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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6430

FusionGeneSummary for CDH13_WFDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH13_WFDC1
Fusion gene ID: 6430
HgeneTgene
Gene symbol

CDH13

WFDC1

Gene ID

1012

58189

Gene namecadherin 13WAP four-disulfide core domain 1
SynonymsCDHH|P105PS20
Cytomap

16q23.3

16q24.1

Type of geneprotein-codingprotein-coding
Descriptioncadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherinWAP four-disulfide core domain protein 1WAP four-disulfide core domain 1 homologprostate stromal protein ps20ps20 growth inhibitor
Modification date2018052320180523
UniProtAcc

P55290

Q9HC57

Ensembl transtripts involved in fusion geneENST00000566620, ENST00000268613, 
ENST00000565636, ENST00000431540, 
ENST00000428848, ENST00000567445, 
ENST00000446376, ENST00000569454, 
ENST00000219454, ENST00000568638, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 1 X 2=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: CDH13 [Title/Abstract] AND WFDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH13

GO:0002040

sprouting angiogenesis

16873731

HgeneCDH13

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

10601632

HgeneCDH13

GO:0007162

negative regulation of cell adhesion

14729458

HgeneCDH13

GO:0008285

negative regulation of cell proliferation

10737605

HgeneCDH13

GO:0016339

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

10601632

HgeneCDH13

GO:0030032

lamellipodium assembly

15703273

HgeneCDH13

GO:0030335

positive regulation of cell migration

14729458

HgeneCDH13

GO:0043542

endothelial cell migration

14729458

HgeneCDH13

GO:0043616

keratinocyte proliferation

15816843

HgeneCDH13

GO:0050850

positive regulation of calcium-mediated signaling

16013438

HgeneCDH13

GO:0050927

positive regulation of positive chemotaxis

16013438

HgeneCDH13

GO:0055096

low-density lipoprotein particle mediated signaling

16013438


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-JY-A6FA-01ACDH13chr16

83520260

+WFDC1chr16

84358025

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000566620ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shitENST00000566620ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shitENST00000268613ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shitENST00000268613ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000565636ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000565636ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000431540ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000431540ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shitENST00000428848ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shitENST00000428848ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000567445ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000567445ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000446376ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000446376ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
In-frameENST00000569454ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
In-frameENST00000569454ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+

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FusionProtFeatures for CDH13_WFDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH13

P55290

WFDC1

Q9HC57

Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. May act as a negativeregulator of neural cell growth. {ECO:0000269|PubMed:10737605}. Has growth inhibitory activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDH13_WFDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000219454_chr16_84358025_+_326aa
SRAANQSL_STQDNQQESWWNSRQCDLQ_L_GKRQATL_GLEPILQGEQRWRLSCSEKHNCSGQNSVRPCTDPPCGRTGRTRDCRGERHP
GLLAGTI_ICKNFSCPKTKEVHCGISHFNSRESETAFPKRCWQGSR__QARKVQVPAHWKGSGSRA_RNFQNQ_EHRERLRDTDLGQRSN
RCLSTICGDH_CQWQNSRGAGASGSHCD_SE_QPTDLSGRPLHRPRHGRVTHRHHSDADDSL_CR_PSHR_CPPAV_TPSADA_QAISQH

>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000568638_chr16_84358025_+_326aa
SRAANQSL_STQDNQQESWWNSRQCDLQ_L_GKRQATL_GLEPILQGEQRWRLSCSEKHNCSGQNSVRPCTDPPCGRTGRTRDCRGERHP
GLLAGTI_ICKNFSCPKTKEVHCGISHFNSRESETAFPKRCWQGSR__QARKVQVPAHWKGSGSRA_RNFQNQ_EHRERLRDTDLGQRSN
RCLSTICGDH_CQWQNSRGAGASGSHCD_SE_QPTDLSGRPLHRPRHGRVTHRHHSDADDSL_CR_PSHR_CPPAV_TPSADA_QAISQH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000219454_chr16_84358025_+_978nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA

>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000568638_chr16_84358025_+_978nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000219454_chr16_84358025_+_1516nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA
CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG
CAGCTAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGC
TCAGCAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGG
AGCCACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCC
ACCCATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGA
GGTATGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGT

>In-frame_CDH13_ENST00000569454_chr16_83520260_+_WFDC1_ENST00000568638_chr16_84358025_+_1508nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA
CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG
CAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGCTCAG
CAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGGAGCC
ACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCCACCC
ATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGAGGTA
TGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGTAGCC


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FusionGenePPI for CDH13_WFDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDH13MAPK6, HAX1, NUFIP1, DGUOK, DNAAF2, AURKA, CASP8, CCND1, CHEK2, HMMR, PTPN1, RAD51, SEC14L1, AGPAT5, INSIG1, DSTYK, RRAGB, ERMP1, VMP1, UQCC1, TUBB3, CHPT1, TUBB8, GHITM, ARF5, PIGU, TMX4, RPL23, MTNR1BWFDC1EZR, XRCC2, FOSL1, RAB40B, ZNF677, MOV10, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDH13_WFDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDH13_WFDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH13C0001973Alcoholic Intoxication, Chronic3PSYGENET
HgeneCDH13C0033578Prostatic Neoplasms2CTD_human
HgeneCDH13C2239176Liver carcinoma2CTD_human
HgeneCDH13C0004763Barrett Esophagus1CTD_human
HgeneCDH13C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCDH13C0011570Mental Depression1PSYGENET
HgeneCDH13C0011581Depressive disorder1PSYGENET
HgeneCDH13C0014859Esophageal Neoplasms1CTD_human
HgeneCDH13C0024121Lung Neoplasms1CTD_human
HgeneCDH13C0236733Amphetamine-Related Disorders1CTD_human
HgeneCDH13C0236969Substance-Related Disorders1CTD_human
TgeneWFDC1C0025202melanoma1CTD_human