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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 6447

FusionGeneSummary for CDH1_TRHDE

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH1_TRHDE
Fusion gene ID: 6447
HgeneTgene
Gene symbol

CDH1

TRHDE

Gene ID

51343

29953

Gene namefizzy and cell division cycle 20 related 1thyrotropin releasing hormone degrading enzyme
SynonymsCDC20C|CDH1|FZR|FZR2|HCDH|HCDH1PAP-II|PGPEP2|TRH-DE
Cytomap

19p13.3

12q21.1

Type of geneprotein-codingprotein-coding
Descriptionfizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1thyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase
Modification date2018051920180523
UniProtAcc

P12830

Q9UKU6

Ensembl transtripts involved in fusion geneENST00000261769, ENST00000422392, 
ENST00000562836, 
ENST00000261180, 
ENST00000549138, 
Fusion gene scores* DoF score11 X 10 X 4=44014 X 6 X 5=420
# samples 1313
** MAII scorelog2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH1 [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

HgeneCDH1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

HgeneCDH1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-VP-A879-01ACDH1chr16

68835796

+TRHDEchr12

72771775

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261769ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771775

+
5CDS-intronENST00000261769ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771775

+
In-frameENST00000422392ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771775

+
5CDS-intronENST00000422392ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771775

+
3UTR-3CDSENST00000562836ENST00000261180CDH1chr16

68835796

+TRHDEchr12

72771775

+
3UTR-intronENST00000562836ENST00000549138CDH1chr16

68835796

+TRHDEchr12

72771775

+

Top

FusionProtFeatures for CDH1_TRHDE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH1

P12830

TRHDE

Q9UKU6

Cadherins are calcium-dependent cell adhesion proteins(PubMed:11976333). They preferentially interact with themselves ina homophilic manner in connecting cells; cadherins may thuscontribute to the sorting of heterogeneous cell types. CDH1 isinvolved in mechanisms regulating cell-cell adhesions, mobilityand proliferation of epithelial cells (PubMed:11976333). Has apotent invasive suppressor role. It is a ligand for integrinalpha-E/beta-7. {ECO:0000269|PubMed:11976333,ECO:0000269|PubMed:16417575}. E-Cad/CTF2 promotes non-amyloidogenic degradation ofAbeta precursors. Has a strong inhibitory effect on APP C99 andC83 production. {ECO:0000269|PubMed:16417575}. Specific inactivation of TRH after its release.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRHDEchr16:68835796chr12:72771775ENST00000261180+119404_4083511025RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316838_851129883Compositional biasNote=Ser-rich
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316155_262129883DomainCadherin 1
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316263_375129883DomainCadherin 2
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316376_486129883DomainCadherin 3
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316487_593129883DomainCadherin 4
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316594_697129883DomainCadherin 5
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316758_769129883RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316811_882129883RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316155_709129883Topological domainExtracellular
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316731_882129883Topological domainCytoplasmic
HgeneCDH1chr16:68835796chr12:72771775ENST00000261769+316710_730129883TransmembraneHelical
TgeneTRHDEchr16:68835796chr12:72771775ENST00000261180+1191_403511025Topological domainCytoplasmic
TgeneTRHDEchr16:68835796chr12:72771775ENST00000261180+11962_10243511025Topological domainExtracellular
TgeneTRHDEchr16:68835796chr12:72771775ENST00000261180+11941_613511025TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

FusionGeneSequence for CDH1_TRHDE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDH1_ENST00000261769_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_803aa
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHP
YAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDV
LHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV
NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY
LDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY
PLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNV
RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRD

>In-frame_CDH1_ENST00000422392_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_803aa
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHP
YAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDV
LHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV
NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITY
LDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALY
PLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNV
RDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDH1_ENST00000261769_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_2409nt
ATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCT
GGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGC
ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG
TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG
CACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATA
ACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCG
TATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTG
GATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAG
GAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTT
CTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTT
GACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGAT
TATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTA
AATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATA
ATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCA
TTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTAT
TTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATT
GATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTAT
TTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTAT
CCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTT
GGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGC
AGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTT
AGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTT
TCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAG
GTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGAT
AAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAA
GGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCC

>In-frame_CDH1_ENST00000422392_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_2409nt
ATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCT
GGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGC
ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG
TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG
CACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATA
ACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCG
TATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTG
GATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAG
GAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTT
CTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTT
GACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGAT
TATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTA
AATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATA
ATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCA
TTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTAT
TTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATT
GATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTAT
TTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTAT
CCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTT
GGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGC
AGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTT
AGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTT
TCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAG
GTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGAT
AAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAA
GGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDH1_ENST00000261769_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_5047nt
AGCCAATCAGCGGTACGGGGGGCGGTGCCTCCGGGGCTCACCTGGCTGCAGCCACGCACCCCCTCTCAGTGGCGTCGGAACTGCAAAGCA
CCTGTGAGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTC
CCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGC
CCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATT
TTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAA
GGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGA
ATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATG
CTCTCCATATAACAAAGAGATTAATAGAATTTTATGAAGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGC
CTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACTAAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTT
CTTATTTGCTGGATGTCACCATGGTCATTGTTCATGAGATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACG
TGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATTTGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTC
TGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGGTTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTG
ACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGCTGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGG
GTTTGCAAGATTATTTAACCATTCATAAGTATGGTAATGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATG
GGAAATATGTAAATATACAAGAAGTAATGGATCAGTGGACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAG
AAAATAGAATAATAATTACCCAACAGCATTTTATCTATGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGT
GGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAGCCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACA
GAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGGGAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGA
GATTATTAATTGATCAATTAATCCGGAATCATGAGGTTCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCA
GGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGATTATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCC
GAGCTCTTTATCCTCTAGATAAATTACTGGACCGCATGGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACAT
ATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGGATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAA
TGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCAACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATAC
CACTAAATGTTAGAGACATCGTATACTGTACAGGAGTGTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCA
CCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGCCTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCAC
TGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGATGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGT
TTTTCAGGGATAAATGGAAGATATTAAATACCAGGTATGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTC
TTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTTCATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAA
CTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCAAGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATC
TTATAAACAAACAATTCAACTCAGAAGTTTATGAGAAGACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATT
TTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGTTTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTC
TGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCTTGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGG
ACCAAATATGATAGTGATGCATGTTGATGTTACAGTCAATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTG
TGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTGTGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTAT
ATATGACAATCAGTATTGCAATGAAAGAAAAACTAAAAACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTG
ACATGATGAACATCACTTATTTCAGCACTTGGATTGTCTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTA
TACATTTTAAAAGGCATATAGATAGTGTATGCATATGTATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACAT
GTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCTCTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAAC
ATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTGTTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGA
TGAATACAAACAAAATTTTTGTATAAACTACTATTCCAGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAG
TTCCTTTTGCATGAAACAATTATGCAAACTTATAATTATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATG
CTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATGTTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCA
AGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAGTTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGC
TTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGAATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAA
ATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGTTGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCA
ATGCAACTACTCTACATAGCCAAATGTTTGTAAATCACGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAA
GAAATATATTCTAACAGTACGCACTGAATAGTGAAAATAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAA
AGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCACCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAA
ATTTTTCAGCACTTCATTCAATTAAAATACATGAATTTTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATC
TAAACTTTTTCCATTTATCAGAAATGATAAAATCCAGTTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAAT
ATAACAATACTAAATATCACACTGCGATGGAGGTCCCAAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAG
AGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAATCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGA
GTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCACTGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTT
TATCTACAATCTCAAATCCTAAGTGTATAATTATGTGCAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGG
CATTAAGATGGTGTTTTTGTTCTACATATTTTTCAATAATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGT
TGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAACCAATGATATCTCTTGGAATAATCTGTAAAACGTAGTTATAAAATTCTATTTT

>In-frame_CDH1_ENST00000422392_chr16_68835796_+_TRHDE_ENST00000261180_chr12_72771775_+_4920nt
GCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTC
GGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTT
CACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTT
TTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTT
GGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCA
GGTACGATTATATGCAAGACCTGATGCTATCAGAAGAGGATCCGGGGACTATGCTCTCCATATAACAAAGAGATTAATAGAATTTTATGA
AGACTACTTTAAAGTGCCCTATTCCTTGCCAAAACTAGATCTTTTAGCTGTGCCTAAGCATCCGTATGCTGCTATGGAGAACTGGGGACT
AAGTATTTTTGTGGAACAAAGAATACTGCTGGATCCCAGTGTTTCATCTATTTCTTATTTGCTGGATGTCACCATGGTCATTGTTCATGA
GATATGTCACCAGTGGTTTGGTGACCTTGTGACGCCTGTGTGGTGGGAAGACGTGTGGCTGAAGGAAGGGTTTGCTCACTACTTTGAATT
TGTTGGTACAGACTACCTCTATCCTGGCTGGAACATGGAAAAGCAGAGGTTTCTGACCGATGTTCTGCATGAAGTGATGCTGCTGGACGG
TTTGGCCAGTTCCCATCCAGTATCACAGGAAGTGCTGCAGGCAACAGATATTGACAGGGTGTTTGACTGGATCGCATATAAAAAGGGTGC
TGCTTTAATAAGAATGCTGGCTAATTTTATGGGCCATTCAGTTTTCCAGAGGGGTTTGCAAGATTATTTAACCATTCATAAGTATGGTAA
TGCAGCCAGAAATGATCTCTGGAATACATTATCGGAGGCTTTAAAAAGAAATGGGAAATATGTAAATATACAAGAAGTAATGGATCAGTG
GACACTCCAGATGGGTTATCCTGTTATCACCATCTTGGGAAACACAACAGCAGAAAATAGAATAATAATTACCCAACAGCATTTTATCTA
TGATATCAGTGCTAAAACTAAAGCACTTAAACTTCAGAATAACAGTTACCTGTGGCAGATTCCATTAACTATTGTGGTAGGAAATAGAAG
CCATGTGTCTTCAGAAGCAATTATTTGGGTGTCTAACAAATCAGAGCACCACAGAATAACTTATTTGGACAAAGGAAGCTGGCTGCTGGG
GAACATCAATCAAACTGGCTATTTTAGAGTCAACTATGACCTAAGGAACTGGAGATTATTAATTGATCAATTAATCCGGAATCATGAGGT
TCTTTCTGTCAGTAACCGAGCGGGCTTGATCGATGATGCCTTCAGCCTAGCCAGGGCTGGCTATTTGCCTCAGAATATTCCTCTGGAGAT
TATCAGATACCTGTCTGAGGAGAAGGATTTTCTTCCTTGGCATGCTGCCAGCCGAGCTCTTTATCCTCTAGATAAATTACTGGACCGCAT
GGAAAACTACAACATTTTCAATGAATATATTTTAAAGCAAGTTGCAACAACATATATCAAGCTTGGGTGGCCGAAAAATAATTTTAATGG
ATCTCTTGTTCAAGCATCCTACCAACATGAAGAACTACGTAGAGAAGTTATAATGCTGGCCTGCAGTTTTGGCAACAAGCACTGTCACCA
ACAGGCATCAACACTTATTTCAGATTGGATTTCCAGCAACAGGAACAGAATACCACTAAATGTTAGAGACATCGTATACTGTACAGGAGT
GTCACTACTGGATGAGGATGTCTGGGAATTCATATGGATGAAATTCCATTCCACCACAGCAGTTTCTGAGAAGAAAATATTATTGGAAGC
CTTAACTTGCAGTGATGACAGGAATTTATTAAACAGGCTTCTAAATCTGTCACTGAATTCTGAGGTGGTGCTGGATCAAGATGCAATTGA
TGTCATAATCCATGTAGCTCGAAATCCACATGGTCGAGACCTTGCCTGGAAGTTTTTCAGGGATAAATGGAAGATATTAAATACCAGGTA
TGGAGAAGCATTGTTTATGAATTCCAAACTCATCAGTGGTGTCACAGAATTTCTTAATACTGAAGGTGAACTCAAAGAGCTCAAGAACTT
CATGAAAAACTATGATGGGGTAGCTGCTGCTTCTTTCTCACGAGCTGTGGAAACTGTCGAAGCCAATGTGCGCTGGAAAATGCTTTACCA
AGACGAGCTTTTCCAATGGTTAGGAAAAGCTCTAAGACACTAATATATGTATCTTATAAACAAACAATTCAACTCAGAAGTTTATGAGAA
GACACGCTTTTTGTGGAATGAGGAAAATGTACTACCTAGAAAATGGCCAGATTTTCAGTGTTAACGTGTGGGAGGAATTTTTTTTTTAGT
TTTTATTTTTTGGTTTTGGGGGATATTTTTTATTTGTTTCATTCATTCTGTTCTGTTTCTCTACTGGGTGTTCCTCTCTAAAGAAACTCT
TGCAAGTGAAACTAGCCATGATTGCTTCAGCTGTACATTCCTTGCTGTACAGGACCAAATATGATAGTGATGCATGTTGATGTTACAGTC
AATTTGGAAAAACATATTCAGAATATCTGTGCATGGATATATTGTCCTGCCTGTGTTCCAGCATGCTTATTTCAAACGTCCAGTGTTGTG
TGTGAATATGTGTTACACCTAGGATGGGCATTATGCAAAAGCACAAAGATTATATATGACAATCAGTATTGCAATGAAAGAAAAACTAAA
AACAGAAATGATATTCTCAATTTTGGGCAATGTGAGAGGTAAAATAGCCCTTGACATGATGAACATCACTTATTTCAGCACTTGGATTGT
CTGGCAATGATTACTGTGTTGCTAACTCATTTTCTTTGAGTTAAAGCTGTGTATACATTTTAAAAGGCATATAGATAGTGTATGCATATG
TATATGTACATAGGGAAGCCCCATATGTATATAGTATGTTGTACACTGCACATGTACAAAGAATGTCTTCAGATCAAAGAAAATTTATCT
CTTTTTATAAACTTAAGGACAGTTGCAAAAGGCTTCAAGGAATTTATCTCAACATTATTCTTTCTATGTCCTAACTAAATTTCTCAACTG
TTATGAATTTTTCATCTACTTCTTGAACAGTGGTCTATTCTGCTACATGAAGATGAATACAAACAAAATTTTTGTATAAACTACTATTCC
AGTTCTCCTGTGTCAGTCTTGCCTATAGATTTTGCCATCGTTTTCTGTCAAAGTTCCTTTTGCATGAAACAATTATGCAAACTTATAATT
ATTAGTGCTGAAAAAGAGTTTATTTTCCATCTTGTTTGTTTTCCTACCTTATGCTGAGTAGTCCAGAGAGTTAAAAAAATTCTCTGCATG
TTGGTCTTTTAAGTCTGTTTTGCTCTAATCCTCCATTAAGCGAGCATACCTCAAGTGGGTCTATTAGCATTTAATGACCTTTTGTGCCAG
TTGTGCCATCCCTTAAGATGAAAAGTTCCTTTTCTTGTGTTAATGTACAAAGCTTTTCTTTTGGCACTGACAACTGTGTTCTACCTGGGA
ATTTTGAATAGCCATTTTCATGGCTGTGTGTTGTGTAACACAAATGTTTTTAAATGGTATTCTCACCCAGTAGGCCAGCTCTCCAAACGT
TGCTTAGATGCTTCAAAATTAGCATATTTTAAGTTTACCAGTATAAAATACCAATGCAACTACTCTACATAGCCAAATGTTTGTAAATCA
CGTCTTATTTTCCTGAGGTTTTTCACTCCACCAAATCTTACAAATCATTGAAAGAAATATATTCTAACAGTACGCACTGAATAGTGAAAA
TAATTAGACATTTTAAGAACCAGAGCCATAGAATTATTTTAAATTAGTAGAAAAGAGGAGCTATTTCCGAATCTATAGAATAAAGTACCA
CCTAAAACTGAATTTTATCATATAAGCAAGTAATACCTATTAGTCATACCTAAATTTTTCAGCACTTCATTCAATTAAAATACATGAATT
TTAAATATTTTACATGATGTGAATAGGCATGATAATACTTTTAGTATAAAATCTAAACTTTTTCCATTTATCAGAAATGATAAAATCCAG
TTACCACATATCACGTTTATAAAATCCTTAATTAAATGAGTAACTTCTAAAATATAACAATACTAAATATCACACTGCGATGGAGGTCCC
AAATATGTGGTCTATCACCACTGAATTCATGTAATAGATAAGAAAAAAATTAGAGGTGGATGTCTTGTTTTGTGTCATGAATTACTAAAA
TCTCTTAGTAGTTGTGGTATATTTTTGAGTAAAATTACCATTTCCAGATTTGAGTTTGAAGGGCTTTTATAGTTGTATTTTCCTCCTCAC
TGTTAATAATCATAATCCTTTTTCAGTATTTTAGTGGCCTTGAACAACTGGTTTATCTACAATCTCAAATCCTAAGTGTATAATTATGTG
CAATGTTCAATACCTCATATAATACTTGCTCAACAGTATAGTGGTACCAATGGCATTAAGATGGTGTTTTTGTTCTACATATTTTTCAAT
AATTTATTCTTTCTAATGTTGAAATTATATCAGGCTTTACCGGTTTTTTTAGTTGTTTAAATAAGTAATATTTTCAAAAGAATAAAATAA


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FusionGenePPI for CDH1_TRHDE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDH1CTNND1, CBLL1, HDAC1, HDAC2, CTNNB1, MET, SRC, VCL, ITGAE, CTNNA1, JUP, CSE1L, ACTG1, ACTN1, GNA13, CDH1, CDH3, GNA12, AJAP1, CA9, FYN, FER, YES1, RAB8B, PKP4, EGFR, MYO7A, VEZT, MAGI1, ARPC2, PSEN1, EZR, IQGAP1, MDM2, ADAM9, CREBBP, EP300, USP9X, NKD2, CDC42, NDRG1, PPP1CA, SMAD7, RAD17, ACTN4, HSP90AA1, HSPD1, HSPA8, POLR2E, XRCC5, KRT1, KRT9, LMNA, ACADVL, IGHA1, TGM2, HSPA5, HSPA9, KRT18, KRT8, SET, ANP32B, C1QBP, NIPSNAP1, GBAS, CRYAB, CFTR, GMNN, AP2M1, PIP5K1C, UCHL3, PTEN, CDC27, RNF2, ECT2, KLF4, E2F1, SKP2, DDR1, DDR2, ILK, MYO6, CASP3, FGFR1, GSK3B, NFE2L2, KEAP1, BRCA1, ADCY9, ADD1, ADD3, AIM1, ALDOA, ANK3, ANXA1, ANXA2, ANXA4, ARHGAP1, ARHGAP5, ARHGDIB, ARVCF, ATIC, ATP2B1, ATP2B4, BCL2L2, BMPR2, DST, BSG, CALD1, CAPG, CAPS, CAPZA1, CAST, CAPZB, CBL, SCARB1, SEPT7, CLIC1, CNN2, CNN3, COL17A1, CRK, CRKL, CSNK1A1, CSNK1D, CTNNA2, CTSB, CXADR, DAG1, DBN1, DDX3X, DDX6, DLG1, DSC3, DSG2, DVL3, EEF1A1, EEF1D, EEF1G, EEF2, EIF2S3, EPHA2, EIF4B, EIF4G1, EIF4G2, EIF5, EIF5A, EMD, MARK2, CTTN, ENO1, EPB41, EPB41L1, EPS15, ERBB2, ERBB3, EVPL, FASN, FLNA, FLNB, FTH1, GAB1, GM2A, GOLGA2, GOLGA3, GOLGB1, SFN, GSPT1, HCFC1, HDLBP, HLA-C, HNRNPK, AGFG1, HSPA1A, HSP90AB1, DNAJB1, IDH1, IGBP1, IGF2R, IL6ST, INPPL1, EIF3E, IRAK1, ITGA6, ITGB1, IVL, KCNN4, KIF5B, KTN1, LAD1, LASP1, LBR, LDHA, ABLIM1, LLGL1, LMO7, LPP, MARCKS, MAP4, MARK3, CD99, MLLT4, MRE11A, MYO1B, MYH9, NCK1, SEPT2, NF2, NFKBIE, NHS, NOTCH1, NOTCH2, NOTCH3, PRDX1, PAK2, PCBP1, PCBP2, PCDH1, PCMT1, PFKP, PFN1, PI4KA, PKM, PKP2, PLCB3, PLEC, PLSCR1, PPL, PKN2, PSMB6, TWF1, PTPN1, PTPRJ, PVRL1, PVRL2, PXN, RAB1A, RAN, RANBP1, RANGAP1, RARS, RDX, RPL6, RPL7A, RPL15, RPL23A, RPL24, RPL29, RPL34, RPL36AL, RPL37, RPL36A, RPS2, RPS26, S100A11, S100P, SDCBP, SH3GL1, SHB, SLC1A5, SLC3A2, SLC9A1, SLC12A2, SNAP25, FSCN1, SNX1, SNX2, SPAG1, SPRR3, SPTAN1, SPTBN1, SPTBN2, SSFA2, STAT1, STAT2, STIM1, CDKL5, STX4, SVIL, ADAM17, TJP1, TLN1, TMPO, TP53BP2, TPD52, TPD52L2, TRIP6, TTK, TTN, UBC, UTRN, VASP, EIF4H, YWHAB, YWHAE, YWHAZ, TRIM25, ZNF185, SLC30A1, ZYX, LUZP1, DDX39B, NUP214, PICALM, HIST1H3A, TAGLN2, STK24, NCK2, PPFIBP1, RUVBL1, USO1, NUMB, SNAP23, SCEL, SYNJ1, SYNJ2, H1FX, MPZL1, RPL14, GPRC5A, SYT7, USP8, SLC16A3, PDLIM1, CCNB2, LRRFIP1, VAPB, VAPA, RAB11B, DLG5, NUMBL, PDLIM7, TRIP11, VAMP3, SNAP29, SLC9A3R2, SLC9A3R1, ARHGAP29, TJP2, SLC4A7, BAG3, H2AFY, PRDX6, N4BP1, CLINT1, BZW1, USP6NL, ARHGAP32, SLK, PHACTR2, ZFYVE16, CKAP5, IST1, RB1CC1, GOLGA5, USP15, CCS, ABI1, WASF2, TXNDC9, INADL, FLOT1, PLIN3, PAK4, TUBB4B, GNB2L1, YAP1, PGRMC2, SEC24B, BAIAP2, NOP56, NEBL, SORBS1, AHSA1, PAICS, PDLIM5, YKT6, CCT8, NUDC, GIPC1, SEPT9, FRS2, PPP1R13L, RAB10, EHD1, EBNA1BP2, GCN1L1, CDC42EP1, NUDT5, PKP3, AKAP2, PACSIN2, ATXN2L, LYPLA2, PARK7, STK38, PDAP1, EXOC3, TWF2, PUF60, COBLL1, AAK1, PLEKHA6, ABLIM3, EPN2, MAPRE1, SHANK2, LIMCH1, DAAM1, PDXDC1, SWAP70, ERC1, SIPA1L3, EPB41L3, GGA3, MPRIP, EFR3A, LPHN2, EHBP1, ESYT1, DOCK9, ARHGEF12, LARP1, PPP1R13B, SRGAP2, MACF1, SCRIB, CDC42EP4, CD2AP, ARFIP2, TRIM29, TMEM2, ZDHHC5, KANK2, TMEM87A, CHMP2B, NGDN, TBC1D10B, GORASP2, GIGYF2, RAI14, GAPVD1, SERBP1, TES, RSL1D1, ELP4, COPG2, SND1, SNX5, ARFIP1, ARHGEF16, BZW2, DBNL, STXBP6, TMOD3, OLA1, SH3KBP1, EHD4, MINK1, ASAP1, F11R, GLOD4, SH3GLB1, HN1, PPME1, SNX9, LIMA1, ISYNA1, CHMP5, LSR, WWOX, ANLN, XRN1, PLEKHA5, DHX29, EPB41L4B, CC2D1A, EPS8L1, FNBP1L, SSH3, EPN3, UACA, ARGLU1, TMEM51, STEAP3, ABCF3, LRRC59, LRRC16A, FERMT1, TBC1D22B, NLRP2, DENND4C, SCYL2, PARVA, C1orf106, PAG1, UBAP2, ZC3H15, UNC45A, ERBB2IP, NSFL1C, BAIAP2L1, UBFD1, KIAA1217, PARD3, ZC3HAV1, SH3GLB2, PAK6, CIAPIN1, PLSCR3, CAMK1D, RTN4, CORO1B, TTC7A, NHSL1, SCYL1, NDRG2, ESYT2, MKL2, KIDINS220, MAVS, CASKIN2, CGN, LRRC7, ARHGAP21, KIAA1462, SHROOM3, SH3RF1, ARHGAP23, KIAA1522, KIAA1524, KIAA1598, EPS15L1, PLEKHA1, PLEKHA2, ACBD3, EPS8L2, KLC2, FAM129B, RAPH1, PHACTR4, AHNAK, EFHD2, CLMN, PEAK1, POF1B, VCPIP1, PLEKHO2, SRCIN1, SLC38A1, PVRL4, DIAPH3, CDCA3, FAM110A, TBC1D10A, EIF2A, ELMOD3, ARFGAP2, LZTS2, FAM126A, C1orf198, MICALL1, KIAA1671, TNKS1BP1, TANC1, NAV2, CCDC120, PHLDB2, HN1L, SPECC1, ARHGAP18, SYAP1, GPRIN1, FMNL2, ELFN2, VASN, ZG16B, CANT1, USP43, CCDC43, CHMP4B, SIRPA, MPP7, PLEKHA7, SLC2A14, GCOM1, TMEM199, WIPF2, VSIG10L, PROM2, MB21D2, SH3D19, DAB2IP, MARVELD2, FAM84B, FAM91A1, SPRED1, FAM171B, PPP1R18, TUBB, FAM83B, EHBP1L1, LRRC57, MAGI3, PPP1R37, FAM126B, SH3PXD2B, FAM83H, CCDC85C, FMN1, PALM3, MACC1, SBSN, GOLGA8B, FAM110C, C6orf132, RELL1, OCLN, STX5, C1orf116, ARPIN, KDF1, C1orf35, TENM3, CCSER2, CTNNA3, PCDHGC3TRHDEAKT1, EGFR, MUL1, TSPAN3, DNAJB9, LEMD3, EMILIN2, MANEA, FKBP14, KIRREL, CANX, TMTC3, MESDC2, MAN1A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDH1_TRHDE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDH1_TRHDE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH1C0038356Stomach Neoplasms6CTD_human
HgeneCDH1C1458155Mammary Neoplasms4CTD_human
HgeneCDH1C0005695Bladder Neoplasm2CTD_human
HgeneCDH1C0009404Colorectal Neoplasms2CTD_human
HgeneCDH1C0023904Liver Neoplasms, Experimental2CTD_human
HgeneCDH1C0027626Neoplasm Invasiveness2CTD_human
HgeneCDH1C0027627Neoplasm Metastasis2CTD_human
HgeneCDH1C0033578Prostatic Neoplasms2CTD_human
HgeneCDH1C0206692Carcinoma, Lobular2CTD_human
HgeneCDH1C1134719Invasive Ductal Breast Carcinoma2CTD_human
HgeneCDH1C1708349Hereditary Diffuse Gastric Cancer2ORPHANET;UNIPROT
HgeneCDH1C2931456Prostate cancer, familial2CTD_human
HgeneCDH1C0007137Squamous cell carcinoma1CTD_human
HgeneCDH1C0007621Neoplastic Cell Transformation1CTD_human
HgeneCDH1C0009324Ulcerative Colitis1CTD_human
HgeneCDH1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCDH1C0014170Endometrial Neoplasms1CTD_human
HgeneCDH1C0024667Animal Mammary Neoplasms1CTD_human
HgeneCDH1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDH1C0025500Mesothelioma1CTD_human
HgeneCDH1C0026936Mycoplasma Infections1CTD_human
HgeneCDH1C0027746Nerve Degeneration1CTD_human
HgeneCDH1C0030297Pancreatic Neoplasm1CTD_human
HgeneCDH1C0032927Precancerous Conditions1CTD_human
HgeneCDH1C0036095Salivary Gland Neoplasms1CTD_human
HgeneCDH1C0079487Helicobacter Infections1CTD_human
HgeneCDH1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneCDH1C0919267ovarian neoplasm1CTD_human