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Fusion gene ID: 6405 |
FusionGeneSummary for CDC73_KCNT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDC73_KCNT2 | Fusion gene ID: 6405 | Hgene | Tgene | Gene symbol | CDC73 | KCNT2 | Gene ID | 79577 | 343450 |
| Gene name | cell division cycle 73 | potassium sodium-activated channel subfamily T member 2 | |
| Synonyms | C1orf28|FIHP|HPTJT|HRPT1|HRPT2|HYX | EIEE57|KCa4.2|SLICK|SLO2.1 | |
| Cytomap | 1q31.2 | 1q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | parafibrominPaf1/RNA polymerase II complex componentcell division cycle 73 Paf1/RNA polymerase II complex component-like proteincell division cycle 73, Paf1/RNA polymerase II complex component, homologcell division cycle protein 73 homologhyperparath | potassium channel subfamily T member 2potassium channel, subfamily T, member 2sequence like an intermediate conductance potassium channel subunitsodium and chloride-activated ATP-sensitive potassium channel Slo2.1sodium-and chloride-activated ATP-sens | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6P1J9 | Q6UVM3 | |
| Ensembl transtripts involved in fusion gene | ENST00000367435, ENST00000477868, | ENST00000367433, ENST00000498426, ENST00000367431, ENST00000609185, ENST00000451324, ENST00000294725, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 5 X 4 X 4=80 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDC73 [Title/Abstract] AND KCNT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDC73 | GO:0008285 | negative regulation of cell proliferation | 16989776 |
| Hgene | CDC73 | GO:0010390 | histone monoubiquitination | 16307923 |
| Hgene | CDC73 | GO:0030177 | positive regulation of Wnt signaling pathway | 16630820 |
| Hgene | CDC73 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 20178742 |
| Hgene | CDC73 | GO:0033523 | histone H2B ubiquitination | 16307923 |
| Hgene | CDC73 | GO:0045638 | negative regulation of myeloid cell differentiation | 20541477 |
| Hgene | CDC73 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20178742 |
| Hgene | CDC73 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | 16989776 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-FS-A1ZU-06A | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367435 | ENST00000367433 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| 5CDS-intron | ENST00000367435 | ENST00000498426 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| 5CDS-intron | ENST00000367435 | ENST00000367431 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| 5CDS-intron | ENST00000367435 | ENST00000609185 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| 5CDS-5UTR | ENST00000367435 | ENST00000451324 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| 5CDS-5UTR | ENST00000367435 | ENST00000294725 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| intron-3CDS | ENST00000477868 | ENST00000367433 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| intron-intron | ENST00000477868 | ENST00000498426 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| intron-intron | ENST00000477868 | ENST00000367431 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| intron-intron | ENST00000477868 | ENST00000609185 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| intron-5UTR | ENST00000477868 | ENST00000451324 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
| intron-5UTR | ENST00000477868 | ENST00000294725 | CDC73 | chr1 | 193121574 | + | KCNT2 | chr1 | 196448368 | - |
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FusionProtFeatures for CDC73_KCNT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDC73 | KCNT2 |
| Tumor suppressor probably involved in transcriptionaland post-transcriptional control pathways. May be involved in cellcycle progression through the regulation of cyclin D1/PRAD1expression. Component of the PAF1 complex (PAF1C) which hasmultiple functions during transcription by RNA polymerase II andis implicated in regulation of development and maintenance ofembryonic stem cell pluripotency. PAF1C associates with RNApolymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms andis involved in transcriptional elongation, acting bothindepentently and synergistically with TCEA1 and in cooperationwith the DSIF complex and HTATSF1. PAF1C is required fortranscription of Hox and Wnt target genes. PAF1C is involved inhematopoiesis and stimulates transcriptional activity ofKMT2A/MLL1; it promotes leukemogenesis through association withKMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histonemodifications such as ubiquitination of histone H2B andmethylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits theRNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzymeUBE2A or UBE2B to chromatin which mediate monoubiquitination of'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2Bubiquitination is proposed to be coupled to transcription. PAF1Cis involved in mRNA 3' end formation probably through associationwith cleavage and poly(A) factors. In case of infection byinfluenza A strain H3N2, PAF1C associates with viral NS1 protein,thereby regulating gene transcription. Connects PAF1C with thecleavage and polyadenylation specificity factor (CPSF) complex andthe cleavage stimulation factor (CSTF) complex, and with Wntsignaling. Involved in polyadenylation of mRNA precursors.{ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063,ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820,ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632,ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742,ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. | Outward rectifying potassium channel. Produces rapidlyactivating outward rectifier K(+) currents. Activated by highintracellular sodium and chloride levels. Channel activity isinhibited by ATP and by inhalation anesthetics, such as isoflurane(By similarity). Inhibited upon stimulation of G-protein coupledreceptors, such as CHRM1 and GRIA1. {ECO:0000250,ECO:0000269|PubMed:14684870, ECO:0000269|PubMed:16687497}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDC73 | chr1:193121574 | chr1:196448368 | ENST00000367435 | + | 10 | 17 | 125_139 | 324 | 532 | Motif | Note=Nuclear localization signal |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 422_543 | 108 | 1136 | Domain | Note=RCK N-terminal |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 422_543 | 108 | 1112 | Domain | Note=RCK N-terminal |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 229_249 | 108 | 1136 | Intramembrane | Pore-forming |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 229_249 | 108 | 1112 | Intramembrane | Pore-forming |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 1025_1032 | 108 | 1136 | Nucleotide binding | ATP |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 1025_1032 | 108 | 1112 | Nucleotide binding | ATP |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 123_137 | 108 | 1136 | Topological domain | Cytoplasmic |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 159_164 | 108 | 1136 | Topological domain | Extracellular |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 186_198 | 108 | 1136 | Topological domain | Cytoplasmic |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 220_228 | 108 | 1136 | Topological domain | Extracellular |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 250_256 | 108 | 1136 | Topological domain | Extracellular |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 278_1135 | 108 | 1136 | Topological domain | Cytoplasmic |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 123_137 | 108 | 1112 | Topological domain | Cytoplasmic |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 159_164 | 108 | 1112 | Topological domain | Extracellular |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 186_198 | 108 | 1112 | Topological domain | Cytoplasmic |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 220_228 | 108 | 1112 | Topological domain | Extracellular |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 250_256 | 108 | 1112 | Topological domain | Extracellular |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 278_1135 | 108 | 1112 | Topological domain | Cytoplasmic |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 138_158 | 108 | 1136 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 165_185 | 108 | 1136 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 199_219 | 108 | 1136 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 257_277 | 108 | 1136 | Transmembrane | Helical%3B Name%3DSegment S6 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 138_158 | 108 | 1112 | Transmembrane | Helical%3B Name%3DSegment S3 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 165_185 | 108 | 1112 | Transmembrane | Helical%3B Name%3DSegment S4 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 199_219 | 108 | 1112 | Transmembrane | Helical%3B Name%3DSegment S5 |
| Tgene | >KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 257_277 | 108 | 1112 | Transmembrane | Helical%3B Name%3DSegment S6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDC73 | chr1:193121574 | chr1:196448368 | ENST00000367435 | + | 10 | 17 | 361_364 | 324 | 532 | Compositional bias | Note=Poly-Ile |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 1_63 | 108 | 1136 | Topological domain | Cytoplasmic |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 85_101 | 108 | 1136 | Topological domain | Extracellular |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 1_63 | 108 | 1112 | Topological domain | Cytoplasmic |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 85_101 | 108 | 1112 | Topological domain | Extracellular |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 102_122 | 108 | 1136 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000294725 | - | 3 | 28 | 64_84 | 108 | 1136 | Transmembrane | Helical%3B Name%3DSegment S1 |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 102_122 | 108 | 1112 | Transmembrane | Helical%3B Name%3DSegment S2 |
| Tgene | KCNT2 | chr1:193121574 | chr1:196448368 | ENST00000367433 | - | 3 | 27 | 64_84 | 108 | 1112 | Transmembrane | Helical%3B Name%3DSegment S1 |
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FusionGeneSequence for CDC73_KCNT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDC73_ENST00000367435_chr1_193121574_+_KCNT2_ENST00000367433_chr1_196448368_-_1328aa MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWGTGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPD RKDLLGYLNGEASTSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGHKEGIVQTEQIRSLSEAMSVE KIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEVDVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPA PNAAPVDPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTVSVALISLFETILLGYLSYKGNIWEQILRIPFILEI INAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLY FCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAH PRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCP LYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYE GKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASM GTVAIDLQDTSCRSASGPTLSLPTEGSKEIRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTF CHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPLDDLLRCGVTFAANM VVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVF SISMLDTLLYQSFVKDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVE EWEDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDC73_ENST00000367435_chr1_193121574_+_KCNT2_ENST00000367433_chr1_196448368_-_3984nt ATGGCGGACGTGCTTAGCGTCCTGCGACAGTACAACATCCAGAAGAAGGAGATTGTGGTGAAGGGAGACGAAGTGATCTTCGGGGAGTTC TCCTGGCCCAAGAATGTGAAGACCAACTATGTTGTTTGGGGGACTGGAAAGGAAGGCCAACCCAGAGAGTACTACACATTGGATTCCATT TTATTTCTACTTAATAACGTGCACCTTTCTCATCCTGTTTATGTCCGACGTGCAGCTACTGAAAATATTCCTGTGGTTAGAAGACCTGAT CGAAAAGATCTACTTGGATATCTCAATGGTGAAGCGTCAACATCGGCAAGTATAGACAGAAGCGCTCCCTTAGAAATAGGTCTTCAGCGA TCTACTCAAGTCAAACGAGCTGCAGATGAAGTTTTAGCAGAAGCAAAGAAACCACGAATTGAGGATGAAGAGTGTGTGCGCCTTGATAAA GAGAGATTGGCTGCCCGTTTGGAGGGTCACAAAGAAGGGATTGTACAGACTGAACAGATTAGGTCTTTGTCTGAAGCTATGTCAGTGGAA AAAATTGCTGCAATCAAAGCCAAAATTATGGCTAAGAAAAGATCTACTATCAAGACTGATCTAGATGATGACATAACTGCCCTTAAACAG AGGAGTTTTGTGGATGCTGAGGTAGATGTGACCCGAGATATTGTCAGCAGAGAGAGAGTATGGAGGACACGAACAACTATCTTACAAAGC ACAGGAAAGAATTTTTCCAAGAACATTTTTGCAATTCTTCAATCTGTAAAAGCCAGAGAAGAAGGGCGTGCACCTGAACAGCGACCTGCC CCAAATGCAGCACCTGTGGATCCCACTTTGCGCACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAAAGGA AAAGAAGAAACGGAAGGCTTCAAAATTGACACTATGGGAACCTACCATGGTATGACACTGAAATCTGTAACGGTTTCAGTGGCATTGATA AGTCTGTTTGAAACAATATTACTTGGTTATCTTAGTTATAAGGGAAACATCTGGGAACAGATTTTACGAATACCCTTCATCTTGGAAATA ATTAATGCAGTTCCCTTCATTATCTCAATATTCTGGCCTTCCTTAAGGAATCTATTTGTCCCAGTCTTTCTGAACTGTTGGCTTGCCAAA CATGCCTTGGAAAATATGATTAATGATCTACACAGAGCCATTCAGCGTACACAGTCTGCAATGTTTAATCAAGTTTTGATTTTAATATCT ACATTACTATGCCTTATCTTCACCTGCATTTGTGGGATCCAACATCTGGAACGAATAGGAAAGAAGCTGAATCTCTTTGACTCCCTTTAT TTCTGCATTGTGACGTTTTCTACTGTGGGCTTCGGGGATGTCACTCCTGAAACATGGTCCTCCAAGCTTTTTGTAGTTGCTATGATTTGT GTTGCTCTTGTGGTTCTACCCATACAGTTTGAACAGCTGGCTTATTTGTGGATGGAGAGACAAAAGTCAGGAGGAAACTATAGTCGACAT AGAGCTCAAACTGAAAAGCATGTCGTCCTGTGTGTCAGCTCACTGAAGATTGATTTACTTATGGATTTTTTAAATGAATTCTATGCTCAT CCTAGGCTCCAGGATTATTATGTGGTGATTTTGTGTCCTACTGAAATGGATGTACAGGTTCGAAGGGTACTGCAGATTCCAATGTGGTCC CAACGAGTTATCTACCTTCAAGGTTCAGCCCTTAAAGATCAAGACCTATTGAGAGCAAAGATGGATGACGCTGAGGCCTGTTTTATTCTC AGTAGCCGTTGTGAAGTGGATAGGACATCATCTGATCACCAAACAATTTTGAGAGCATGGGCTGTGAAAGATTTTGCTCCAAATTGTCCT TTGTATGTCCAGATATTAAAGCCTGAAAATAAATTTCACATCAAATTTGCTGATCATGTTGTTTGTGAAGAAGAGTTTAAATACGCCATG TTAGCTTTAAACTGTATATGCCCAGCAACATCTACACTTATTACACTACTGGTTCATACCTCTAGAGGGCAAGAAGGCCAGCAATCGCCA GAACAATGGCAGAAGATGTACGGTAGATGCTCCGGGAATGAAGTCTACCACATTGTTTTGGAAGAAAGTACATTTTTTGCTGAATATGAA GGAAAGAGTTTTACATATGCCTCTTTCCATGCACACAAAAAGTTTGGCGTCTGCTTGATTGGTGTTAGGAGGGAGGATAATAAAAACATT TTGCTGAATCCAGGTCCTCGATACATTATGAATTCTACAGACATATGCTTTTATATTAATATTACCAAAGAAGAGAATTCAGCATTTAAA AACCAAGACCAGCAGAGAAAAAGCAATGTGTCCAGGTCGTTTTATCATGGACCTTCCAGATTACCTGTACATAGCATAATTGCCAGCATG GGTACTGTGGCTATAGACTTGCAAGATACAAGCTGTAGATCAGCAAGTGGCCCTACCCTGTCTCTTCCTACAGAGGGAAGCAAAGAAATA AGAAGACCTAGCATTGCTCCTGTTTTAGAGGTTGCAGATACATCATCGATTCAAACATGTGATCTTCTAAGTGACCAATCAGAAGATGAA ACTACACCAGATGAAGAAATGTCTTCAAACTTAGAGTATGCTAAAGGTTACCCACCTTATTCTCCATATATAGGAAGTTCACCCACTTTT TGTCATCTCCTTCATGAAAAAGTACCATTTTGCTGCTTAAGATTAGACAAGAGTTGCCAACATAACTACTATGAGGATGCAAAAGCCTAT GGATTCAAAAATAAACTAATTATAGTTGCAGCTGAAACAGCTGGAAATGGATTATATAACTTTATTGTTCCTCTCAGGGCATATTATAGA CCAAAGAAAGAACTTAATCCCATAGTACTGCTATTGGATAACCCCCTAGATGACTTACTCAGGTGTGGAGTGACTTTTGCTGCTAATATG GTGGTTGTGGATAAAGAGAGCACCATGAGTGCCGAGGAAGACTACATGGCAGATGCCAAAACCATTGTGAACGTGCAGACACTCTTCAGG TTGTTTTCCAGTCTCAGTATTATCACAGAGCTAACTCACCCCGCCAACATGAGATTCATGCAATTCAGAGCCAAAGACTGTTACTCTCTT GCTCTTTCAAAACTGGAAAAGAAAGAACGGGAGAGAGGCTCTAACTTGGCCTTTATGTTTCGACTGCCTTTTGCTGCTGGGAGGGTGTTT AGCATCAGTATGTTGGACACTCTGCTGTATCAGTCATTTGTGAAGGATTATATGATTTCTATCACGAGACTTCTGTTGGGACTGGACACT ACACCAGGATCTGGGTTTCTTTGTTCTATGAAAATCACTGCAGATGACTTATGGATCAGAACTTATGCCAGACTTTATCAGAAGTTGTGT TCTTCTACTGGAGATGTTCCCATTGGAATCTACAGGACTGAGTCTCAGAAACTTACTACATCTGAGTCTCAAATATCTATCAGTGTAGAA GAGTGGGAAGACACCAAAGACTCCAAAGAACAAGGGCACCACCGCAGCAACCACCGCAACTCAACATCCAGTGATCAGTCGGACCATCCC TTGCTGCGGAGAAAAAGCATGCAGTGGGCCCGAAGACTGAGCAGAAAAGGCCCAAAACACTCTGGTAAAACAGCTGAAAAAATAACCCAG CAGCGACTGAACCTCTACAGGAGGTCAGAAAGACAAGAGCTTGCTGAACTTGTGAAAAATAGAATGAAACACTTGGGTCTTTCTACAGTG GGATATGATGAAATGAATGATCATCAAAGTACCCTCTCCTACATCCTGATTAACCCATCTCCAGATACCAGAATAGAGCTGAATGATGTT GTATACTTAATTCGACCAGATCCACTGGCCTACCTTCCAAACAGTGAGCCCAGTCGAAGAAACAGCATCTGCAATGTCACTGGTCAAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDC73_ENST00000367435_chr1_193121574_+_KCNT2_ENST00000367433_chr1_196448368_-_6613nt CGGCGGCCTGGGTGGCTACTGCCCCTGCTGCTGTCGTAGGCGAGGACGGCTGTTAGTGCTGCTGCTGTTGGTTCGTCGCGGCGGCGAAGG AGGAGGAGGAAGAGGGCGAGGCGACAAGAGAAGAAGGAGGCAGGCGCGGCGGCAGCGGCGGCGCCCCGAGCCGGCGGAGGCGAGGGGGGG GAAGATGGCGGACGTGCTTAGCGTCCTGCGACAGTACAACATCCAGAAGAAGGAGATTGTGGTGAAGGGAGACGAAGTGATCTTCGGGGA GTTCTCCTGGCCCAAGAATGTGAAGACCAACTATGTTGTTTGGGGGACTGGAAAGGAAGGCCAACCCAGAGAGTACTACACATTGGATTC CATTTTATTTCTACTTAATAACGTGCACCTTTCTCATCCTGTTTATGTCCGACGTGCAGCTACTGAAAATATTCCTGTGGTTAGAAGACC TGATCGAAAAGATCTACTTGGATATCTCAATGGTGAAGCGTCAACATCGGCAAGTATAGACAGAAGCGCTCCCTTAGAAATAGGTCTTCA GCGATCTACTCAAGTCAAACGAGCTGCAGATGAAGTTTTAGCAGAAGCAAAGAAACCACGAATTGAGGATGAAGAGTGTGTGCGCCTTGA TAAAGAGAGATTGGCTGCCCGTTTGGAGGGTCACAAAGAAGGGATTGTACAGACTGAACAGATTAGGTCTTTGTCTGAAGCTATGTCAGT GGAAAAAATTGCTGCAATCAAAGCCAAAATTATGGCTAAGAAAAGATCTACTATCAAGACTGATCTAGATGATGACATAACTGCCCTTAA ACAGAGGAGTTTTGTGGATGCTGAGGTAGATGTGACCCGAGATATTGTCAGCAGAGAGAGAGTATGGAGGACACGAACAACTATCTTACA AAGCACAGGAAAGAATTTTTCCAAGAACATTTTTGCAATTCTTCAATCTGTAAAAGCCAGAGAAGAAGGGCGTGCACCTGAACAGCGACC TGCCCCAAATGCAGCACCTGTGGATCCCACTTTGCGCACCAAACAGCCTATCCCAGCTGCCTATAACAGATACGATCAGGAAAGATTCAA AGGAAAAGAAGAAACGGAAGGCTTCAAAATTGACACTATGGGAACCTACCATGGTATGACACTGAAATCTGTAACGGTTTCAGTGGCATT GATAAGTCTGTTTGAAACAATATTACTTGGTTATCTTAGTTATAAGGGAAACATCTGGGAACAGATTTTACGAATACCCTTCATCTTGGA AATAATTAATGCAGTTCCCTTCATTATCTCAATATTCTGGCCTTCCTTAAGGAATCTATTTGTCCCAGTCTTTCTGAACTGTTGGCTTGC CAAACATGCCTTGGAAAATATGATTAATGATCTACACAGAGCCATTCAGCGTACACAGTCTGCAATGTTTAATCAAGTTTTGATTTTAAT ATCTACATTACTATGCCTTATCTTCACCTGCATTTGTGGGATCCAACATCTGGAACGAATAGGAAAGAAGCTGAATCTCTTTGACTCCCT TTATTTCTGCATTGTGACGTTTTCTACTGTGGGCTTCGGGGATGTCACTCCTGAAACATGGTCCTCCAAGCTTTTTGTAGTTGCTATGAT TTGTGTTGCTCTTGTGGTTCTACCCATACAGTTTGAACAGCTGGCTTATTTGTGGATGGAGAGACAAAAGTCAGGAGGAAACTATAGTCG ACATAGAGCTCAAACTGAAAAGCATGTCGTCCTGTGTGTCAGCTCACTGAAGATTGATTTACTTATGGATTTTTTAAATGAATTCTATGC TCATCCTAGGCTCCAGGATTATTATGTGGTGATTTTGTGTCCTACTGAAATGGATGTACAGGTTCGAAGGGTACTGCAGATTCCAATGTG GTCCCAACGAGTTATCTACCTTCAAGGTTCAGCCCTTAAAGATCAAGACCTATTGAGAGCAAAGATGGATGACGCTGAGGCCTGTTTTAT TCTCAGTAGCCGTTGTGAAGTGGATAGGACATCATCTGATCACCAAACAATTTTGAGAGCATGGGCTGTGAAAGATTTTGCTCCAAATTG TCCTTTGTATGTCCAGATATTAAAGCCTGAAAATAAATTTCACATCAAATTTGCTGATCATGTTGTTTGTGAAGAAGAGTTTAAATACGC CATGTTAGCTTTAAACTGTATATGCCCAGCAACATCTACACTTATTACACTACTGGTTCATACCTCTAGAGGGCAAGAAGGCCAGCAATC GCCAGAACAATGGCAGAAGATGTACGGTAGATGCTCCGGGAATGAAGTCTACCACATTGTTTTGGAAGAAAGTACATTTTTTGCTGAATA TGAAGGAAAGAGTTTTACATATGCCTCTTTCCATGCACACAAAAAGTTTGGCGTCTGCTTGATTGGTGTTAGGAGGGAGGATAATAAAAA CATTTTGCTGAATCCAGGTCCTCGATACATTATGAATTCTACAGACATATGCTTTTATATTAATATTACCAAAGAAGAGAATTCAGCATT TAAAAACCAAGACCAGCAGAGAAAAAGCAATGTGTCCAGGTCGTTTTATCATGGACCTTCCAGATTACCTGTACATAGCATAATTGCCAG CATGGGTACTGTGGCTATAGACTTGCAAGATACAAGCTGTAGATCAGCAAGTGGCCCTACCCTGTCTCTTCCTACAGAGGGAAGCAAAGA AATAAGAAGACCTAGCATTGCTCCTGTTTTAGAGGTTGCAGATACATCATCGATTCAAACATGTGATCTTCTAAGTGACCAATCAGAAGA TGAAACTACACCAGATGAAGAAATGTCTTCAAACTTAGAGTATGCTAAAGGTTACCCACCTTATTCTCCATATATAGGAAGTTCACCCAC TTTTTGTCATCTCCTTCATGAAAAAGTACCATTTTGCTGCTTAAGATTAGACAAGAGTTGCCAACATAACTACTATGAGGATGCAAAAGC CTATGGATTCAAAAATAAACTAATTATAGTTGCAGCTGAAACAGCTGGAAATGGATTATATAACTTTATTGTTCCTCTCAGGGCATATTA TAGACCAAAGAAAGAACTTAATCCCATAGTACTGCTATTGGATAACCCCCTAGATGACTTACTCAGGTGTGGAGTGACTTTTGCTGCTAA TATGGTGGTTGTGGATAAAGAGAGCACCATGAGTGCCGAGGAAGACTACATGGCAGATGCCAAAACCATTGTGAACGTGCAGACACTCTT CAGGTTGTTTTCCAGTCTCAGTATTATCACAGAGCTAACTCACCCCGCCAACATGAGATTCATGCAATTCAGAGCCAAAGACTGTTACTC TCTTGCTCTTTCAAAACTGGAAAAGAAAGAACGGGAGAGAGGCTCTAACTTGGCCTTTATGTTTCGACTGCCTTTTGCTGCTGGGAGGGT GTTTAGCATCAGTATGTTGGACACTCTGCTGTATCAGTCATTTGTGAAGGATTATATGATTTCTATCACGAGACTTCTGTTGGGACTGGA CACTACACCAGGATCTGGGTTTCTTTGTTCTATGAAAATCACTGCAGATGACTTATGGATCAGAACTTATGCCAGACTTTATCAGAAGTT GTGTTCTTCTACTGGAGATGTTCCCATTGGAATCTACAGGACTGAGTCTCAGAAACTTACTACATCTGAGTCTCAAATATCTATCAGTGT AGAAGAGTGGGAAGACACCAAAGACTCCAAAGAACAAGGGCACCACCGCAGCAACCACCGCAACTCAACATCCAGTGATCAGTCGGACCA TCCCTTGCTGCGGAGAAAAAGCATGCAGTGGGCCCGAAGACTGAGCAGAAAAGGCCCAAAACACTCTGGTAAAACAGCTGAAAAAATAAC CCAGCAGCGACTGAACCTCTACAGGAGGTCAGAAAGACAAGAGCTTGCTGAACTTGTGAAAAATAGAATGAAACACTTGGGTCTTTCTAC AGTGGGATATGATGAAATGAATGATCATCAAAGTACCCTCTCCTACATCCTGATTAACCCATCTCCAGATACCAGAATAGAGCTGAATGA TGTTGTATACTTAATTCGACCAGATCCACTGGCCTACCTTCCAAACAGTGAGCCCAGTCGAAGAAACAGCATCTGCAATGTCACTGGTCA AGATTCTCGGGAGGAAACTCAACTTTGATAAAAATAAAATGAGAAACTTTTTTCCTACAAAGACCTTGCTTGAAACCACAAAAGTTTTGC TGGCACGAAAGAAACTAGATGGAAATATATGTAATTCTCTCATATTTAAAAACGTAATCTCTTCTCTTAGAAGTATAGATCATTTTGAAA CTTAATGTACTACTTACTGGTACTCTCCCTATTAATATTTGAAGGACCTCAATGGAATAAATTTGAAAAGCTAAATTAAAATACAAAAAT TTAAATCTGACATTTAATTGTTTTATAATAATCCAAACTCTATGAAAGCAATTTTAAAAATTATTAAGGTTTTATGAAGTTGACAAAATC TAACTATATTTGGTGCATCACAATGGACACAGAATGCTGCTGCTCCTCTTAAAAATTAAATGTGTCATATTATATTCTTTAAACTTACTG TTTTACAAAATTGAGCTCATCGTAAATGTCTAGTCTTCTCACATAGAGATTAACCAACAAACTTGTGTGGCTGACTTTTGTGTAAGAATC ATAGTTTGCTTTAGAATACAAATCTTTAAGTCATTTTAACTTTTTTTTCTGCCTTACGATATAAAAATATTTATCTTAGAATTTGAGATG TTCATAGCATGTTTTATTACATTGAAGAAACTAAAACATAAATGAAAAGAAACACTAGGTTCCTGCACTTTTTGGTAACTTTATGTCTAG CAAATATTTTATGCCAAGAAAAGCATACTATAAAGCAAATATCTATTATTCTCCTAAACGAATGCCTAGCATAGAGAAAATACTTAATAC ACATTTGTTGACTTAAATTTAATTCAAGGATTGAAAAATTAACTGGATATCTTGAAATATACAGTAATGATTGTCCTTAGACTCTTGAAC TTTACCATCTTTCCTATTCATATATCTATATAGTAAATTTCACTAGAAAAATTCTTTTAAAATTGACAGAAGATAATTTATACCTTTTAT GGACTCTGAAGACACTTCAAAACATTAAAAGTCCTTATGTCTTTGGTAATGAAACAATAACACTCAATGAAGGATGTATTAAAATTTTTG ACTTAATTTTGAAATCGTATATATGAGCTATACTTTAACATTATGAGAGAAAAGCATAAAACAAAAATAGGTAGTTCTTGGCTTTTAACA TTAATGCAAATCATGCAGAATTTGAGTTATAAATTTAAATATAAATTGACCATTGATGATATCCAGTTTTTCATTTTTTACCTGTATTGC ATTTTCCCCCTAGAGAAATAGATCAAAAGAGCACAAGAGTATGCGTACATAGTTTACCAGGTAGTAGAAGTGTGTTAAAATGTTCCTGTA AAAGAAACATTGGTAAATTTAAATACATACTGTTCTAATTTTGTATTTTTTAATTTTTGAATTTGACATTGAGTTTAATTCAGCAACAAC AAAAAATACATATAAAACTAGAAAGGGACTTTTTTTCCTTTCTTTTCATAATGAAGCAGATCAACTTAAAGGATAATAAAATTTTTAAAG AAAAGATATTCTAATGTACTCTCAATAATTCTACAGAAATAAAACTGTAAAGTGCAATGTGAAATCAAAGATTATAGTCATTGTATAATT TGGCTTGGAGGCTATGAAATGTCTTTTTTTCTTTTTGGTATTTTACATTATTCACATTTTAGAATAACAAGAACACCAAGAATTACCCCT AAAACAGAGACCCTGTATTTAATCTACTTTGATCAGAGAAGTAGAATTTATAACAGGTTAGCTAAAATTGGGAGCATGCCTTAAAACTTA AAGATTGTATGCATATATGTGTATATGTTATAAACGTGAAATATATTTGACACACACATTCACATATAAATTGTTAAAAACTGAAGGCAG AATGGAACTAATATATGTAACAGAGAAAAACAATAAATTTTATGAACTTGTTTTATATTTGCATATCAAGAGTCAAGTATGATGTTTCTT TAAGTTGACTTTTTTTACTTCATTATTTTTAGGAATAAATGTAAGATTTTACAAATCTTTTATTTCCCCACAAGATCTGAAGTTTGGTAT TTTTGCATTATGACAGTTGTTGAGACTAGGATTTTAAGCTAGGATATGATTATATTTCCTATATAACTAAAAATTTTGTTTCATAAATTT TAAAATAATTATTTTTGACTATGAACATTAGTCCAAATTTAATATTTGACACAGTTCATACCAGCTTGCTACAATAATGATAATTTATTA GTCTTTCTGTTATTTAAAGAATAAAAACATGCTTATAAAAGACTTTTAATGAAATGTTGCCTTTTTAAAATAATTATACTTGCACATGAA AATAAAATATAAAGTCAATAATAGTCCTTGTAGCCCAATGGGAATTGATTCTGTTTATTGTCTGTACCATTTTGCTACCAGTTACATTGA |
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FusionGenePPI for CDC73_KCNT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDC73 | ANXA6, HSPA4, PITHD1, KCNH2, GC, WWC1, RANBP2, CTR9, LEO1, PAF1, POLR2A, CDK9, MEPCE, KMT2A, CPSF1, CPSF2, CPSF3, RRAGA, CSTF2, KMT2C, ASH2L, RBBP5, CPSF4, CSTF3, TCEA1, RTF1, MCM3AP, DDAH2, HAP1, CEP70, HSF2BP, ITFG1, FAF1, RNF20, RNF40, HSP90AA1, WDR61, HIST1H3A, PTPN11, CTNNB1, SUV39H1, GTF2F1, BCL9L, SOX2, DNMT3A, DNMT3B, ARFGEF2, CHUK, COG3, MYH14, NUP98, MYH9, MYL12A, GPRASP2, CIAO1, AURKB, ALAS1, GOLGA2, TFCP2, MTUS2, VPS37B, TSGA10, FSD2, CCDC155, HIST1H1A, HIST1H1C, NTRK1, AP3B1, AP3D1, AP3S1, SRRM2, NUMA1, TCF7L2, KRAS, XPO1, RAD51, TCEB2, BRPF1, SCAMP3, UQCRQ, IMPACT, MRPS15, CD44, POLR2G, RFX5, SUPT5H, AP4S1, CNTROB, C1orf131, MYC, SNW1, CDC5L, NANOG, HIST2H2BE, HIST3H3, PDIA6, DHRS2, LANCL1, ANP32B, CCT4, CCT2, PAICS, GNA13, CCT8, CFL1, RAB10, YWHAQ, DCD, CLTC, CNN3, MYO3B, RAB40A, CSE1L, DSG1, DSP, EEF1A1, EEF1A2, EEF1D, EEF1G, EEF2, EIF2S1, EIF2S3, ENO1, EPRS, ALB, ALCAM, ALDOA, FKBP4, CCT5, ERP44, FLNA, FLNB, FLNC, EXOC7, G6PD, GAPDH, PHGDH, FBXO3, RAB30, GNA12, SFN, RAB40AL, CCDC88B, ANXA1, ANXA2, HADHA, HK1, HNRNPF, HNRNPK, HSD17B4, DNAJA1, HSPA2, HSPA5, HSPA8, HSPA9, HSPB1, HSP90AB1, HSPD1, TUBB8, ITGB1, JUP, KARS, ARF1, ARF3, ARF4, FLG2, RPSA, LDHA, RAB8A, MIF, POTEE, MSN, MTHFD1, NEFH, NNMT, NUCB2, ATP5A1, PRDX1, ATP5B, PCBP1, PCNA, SAR1B, PFN1, PGD, PKM, PLG, PCBP3, PPA1, PRKDC, PRSS1, PSMC2, PSMD2, RAB1A, RAB2A, RAB5A, RAB5C, RAN, RARS, RNH1, RPL7, RPL11, RPL22, RPLP0, RPN1, RPN2, RPS3, RPS5, RPS10, RPS17, RPS27A, SLC3A2, SNRPA1, TCP1, TFRC, HSP90B1, CCT3, UBA52, UBB, UBC, VCP, VIM, YWHAB, YWHAE, YWHAZ, ACTN4, CALR, SLC7A5, HM13, RAB1B, CANX, CLTCL1, CAPZB, TAGLN2, ACTN1, GBF1, CCT6A, CAND1, CUL1, UBA1, FBXO21, RUVBL2, TULP2, ERMAP, CHEK2, CHEK1, TOP1, TOP2A, TOP3A, DHFR, WEE1, IMPDH1, TUBA1A, NCL, G3BP1, UHRF2, TES | KCNT2 | ZNRF4, SLC17A2, IL17RC, PCDHA3, PCDHB16, TNFRSF10A, IL4R, FAM189B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | CDC73 | chr1:193121574 | chr1:196448368 | ENST00000367435 | + | 10 | 17 | 200_250 | 324 | 532 | CTNNB1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CDC73 | chr1:193121574 | chr1:196448368 | ENST00000367435 | + | 10 | 17 | 200_531 | 324 | 532 | POLR2A and PAF1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC73_KCNT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC73_KCNT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CDC73 | C1840402 | HYPERPARATHYROIDISM 1 | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | CDC73 | C1704981 | Hyperparathyroidism-Jaw Tumor Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
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