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Fusion gene ID: 6430 |
FusionGeneSummary for CDH13_WFDC1 |
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Fusion gene information | Fusion gene name: CDH13_WFDC1 | Fusion gene ID: 6430 | Hgene | Tgene | Gene symbol | CDH13 | WFDC1 | Gene ID | 1012 | 58189 |
Gene name | cadherin 13 | WAP four-disulfide core domain 1 | |
Synonyms | CDHH|P105 | PS20 | |
Cytomap | 16q23.3 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherin | WAP four-disulfide core domain protein 1WAP four-disulfide core domain 1 homologprostate stromal protein ps20ps20 growth inhibitor | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P55290 | Q9HC57 | |
Ensembl transtripts involved in fusion gene | ENST00000566620, ENST00000268613, ENST00000565636, ENST00000431540, ENST00000428848, ENST00000567445, ENST00000446376, ENST00000569454, | ENST00000219454, ENST00000568638, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: CDH13 [Title/Abstract] AND WFDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDH13 | GO:0002040 | sprouting angiogenesis | 16873731 |
Hgene | CDH13 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 10601632 |
Hgene | CDH13 | GO:0007162 | negative regulation of cell adhesion | 14729458 |
Hgene | CDH13 | GO:0008285 | negative regulation of cell proliferation | 10737605 |
Hgene | CDH13 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 10601632 |
Hgene | CDH13 | GO:0030032 | lamellipodium assembly | 15703273 |
Hgene | CDH13 | GO:0030335 | positive regulation of cell migration | 14729458 |
Hgene | CDH13 | GO:0043542 | endothelial cell migration | 14729458 |
Hgene | CDH13 | GO:0043616 | keratinocyte proliferation | 15816843 |
Hgene | CDH13 | GO:0050850 | positive regulation of calcium-mediated signaling | 16013438 |
Hgene | CDH13 | GO:0050927 | positive regulation of positive chemotaxis | 16013438 |
Hgene | CDH13 | GO:0055096 | low-density lipoprotein particle mediated signaling | 16013438 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-JY-A6FA-01A | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000566620 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000566620 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000268613 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000268613 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000565636 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000565636 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000431540 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000431540 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000428848 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000428848 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000567445 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000567445 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000446376 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000446376 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
In-frame | ENST00000569454 | ENST00000219454 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
In-frame | ENST00000569454 | ENST00000568638 | CDH13 | chr16 | 83520260 | + | WFDC1 | chr16 | 84358025 | + |
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FusionProtFeatures for CDH13_WFDC1 |
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Hgene | Tgene |
CDH13 | WFDC1 |
Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May act as a negativeregulator of neural cell growth. {ECO:0000269|PubMed:10737605}. | Has growth inhibitory activity. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDH13_WFDC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000219454_chr16_84358025_+_326aa SRAANQSLXSTQDNQQESWWNSRQCDLQXLXGKRQATLXGLEPILQGEQRWRLSCSEKHNCSGQNSVRPCTDPPCGRYGRTRDCRGERHP GLLAGYIXICKNFSCPKTKEVHCGISHFNSRESETAFPKRCWQGSRXXQARKVQVPAHWKGSGSRAXRNFQNQXEHRERLRDTDLGQRSN RCLSTICGDHXCQWQNSRGAGASGSHCDXSEXQPTDLSGRPLHRPRHGRVTHRHHSDADDSLXCRXPSHRXCPPAVXYPSADAXQAISQH >In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000568638_chr16_84358025_+_326aa SRAANQSLXSTQDNQQESWWNSRQCDLQXLXGKRQATLXGLEPILQGEQRWRLSCSEKHNCSGQNSVRPCTDPPCGRYGRTRDCRGERHP GLLAGYIXICKNFSCPKTKEVHCGISHFNSRESETAFPKRCWQGSRXXQARKVQVPAHWKGSGSRAXRNFQNQXEHRERLRDTDLGQRSN RCLSTICGDHXCQWQNSRGAGASGSHCDXSEXQPTDLSGRPLHRPRHGRVTHRHHSDADDSLXCRXPSHRXCPPAVXYPSADAXQAISQH |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000219454_chr16_84358025_+_978nt AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA >In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000568638_chr16_84358025_+_978nt AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000219454_chr16_84358025_+_1516nt AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG CAGCTAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGC TCAGCAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGG AGCCACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCC ACCCATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGA GGTATGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGT >In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000568638_chr16_84358025_+_1508nt AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG CAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGCTCAG CAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGGAGCC ACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCCACCC ATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGAGGTA TGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGTAGCC |
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FusionGenePPI for CDH13_WFDC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDH13 | MAPK6, HAX1, NUFIP1, DGUOK, DNAAF2, AURKA, CASP8, CCND1, CHEK2, HMMR, PTPN1, RAD51, SEC14L1, AGPAT5, INSIG1, DSTYK, RRAGB, ERMP1, VMP1, UQCC1, TUBB3, CHPT1, TUBB8, GHITM, ARF5, PIGU, TMX4, RPL23, MTNR1B | WFDC1 | EZR, XRCC2, FOSL1, RAB40B, ZNF677, MOV10, NXF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDH13_WFDC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDH13_WFDC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDH13 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Hgene | CDH13 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | CDH13 | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | CDH13 | C0004763 | Barrett Esophagus | 1 | CTD_human |
Hgene | CDH13 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CDH13 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | CDH13 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | CDH13 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | CDH13 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | CDH13 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | CDH13 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | WFDC1 | C0025202 | melanoma | 1 | CTD_human |