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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 6342

FusionGeneSummary for CDC37_KMT2C

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC37_KMT2C
Fusion gene ID: 6342
HgeneTgene
Gene symbol

CDC37

KMT2C

Gene ID

11140

58508

Gene namecell division cycle 37lysine methyltransferase 2C
SynonymsP50CDC37HALR|KLEFS2|MLL3
Cytomap

19p13.2

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionhsp90 co-chaperone Cdc37CDC37 (cell division cycle 37, S. cerevisiae, homolog)CDC37 cell division cycle 37 homologcell division cycle 37 homologhsp90 chaperone protein kinase-targeting subunithistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage le
Modification date2018052320180523
UniProtAcc

Q16543

Q8NEZ4

Ensembl transtripts involved in fusion geneENST00000222005, ENST00000262189, 
ENST00000355193, ENST00000485655, 
ENST00000485241, 
Fusion gene scores* DoF score5 X 4 X 3=609 X 13 X 6=702
# samples 615
** MAII scorelog2(6/60*10)=0log2(15/702*10)=-2.22650852980868
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDC37 [Title/Abstract] AND KMT2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-67-6217-01ACDC37chr19

10514054

-KMT2Cchr7

151836876

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000222005ENST00000262189CDC37chr19

10514054

-KMT2Cchr7

151836876

-
In-frameENST00000222005ENST00000355193CDC37chr19

10514054

-KMT2Cchr7

151836876

-
5CDS-5UTRENST00000222005ENST00000485655CDC37chr19

10514054

-KMT2Cchr7

151836876

-
5CDS-intronENST00000222005ENST00000485241CDC37chr19

10514054

-KMT2Cchr7

151836876

-

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FusionProtFeatures for CDC37_KMT2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC37

Q16543

KMT2C

Q8NEZ4

Co-chaperone that binds to numerous kinases and promotestheir interaction with the Hsp90 complex, resulting instabilization and promotion of their activity (PubMed:8666233).Inhibits HSP90AA1 ATPase activity (PubMed:23569206).{ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. Histone methyltransferase. Methylates 'Lys-4' of histoneH3. H3 'Lys-4' methylation represents a specific tag forepigenetic transcriptional activation. Central component of theMLL2/3 complex, a coactivator complex of nuclear receptors,involved in transcriptional coactivation. KMT2C/MLL3 may be acatalytic subunit of this complex. May be involved inleukemogenesis and developmental disorder.{ECO:0000269|PubMed:17500065}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594895_491147814912DomainPost-SET
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604895_491148384969DomainPost-SET
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594848_484947814912RegionS-adenosyl-L-methionine binding
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604848_484948384969RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54591338_136647814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54591754_178747814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54593054_308147814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54593173_327247814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54593391_343347814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459644_67247814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-545992_11247814912Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55601338_136648384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55601754_178748384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55603054_308148384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55603173_327248384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55603391_343348384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560644_67248384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-556092_11248384969Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54591719_179647814912Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54591834_228147814912Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54592412_263047814912Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54592690_278647814912Compositional biasNote=Asp-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54593012_350947814912Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54593277_338147814912Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55601719_179648384969Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55601834_228148384969Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55602412_263048384969Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55602690_278648384969Compositional biasNote=Asp-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55603012_350948384969Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55603277_338148384969Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-545934_4647814912DNA bindingNote=A.T hook
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-556034_4648384969DNA bindingNote=A.T hook
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459436_48947814912DomainDHHC
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594545_460547814912DomainFYR N-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594606_469147814912DomainFYR C-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594771_488747814912DomainSET
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560436_48948384969DomainDHHC
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604545_460548384969DomainFYR N-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604606_469148384969DomainFYR C-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604771_488748384969DomainSET
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54591007_105747814912Zinc fingerPHD-type 6
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54591084_113947814912Zinc fingerPHD-type 7
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459227_26247814912Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459283_33147814912Zinc fingerPHD-type 1
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459341_39147814912Zinc fingerPHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459344_38947814912Zinc fingerRING-type
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459388_43847814912Zinc fingerPHD-type 3
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594399_443947814912Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-54594460_450747814912Zinc fingerPHD-type 8
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459464_52047814912Zinc fingerPHD-type 4
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189-5459957_101047814912Zinc fingerPHD-type 5
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55601007_105748384969Zinc fingerPHD-type 6
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55601084_113948384969Zinc fingerPHD-type 7
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560227_26248384969Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560283_33148384969Zinc fingerPHD-type 1
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560341_39148384969Zinc fingerPHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560344_38948384969Zinc fingerRING-type
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560388_43848384969Zinc fingerPHD-type 3
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604399_443948384969Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-55604460_450748384969Zinc fingerPHD-type 8
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560464_52048384969Zinc fingerPHD-type 4
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193-5560957_101048384969Zinc fingerPHD-type 5


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FusionGeneSequence for CDC37_KMT2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000262189_chr7_151836876_-_165aa
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDA

>In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000355193_chr7_151836876_-_165aa
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000262189_chr7_151836876_-_495nt
ATGGTGGACTACAGCGTGTGGGACCACATTGAGGTGTCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGC
TGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGAGACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAAC
GAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCTCAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCG
ACGCTCACAGGAGGGCCCGCAAGGTATATCAACCATTCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAA
ATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGAGAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATT

>In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000355193_chr7_151836876_-_495nt
ATGGTGGACTACAGCGTGTGGGACCACATTGAGGTGTCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGC
TGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGAGACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAAC
GAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCTCAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCG
ACGCTCACAGGAGGGCCCGCAAGGTATATCAACCATTCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAA
ATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGAGAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000262189_chr7_151836876_-_2456nt
TGCTGCCGCCGTCGCCGCCACCCGAGCCGGAGCGGGCTGGGCCGCCAAGGCAAGATGGTGGACTACAGCGTGTGGGACCACATTGAGGTG
TCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGCTGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGA
GACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAACGAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCT
CAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCGACGCTCACAGGAGGGCCCGCAAGGTATATCAACCAT
TCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAAATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGA
GAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATTCCGTGTCACTGTGGAGCTGTGAACTGCCGGAAGTGG
ATGAACTGAAATGCATTCCTTGCTAGCTCAGCGGGCGGCTTGTCCCTAGGAAGAGGCGATTCAACACACCATTGGAATTTTGCAGACAGA
AAGAGATTTTTGTTTTCTGTTTTATGACTTTTTGAAAAAGCTTCTGGGAGTTCTGATTTCCTCAGTCCTTTAGGTTAAAGCAGCGCCAGG
AGGAAGCTGACAGAAGCAGCGTTCCTGAAGTGGCCGAGGTTAAACGGAATCACAGAATGGTCCAGCACTTTTGCTTTTTTTTCTTTTCCT
TTTCTTTTTTTTTTGTTTGTTTTTTGTTTTGTTTTTCCCTTGTGGGTGGGTTTCATTGTTTTGGTTTTCTAGTCTCACTAAGGAGAAACT
TTTACTGGGGCAAAGAGCCGATGGCTGCCCTGCCCCGGGCAGGGGCCTTCCTATGAATGTAAGACTGAAATCACCAGCGAGGGGGACAGA
GAGTGCTGGCCACGGCCTTATTAAAAAGGGGCAGGCCCTCTAACTTCAAAATGTTTTTAAATAAAGTAGACACCACTGAACAAGGAATGT
ACTGAAATGACTTCCTTAGGGATAGAGCTAAGGGATAATAACTTGCACTAAATACATTTAAATACTTGATTCCATGAGTCAGTTTATTGT
AGTTTTTGATTTCTGTAAAATAAGAGAAACTTTTGTATTTATTATTGAATAAGTGAATGAAGCTATTTTTAAATAAAGTTAGAAGAAAGC
CAAGCTGCTGCTGTTACCTGCAGAACTAACAAACCCTGTTACTTTGTACAGATATGTAAATATTTTGAGAAAAAATACAGTATAAAAATA
GTTATTGACCAAATGCTACCAGGCTCTGCAGCAGCTCGGGGGCTTATAAAATGTTCATAGGGATGTTACAATATAATTTTGTGTTATAAA
ATATGCCATTATAATTATGTAATAACCAAAATTTCAACCTAGAGTGTTGGGGGTTTTTTGGAAACCGCAGTCTATTAGTACTCAATGGTT
TTATACACCTTACTTCTGACAGAGCGGGGCGTATGCTACGACTACAACTTTTATAGCTGTTTTGGTAATTTAAACTAATTTTTTCATATT
ATATTGTTGCATCCCTACTTCTTCAGTCAGGTTTTTTTGTGCTTACAATTTGTGATAACTGTGAATAACTGCTTAAAAATACACCCAAAT
GGAGGCTGAATTTTTTCTTCAGCAAAAGTAGTTTTGATTAGAACTTTGTTTCAGCCACAGAGAATCATGTAAACGTAATAGGATCATGTA
GCAGAAACTTAAATCTAACCCTTTAGCCTTCTATTTAACACAAAAATTTGAAAAAGTTAAAAAAAAAAAGGAGATGTGATTATGCTTACA
GCTGCAGGACTCTGGCAATAGGGTTTTTGGAAGATGTAATTTTAAAATGTGTTTGTATGAACTGTTTGTTTACATTTCTTTAATAAAAAA
AACACTGTTTTGTGTTTGCTTGTAGAAACTTAATCAGCATTTTGAACCAGGTTAGCTTTTTATTTTGTACTTAAAATTCTGGTACTGACA
CTTCACAGGCTAAGTATAAAATGAAGTTTTGTGTGCACAATTCAAGTGGACTGTAAACTGTTGGTATATTCAGTGATGCAGTTCTGAACT
TGTATATGGCATGATGTATTTTTATCTTACAGAATAAATCAATTGTATATATTTTTCTCTTGATAAATAGCTGTATGAAATTTGTTTCCT
GAATATTTTTCTTCTCTTGTACAATATCCTGACATCCTACCAGTATTTGTCCTACCGGGTTTTTGTTGTTTTCTGTTCTGTATAATAGTA
TCTAATGTTGGCAAAAATTGAATTTTTTGAAGTATACAGAGTGTTATGGGTTTTGGAATTTGTGGACACAGATTTAGAAGATCACCATTT

>In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000355193_chr7_151836876_-_2452nt
TGCTGCCGCCGTCGCCGCCACCCGAGCCGGAGCGGGCTGGGCCGCCAAGGCAAGATGGTGGACTACAGCGTGTGGGACCACATTGAGGTG
TCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGCTGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGA
GACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAACGAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCT
CAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCGACGCTCACAGGAGGGCCCGCAAGGTATATCAACCAT
TCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAAATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGA
GAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATTCCGTGTCACTGTGGAGCTGTGAACTGCCGGAAGTGG
ATGAACTGAAATGCATTCCTTGCTAGCTCAGCGGGCGGCTTGTCCCTAGGAAGAGGCGATTCAACACACCATTGGAATTTTGCAGACAGA
AAGAGATTTTTGTTTTCTGTTTTATGACTTTTTGAAAAAGCTTCTGGGAGTTCTGATTTCCTCAGTCCTTTAGGTTAAAGCAGCGCCAGG
AGGAAGCTGACAGAAGCAGCGTTCCTGAAGTGGCCGAGGTTAAACGGAATCACAGAATGGTCCAGCACTTTTGCTTTTTTTTCTTTTCCT
TTTCTTTTTTTTTTGTTTGTTTTTTGTTTTGTTTTTCCCTTGTGGGTGGGTTTCATTGTTTTGGTTTTCTAGTCTCACTAAGGAGAAACT
TTTACTGGGGCAAAGAGCCGATGGCTGCCCTGCCCCGGGCAGGGGCCTTCCTATGAATGTAAGACTGAAATCACCAGCGAGGGGGACAGA
GAGTGCTGGCCACGGCCTTATTAAAAAGGGGCAGGCCCTCTAACTTCAAAATGTTTTTAAATAAAGTAGACACCACTGAACAAGGAATGT
ACTGAAATGACTTCCTTAGGGATAGAGCTAAGGGATAATAACTTGCACTAAATACATTTAAATACTTGATTCCATGAGTCAGTTTATTGT
AGTTTTTGATTTCTGTAAAATAAGAGAAACTTTTGTATTTATTATTGAATAAGTGAATGAAGCTATTTTTAAATAAAGTTAGAAGAAAGC
CAAGCTGCTGCTGTTACCTGCAGAACTAACAAACCCTGTTACTTTGTACAGATATGTAAATATTTTGAGAAAAAATACAGTATAAAAATA
GTTATTGACCAAATGCTACCAGGCTCTGCAGCAGCTCGGGGGCTTATAAAATGTTCATAGGGATGTTACAATATAATTTTGTGTTATAAA
ATATGCCATTATAATTATGTAATAACCAAAATTTCAACCTAGAGTGTTGGGGGTTTTTTGGAAACCGCAGTCTATTAGTACTCAATGGTT
TTATACACCTTACTTCTGACAGAGCGGGGCGTATGCTACGACTACAACTTTTATAGCTGTTTTGGTAATTTAAACTAATTTTTTCATATT
ATATTGTTGCATCCCTACTTCTTCAGTCAGGTTTTTTTGTGCTTACAATTTGTGATAACTGTGAATAACTGCTTAAAAATACACCCAAAT
GGAGGCTGAATTTTTTCTTCAGCAAAAGTAGTTTTGATTAGAACTTTGTTTCAGCCACAGAGAATCATGTAAACGTAATAGGATCATGTA
GCAGAAACTTAAATCTAACCCTTTAGCCTTCTATTTAACACAAAAATTTGAAAAAGTTAAAAAAAAAAAGGAGATGTGATTATGCTTACA
GCTGCAGGACTCTGGCAATAGGGTTTTTGGAAGATGTAATTTTAAAATGTGTTTGTATGAACTGTTTGTTTACATTTCTTTAATAAAAAA
AACACTGTTTTGTGTTTGCTTGTAGAAACTTAATCAGCATTTTGAACCAGGTTAGCTTTTTATTTTGTACTTAAAATTCTGGTACTGACA
CTTCACAGGCTAAGTATAAAATGAAGTTTTGTGTGCACAATTCAAGTGGACTGTAAACTGTTGGTATATTCAGTGATGCAGTTCTGAACT
TGTATATGGCATGATGTATTTTTATCTTACAGAATAAATCAATTGTATATATTTTTCTCTTGATAAATAGCTGTATGAAATTTGTTTCCT
GAATATTTTTCTTCTCTTGTACAATATCCTGACATCCTACCAGTATTTGTCCTACCGGGTTTTTGTTGTTTTCTGTTCTGTATAATAGTA
TCTAATGTTGGCAAAAATTGAATTTTTTGAAGTATACAGAGTGTTATGGGTTTTGGAATTTGTGGACACAGATTTAGAAGATCACCATTT


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FusionGenePPI for CDC37_KMT2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC37CDK4, SGK1, SMYD2, NEK6, MAP3K1, MAP3K3, TBK1, IKBKG, IKBKE, HSP90AA1, IKBKB, CHUK, AR, SRC, CDK7, CDK6, DMWD, ATG101, STK11, ULK1, CDK11B, AKT1, EMD, TERF1, TERF2, FGFR3, RYK, PRKAA1, PRKCI, MAP3K7, IRAK2, RIPK3, C19orf44, DEAF1, IMMT, CRYM, ZNF667, MTOR, PRMT1, CC2D1A, PPHLN1, PSME1, SPTBN4, ZNF205, CHGA, ZNF266, RPS15A, SQSTM1, SAFB, GCH1, BTBD10, NCOA5, MZT2B, LUC7L2, SNX5, DCTN1, ZNF235, EIF2AK1, NTRK1, CDK9, CDC37, UBE2I, PINK1, STK36, IRAK1, LRRK2, LRRK1, STK33, GRK5, NOS3, APOE, APP, CDK5, DNAJB1, ECSIT, ELAVL3, EXOSC1, FBXL12, GCDH, IFIT3, IFIT5, LONP1, LOXL4, MGEA5, PRAM1, PRDX2, RAD23A, RNF32, FBXW4, CYP2C9, STAMBPL1, PSEN1, A2M, RPS6KA6, EGFR, YWHAE, VCP, BRAF, PPP5C, MAP3K11, NPM1, HSP90AB1, MAPK7, FBXO6, CKS2, CKS1B, OGFR, PPP6R3, TPM1, USP7, RHOBTB2, AIP, RAF1, AURKB, FKBP5, FKBP4, USP19, AHSA1, SMYD3, CTTN, UPF1, STUB1, SKP1, UNC45A, CHORDC1, TTC4, TOMM34, RAE1, SYNE2, PPID, TTC9C, ARAF, CDK1, CDK11A, NUP98, FKBPL, FER, GLMN, DDX17, RPAP3, ABL2, TARS2, DNAJC7, HNRNPM, CDC37L1, FKBP6, PDZK1, AURKA, CDC25C, MOV10, NXF1, ULK3, RSG1, PSKH2, MYLK4, STK32C, PCBP1, CDKL1, CDKL2, AURKC, CDK15, CDK18, CDK13, STK4, RASSF3, STK38L, RPS6KB2, AHCYL1, PATL1, SSB, EWSR1, OFD1, CEP104, EVC2, NEK8, POC1B, STIL, PRPF4, FTSJ1, CDCA5, WDR6, PANX1, ERBB3, ESRRB, YWHAQ, SLC25A5, SLC25A6, CLK3, DDR1, DDX5, EIF2AK2, EEF1A1, EEF1A2, EEF1A1P5, EIF3B, ERBB2, GFAP, HSPA5, HSPA1A, HSPA8, PKM, RPS6KA1, RPS6KA3, RPS6KA4, MASP1, RPS2, RPS27, RPS27L, TUBA1B, TUBA1C, TUBB, U2AF2, EIF2S1, HCK, PTGES3, FLCN, FNIP1, FNIP2, STK35, AKT3, PDIK1L, BTK, YES1, ITK, MAP3K6, FYN, TNK2, MAP2K5, CYLD, DLD, DNM1L, EDEM3, SNRPE, BRCA1KMT2CAK1, NCOA6, ASH2L, RBBP5, HIST2H3C, ASCL2, KDM6A, SMARCB1, MAPK14, JUN, PAXIP1, H3F3A, PAGR1, WDR82, CDC73, TSC22D1, KDM4B, ELAVL1, WDR5, HIST1H3A, APPL2, ERP44, HIST3H3, DPY30, MTNR1B, FOXA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC37_KMT2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC37_KMT2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKMT2CC0001418Adenocarcinoma1CTD_human
TgeneKMT2CC0005695Bladder Neoplasm1CTD_human
TgeneKMT2CC0007138Carcinoma, Transitional Cell1CTD_human
TgeneKMT2CC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneKMT2CC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneKMT2CC0023897Liver Diseases, Parasitic1CTD_human
TgeneKMT2CC0036920Sezary Syndrome1CTD_human
TgeneKMT2CC0038356Stomach Neoplasms1CTD_human
TgeneKMT2CC0206698Cholangiocarcinoma1CTD_human
TgeneKMT2CC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneKMT2CC2239176Liver carcinoma1CTD_human