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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6393

FusionGeneSummary for CDC5L_SPATS1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC5L_SPATS1
Fusion gene ID: 6393
HgeneTgene
Gene symbol

CDC5L

SPATS1

Gene ID

988

221409

Gene namecell division cycle 5 likespermatogenesis associated serine rich 1
SynonymsCDC5|CDC5-LIKE|CEF1|PCDC5RP|dJ319D22.1DDIP|SPATA8|SRSP1
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related proteinspermatogenesis-associated serine-rich protein 1
Modification date2018052220180519
UniProtAcc

Q99459

Q496A3

Ensembl transtripts involved in fusion geneENST00000371477, ENST00000323108, 
ENST00000288390, 
Fusion gene scores* DoF score9 X 5 X 6=2703 X 3 X 3=27
# samples 93
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDC5L [Title/Abstract] AND SPATS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC5L

GO:0000398

mRNA splicing, via spliceosome

28076346

HgeneCDC5L

GO:0045944

positive regulation of transcription by RNA polymerase II

11082045


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A12L-01ACDC5Lchr6

44387334

+SPATS1chr6

44344095

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371477ENST00000323108CDC5Lchr6

44387334

+SPATS1chr6

44344095

+
In-frameENST00000371477ENST00000288390CDC5Lchr6

44387334

+SPATS1chr6

44344095

+

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FusionProtFeatures for CDC5L_SPATS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC5L

Q99459

SPATS1

Q496A3

DNA-binding protein involved in cell cycle control. Mayact as a transcription activator. Component of the PRP19-CDC5Lcomplex that forms an integral part of the spliceosome and isrequired for activating pre-mRNA splicing. The PRP19-CDC5L complexmay also play a role in the response to DNA damage (DDR).{ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045,ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257,ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928,ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199,ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916142_245413803Coiled coilOntology_term=ECO:0000255
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+91631_54413803DNA bindingH-T-H motif
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+91682_104413803DNA bindingH-T-H motif
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+9161_56413803DomainHTH myb-type 1
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+91657_108413803DomainHTH myb-type 2
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916165_271413803MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916676_701413803Coiled coilOntology_term=ECO:0000255
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916764_802413803Coiled coilOntology_term=ECO:0000255
TgeneSPATS1chr6:44387334chr6:44344095ENST00000288390+5869_75252301Compositional biasNote=Poly-Ser
TgeneSPATS1chr6:44387334chr6:44344095ENST00000323108+6969_75252301Compositional biasNote=Poly-Ser


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FusionGeneSequence for CDC5L_SPATS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDC5L_SPATS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC5LTTF2, PLRG1, CDK2, SF3B1, SF3B2, SF3A1, SF3B4, SNRPD1, SNRPD2, SNRPD3, SNRPA, SRSF2, SRRM1, ILF2, SNRPA1, SRSF1, RBMX, SFPQ, TOP2A, PPM1D, PRKDC, PPP1CA, CWC15, PRPF19, RPL12, RPS16, RPS25, HSPA8, BZW1, DYNC1H1, GCN1L1, SCAF8, SFI1, RPL13, BCAS2, PMS1, ZNF35, PCBD2, ZSCAN1, SRRM2, CTNNBL1, TADA2A, SNW1, PRPF3, HDAC5, YWHAG, CALM1, KIF3C, MYT1L, SPTBN1, YWHAQ, KDM1A, HOOK1, MACF1, PDE4DIP, KALRN, TRAK1, SH3BP5, EXOC1, WWC1, TRIO, DST, GLTSCR1L, ZNF451, SYNE1, AKAP9, CCDC136, YWHAZ, SFR1, KIF5B, DIXDC1, PPFIA2, AKAP6, PPP1R13B, GSE1, EXOC7, KANSL1, DISC1, TRAF3IP1, HDGF, SF3A2, RNU1-1, RNU2-1, RNU4-1, RNU6-1, SNRNP200, PSMA2, HNRNPA1, CUL3, CUL1, CAND1, ATR, WRN, KIAA0907, CDC5L, U2AF2, USB1, EFTUD2, PRPF8, U2AF1, EIF4A3, SRSF5, DHX15, HNRNPR, SAP18, WDR18, TRA2A, UTP14A, ZC3H18, VTN, TPBG, RPS3, RPS11, SEPT7, SON, TRIM55, SUB1, HSPA1L, RPS4X, MDC1, PAXIP1, MAGOH, ORC1, MCM3, ORC2, MCM4, MCM10, MCM5, ORC5, CDKN2A, CDT1, CDKN1A, KRT18, EMID1, GRB14, LMO2, SMARCD1, TARDBP, RPA3, RPA2, RPA1, WWOX, TCP1, ERG, CSNK2A2, LIN28A, STAU1, FUS, GOLGA2, GOLGA8EP, GOLGA8F, CUL7, OBSL1, EED, DHX8, TSSC4, NMNAT1, EAPP, PPIE, WDR83, CCDC94, RBM4B, HNRNPM, LGALS3, NTRK1, DDX47, PDIA5, DHX9, EIF2S2, FTSJ3, ISY1-RAB43, ISY1, MRPL40, NOP2, RBM39, RPL39, RPL9, RPN1, SF3B3, SRP14, SRP72, SCARNA22, CDC25B, LOC102724594, CHERP, SF3A3, DDX42, HNRNPK, TRUB1, CSTF3, ELAVL1, XRN2, U2SURP, PRPF6, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPH1, HNRNPU, NONO, GEMIN4, PCBP1, SF3B6, CPSF3, EXOSC10, CPSF2, LUC7L, RBM4, SMN1, SMN2, SNRNP70, CPSF7, RBM17, HNRNPLL, SNRNP40, RBM7, USP39, NUDT21, SREK1, SNRPE, ILF3, PCBP2, PRCC, PTBP1, PTBP2, SRSF4, SRSF7, GEMIN6, PRPF4B, SART1, NOLC1, PTBP3, PSMC3, ACTB, SMC4, DNM1L, TUBB, ACTR2, RAD50, TRAP1, TUBA4A, PSMC6, DDX39A, CDK9, PAK4, TUBB4B, NDC80, TUBGCP3, DCTN2, CCT7, CCT4, CCT2, EXOC5, KHDRBS1, CCT8, NUDC, SEPT9, TUBGCP2, RUVBL2, SUGT1, EHD1, KIF2C, CHEK1, DDX19B, PSMC1, RBM45, COPA, COPB1, CSE1L, AP1B1, SPATA5, DFNA5, DIAPH1, DYNC1LI2, DNM2, DSP, FASN, LRWD1, FEN1, COPG1, RALY, CCT5, CNOT1, MDN1, SMCHD1, NCAPH, ORC6, ORC3, KIF4A, HSPA12A, INTS1, PHGDH, VPS33B, COPG2, ZNF638, FHOD1, RACGAP1, MSH6, PARVB, HDLBP, HELLS, EHD4, DNAJA1, HSPA5, HSPB1, HSP90AA1, HSP90AB1, HSPD1, ARCN1, KIF11, KPNB1, KPNA2, LIMS1, LMNA, MRE11A, MSH2, MYH9, NBN, DRG1, NSF, ORC4, UCHL5, DDX41, GULP1, RTCB, PFKM, PFKP, PLEC, PLK1, PNN, POLD1, ANLN, PPP2R1A, RIF1, FANCI, DDX19A, ABCF3, WDR33, CDKN2AIP, KIF21A, FERMT1, LRRC40, SCYL2, NSUN5, IPO9, ENAH, PARVA, EXOC2, PKN2, UNC45A, MAP2K7, RAD18, SMARCAD1, PSMC2, PSMC4, PSMC5, PSMD1, PSMD2, PSMD3, PSMD11, PSMD12, PSMD13, TWF1, SHROOM3, CHD8, RANBP2, RANGAP1, RBBP5, RBBP7, UPF1, RFC2, RFC3, RFC4, RFC5, EXOC4, ANAPC1, EPS8L2, FAM129B, INTS3, HLTF, SPTAN1, SRP54, SRP68, BUB1, BUB1B, TLN1, TMPO, HSP90B1, CCT3, TUBG1, UBE2N, VIM, AHNAK, DDX39B, CDC73, UBA5, MYO15B, SYMPK, SEH1L, CAPG, SMC1A, UBL4A, ARID1A, CAPZA1, PICALM, EPPK1, NUF2, MAD1L1, SMARCA5, API5, RUVBL1, CDC23, IQGAP1, CCNB1, HIP1R, UBE2M, BTAF1, CCT6A, SMC3, ARHGEF1, DEPDC7, ARHGEF2, BUB3, PDLIM7, TRIP13, ROCK2, CHD1L, NUP155, CKAP5, NCAPD2, OXSR1, CDC27, MVP, TUBA1B, WRNIP1, DDX5, UBE2D1, FAM120C, HUWE1, ACTR1A, AKAP8, SEC23A, MYBBP1A, DDX17, IPO7, SMC2, STAG2, BRD8, MORF4L1, COPS5, FAF1, MED12L, ARF5, RAVER1, EIF4A1, MAGEE2, PARP1, PARP4, CTNNA1, CTNND1, DDB1, DDX6, DTYMK, ECT2, EIF2D, EIF4A2, MARK2, ZBTB7C, ERCC1, FANCD2, CCZ1B, SUMO1, TPX2, SETX, EPB41L3, STAB1, MTCL1, CLASP1, USP24, BRD4, SCRIB, SKIV2L2, EDC4, NIPBL, GAPDH, TANC2, SENP3, ERAL1, INTS6, TUBGCP4, ARFIP1, UBE2S, GNAS, GNB3, GOLGB1, BRD7, TMOD3, CARD10, UBN1, ANAPC2, SNX12, NRG1, ANXA11, HSPA6, ITPK1, ARF4, TNPO1, IPO5, LMO7, MPP2, NF1, VPS36, SSUH2, DYNC1LI1, PCNT, ANAPC7, ZC3HC1, CCZ1, PELO, ERCC6L, ARGLU1, THAP1, NAT10, LRRC1, HAUS7, INTS8, RNF130, RNF17, YLPM1, CASC5, NUP107, XPO5, RBBP4, RNF2, BRD2, RXRB, BID, MAP2K4, SHC1, VPS33A, SMARCA2, SMARCA4, SMARCC2, SNX2, TRIM21, SUPV3L1, TNFAIP2, TOP1, TPR, UMPS, VPS51, YWHAE, DOCK5, TRMT1L, DOCK8, LAS1L, TLN2, STK24, TUBA1C, PPFIA1, IKBKAP, TNKS1BP1, USO1, GMPS, CDC16, PSTPIP2, MAP7, USP10, DDX21, AURKB, COPB2, LENG9, GTPBP1, SEC24C, CLINT1, NUP93, MELK, DDX46, CDC20, POU5F1, ZNF746, PPP4C, KIAA1143, SYF2, CD44, DVL3, ELAVL2, NCL, CYLD, CD2BP2, G3BP1, BRCA1SPATS1SPG7, CFLAR, GPHN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916501_659413803DAPK3
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916706_800413803PLRG1
HgeneCDC5Lchr6:44387334chr6:44344095ENST00000371477+916260_606413803PPP1R8


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC5L_SPATS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC5L_SPATS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource