	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 6394

FusionGeneSummary for CDC5L_TMEM63B

Fusion gene summary

Fusion gene information	Fusion gene name: CDC5L_TMEM63B
	Fusion gene ID: 6394
		Hgene	Tgene
	Gene symbol	CDC5L	TMEM63B
	Gene ID	988	55362
	Gene name	cell division cycle 5 like	transmembrane protein 63B
	Synonyms	CDC5\|CDC5-LIKE\|CEF1\|PCDC5RP\|dJ319D22.1	C6orf110
	Cytomap	6p21.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	cell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related protein	CSC1-like protein 2
	Modification date	20180522	20180519
	UniProtAcc	Q99459	Q5T3F8
	Ensembl transtripts involved in fusion gene	ENST00000371477,	ENST00000259746, ENST00000323267, ENST00000527188,
Fusion gene scores	* DoF score	9 X 5 X 6=270	2 X 2 X 2=8
	# samples	9	2
	** MAII score	log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: CDC5L [Title/Abstract] AND TMEM63B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDC5L	GO:0000398	mRNA splicing, via spliceosome	28076346
Hgene	CDC5L	GO:0045944	positive regulation of transcription by RNA polymerase II	11082045

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-GC-A3RB-01A	CDC5L	chr6	44376369	+	TMEM63B	chr6	44102298	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000371477	ENST00000259746	CDC5L	chr6	44376369	+	TMEM63B	chr6	44102298	+
5CDS-5UTR	ENST00000371477	ENST00000323267	CDC5L	chr6	44376369	+	TMEM63B	chr6	44102298	+
5CDS-intron	ENST00000371477	ENST00000527188	CDC5L	chr6	44376369	+	TMEM63B	chr6	44102298	+

Top

FusionProtFeatures for CDC5L_TMEM63B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDC5L Q99459	TMEM63B Q5T3F8
DNA-binding protein involved in cell cycle control. Mayact as a transcription activator. Component of the PRP19-CDC5Lcomplex that forms an integral part of the spliceosome and isrequired for activating pre-mRNA splicing. The PRP19-CDC5L complexmay also play a role in the response to DNA damage (DDR).{ECO:0000269\|PubMed:10570151, ECO:0000269\|PubMed:11082045,ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:11544257,ECO:0000269\|PubMed:12927788, ECO:0000269\|PubMed:18583928,ECO:0000269\|PubMed:24332808, ECO:0000269\|PubMed:9038199,ECO:0000269\|PubMed:9468527, ECO:0000269\|PubMed:9632794}.	Acts as an osmosensitive calcium-permeable cationchannel. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for CDC5L_TMEM63B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CDC5L_TMEM63B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
CDC5L	TTF2, PLRG1, CDK2, SF3B1, SF3B2, SF3A1, SF3B4, SNRPD1, SNRPD2, SNRPD3, SNRPA, SRSF2, SRRM1, ILF2, SNRPA1, SRSF1, RBMX, SFPQ, TOP2A, PPM1D, PRKDC, PPP1CA, CWC15, PRPF19, RPL12, RPS16, RPS25, HSPA8, BZW1, DYNC1H1, GCN1L1, SCAF8, SFI1, RPL13, BCAS2, PMS1, ZNF35, PCBD2, ZSCAN1, SRRM2, CTNNBL1, TADA2A, SNW1, PRPF3, HDAC5, YWHAG, CALM1, KIF3C, MYT1L, SPTBN1, YWHAQ, KDM1A, HOOK1, MACF1, PDE4DIP, KALRN, TRAK1, SH3BP5, EXOC1, WWC1, TRIO, DST, GLTSCR1L, ZNF451, SYNE1, AKAP9, CCDC136, YWHAZ, SFR1, KIF5B, DIXDC1, PPFIA2, AKAP6, PPP1R13B, GSE1, EXOC7, KANSL1, DISC1, TRAF3IP1, HDGF, SF3A2, RNU1-1, RNU2-1, RNU4-1, RNU6-1, SNRNP200, PSMA2, HNRNPA1, CUL3, CUL1, CAND1, ATR, WRN, KIAA0907, CDC5L, U2AF2, USB1, EFTUD2, PRPF8, U2AF1, EIF4A3, SRSF5, DHX15, HNRNPR, SAP18, WDR18, TRA2A, UTP14A, ZC3H18, VTN, TPBG, RPS3, RPS11, SEPT7, SON, TRIM55, SUB1, HSPA1L, RPS4X, MDC1, PAXIP1, MAGOH, ORC1, MCM3, ORC2, MCM4, MCM10, MCM5, ORC5, CDKN2A, CDT1, CDKN1A, KRT18, EMID1, GRB14, LMO2, SMARCD1, TARDBP, RPA3, RPA2, RPA1, WWOX, TCP1, ERG, CSNK2A2, LIN28A, STAU1, FUS, GOLGA2, GOLGA8EP, GOLGA8F, CUL7, OBSL1, EED, DHX8, TSSC4, NMNAT1, EAPP, PPIE, WDR83, CCDC94, RBM4B, HNRNPM, LGALS3, NTRK1, DDX47, PDIA5, DHX9, EIF2S2, FTSJ3, ISY1-RAB43, ISY1, MRPL40, NOP2, RBM39, RPL39, RPL9, RPN1, SF3B3, SRP14, SRP72, SCARNA22, CDC25B, LOC102724594, CHERP, SF3A3, DDX42, HNRNPK, TRUB1, CSTF3, ELAVL1, XRN2, U2SURP, PRPF6, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPH1, HNRNPU, NONO, GEMIN4, PCBP1, SF3B6, CPSF3, EXOSC10, CPSF2, LUC7L, RBM4, SMN1, SMN2, SNRNP70, CPSF7, RBM17, HNRNPLL, SNRNP40, RBM7, USP39, NUDT21, SREK1, SNRPE, ILF3, PCBP2, PRCC, PTBP1, PTBP2, SRSF4, SRSF7, GEMIN6, PRPF4B, SART1, NOLC1, PTBP3, PSMC3, ACTB, SMC4, DNM1L, TUBB, ACTR2, RAD50, TRAP1, TUBA4A, PSMC6, DDX39A, CDK9, PAK4, TUBB4B, NDC80, TUBGCP3, DCTN2, CCT7, CCT4, CCT2, EXOC5, KHDRBS1, CCT8, NUDC, SEPT9, TUBGCP2, RUVBL2, SUGT1, EHD1, KIF2C, CHEK1, DDX19B, PSMC1, RBM45, COPA, COPB1, CSE1L, AP1B1, SPATA5, DFNA5, DIAPH1, DYNC1LI2, DNM2, DSP, FASN, LRWD1, FEN1, COPG1, RALY, CCT5, CNOT1, MDN1, SMCHD1, NCAPH, ORC6, ORC3, KIF4A, HSPA12A, INTS1, PHGDH, VPS33B, COPG2, ZNF638, FHOD1, RACGAP1, MSH6, PARVB, HDLBP, HELLS, EHD4, DNAJA1, HSPA5, HSPB1, HSP90AA1, HSP90AB1, HSPD1, ARCN1, KIF11, KPNB1, KPNA2, LIMS1, LMNA, MRE11A, MSH2, MYH9, NBN, DRG1, NSF, ORC4, UCHL5, DDX41, GULP1, RTCB, PFKM, PFKP, PLEC, PLK1, PNN, POLD1, ANLN, PPP2R1A, RIF1, FANCI, DDX19A, ABCF3, WDR33, CDKN2AIP, KIF21A, FERMT1, LRRC40, SCYL2, NSUN5, IPO9, ENAH, PARVA, EXOC2, PKN2, UNC45A, MAP2K7, RAD18, SMARCAD1, PSMC2, PSMC4, PSMC5, PSMD1, PSMD2, PSMD3, PSMD11, PSMD12, PSMD13, TWF1, SHROOM3, CHD8, RANBP2, RANGAP1, RBBP5, RBBP7, UPF1, RFC2, RFC3, RFC4, RFC5, EXOC4, ANAPC1, EPS8L2, FAM129B, INTS3, HLTF, SPTAN1, SRP54, SRP68, BUB1, BUB1B, TLN1, TMPO, HSP90B1, CCT3, TUBG1, UBE2N, VIM, AHNAK, DDX39B, CDC73, UBA5, MYO15B, SYMPK, SEH1L, CAPG, SMC1A, UBL4A, ARID1A, CAPZA1, PICALM, EPPK1, NUF2, MAD1L1, SMARCA5, API5, RUVBL1, CDC23, IQGAP1, CCNB1, HIP1R, UBE2M, BTAF1, CCT6A, SMC3, ARHGEF1, DEPDC7, ARHGEF2, BUB3, PDLIM7, TRIP13, ROCK2, CHD1L, NUP155, CKAP5, NCAPD2, OXSR1, CDC27, MVP, TUBA1B, WRNIP1, DDX5, UBE2D1, FAM120C, HUWE1, ACTR1A, AKAP8, SEC23A, MYBBP1A, DDX17, IPO7, SMC2, STAG2, BRD8, MORF4L1, COPS5, FAF1, MED12L, ARF5, RAVER1, EIF4A1, MAGEE2, PARP1, PARP4, CTNNA1, CTNND1, DDB1, DDX6, DTYMK, ECT2, EIF2D, EIF4A2, MARK2, ZBTB7C, ERCC1, FANCD2, CCZ1B, SUMO1, TPX2, SETX, EPB41L3, STAB1, MTCL1, CLASP1, USP24, BRD4, SCRIB, SKIV2L2, EDC4, NIPBL, GAPDH, TANC2, SENP3, ERAL1, INTS6, TUBGCP4, ARFIP1, UBE2S, GNAS, GNB3, GOLGB1, BRD7, TMOD3, CARD10, UBN1, ANAPC2, SNX12, NRG1, ANXA11, HSPA6, ITPK1, ARF4, TNPO1, IPO5, LMO7, MPP2, NF1, VPS36, SSUH2, DYNC1LI1, PCNT, ANAPC7, ZC3HC1, CCZ1, PELO, ERCC6L, ARGLU1, THAP1, NAT10, LRRC1, HAUS7, INTS8, RNF130, RNF17, YLPM1, CASC5, NUP107, XPO5, RBBP4, RNF2, BRD2, RXRB, BID, MAP2K4, SHC1, VPS33A, SMARCA2, SMARCA4, SMARCC2, SNX2, TRIM21, SUPV3L1, TNFAIP2, TOP1, TPR, UMPS, VPS51, YWHAE, DOCK5, TRMT1L, DOCK8, LAS1L, TLN2, STK24, TUBA1C, PPFIA1, IKBKAP, TNKS1BP1, USO1, GMPS, CDC16, PSTPIP2, MAP7, USP10, DDX21, AURKB, COPB2, LENG9, GTPBP1, SEC24C, CLINT1, NUP93, MELK, DDX46, CDC20, POU5F1, ZNF746, PPP4C, KIAA1143, SYF2, CD44, DVL3, ELAVL2, NCL, CYLD, CD2BP2, G3BP1, BRCA1	TMEM63B	ELAVL1, MAPK14, NRG1, LGALS8, SLC39A4, ATP1A1, ATP2A2, ATP2B1, ATP5A1, ATP5B, ATP5E, ATP5I, ATP6V1A, ATP6V1B2, ATP5O, CAV1, CD97, CLCN7, EMD, FLOT2, GNA11, GOLGA4, HMMR, TNPO1, LGALS3BP, LMNB1, PHB, ABCD3, RAF1, RPN1, SLC1A5, SOAT1, TAP1, TMPO, VDAC2, CXCR4, PABPN1, SLC7A5, OASL, ATP6V0D1, AIFM1, VAPA, ATP6V1G1, SCAMP3, FLOT1, DDX39A, ATP5H, ERLIN1, YME1L1, MAGED2, CKAP4, ERLIN2, PHB2, APOL2, MYOF, DERL2, SARAF, SLC38A2, TMCO1, SLC35F6, CHMP4B, PCID2, C20orf24, SRPRB, ENOPH1, VKORC1, TMEM109, SLC35E1, SGPP1, YIPF5, YIPF4, SLC38A5, ORMDL1, PRKCDBP, PTRF, RABL3, HLA-C, PCDHA3, IL17RB, MTUS2, SLC4A8, ATP2B2, TPRA1, MUC1, ATP6V0A2, PCDHGB4, PTGIR, GPR21, YIPF3, IPPK

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for CDC5L_TMEM63B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for CDC5L_TMEM63B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 6394

FusionGeneSummary for CDC5L_TMEM63B

FusionProtFeatures for CDC5L_TMEM63B

FusionGeneSequence for CDC5L_TMEM63B

FusionGenePPI for CDC5L_TMEM63B

RelatedDrugs for CDC5L_TMEM63B

RelatedDiseases for CDC5L_TMEM63B