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Fusion gene ID: 6360 |
FusionGeneSummary for CDC42BPB_SYNJ2BP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDC42BPB_SYNJ2BP | Fusion gene ID: 6360 | Hgene | Tgene | Gene symbol | CDC42BPB | SYNJ2BP | Gene ID | 9578 | 55333 |
| Gene name | CDC42 binding protein kinase beta | synaptojanin 2 binding protein | |
| Synonyms | MRCKB | ARIP2|OMP25 | |
| Cytomap | 14q32.32 | 14q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase MRCK betaCDC42 binding protein kinase beta (DMPK-like)CDC42BP-betaDMPK-like betaMRCK betamyotonic dystrophy kinase-related CDC42-binding kinase betamyotonic dystrophy protein kinase-like beta | synaptojanin-2-binding proteinactivin receptor interacting protein 5mitochondrial outer membrane protein 25 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9Y5S2 | P57105 | |
| Ensembl transtripts involved in fusion gene | ENST00000361246, | ENST00000256366, ENST00000554216, | |
| Fusion gene scores | * DoF score | 7 X 6 X 7=294 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CDC42BPB [Title/Abstract] AND SYNJ2BP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDC42BPB | GO:0006468 | protein phosphorylation | 21949762 |
| Tgene | SYNJ2BP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 24025447 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-04-1365-01A | CDC42BPB | chr14 | 103414058 | - | SYNJ2BP | chr14 | 70842488 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361246 | ENST00000256366 | CDC42BPB | chr14 | 103414058 | - | SYNJ2BP | chr14 | 70842488 | - |
| 5CDS-5UTR | ENST00000361246 | ENST00000554216 | CDC42BPB | chr14 | 103414058 | - | SYNJ2BP | chr14 | 70842488 | - |
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FusionProtFeatures for CDC42BPB_SYNJ2BP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDC42BPB | SYNJ2BP |
| Serine/threonine-protein kinase which is an importantdownstream effector of CDC42 and plays a role in the regulation ofcytoskeleton reorganization and cell migration. Regulates actincytoskeletal reorganization via phosphorylation of PPP1R12C andMYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert withMYO18A and LURAP1, is involved in modulating lamellar actomyosinretrograde flow that is crucial to cell protrusion and migration(PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). Inconcert with FAM89B/LRAP25 mediates the targeting of LIMK1 to thelamellipodium resulting in its activation and subsequentphosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50,ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715,ECO:0000269|PubMed:21949762}. | Regulates endocytosis of activin type 2 receptor kinasesthrough the Ral/RALBP1-dependent pathway and may be involved insuppression of activin-induced signal transduction.{ECO:0000250|UniProtKB:Q9D6K5}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 431_815 | 1177 | 1712 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 878_939 | 1177 | 1712 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 343_413 | 1177 | 1712 | Domain | Note=AGC-kinase C-terminal |
| Hgene | CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 76_342 | 1177 | 1712 | Domain | Protein kinase |
| Hgene | CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 82_90 | 1177 | 1712 | Nucleotide binding | ATP |
| Hgene | CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 1025_1075 | 1177 | 1712 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | >SYNJ2BP | chr14:103414058 | chr14:70842488 | ENST00000256366 | - | 1 | 4 | 139_145 | 67 | 146 | Topological domain | Mitochondrial intermembrane |
| Tgene | >SYNJ2BP | chr14:103414058 | chr14:70842488 | ENST00000256366 | - | 1 | 4 | 118_138 | 67 | 146 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 1095_1214 | 1177 | 1712 | Domain | PH |
| Hgene | >CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 1240_1513 | 1177 | 1712 | Domain | CNH |
| Hgene | >CDC42BPB | chr14:103414058 | chr14:70842488 | ENST00000361246 | - | 27 | 37 | 1583_1596 | 1177 | 1712 | Domain | CRIB |
| Tgene | SYNJ2BP | chr14:103414058 | chr14:70842488 | ENST00000256366 | - | 1 | 4 | 13_100 | 67 | 146 | Domain | PDZ |
| Tgene | SYNJ2BP | chr14:103414058 | chr14:70842488 | ENST00000256366 | - | 1 | 4 | 1_117 | 67 | 146 | Topological domain | Cytoplasmic |
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FusionGeneSequence for CDC42BPB_SYNJ2BP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDC42BPB_ENST00000361246_chr14_103414058_-_SYNJ2BP_ENST00000256366_chr14_70842488_-_1256aa MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEV AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVC MYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPD VSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRL EQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELE AQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVH DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKES VAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMSVA ASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPE QSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDC42BPB_ENST00000361246_chr14_103414058_-_SYNJ2BP_ENST00000256366_chr14_70842488_-_3768nt ATGTCGGCCAAGGTGCGGCTCAAGAAGCTGGAGCAGCTGCTCCTGGACGGGCCCTGGCGCAACGAGAGCGCCCTGAGCGTGGAAACGCTG CTCGACGTGCTCGTCTGCCTGTACACCGAGTGCAGCCACTCGGCCCTGCGCCGCGACAAGTACGTGGCCGAGTTCCTCGAGTGGGCTAAA CCATTTACACAGCTGGTGAAAGAAATGCAGCTTCATCGAGAAGACTTTGAAATAATTAAAGTAATTGGAAGAGGTGCTTTTGGTGAGGTT GCTGTTGTCAAAATGAAGAATACTGAACGAATTTATGCAATGAAAATCCTCAACAAGTGGGAGATGCTGAAAAGAGCAGAGACCGCGTGC TTCCGAGAGGAGCGCGATGTGCTGGTGAACGGCGACTGCCAGTGGATCACCGCGCTGCACTACGCCTTTCAGGACGAGAACCACCTGTAC TTAGTCATGGATTACTATGTGGGTGGTGATTTACTGACCCTGCTCAGCAAATTTGAAGACAAGCTTCCGGAAGATATGGCGAGGTTCTAC ATTGGTGAAATGGTGCTGGCCATTGACTCCATCCATCAGCTTCATTACGTGCACAGAGACATTAAACCTGACAATGTCCTTTTGGACGTG AATGGTCATATCCGCCTGGCTGACTTTGGATCATGTTTGAAGATGAATGATGATGGCACTGTGCAGTCCTCCGTGGCCGTGGGCACACCT GACTACATCTCGCCGGAGATCCTGCAGGCGATGGAGGACGGCATGGGCAAATACGGGCCTGAGTGTGACTGGTGGTCTCTGGGTGTCTGC ATGTATGAGATGCTCTATGGAGAAACGCCGTTTTATGCGGAGTCACTCGTGGAGACCTATGGGAAGATCATGAACCATGAAGAGCGATTC CAGTTCCCATCCCATGTCACGGATGTATCTGAAGAAGCGAAGGACCTCATCCAGAGACTGATCTGCAGTAGAGAACGCCGGCTGGGGCAG AATGGAATAGAGGATTTCAAAAAGCATGCGTTTTTTGAAGGTCTAAATTGGGAAAATATACGAAACCTAGAAGCACCTTATATTCCTGAT GTGAGCAGTCCCTCTGACACATCCAACTTCGACGTGGATGACGACGTGCTGAGAAACACGGAAATATTACCTCCTGGTTCTCACACAGGC TTTTCTGGATTACATTTGCCATTCATTGGTTTTACATTCACAACGGAAAGCTGTTTTTCTGATCGAGGCTCTCTGAAGAGCATAATGCAG TCCAACACATTAACCAAAGATGAGGATGTGCAGCGGGACCTGGAGCACAGCCTGCAGATGGAAGCTTACGAGAGGAGGATTCGGAGGCTG GAACAGGAGAAGCTGGAGCTGAGCAGGAAGCTGCAAGAGTCCACCCAGACCGTGCAGTCCCTCCACGGCTCATCTCGGGCCCTCAGCAAT TCAAACCGAGATAAAGAAATCAAAAAGCTAAATGAAGAAATCGAACGCTTGAAGAATAAAATAGCAGATTCAAACAGGCTCGAGCGACAG CTTGAGGACACAGTGGCGCTTCGCCAAGAGCGTGAGGACTCCACGCAGCGGCTGCGGGGGCTGGAGAAGCAGCACCGCGTGGTCCGGCAG GAGAAGGAGGAGCTGCACAAGCAACTGGTTGAAGCCTCAGAGCGGTTGAAATCCCAGGCCAAGGAACTCAAAGATGCCCATCAGCAGCGA AAGCTGGCCCTGCAGGAGTTCTCGGAGCTGAACGAGCGCATGGCAGAGCTCCGTGCCCAGAAGCAGAAGGTGTCCCGGCAGCTGCGAGAC AAGGAGGAGGAGATGGAGGTGGCCACGCAGAAGGTGGACGCCATGCGGCAGGAAATGCGGAGAGCTGAGAAGCTCAGGAAAGAGCTGGAA GCTCAGCTTGATGATGCTGTTGCTGAGGCCTCCAAGGAGCGCAAGCTTCGTGAGCACAGCGAGAACTTCTGCAAGCAAATGGAAAGCGAG CTGGAGGCCCTCAAGGTGAAGCAAGGAGGCCGGGGAGCGGGTGCCACCTTAGAGCACCAGCAAGAGATTTCCAAAATCAAATCCGAGCTG GAGAAGAAAGTCTTATTTTATGAAGAGGAATTGGTCAGACGTGAGGCCTCCCATGTGCTAGAAGTGAAAAATGTGAAGAAGGAGGTGCAT GATTCAGAAAGCCACCAGCTGGCCCTGCAGAAAGAAATCTTGATGTTAAAAGATAAGTTAGAAAAGTCAAAGCGAGAACGGCATAACGAG ATGGAGGAGGCAGTAGGTACAATAAAAGATAAATACGAACGAGAAAGAGCGATGCTGTTTGATGAAAACAAGAAGCTAACTGCTGAAAAT GAAAAGCTCTGTTCCTTTGTGGATAAACTCACAGCTCAAAATAGACAGCTGGAGGATGAGCTGCAGGATCTGGCAGCCAAGAAGGAGTCA GTGGCCCACTGGGAAGCTCAGATTGCGGAAATCATTCAGTGGGTCAGTGACGAGAAAGATGCCCGGGGTTACCTTCAAGCTCTTGCTTCC AAGATGACCGAAGAGCTCGAGGCTTTGAGGAGTTCTAGTCTGGGGTCAAGAACACTGGACCCGCTGTGGAAGGTGCGCCGCAGCCAGAAG CTGGACATGTCCGCGCGGCTGGAGCTGCAGTCGGCCCTGGAGGCGGAGATCCGGGCCAAGCAGCTTGTCCAGGAGGAGCTCAGGAAGGTC AAGGACGCCAACCTCACCTTGGAAAGCAAACTAAAGGATTCCGAAGCCAAAAACAGAGAATTATTAGAAGAAATGGAAATTTTGAAGAAA AAGATGGAAGAAAAATTCAGAGCAGATACTGGGCTCAAACTTCCAGATTTTCAGGATTCCATTTTTGAGTATTTCAACACTGCTCCTCTT GCACATGACCTGACATTTAGAACCAGCTCAGCTAGTGAGCAAGAAACACAAGCTCCGAAGCCAGAAGCGTCCCCGTCGATGTCTGTGGCT GCATCAGAGCAGCAGGAGGACATGGCTCGGCCCCCGCAGAGGCCATCCGCTGTGCCGTTGCCCACCACGCAGGCCCTGGCTCTGGCTGGA CCGAAGCCAAAAGCTCACCAGTTCAGCATCAAGTCCTTCTCCAGCCCTACTCAGTGCAGCCACTGCACCTCCCTGATGGTTGGGCTGATC CGGCAGGGCTACGCCTGCGAGGTGTGTTCCTTTGCTTGCCACGTGTCCTGCAAAGACGGTGCCCCCCAGGTGTGCCCAATACCTCCCGAG CAGTCCAAGAGGCCTCTGGGCGTGGACGTGCAGCGAGGCATCGGAACAGCCTACAAAGGCCATGTCAAGGTCCCAAAGCCCACGGGGGTG AAGAAGGGATGGCAGCGCGCATATGCAGTCGTCTGTGACTGCAAGCTCTTCCTGTATGATCTGCCTGAAGGAAAATCCACCCAGCCTGGT GTCATTGCGAGCCAAGTCTTGGATCTCAGAGATGACGAGTTTTCCGTGAGCTCAGTCCTGGCCTCAGATGTCATTCATGCTACACGCCGA GATATTCCATGTATATTCAGGGTAAATGGCCAAGACCTAAAGAACCTGCTGCACCAGGATGCTGTAGACCTCTTTCGTAATGCAGGCTAT GCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGCAGAATGGACCTATAGGACATCGAGGTGAAGGGGACCCAAGTGGTATTCCCATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDC42BPB_ENST00000361246_chr14_103414058_-_SYNJ2BP_ENST00000256366_chr14_70842488_-_5617nt GGGCGGGGCTGAGGGCGGCGGGGGCGGGCCGCCCGAGCTGGGAGGGCGGCGGCGCCGAGGGGAGGAGAGCGGCCCATGGACCCGCGGGGC CCGGCGCCCCAGACTCTGCGCCGTCGGGACGGAGCCCAAGATGTCGGCCTAGGCCGGGGCGCGACGACGCGGACGGGGCGGCGAGGAGGC GCCGCTGCTGCCGGGGCTCGCAGCCGCCGAGCCCCCGAGGGCGCGCCCTGACGGACTGGCCGAGCCGGCGGTGAGAGGCCGGCGCGTCGG GAGCGGGCCGCGCGGCACCATGTCGGCCAAGGTGCGGCTCAAGAAGCTGGAGCAGCTGCTCCTGGACGGGCCCTGGCGCAACGAGAGCGC CCTGAGCGTGGAAACGCTGCTCGACGTGCTCGTCTGCCTGTACACCGAGTGCAGCCACTCGGCCCTGCGCCGCGACAAGTACGTGGCCGA GTTCCTCGAGTGGGCTAAACCATTTACACAGCTGGTGAAAGAAATGCAGCTTCATCGAGAAGACTTTGAAATAATTAAAGTAATTGGAAG AGGTGCTTTTGGTGAGGTTGCTGTTGTCAAAATGAAGAATACTGAACGAATTTATGCAATGAAAATCCTCAACAAGTGGGAGATGCTGAA AAGAGCAGAGACCGCGTGCTTCCGAGAGGAGCGCGATGTGCTGGTGAACGGCGACTGCCAGTGGATCACCGCGCTGCACTACGCCTTTCA GGACGAGAACCACCTGTACTTAGTCATGGATTACTATGTGGGTGGTGATTTACTGACCCTGCTCAGCAAATTTGAAGACAAGCTTCCGGA AGATATGGCGAGGTTCTACATTGGTGAAATGGTGCTGGCCATTGACTCCATCCATCAGCTTCATTACGTGCACAGAGACATTAAACCTGA CAATGTCCTTTTGGACGTGAATGGTCATATCCGCCTGGCTGACTTTGGATCATGTTTGAAGATGAATGATGATGGCACTGTGCAGTCCTC CGTGGCCGTGGGCACACCTGACTACATCTCGCCGGAGATCCTGCAGGCGATGGAGGACGGCATGGGCAAATACGGGCCTGAGTGTGACTG GTGGTCTCTGGGTGTCTGCATGTATGAGATGCTCTATGGAGAAACGCCGTTTTATGCGGAGTCACTCGTGGAGACCTATGGGAAGATCAT GAACCATGAAGAGCGATTCCAGTTCCCATCCCATGTCACGGATGTATCTGAAGAAGCGAAGGACCTCATCCAGAGACTGATCTGCAGTAG AGAACGCCGGCTGGGGCAGAATGGAATAGAGGATTTCAAAAAGCATGCGTTTTTTGAAGGTCTAAATTGGGAAAATATACGAAACCTAGA AGCACCTTATATTCCTGATGTGAGCAGTCCCTCTGACACATCCAACTTCGACGTGGATGACGACGTGCTGAGAAACACGGAAATATTACC TCCTGGTTCTCACACAGGCTTTTCTGGATTACATTTGCCATTCATTGGTTTTACATTCACAACGGAAAGCTGTTTTTCTGATCGAGGCTC TCTGAAGAGCATAATGCAGTCCAACACATTAACCAAAGATGAGGATGTGCAGCGGGACCTGGAGCACAGCCTGCAGATGGAAGCTTACGA GAGGAGGATTCGGAGGCTGGAACAGGAGAAGCTGGAGCTGAGCAGGAAGCTGCAAGAGTCCACCCAGACCGTGCAGTCCCTCCACGGCTC ATCTCGGGCCCTCAGCAATTCAAACCGAGATAAAGAAATCAAAAAGCTAAATGAAGAAATCGAACGCTTGAAGAATAAAATAGCAGATTC AAACAGGCTCGAGCGACAGCTTGAGGACACAGTGGCGCTTCGCCAAGAGCGTGAGGACTCCACGCAGCGGCTGCGGGGGCTGGAGAAGCA GCACCGCGTGGTCCGGCAGGAGAAGGAGGAGCTGCACAAGCAACTGGTTGAAGCCTCAGAGCGGTTGAAATCCCAGGCCAAGGAACTCAA AGATGCCCATCAGCAGCGAAAGCTGGCCCTGCAGGAGTTCTCGGAGCTGAACGAGCGCATGGCAGAGCTCCGTGCCCAGAAGCAGAAGGT GTCCCGGCAGCTGCGAGACAAGGAGGAGGAGATGGAGGTGGCCACGCAGAAGGTGGACGCCATGCGGCAGGAAATGCGGAGAGCTGAGAA GCTCAGGAAAGAGCTGGAAGCTCAGCTTGATGATGCTGTTGCTGAGGCCTCCAAGGAGCGCAAGCTTCGTGAGCACAGCGAGAACTTCTG CAAGCAAATGGAAAGCGAGCTGGAGGCCCTCAAGGTGAAGCAAGGAGGCCGGGGAGCGGGTGCCACCTTAGAGCACCAGCAAGAGATTTC CAAAATCAAATCCGAGCTGGAGAAGAAAGTCTTATTTTATGAAGAGGAATTGGTCAGACGTGAGGCCTCCCATGTGCTAGAAGTGAAAAA TGTGAAGAAGGAGGTGCATGATTCAGAAAGCCACCAGCTGGCCCTGCAGAAAGAAATCTTGATGTTAAAAGATAAGTTAGAAAAGTCAAA GCGAGAACGGCATAACGAGATGGAGGAGGCAGTAGGTACAATAAAAGATAAATACGAACGAGAAAGAGCGATGCTGTTTGATGAAAACAA GAAGCTAACTGCTGAAAATGAAAAGCTCTGTTCCTTTGTGGATAAACTCACAGCTCAAAATAGACAGCTGGAGGATGAGCTGCAGGATCT GGCAGCCAAGAAGGAGTCAGTGGCCCACTGGGAAGCTCAGATTGCGGAAATCATTCAGTGGGTCAGTGACGAGAAAGATGCCCGGGGTTA CCTTCAAGCTCTTGCTTCCAAGATGACCGAAGAGCTCGAGGCTTTGAGGAGTTCTAGTCTGGGGTCAAGAACACTGGACCCGCTGTGGAA GGTGCGCCGCAGCCAGAAGCTGGACATGTCCGCGCGGCTGGAGCTGCAGTCGGCCCTGGAGGCGGAGATCCGGGCCAAGCAGCTTGTCCA GGAGGAGCTCAGGAAGGTCAAGGACGCCAACCTCACCTTGGAAAGCAAACTAAAGGATTCCGAAGCCAAAAACAGAGAATTATTAGAAGA AATGGAAATTTTGAAGAAAAAGATGGAAGAAAAATTCAGAGCAGATACTGGGCTCAAACTTCCAGATTTTCAGGATTCCATTTTTGAGTA TTTCAACACTGCTCCTCTTGCACATGACCTGACATTTAGAACCAGCTCAGCTAGTGAGCAAGAAACACAAGCTCCGAAGCCAGAAGCGTC CCCGTCGATGTCTGTGGCTGCATCAGAGCAGCAGGAGGACATGGCTCGGCCCCCGCAGAGGCCATCCGCTGTGCCGTTGCCCACCACGCA GGCCCTGGCTCTGGCTGGACCGAAGCCAAAAGCTCACCAGTTCAGCATCAAGTCCTTCTCCAGCCCTACTCAGTGCAGCCACTGCACCTC CCTGATGGTTGGGCTGATCCGGCAGGGCTACGCCTGCGAGGTGTGTTCCTTTGCTTGCCACGTGTCCTGCAAAGACGGTGCCCCCCAGGT GTGCCCAATACCTCCCGAGCAGTCCAAGAGGCCTCTGGGCGTGGACGTGCAGCGAGGCATCGGAACAGCCTACAAAGGCCATGTCAAGGT CCCAAAGCCCACGGGGGTGAAGAAGGGATGGCAGCGCGCATATGCAGTCGTCTGTGACTGCAAGCTCTTCCTGTATGATCTGCCTGAAGG AAAATCCACCCAGCCTGGTGTCATTGCGAGCCAAGTCTTGGATCTCAGAGATGACGAGTTTTCCGTGAGCTCAGTCCTGGCCTCAGATGT CATTCATGCTACACGCCGAGATATTCCATGTATATTCAGGGTAAATGGCCAAGACCTAAAGAACCTGCTGCACCAGGATGCTGTAGACCT CTTTCGTAATGCAGGCTATGCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGCAGAATGGACCTATAGGACATCGAGGTGAAGGGGA CCCAAGTGGTATTCCCATATTTATGGTGCTGGTGCCAGTGTTTGCCCTCACCATGGTAGCAGCCTGGGCTTTCATGAGATACCGGCAACA ACTTTGAAAAACTTGCTCTCTTTCAATACTCCCAATGAAGATACATTTCACTCACCCTCCACCCCTGCTATTCTGCCATGTCTTTCCCTC TCTCTGCATAGCCAGATTTGAAGTGACTGATACCCACCCCAAACCTTGCTGTTCACAGTCTCCAATTCTTCATATTCTAATGGGAAAGTA AAGGTATTGTTTGAAGGAAAACTGAAGAAAAGACTTGGCTTAGAACAAATGAGGAGTTATATATTTTACTAGGACTTTTGATAGAAATTC AGCTACAACCCAAAGAGAGAAAGATTGAGTCTTCCTGTCACCATAGGCAATACCTTTTTTCTTAGCTGGCATGCCATAAAGGCCAGCTAT GTGATATTAGAGGAAGAAAGGATTTTTCTTTTTAATGATCTTCCTTGGGAAATTATTGTGGCCTTTATTTAATTTCTAACTACGTACCTG GGTGCCTATATCGACAAAGAGTGAGAAGAGCATTTTTACTTTTTTAAAAAAGCAAATACATATATACACATACGTATGCAAATATTATAG TATAATAGTGATCCCTATGGAGAATTAAAGGTGAGAAAGCTACTTTGTGGTGTCTAGGTTTCTGATAAAAGGGATGATCTTAACTGAAGA ATTTAAAGAGATACTTAAACAGAGCAAATGTAGTAGGAACAAGGGAGTGAGCCTTATAAGAGGACGTTCAGTCTCATTTATTAAAATAAT AACTGAGACTGGGAGAGGTGGCTCATGCCTGTAAATCCCAGCACTTTGGTAGCCTGAAGTGGGAGATTGCTTGAGTCCAGGAGACCAGCC TGGGCAACATAGCAAAACCTCATCTCTATTTAAAAAAAAAATAGAAAAAAATGTAATAACTGAAGCAACTAATTAAAAATCTTAGAAGAA CAATATTTATTCTTATAACAGCCAACTATGGTGAGTTATTATAAGGTAAATTGCCATAATCCAGCGCTGCTCACATCTAAAAAACTTTGA GGTGTAAAGGTAAATCGTACCAATCTCTGGGCTGCCCTAGTGACTTTTTTGATACCTCAGAGTCCTATTGAAGAACCAGGTGGAATGATT GTGGTAAGGGCTATAGTGCTGGAGCCAAACACCCCAGCAAGAAAACTCTAAAAGGACAAAAGATAAGGTAGTGCCTCCAAGGTGGCACCT GAACCCTCTCAGGCTACTTTTTGGTTTCTACTAACAAACCTGAGGGAAGGAACTGCCTCCCTGGCAGGATGGGCATCAAATCAACTCTGG CTTCAGATTTAGTTAAAATGAGGCCGGGTGCAGCGGCTCACACCTGTCATCTCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACAAGGT CAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTGAAAATACAAAAATTACCTGGACATGGTGGCGCGTTCCTGT AATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAACTGTTTGAACCAGGACCTGGGAGACGGAGGTTGCAGTGAGCCAAGATCACGCCACT |
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FusionGenePPI for CDC42BPB_SYNJ2BP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDC42BPB | RPL3, DCD, BRIX1, MAP2K5, RIPK1, CDC42, SP1, LGR4, FAM212B, LURAP1L, UBXN2B, ORC2, NTRK1, RXRB, MYO18A, CDKN3, PTPRG, MTMR7, FAM167A, GRPR, PRKCZ, PPM1A | SYNJ2BP | ACVR2A, LRP2, LRP1, LRP8, SYNJ2, ACVR2B, RALBP1, APP, ICT1, MRPL45, ZMPSTE24, MGAT4B, ABCD3, CD55, NT5E, SEL1L, ABCC2, MRPL44, ADRB2, USHBP1, ESYT1, AKAP14, COQ9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC42BPB_SYNJ2BP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC42BPB_SYNJ2BP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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