAP29, TJP2, SLC4A7, BAG3, H2AFY, PRDX6, N4BP1, CLINT1, BZW1, USP6NL, ARHGAP32, SLK, PHACTR2, ZFYVE16, CKAP5, IST1, RB1CC1, GOLGA5, USP15, CCS, ABI1, WASF2, TXNDC9, INADL, FLOT1, PLIN3, PAK4, TUBB4B, GNB2L1, YAP1, PGRMC2, SEC24B, BAIAP2, NOP56, NEBL, SORBS1, AHSA1, PAICS, PDLIM5, YKT6, CCT8, NUDC, GIPC1, SEPT9, FRS2, PPP1R13L, RAB10, EHD1, EBNA1BP2, GCN1L1, CDC42EP1, NUDT5, PKP3, AKAP2, PACSIN2, ATXN2L, LYPLA2, PARK7, STK38, PDAP1, EXOC3, TWF2, PUF60, COBLL1, AAK1, PLEKHA6, ABLIM3, EPN2, MAPRE1, SHANK2, LIMCH1, DAAM1, PDXDC1, SWAP70, ERC1, SIPA1L3, EPB41L3, GGA3, MPRIP, EFR3A, LPHN2, EHBP1, ESYT1, DOCK9, ARHGEF12, LARP1, PPP1R13B, SRGAP2, MACF1, SCRIB, CDC42EP4, CD2AP, ARFIP2, TRIM29, TMEM2, ZDHHC5, KANK2, TMEM87A, CHMP2B, NGDN, TBC1D10B, GORASP2, GIGYF2, RAI14, GAPVD1, SERBP1, TES, RSL1D1, ELP4, COPG2, SND1, SNX5, ARFIP1, ARHGEF16, BZW2, DBNL, STXBP6, TMOD3, OLA1, SH3KBP1, EHD4, MINK1, ASAP1, F11R, GLOD4, SH3GLB1, HN1, PPME1, SNX9, LIMA1, ISYNA1, CHMP5, LSR, WWOX, ANLN, XRN1, PLEKHA5, DHX29, EPB41L4B, CC2D1A, EPS8L1, FNBP1L, SSH3, EPN3, UACA, ARGLU1, TMEM51, STEAP3, ABCF3, LRRC59, LRRC16A, FERMT1, TBC1D22B, NLRP2, DENND4C, SCYL2, PARVA, C1orf106, PAG1, UBAP2, ZC3H15, UNC45A, ERBB2IP, NSFL1C, BAIAP2L1, UBFD1, KIAA1217, PARD3, ZC3HAV1, SH3GLB2, PAK6, CIAPIN1, PLSCR3, CAMK1D, RTN4, CORO1B, TTC7A, NHSL1, SCYL1, NDRG2, ESYT2, MKL2, KIDINS220, MAVS, CASKIN2, CGN, LRRC7, ARHGAP21, KIAA1462, SHROOM3, SH3RF1, ARHGAP23, KIAA1522, KIAA1524, KIAA1598, EPS15L1, PLEKHA1, PLEKHA2, ACBD3, EPS8L2, KLC2, FAM129B, RAPH1, PHACTR4, AHNAK, EFHD2, CLMN, PEAK1, POF1B, VCPIP1, PLEKHO2, SRCIN1, SLC38A1, PVRL4, DIAPH3, CDCA3, FAM110A, TBC1D10A, EIF2A, ELMOD3, ARFGAP2, LZTS2, FAM126A, C1orf198, MICALL1, KIAA1671, TNKS1BP1, TANC1, NAV2, CCDC120, PHLDB2, HN1L, SPECC1, ARHGAP18, SYAP1, GPRIN1, FMNL2, ELFN2, VASN, ZG16B, CANT1, USP43, CCDC43, CHMP4B, SIRPA, MPP7, PLEKHA7, SLC2A14, GCOM1, TMEM199, WIPF2, VSIG10L, PROM2, MB21D2, SH3D19, DAB2IP, MARVELD2, FAM84B, FAM91A1, SPRED1, FAM171B, PPP1R18, TUBB, FAM83B, EHBP1L1, LRRC57, MAGI3, PPP1R37, FAM126B, SH3PXD2B, FAM83H, CCDC85C, FMN1, PALM3, MACC1, SBSN, GOLGA8B, FAM110C, C6orf132, RELL1, OCLN, STX5, C1orf116, ARPIN, KDF1, C1orf35, TENM3, CCSER2, CTNNA3, PCDHGC3 | TRHDE | AKT1, EGFR, MUL1, TSPAN3, DNAJB9, LEMD3, EMILIN2, MANEA, FKBP14, KIRREL, CANX, TMTC3, MESDC2, MAN1A2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDH1_TRHDE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDH1_TRHDE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDH1 | C0038356 | Stomach Neoplasms | 6 | CTD_human |
| Hgene | CDH1 | C1458155 | Mammary Neoplasms | 4 | CTD_human |
| Hgene | CDH1 | C0005695 | Bladder Neoplasm | 2 | CTD_human |
| Hgene | CDH1 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Hgene | CDH1 | C0023904 | Liver Neoplasms, Experimental | 2 | CTD_human |
| Hgene | CDH1 | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
| Hgene | CDH1 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Hgene | CDH1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | CDH1 | C0206692 | Carcinoma, Lobular | 2 | CTD_human |
| Hgene | CDH1 | C1134719 | Invasive Ductal Breast Carcinoma | 2 | CTD_human |
| Hgene | CDH1 | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | ORPHANET;UNIPROT |
| Hgene | CDH1 | C2931456 | Prostate cancer, familial | 2 | CTD_human |
| Hgene | CDH1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | CDH1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | CDH1 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Hgene | CDH1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | CDH1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | CDH1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | CDH1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | CDH1 | C0025500 | Mesothelioma | 1 | CTD_human |
| Hgene | CDH1 | C0026936 | Mycoplasma Infections | 1 | CTD_human |
| Hgene | CDH1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | CDH1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Hgene | CDH1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | CDH1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Hgene | CDH1 | C0079487 | Helicobacter Infections | 1 | CTD_human |
| Hgene | CDH1 | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
| Hgene | CDH1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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