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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 6407

FusionGeneSummary for CDC73_SWT1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC73_SWT1
Fusion gene ID: 6407
HgeneTgene
Gene symbol

CDC73

SWT1

Gene ID

79577

54823

Gene namecell division cycle 73SWT1, RNA endoribonuclease homolog
SynonymsC1orf28|FIHP|HPTJT|HRPT1|HRPT2|HYXC1orf26|HsSwt1
Cytomap

1q31.2

1q25.3

Type of geneprotein-codingprotein-coding
DescriptionparafibrominPaf1/RNA polymerase II complex componentcell division cycle 73 Paf1/RNA polymerase II complex component-like proteincell division cycle 73, Paf1/RNA polymerase II complex component, homologcell division cycle protein 73 homologhyperparathtranscriptional protein SWT1
Modification date2018052320180523
UniProtAcc

Q6P1J9

Q5T5J6

Ensembl transtripts involved in fusion geneENST00000367435, ENST00000477868, 
ENST00000367501, ENST00000367500, 
Fusion gene scores* DoF score5 X 4 X 5=1001 X 1 X 1=1
# samples 51
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CDC73 [Title/Abstract] AND SWT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC73

GO:0008285

negative regulation of cell proliferation

16989776

HgeneCDC73

GO:0010390

histone monoubiquitination

16307923

HgeneCDC73

GO:0030177

positive regulation of Wnt signaling pathway

16630820

HgeneCDC73

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

20178742

HgeneCDC73

GO:0033523

histone H2B ubiquitination

16307923

HgeneCDC73

GO:0045638

negative regulation of myeloid cell differentiation

20541477

HgeneCDC73

GO:0045944

positive regulation of transcription by RNA polymerase II

20178742

HgeneCDC73

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

16989776


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A23R-01ACDC73chr1

193205486

+SWT1chr1

185153375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367435ENST00000367501CDC73chr1

193205486

+SWT1chr1

185153375

+
In-frameENST00000367435ENST00000367500CDC73chr1

193205486

+SWT1chr1

185153375

+
intron-3CDSENST00000477868ENST00000367501CDC73chr1

193205486

+SWT1chr1

185153375

+
intron-3CDSENST00000477868ENST00000367500CDC73chr1

193205486

+SWT1chr1

185153375

+

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FusionProtFeatures for CDC73_SWT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC73

Q6P1J9

SWT1

Q5T5J6

Tumor suppressor probably involved in transcriptionaland post-transcriptional control pathways. May be involved in cellcycle progression through the regulation of cyclin D1/PRAD1expression. Component of the PAF1 complex (PAF1C) which hasmultiple functions during transcription by RNA polymerase II andis implicated in regulation of development and maintenance ofembryonic stem cell pluripotency. PAF1C associates with RNApolymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms andis involved in transcriptional elongation, acting bothindepentently and synergistically with TCEA1 and in cooperationwith the DSIF complex and HTATSF1. PAF1C is required fortranscription of Hox and Wnt target genes. PAF1C is involved inhematopoiesis and stimulates transcriptional activity ofKMT2A/MLL1; it promotes leukemogenesis through association withKMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histonemodifications such as ubiquitination of histone H2B andmethylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits theRNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzymeUBE2A or UBE2B to chromatin which mediate monoubiquitination of'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2Bubiquitination is proposed to be coupled to transcription. PAF1Cis involved in mRNA 3' end formation probably through associationwith cleavage and poly(A) factors. In case of infection byinfluenza A strain H3N2, PAF1C associates with viral NS1 protein,thereby regulating gene transcription. Connects PAF1C with thecleavage and polyadenylation specificity factor (CPSF) complex andthe cleavage stimulation factor (CSTF) complex, and with Wntsignaling. Involved in polyadenylation of mRNA precursors.{ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063,ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820,ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632,ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742,ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC73chr1:193205486chr1:185153375ENST00000367435+1517361_364472532Compositional biasNote=Poly-Ile
HgeneCDC73chr1:193205486chr1:185153375ENST00000367435+1517125_139472532MotifNote=Nuclear localization signal
TgeneSWT1chr1:193205486chr1:185153375ENST00000367500+619388_515379901DomainNote=PINc
TgeneSWT1chr1:193205486chr1:185153375ENST00000367501+619388_515379901DomainNote=PINc

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSWT1chr1:193205486chr1:185153375ENST00000367500+61938_44379901Compositional biasNote=Poly-Ser
TgeneSWT1chr1:193205486chr1:185153375ENST00000367501+61938_44379901Compositional biasNote=Poly-Ser


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FusionGeneSequence for CDC73_SWT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDC73_ENST00000367435_chr1_193205486_+_SWT1_ENST00000367501_chr1_185153375_+_994aa
MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPD
RKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVE
KIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPA
PNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTP
IIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGP
AWQFKGWPWLLPDGSPVDIFAKTNNTSDRKLLIVIDTNILMNHLKFVRILKTTEVPGFDKLVLIIPWVVMQELDRMKEGKLLKRAQHKAI
PAVHFINDSLKNQDRKLWGQSIQLASQKHYGLSDENNDDRVLKCCLQHQELFPCSFVILCTDDRNLRNKGLISGVKSLSKEELSAELLHL
SLNTDVCHQPCIPKQQLKAETTPLKESYKEESTNSGLSILLESIVSDLEKSLGTGLSSILETEMKIAFGNLWMEILYLKPPWTLLHLLQC
FKKHWLAVFGLVMEKNLLLTIESLYKNLRKANKAVDFTTVKFLLQDSRSLLHAFSTRSNYDGILPQTFAQVNNLLQTFAEVKTKLKPNSS
ENTVTKKQEGTSLKNSHNQEITVFSSSHLPQPSRHQEIWSILESVWITIYQNSTDVFQRLGSNSALTTSNIASFEEAFICLQKLMAAVRD
ILEGIQRILAPNSNYQDVETLYNFLIKYEVNKNVKFTAQEIYDCVSQTEYREKLTIGCRQLVEMEYTMQQCNASVYMEAKNRGWCEDMLN

>In-frame_CDC73_ENST00000367435_chr1_193205486_+_SWT1_ENST00000367500_chr1_185153375_+_994aa
MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPD
RKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVE
KIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPA
PNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQPVPRPVSQARPPPNQKKGSRTP
IIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGP
AWQFKGWPWLLPDGSPVDIFAKTNNTSDRKLLIVIDTNILMNHLKFVRILKTTEVPGFDKLVLIIPWVVMQELDRMKEGKLLKRAQHKAI
PAVHFINDSLKNQDRKLWGQSIQLASQKHYGLSDENNDDRVLKCCLQHQELFPCSFVILCTDDRNLRNKGLISGVKSLSKEELSAELLHL
SLNTDVCHQPCIPKQQLKAETTPLKESYKEESTNSGLSILLESIVSDLEKSLGTGLSSILETEMKIAFGNLWMEILYLKPPWTLLHLLQC
FKKHWLAVFGLVMEKNLLLTIESLYKNLRKANKAVDFTTVKFLLQDSRSLLHAFSTRSNYDGILPQTFAQVNNLLQTFAEVKTKLKPNSS
ENTVTKKQEGTSLKNSHNQEITVFSSSHLPQPSRHQEIWSILESVWITIYQNSTDVFQRLGSNSALTTSNIASFEEAFICLQKLMAAVRD
ILEGIQRILAPNSNYQDVETLYNFLIKYEVNKNVKFTAQEIYDCVSQTEYREKLTIGCRQLVEMEYTMQQCNASVYMEAKNRGWCEDMLN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDC73_ENST00000367435_chr1_193205486_+_SWT1_ENST00000367501_chr1_185153375_+_2982nt
ATGGCGGACGTGCTTAGCGTCCTGCGACAGTACAACATCCAGAAGAAGGAGATTGTGGTGAAGGGAGACGAAGTGATCTTCGGGGAGTTC
TCCTGGCCCAAGAATGTGAAGACCAACTATGTTGTTTGGGGGACTGGAAAGGAAGGCCAACCCAGAGAGTACTACACATTGGATTCCATT
TTATTTCTACTTAATAACGTGCACCTTTCTCATCCTGTTTATGTCCGACGTGCAGCTACTGAAAATATTCCTGTGGTTAGAAGACCTGAT
CGAAAAGATCTACTTGGATATCTCAATGGTGAAGCGTCAACATCGGCAAGTATAGACAGAAGCGCTCCCTTAGAAATAGGTCTTCAGCGA
TCTACTCAAGTCAAACGAGCTGCAGATGAAGTTTTAGCAGAAGCAAAGAAACCACGAATTGAGGATGAAGAGTGTGTGCGCCTTGATAAA
GAGAGATTGGCTGCCCGTTTGGAGGGTCACAAAGAAGGGATTGTACAGACTGAACAGATTAGGTCTTTGTCTGAAGCTATGTCAGTGGAA
AAAATTGCTGCAATCAAAGCCAAAATTATGGCTAAGAAAAGATCTACTATCAAGACTGATCTAGATGATGACATAACTGCCCTTAAACAG
AGGAGTTTTGTGGATGCTGAGGTAGATGTGACCCGAGATATTGTCAGCAGAGAGAGAGTATGGAGGACACGAACAACTATCTTACAAAGC
ACAGGAAAGAATTTTTCCAAGAACATTTTTGCAATTCTTCAATCTGTAAAAGCCAGAGAAGAAGGGCGTGCACCTGAACAGCGACCTGCC
CCAAATGCAGCACCTGTGGATCCCACTTTGCGCACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGA
AAAGAAGAAACGGAAGGCTTCAAAATTGACACTATGGGAACCTACCATGGTATGACACTGAAATCTGTAACGGAGGGTGCATCTGCCCGG
AAGACTCAGACTCCTGCAGCCCAGCCAGTACCAAGACCAGTTTCTCAAGCAAGACCTCCCCCAAATCAGAAGAAAGGATCTCGAACACCC
ATTATCATAATTCCTGCAGCTACCACCTCTTTAATAACCATGCTTAATGCAAAAGACCTTCTACAGGACCTGAAATTTGTCCCATCAGAT
GAAAAGAAGAAACAAGGTTGTCAACGAGAAAATGAAACTCTAATACAAAGAAGAAAAGACCAGATGCAACCAGGGGGCACTGCAATTAGT
GTTACAGTACCTTATAGAGTAGTAGACCAGCCCCTTAAACTTATGCCTCAAGACTGGGACCGCGTTGTAGCCGTTTTTGTGCAGGGTCCT
GCATGGCAGTTCAAAGGTTGGCCATGGCTTTTGCCTGATGGATCACCAGTTGATATATTTGCTAAAACAAATAATACTTCAGACAGAAAG
CTTCTAATTGTTATTGACACAAATATTCTGATGAATCATCTCAAATTTGTTAGAATTTTGAAGACAACAGAAGTACCAGGTTTTGACAAA
CTTGTGTTAATAATTCCCTGGGTCGTTATGCAAGAGCTAGATCGTATGAAGGAAGGAAAACTACTAAAACGTGCCCAGCACAAAGCTATA
CCTGCAGTTCATTTCATCAACGACAGTCTCAAAAATCAAGATAGAAAGCTATGGGGTCAGTCAATACAACTTGCATCCCAAAAACATTAT
GGATTGAGTGATGAGAACAATGATGATCGAGTACTAAAATGCTGTCTCCAGCACCAGGAATTATTCCCTTGTTCTTTTGTTATTCTGTGC
ACGGATGATAGAAACTTAAGAAACAAAGGCCTAATAAGTGGTGTGAAGTCACTCAGTAAAGAAGAATTGAGTGCAGAGTTATTACACTTA
TCTCTGAACACAGATGTGTGTCATCAGCCTTGTATTCCTAAGCAACAGTTGAAAGCAGAAACAACACCCTTGAAAGAGAGCTATAAGGAG
GAATCTACAAATTCTGGACTGTCCATTCTGCTTGAGAGCATTGTATCTGATCTTGAAAAATCTCTTGGAACAGGTTTATCTTCAATATTA
GAAACAGAAATGAAAATTGCTTTTGGAAACCTTTGGATGGAGATCCTGTACCTGAAACCACCATGGACTCTACTACATTTACTACAGTGC
TTTAAAAAACATTGGTTGGCTGTATTTGGATTAGTTATGGAAAAGAACTTGCTTTTAACTATTGAGAGCCTATACAAAAATCTCCGTAAA
GCTAATAAGGCAGTGGATTTTACAACAGTCAAATTCTTGCTTCAGGATTCTAGAAGTTTGTTACATGCTTTCAGTACAAGGTCAAATTAT
GATGGTATTCTTCCACAGACCTTTGCTCAAGTAAACAACCTCCTTCAGACATTTGCAGAGGTCAAGACAAAACTTAAGCCAAATTCTTCA
GAAAACACAGTGACTAAAAAGCAGGAAGGTACTTCATTGAAGAATTCTCATAATCAAGAAATCACTGTTTTCTCGAGTTCTCATCTTCCC
CAACCCAGCAGGCATCAAGAAATCTGGTCTATCCTAGAGAGTGTTTGGATTACAATATATCAGAACAGCACGGATGTATTTCAAAGATTG
GGCTCAAATTCAGCTCTGACTACTTCAAATATAGCATCATTTGAAGAAGCATTTATATGTCTTCAAAAGTTAATGGCAGCTGTGAGGGAT
ATTCTTGAAGGAATTCAAAGGATTTTGGCCCCAAACAGTAATTATCAAGATGTTGAGACCCTCTATAACTTCCTAATCAAGTATGAGGTA
AATAAAAATGTCAAATTTACTGCCCAGGAAATTTATGATTGTGTTTCTCAGACTGAGTATAGGGAAAAGTTAACCATTGGATGCCGCCAG
CTGGTTGAGATGGAATATACCATGCAGCAGTGCAATGCATCTGTTTATATGGAGGCCAAAAACAGGGGATGGTGTGAAGACATGCTCAAC

>In-frame_CDC73_ENST00000367435_chr1_193205486_+_SWT1_ENST00000367500_chr1_185153375_+_2982nt
ATGGCGGACGTGCTTAGCGTCCTGCGACAGTACAACATCCAGAAGAAGGAGATTGTGGTGAAGGGAGACGAAGTGATCTTCGGGGAGTTC
TCCTGGCCCAAGAATGTGAAGACCAACTATGTTGTTTGGGGGACTGGAAAGGAAGGCCAACCCAGAGAGTACTACACATTGGATTCCATT
TTATTTCTACTTAATAACGTGCACCTTTCTCATCCTGTTTATGTCCGACGTGCAGCTACTGAAAATATTCCTGTGGTTAGAAGACCTGAT
CGAAAAGATCTACTTGGATATCTCAATGGTGAAGCGTCAACATCGGCAAGTATAGACAGAAGCGCTCCCTTAGAAATAGGTCTTCAGCGA
TCTACTCAAGTCAAACGAGCTGCAGATGAAGTTTTAGCAGAAGCAAAGAAACCACGAATTGAGGATGAAGAGTGTGTGCGCCTTGATAAA
GAGAGATTGGCTGCCCGTTTGGAGGGTCACAAAGAAGGGATTGTACAGACTGAACAGATTAGGTCTTTGTCTGAAGCTATGTCAGTGGAA
AAAATTGCTGCAATCAAAGCCAAAATTATGGCTAAGAAAAGATCTACTATCAAGACTGATCTAGATGATGACATAACTGCCCTTAAACAG
AGGAGTTTTGTGGATGCTGAGGTAGATGTGACCCGAGATATTGTCAGCAGAGAGAGAGTATGGAGGACACGAACAACTATCTTACAAAGC
ACAGGAAAGAATTTTTCCAAGAACATTTTTGCAATTCTTCAATCTGTAAAAGCCAGAGAAGAAGGGCGTGCACCTGAACAGCGACCTGCC
CCAAATGCAGCACCTGTGGATCCCACTTTGCGCACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGA
AAAGAAGAAACGGAAGGCTTCAAAATTGACACTATGGGAACCTACCATGGTATGACACTGAAATCTGTAACGGAGGGTGCATCTGCCCGG
AAGACTCAGACTCCTGCAGCCCAGCCAGTACCAAGACCAGTTTCTCAAGCAAGACCTCCCCCAAATCAGAAGAAAGGATCTCGAACACCC
ATTATCATAATTCCTGCAGCTACCACCTCTTTAATAACCATGCTTAATGCAAAAGACCTTCTACAGGACCTGAAATTTGTCCCATCAGAT
GAAAAGAAGAAACAAGGTTGTCAACGAGAAAATGAAACTCTAATACAAAGAAGAAAAGACCAGATGCAACCAGGGGGCACTGCAATTAGT
GTTACAGTACCTTATAGAGTAGTAGACCAGCCCCTTAAACTTATGCCTCAAGACTGGGACCGCGTTGTAGCCGTTTTTGTGCAGGGTCCT
GCATGGCAGTTCAAAGGTTGGCCATGGCTTTTGCCTGATGGATCACCAGTTGATATATTTGCTAAAACAAATAATACTTCAGACAGAAAG
CTTCTAATTGTTATTGACACAAATATTCTGATGAATCATCTCAAATTTGTTAGAATTTTGAAGACAACAGAAGTACCAGGTTTTGACAAA
CTTGTGTTAATAATTCCCTGGGTCGTTATGCAAGAGCTAGATCGTATGAAGGAAGGAAAACTACTAAAACGTGCCCAGCACAAAGCTATA
CCTGCAGTTCATTTCATCAACGACAGTCTCAAAAATCAAGATAGAAAGCTATGGGGTCAGTCAATACAACTTGCATCCCAAAAACATTAT
GGATTGAGTGATGAGAACAATGATGATCGAGTACTAAAATGCTGTCTCCAGCACCAGGAATTATTCCCTTGTTCTTTTGTTATTCTGTGC
ACGGATGATAGAAACTTAAGAAACAAAGGCCTAATAAGTGGTGTGAAGTCACTCAGTAAAGAAGAATTGAGTGCAGAGTTATTACACTTA
TCTCTGAACACAGATGTGTGTCATCAGCCTTGTATTCCTAAGCAACAGTTGAAAGCAGAAACAACACCCTTGAAAGAGAGCTATAAGGAG
GAATCTACAAATTCTGGACTGTCCATTCTGCTTGAGAGCATTGTATCTGATCTTGAAAAATCTCTTGGAACAGGTTTATCTTCAATATTA
GAAACAGAAATGAAAATTGCTTTTGGAAACCTTTGGATGGAGATCCTGTACCTGAAACCACCATGGACTCTACTACATTTACTACAGTGC
TTTAAAAAACATTGGTTGGCTGTATTTGGATTAGTTATGGAAAAGAACTTGCTTTTAACTATTGAGAGCCTATACAAAAATCTCCGTAAA
GCTAATAAGGCAGTGGATTTTACAACAGTCAAATTCTTGCTTCAGGATTCTAGAAGTTTGTTACATGCTTTCAGTACAAGGTCAAATTAT
GATGGTATTCTTCCACAGACCTTTGCTCAAGTAAACAACCTCCTTCAGACATTTGCAGAGGTCAAGACAAAACTTAAGCCAAATTCTTCA
GAAAACACAGTGACTAAAAAGCAGGAAGGTACTTCATTGAAGAATTCTCATAATCAAGAAATCACTGTTTTCTCGAGTTCTCATCTTCCC
CAACCCAGCAGGCATCAAGAAATCTGGTCTATCCTAGAGAGTGTTTGGATTACAATATATCAGAACAGCACGGATGTATTTCAAAGATTG
GGCTCAAATTCAGCTCTGACTACTTCAAATATAGCATCATTTGAAGAAGCATTTATATGTCTTCAAAAGTTAATGGCAGCTGTGAGGGAT
ATTCTTGAAGGAATTCAAAGGATTTTGGCCCCAAACAGTAATTATCAAGATGTTGAGACCCTCTATAACTTCCTAATCAAGTATGAGGTA
AATAAAAATGTCAAATTTACTGCCCAGGAAATTTATGATTGTGTTTCTCAGACTGAGTATAGGGAAAAGTTAACCATTGGATGCCGCCAG
CTGGTTGAGATGGAATATACCATGCAGCAGTGCAATGCATCTGTTTATATGGAGGCCAAAAACAGGGGATGGTGTGAAGACATGCTCAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDC73_ENST00000367435_chr1_193205486_+_SWT1_ENST00000367501_chr1_185153375_+_3370nt
CGGCGGCCTGGGTGGCTACTGCCCCTGCTGCTGTCGTAGGCGAGGACGGCTGTTAGTGCTGCTGCTGTTGGTTCGTCGCGGCGGCGAAGG
AGGAGGAGGAAGAGGGCGAGGCGACAAGAGAAGAAGGAGGCAGGCGCGGCGGCAGCGGCGGCGCCCCGAGCCGGCGGAGGCGAGGGGGGG
GAAGATGGCGGACGTGCTTAGCGTCCTGCGACAGTACAACATCCAGAAGAAGGAGATTGTGGTGAAGGGAGACGAAGTGATCTTCGGGGA
GTTCTCCTGGCCCAAGAATGTGAAGACCAACTATGTTGTTTGGGGGACTGGAAAGGAAGGCCAACCCAGAGAGTACTACACATTGGATTC
CATTTTATTTCTACTTAATAACGTGCACCTTTCTCATCCTGTTTATGTCCGACGTGCAGCTACTGAAAATATTCCTGTGGTTAGAAGACC
TGATCGAAAAGATCTACTTGGATATCTCAATGGTGAAGCGTCAACATCGGCAAGTATAGACAGAAGCGCTCCCTTAGAAATAGGTCTTCA
GCGATCTACTCAAGTCAAACGAGCTGCAGATGAAGTTTTAGCAGAAGCAAAGAAACCACGAATTGAGGATGAAGAGTGTGTGCGCCTTGA
TAAAGAGAGATTGGCTGCCCGTTTGGAGGGTCACAAAGAAGGGATTGTACAGACTGAACAGATTAGGTCTTTGTCTGAAGCTATGTCAGT
GGAAAAAATTGCTGCAATCAAAGCCAAAATTATGGCTAAGAAAAGATCTACTATCAAGACTGATCTAGATGATGACATAACTGCCCTTAA
ACAGAGGAGTTTTGTGGATGCTGAGGTAGATGTGACCCGAGATATTGTCAGCAGAGAGAGAGTATGGAGGACACGAACAACTATCTTACA
AAGCACAGGAAAGAATTTTTCCAAGAACATTTTTGCAATTCTTCAATCTGTAAAAGCCAGAGAAGAAGGGCGTGCACCTGAACAGCGACC
TGCCCCAAATGCAGCACCTGTGGATCCCACTTTGCGCACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAA
AGGAAAAGAAGAAACGGAAGGCTTCAAAATTGACACTATGGGAACCTACCATGGTATGACACTGAAATCTGTAACGGAGGGTGCATCTGC
CCGGAAGACTCAGACTCCTGCAGCCCAGCCAGTACCAAGACCAGTTTCTCAAGCAAGACCTCCCCCAAATCAGAAGAAAGGATCTCGAAC
ACCCATTATCATAATTCCTGCAGCTACCACCTCTTTAATAACCATGCTTAATGCAAAAGACCTTCTACAGGACCTGAAATTTGTCCCATC
AGATGAAAAGAAGAAACAAGGTTGTCAACGAGAAAATGAAACTCTAATACAAAGAAGAAAAGACCAGATGCAACCAGGGGGCACTGCAAT
TAGTGTTACAGTACCTTATAGAGTAGTAGACCAGCCCCTTAAACTTATGCCTCAAGACTGGGACCGCGTTGTAGCCGTTTTTGTGCAGGG
TCCTGCATGGCAGTTCAAAGGTTGGCCATGGCTTTTGCCTGATGGATCACCAGTTGATATATTTGCTAAAACAAATAATACTTCAGACAG
AAAGCTTCTAATTGTTATTGACACAAATATTCTGATGAATCATCTCAAATTTGTTAGAATTTTGAAGACAACAGAAGTACCAGGTTTTGA
CAAACTTGTGTTAATAATTCCCTGGGTCGTTATGCAAGAGCTAGATCGTATGAAGGAAGGAAAACTACTAAAACGTGCCCAGCACAAAGC
TATACCTGCAGTTCATTTCATCAACGACAGTCTCAAAAATCAAGATAGAAAGCTATGGGGTCAGTCAATACAACTTGCATCCCAAAAACA
TTATGGATTGAGTGATGAGAACAATGATGATCGAGTACTAAAATGCTGTCTCCAGCACCAGGAATTATTCCCTTGTTCTTTTGTTATTCT
GTGCACGGATGATAGAAACTTAAGAAACAAAGGCCTAATAAGTGGTGTGAAGTCACTCAGTAAAGAAGAATTGAGTGCAGAGTTATTACA
CTTATCTCTGAACACAGATGTGTGTCATCAGCCTTGTATTCCTAAGCAACAGTTGAAAGCAGAAACAACACCCTTGAAAGAGAGCTATAA
GGAGGAATCTACAAATTCTGGACTGTCCATTCTGCTTGAGAGCATTGTATCTGATCTTGAAAAATCTCTTGGAACAGGTTTATCTTCAAT
ATTAGAAACAGAAATGAAAATTGCTTTTGGAAACCTTTGGATGGAGATCCTGTACCTGAAACCACCATGGACTCTACTACATTTACTACA
GTGCTTTAAAAAACATTGGTTGGCTGTATTTGGATTAGTTATGGAAAAGAACTTGCTTTTAACTATTGAGAGCCTATACAAAAATCTCCG
TAAAGCTAATAAGGCAGTGGATTTTACAACAGTCAAATTCTTGCTTCAGGATTCTAGAAGTTTGTTACATGCTTTCAGTACAAGGTCAAA
TTATGATGGTATTCTTCCACAGACCTTTGCTCAAGTAAACAACCTCCTTCAGACATTTGCAGAGGTCAAGACAAAACTTAAGCCAAATTC
TTCAGAAAACACAGTGACTAAAAAGCAGGAAGGTACTTCATTGAAGAATTCTCATAATCAAGAAATCACTGTTTTCTCGAGTTCTCATCT
TCCCCAACCCAGCAGGCATCAAGAAATCTGGTCTATCCTAGAGAGTGTTTGGATTACAATATATCAGAACAGCACGGATGTATTTCAAAG
ATTGGGCTCAAATTCAGCTCTGACTACTTCAAATATAGCATCATTTGAAGAAGCATTTATATGTCTTCAAAAGTTAATGGCAGCTGTGAG
GGATATTCTTGAAGGAATTCAAAGGATTTTGGCCCCAAACAGTAATTATCAAGATGTTGAGACCCTCTATAACTTCCTAATCAAGTATGA
GGTAAATAAAAATGTCAAATTTACTGCCCAGGAAATTTATGATTGTGTTTCTCAGACTGAGTATAGGGAAAAGTTAACCATTGGATGCCG
CCAGCTGGTTGAGATGGAATATACCATGCAGCAGTGCAATGCATCTGTTTATATGGAGGCCAAAAACAGGGGATGGTGTGAAGACATGCT
CAACTATAGGATATAAGTACTGATTTGTAACTTTAAAGGAATTGCATTTGTCCTTAAGAATAACAGAGTAGTTTTCAATCTGGTCACTCT
TTTGGGCCAAACCCAAGAGAATTTTAAGAAATGTTTCATAGGTATAAAAAGGTGATCGCCTATTACTGACAGTCTCATTGTAGCTCTAAA

>In-frame_CDC73_ENST00000367435_chr1_193205486_+_SWT1_ENST00000367500_chr1_185153375_+_4128nt
CGGCGGCCTGGGTGGCTACTGCCCCTGCTGCTGTCGTAGGCGAGGACGGCTGTTAGTGCTGCTGCTGTTGGTTCGTCGCGGCGGCGAAGG
AGGAGGAGGAAGAGGGCGAGGCGACAAGAGAAGAAGGAGGCAGGCGCGGCGGCAGCGGCGGCGCCCCGAGCCGGCGGAGGCGAGGGGGGG
GAAGATGGCGGACGTGCTTAGCGTCCTGCGACAGTACAACATCCAGAAGAAGGAGATTGTGGTGAAGGGAGACGAAGTGATCTTCGGGGA
GTTCTCCTGGCCCAAGAATGTGAAGACCAACTATGTTGTTTGGGGGACTGGAAAGGAAGGCCAACCCAGAGAGTACTACACATTGGATTC
CATTTTATTTCTACTTAATAACGTGCACCTTTCTCATCCTGTTTATGTCCGACGTGCAGCTACTGAAAATATTCCTGTGGTTAGAAGACC
TGATCGAAAAGATCTACTTGGATATCTCAATGGTGAAGCGTCAACATCGGCAAGTATAGACAGAAGCGCTCCCTTAGAAATAGGTCTTCA
GCGATCTACTCAAGTCAAACGAGCTGCAGATGAAGTTTTAGCAGAAGCAAAGAAACCACGAATTGAGGATGAAGAGTGTGTGCGCCTTGA
TAAAGAGAGATTGGCTGCCCGTTTGGAGGGTCACAAAGAAGGGATTGTACAGACTGAACAGATTAGGTCTTTGTCTGAAGCTATGTCAGT
GGAAAAAATTGCTGCAATCAAAGCCAAAATTATGGCTAAGAAAAGATCTACTATCAAGACTGATCTAGATGATGACATAACTGCCCTTAA
ACAGAGGAGTTTTGTGGATGCTGAGGTAGATGTGACCCGAGATATTGTCAGCAGAGAGAGAGTATGGAGGACACGAACAACTATCTTACA
AAGCACAGGAAAGAATTTTTCCAAGAACATTTTTGCAATTCTTCAATCTGTAAAAGCCAGAGAAGAAGGGCGTGCACCTGAACAGCGACC
TGCCCCAAATGCAGCACCTGTGGATCCCACTTTGCGCACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAA
AGGAAAAGAAGAAACGGAAGGCTTCAAAATTGACACTATGGGAACCTACCATGGTATGACACTGAAATCTGTAACGGAGGGTGCATCTGC
CCGGAAGACTCAGACTCCTGCAGCCCAGCCAGTACCAAGACCAGTTTCTCAAGCAAGACCTCCCCCAAATCAGAAGAAAGGATCTCGAAC
ACCCATTATCATAATTCCTGCAGCTACCACCTCTTTAATAACCATGCTTAATGCAAAAGACCTTCTACAGGACCTGAAATTTGTCCCATC
AGATGAAAAGAAGAAACAAGGTTGTCAACGAGAAAATGAAACTCTAATACAAAGAAGAAAAGACCAGATGCAACCAGGGGGCACTGCAAT
TAGTGTTACAGTACCTTATAGAGTAGTAGACCAGCCCCTTAAACTTATGCCTCAAGACTGGGACCGCGTTGTAGCCGTTTTTGTGCAGGG
TCCTGCATGGCAGTTCAAAGGTTGGCCATGGCTTTTGCCTGATGGATCACCAGTTGATATATTTGCTAAAACAAATAATACTTCAGACAG
AAAGCTTCTAATTGTTATTGACACAAATATTCTGATGAATCATCTCAAATTTGTTAGAATTTTGAAGACAACAGAAGTACCAGGTTTTGA
CAAACTTGTGTTAATAATTCCCTGGGTCGTTATGCAAGAGCTAGATCGTATGAAGGAAGGAAAACTACTAAAACGTGCCCAGCACAAAGC
TATACCTGCAGTTCATTTCATCAACGACAGTCTCAAAAATCAAGATAGAAAGCTATGGGGTCAGTCAATACAACTTGCATCCCAAAAACA
TTATGGATTGAGTGATGAGAACAATGATGATCGAGTACTAAAATGCTGTCTCCAGCACCAGGAATTATTCCCTTGTTCTTTTGTTATTCT
GTGCACGGATGATAGAAACTTAAGAAACAAAGGCCTAATAAGTGGTGTGAAGTCACTCAGTAAAGAAGAATTGAGTGCAGAGTTATTACA
CTTATCTCTGAACACAGATGTGTGTCATCAGCCTTGTATTCCTAAGCAACAGTTGAAAGCAGAAACAACACCCTTGAAAGAGAGCTATAA
GGAGGAATCTACAAATTCTGGACTGTCCATTCTGCTTGAGAGCATTGTATCTGATCTTGAAAAATCTCTTGGAACAGGTTTATCTTCAAT
ATTAGAAACAGAAATGAAAATTGCTTTTGGAAACCTTTGGATGGAGATCCTGTACCTGAAACCACCATGGACTCTACTACATTTACTACA
GTGCTTTAAAAAACATTGGTTGGCTGTATTTGGATTAGTTATGGAAAAGAACTTGCTTTTAACTATTGAGAGCCTATACAAAAATCTCCG
TAAAGCTAATAAGGCAGTGGATTTTACAACAGTCAAATTCTTGCTTCAGGATTCTAGAAGTTTGTTACATGCTTTCAGTACAAGGTCAAA
TTATGATGGTATTCTTCCACAGACCTTTGCTCAAGTAAACAACCTCCTTCAGACATTTGCAGAGGTCAAGACAAAACTTAAGCCAAATTC
TTCAGAAAACACAGTGACTAAAAAGCAGGAAGGTACTTCATTGAAGAATTCTCATAATCAAGAAATCACTGTTTTCTCGAGTTCTCATCT
TCCCCAACCCAGCAGGCATCAAGAAATCTGGTCTATCCTAGAGAGTGTTTGGATTACAATATATCAGAACAGCACGGATGTATTTCAAAG
ATTGGGCTCAAATTCAGCTCTGACTACTTCAAATATAGCATCATTTGAAGAAGCATTTATATGTCTTCAAAAGTTAATGGCAGCTGTGAG
GGATATTCTTGAAGGAATTCAAAGGATTTTGGCCCCAAACAGTAATTATCAAGATGTTGAGACCCTCTATAACTTCCTAATCAAGTATGA
GGTAAATAAAAATGTCAAATTTACTGCCCAGGAAATTTATGATTGTGTTTCTCAGACTGAGTATAGGGAAAAGTTAACCATTGGATGCCG
CCAGCTGGTTGAGATGGAATATACCATGCAGCAGTGCAATGCATCTGTTTATATGGAGGCCAAAAACAGGGGATGGTGTGAAGACATGCT
CAACTATAGGATATAAGTACTGATTTGTAACTTTAAAGGAATTGCATTTGTCCTTAAGAATAACAGAGTAGTTTTCAATCTGGTCACTCT
TTTGGGCCAAACCCAAGAGAATTTTAAGAAATGTTTCATAGGTATAAAAAGGTGATCGCCTATTACTGACAGTCTCATTGTAGCTCTAAA
AAGCCTAATGTATCCACTGTGGAATAAACTCCATAGACTCAACTCTTCTGGAGTTCACAATGCCTCCCTACCTCTATTCTTGATAGTGAG
CCAGTATCTCTAAGGAAAGGAGAGCCGTATTTTTAGTCATCCTAGGGCAGGAGCCACTGTGGCATCTGAGGAAGACCCAGGGTACAGTAT
TAGCATTTCTTTCAACCCTAAGTATGGGCATGTGACCAGAGACACTGCCAAACCCTAAGAAATCATTAGGGCATGATCATGCTCACCATA
TTTCACAAATGAAATCTTAATGTGGGCTGTTTTTTATGATCAAACTGTCATCCATGTTGACCTGATGAAAATAACACCCTCCTTCACCTC
CCTCAGGGTAATGAAAGTAGAAATTTGACTGAAGCTCCTACTTCCTTATACAGCCTTTCCTTCTGTGGGCTTGTCACTTTTCAGTACATT
TCTAGTGGGGAAGAGCAGGGCGACCCCTCTGCTGGGTTTCTCCTTAAATGTGAAGCAAAATAAATTTATATAATGGAATTTGGTGGCAGT
GACTGATGTTTGTCTCTAGCTAAAACCAACTGTTTAGTTGACTTTTTAGTTATAGGATAAGTTGGAAGTCCTTGTTTACTGGAATATATT
ATGCTTTTGTTAACACATTAGATTAAATAGAATTTGGTATTCTATTATAAATGTTTATTTTTTAAAGCAATAAATAACTTATTTTTGGTA


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FusionGenePPI for CDC73_SWT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC73ANXA6, HSPA4, PITHD1, KCNH2, GC, WWC1, RANBP2, CTR9, LEO1, PAF1, POLR2A, CDK9, MEPCE, KMT2A, CPSF1, CPSF2, CPSF3, RRAGA, CSTF2, KMT2C, ASH2L, RBBP5, CPSF4, CSTF3, TCEA1, RTF1, MCM3AP, DDAH2, HAP1, CEP70, HSF2BP, ITFG1, FAF1, RNF20, RNF40, HSP90AA1, WDR61, HIST1H3A, PTPN11, CTNNB1, SUV39H1, GTF2F1, BCL9L, SOX2, DNMT3A, DNMT3B, ARFGEF2, CHUK, COG3, MYH14, NUP98, MYH9, MYL12A, GPRASP2, CIAO1, AURKB, ALAS1, GOLGA2, TFCP2, MTUS2, VPS37B, TSGA10, FSD2, CCDC155, HIST1H1A, HIST1H1C, NTRK1, AP3B1, AP3D1, AP3S1, SRRM2, NUMA1, TCF7L2, KRAS, XPO1, RAD51, TCEB2, BRPF1, SCAMP3, UQCRQ, IMPACT, MRPS15, CD44, POLR2G, RFX5, SUPT5H, AP4S1, CNTROB, C1orf131, MYC, SNW1, CDC5L, NANOG, HIST2H2BE, HIST3H3, PDIA6, DHRS2, LANCL1, ANP32B, CCT4, CCT2, PAICS, GNA13, CCT8, CFL1, RAB10, YWHAQ, DCD, CLTC, CNN3, MYO3B, RAB40A, CSE1L, DSG1, DSP, EEF1A1, EEF1A2, EEF1D, EEF1G, EEF2, EIF2S1, EIF2S3, ENO1, EPRS, ALB, ALCAM, ALDOA, FKBP4, CCT5, ERP44, FLNA, FLNB, FLNC, EXOC7, G6PD, GAPDH, PHGDH, FBXO3, RAB30, GNA12, SFN, RAB40AL, CCDC88B, ANXA1, ANXA2, HADHA, HK1, HNRNPF, HNRNPK, HSD17B4, DNAJA1, HSPA2, HSPA5, HSPA8, HSPA9, HSPB1, HSP90AB1, HSPD1, TUBB8, ITGB1, JUP, KARS, ARF1, ARF3, ARF4, FLG2, RPSA, LDHA, RAB8A, MIF, POTEE, MSN, MTHFD1, NEFH, NNMT, NUCB2, ATP5A1, PRDX1, ATP5B, PCBP1, PCNA, SAR1B, PFN1, PGD, PKM, PLG, PCBP3, PPA1, PRKDC, PRSS1, PSMC2, PSMD2, RAB1A, RAB2A, RAB5A, RAB5C, RAN, RARS, RNH1, RPL7, RPL11, RPL22, RPLP0, RPN1, RPN2, RPS3, RPS5, RPS10, RPS17, RPS27A, SLC3A2, SNRPA1, TCP1, TFRC, HSP90B1, CCT3, UBA52, UBB, UBC, VCP, VIM, YWHAB, YWHAE, YWHAZ, ACTN4, CALR, SLC7A5, HM13, RAB1B, CANX, CLTCL1, CAPZB, TAGLN2, ACTN1, GBF1, CCT6A, CAND1, CUL1, UBA1, FBXO21, RUVBL2, TULP2, ERMAP, CHEK2, CHEK1, TOP1, TOP2A, TOP3A, DHFR, WEE1, IMPDH1, TUBA1A, NCL, G3BP1, UHRF2, TESSWT1AURKA, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCDC73chr1:193205486chr1:185153375ENST00000367435+1517200_250472532CTNNB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCDC73chr1:193205486chr1:185153375ENST00000367435+1517200_531472532POLR2A and PAF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC73_SWT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC73_SWT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC73C1840402HYPERPARATHYROIDISM 13CTD_human;ORPHANET;UNIPROT
HgeneCDC73C1704981Hyperparathyroidism-Jaw Tumor Syndrome1CTD_human;ORPHANET;UNIPROT