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Fusion gene ID: 6342 |
FusionGeneSummary for CDC37_KMT2C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDC37_KMT2C | Fusion gene ID: 6342 | Hgene | Tgene | Gene symbol | CDC37 | KMT2C | Gene ID | 11140 | 58508 |
| Gene name | cell division cycle 37 | lysine methyltransferase 2C | |
| Synonyms | P50CDC37 | HALR|KLEFS2|MLL3 | |
| Cytomap | 19p13.2 | 7q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hsp90 co-chaperone Cdc37CDC37 (cell division cycle 37, S. cerevisiae, homolog)CDC37 cell division cycle 37 homologcell division cycle 37 homologhsp90 chaperone protein kinase-targeting subunit | histone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage le | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16543 | Q8NEZ4 | |
| Ensembl transtripts involved in fusion gene | ENST00000222005, | ENST00000262189, ENST00000355193, ENST00000485655, ENST00000485241, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 9 X 13 X 6=702 |
| # samples | 6 | 15 | |
| ** MAII score | log2(6/60*10)=0 | log2(15/702*10)=-2.22650852980868 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDC37 [Title/Abstract] AND KMT2C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-67-6217-01A | CDC37 | chr19 | 10514054 | - | KMT2C | chr7 | 151836876 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000222005 | ENST00000262189 | CDC37 | chr19 | 10514054 | - | KMT2C | chr7 | 151836876 | - |
| In-frame | ENST00000222005 | ENST00000355193 | CDC37 | chr19 | 10514054 | - | KMT2C | chr7 | 151836876 | - |
| 5CDS-5UTR | ENST00000222005 | ENST00000485655 | CDC37 | chr19 | 10514054 | - | KMT2C | chr7 | 151836876 | - |
| 5CDS-intron | ENST00000222005 | ENST00000485241 | CDC37 | chr19 | 10514054 | - | KMT2C | chr7 | 151836876 | - |
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FusionProtFeatures for CDC37_KMT2C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDC37 | KMT2C |
| Co-chaperone that binds to numerous kinases and promotestheir interaction with the Hsp90 complex, resulting instabilization and promotion of their activity (PubMed:8666233).Inhibits HSP90AA1 ATPase activity (PubMed:23569206).{ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. | Histone methyltransferase. Methylates 'Lys-4' of histoneH3. H3 'Lys-4' methylation represents a specific tag forepigenetic transcriptional activation. Central component of theMLL2/3 complex, a coactivator complex of nuclear receptors,involved in transcriptional coactivation. KMT2C/MLL3 may be acatalytic subunit of this complex. May be involved inleukemogenesis and developmental disorder.{ECO:0000269|PubMed:17500065}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4895_4911 | 4781 | 4912 | Domain | Post-SET |
| Tgene | >KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4895_4911 | 4838 | 4969 | Domain | Post-SET |
| Tgene | >KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4848_4849 | 4781 | 4912 | Region | S-adenosyl-L-methionine binding |
| Tgene | >KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4848_4849 | 4838 | 4969 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 1338_1366 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 1754_1787 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 3054_3081 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 3173_3272 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 3391_3433 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 644_672 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 92_112 | 4781 | 4912 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 1338_1366 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 1754_1787 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 3054_3081 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 3173_3272 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 3391_3433 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 644_672 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 92_112 | 4838 | 4969 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 1719_1796 | 4781 | 4912 | Compositional bias | Note=Gln-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 1834_2281 | 4781 | 4912 | Compositional bias | Note=Pro-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 2412_2630 | 4781 | 4912 | Compositional bias | Note=Pro-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 2690_2786 | 4781 | 4912 | Compositional bias | Note=Asp-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 3012_3509 | 4781 | 4912 | Compositional bias | Note=Gln-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 3277_3381 | 4781 | 4912 | Compositional bias | Note=Pro-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 1719_1796 | 4838 | 4969 | Compositional bias | Note=Gln-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 1834_2281 | 4838 | 4969 | Compositional bias | Note=Pro-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 2412_2630 | 4838 | 4969 | Compositional bias | Note=Pro-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 2690_2786 | 4838 | 4969 | Compositional bias | Note=Asp-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 3012_3509 | 4838 | 4969 | Compositional bias | Note=Gln-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 3277_3381 | 4838 | 4969 | Compositional bias | Note=Pro-rich |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 34_46 | 4781 | 4912 | DNA binding | Note=A.T hook |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 34_46 | 4838 | 4969 | DNA binding | Note=A.T hook |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 436_489 | 4781 | 4912 | Domain | DHHC |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4545_4605 | 4781 | 4912 | Domain | FYR N-terminal |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4606_4691 | 4781 | 4912 | Domain | FYR C-terminal |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4771_4887 | 4781 | 4912 | Domain | SET |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 436_489 | 4838 | 4969 | Domain | DHHC |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4545_4605 | 4838 | 4969 | Domain | FYR N-terminal |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4606_4691 | 4838 | 4969 | Domain | FYR C-terminal |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4771_4887 | 4838 | 4969 | Domain | SET |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 1007_1057 | 4781 | 4912 | Zinc finger | PHD-type 6 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 1084_1139 | 4781 | 4912 | Zinc finger | PHD-type 7 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 227_262 | 4781 | 4912 | Zinc finger | C2HC pre-PHD-type 1%3B degenerate |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 283_331 | 4781 | 4912 | Zinc finger | PHD-type 1 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 341_391 | 4781 | 4912 | Zinc finger | PHD-type 2 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 344_389 | 4781 | 4912 | Zinc finger | RING-type |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 388_438 | 4781 | 4912 | Zinc finger | PHD-type 3 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4399_4439 | 4781 | 4912 | Zinc finger | C2HC pre-PHD-type 2 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 4460_4507 | 4781 | 4912 | Zinc finger | PHD-type 8 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 464_520 | 4781 | 4912 | Zinc finger | PHD-type 4 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000262189 | - | 54 | 59 | 957_1010 | 4781 | 4912 | Zinc finger | PHD-type 5 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 1007_1057 | 4838 | 4969 | Zinc finger | PHD-type 6 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 1084_1139 | 4838 | 4969 | Zinc finger | PHD-type 7 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 227_262 | 4838 | 4969 | Zinc finger | C2HC pre-PHD-type 1%3B degenerate |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 283_331 | 4838 | 4969 | Zinc finger | PHD-type 1 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 341_391 | 4838 | 4969 | Zinc finger | PHD-type 2 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 344_389 | 4838 | 4969 | Zinc finger | RING-type |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 388_438 | 4838 | 4969 | Zinc finger | PHD-type 3 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4399_4439 | 4838 | 4969 | Zinc finger | C2HC pre-PHD-type 2 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 4460_4507 | 4838 | 4969 | Zinc finger | PHD-type 8 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 464_520 | 4838 | 4969 | Zinc finger | PHD-type 4 |
| Tgene | KMT2C | chr19:10514054 | chr7:151836876 | ENST00000355193 | - | 55 | 60 | 957_1010 | 4838 | 4969 | Zinc finger | PHD-type 5 |
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FusionGeneSequence for CDC37_KMT2C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000262189_chr7_151836876_-_165aa MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDA >In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000355193_chr7_151836876_-_165aa MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000262189_chr7_151836876_-_495nt ATGGTGGACTACAGCGTGTGGGACCACATTGAGGTGTCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGC TGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGAGACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAAC GAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCTCAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCG ACGCTCACAGGAGGGCCCGCAAGGTATATCAACCATTCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAA ATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGAGAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATT >In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000355193_chr7_151836876_-_495nt ATGGTGGACTACAGCGTGTGGGACCACATTGAGGTGTCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGC TGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGAGACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAAC GAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCTCAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCG ACGCTCACAGGAGGGCCCGCAAGGTATATCAACCATTCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAA ATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGAGAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000262189_chr7_151836876_-_2456nt TGCTGCCGCCGTCGCCGCCACCCGAGCCGGAGCGGGCTGGGCCGCCAAGGCAAGATGGTGGACTACAGCGTGTGGGACCACATTGAGGTG TCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGCTGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGA GACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAACGAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCT CAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCGACGCTCACAGGAGGGCCCGCAAGGTATATCAACCAT TCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAAATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGA GAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATTCCGTGTCACTGTGGAGCTGTGAACTGCCGGAAGTGG ATGAACTGAAATGCATTCCTTGCTAGCTCAGCGGGCGGCTTGTCCCTAGGAAGAGGCGATTCAACACACCATTGGAATTTTGCAGACAGA AAGAGATTTTTGTTTTCTGTTTTATGACTTTTTGAAAAAGCTTCTGGGAGTTCTGATTTCCTCAGTCCTTTAGGTTAAAGCAGCGCCAGG AGGAAGCTGACAGAAGCAGCGTTCCTGAAGTGGCCGAGGTTAAACGGAATCACAGAATGGTCCAGCACTTTTGCTTTTTTTTCTTTTCCT TTTCTTTTTTTTTTGTTTGTTTTTTGTTTTGTTTTTCCCTTGTGGGTGGGTTTCATTGTTTTGGTTTTCTAGTCTCACTAAGGAGAAACT TTTACTGGGGCAAAGAGCCGATGGCTGCCCTGCCCCGGGCAGGGGCCTTCCTATGAATGTAAGACTGAAATCACCAGCGAGGGGGACAGA GAGTGCTGGCCACGGCCTTATTAAAAAGGGGCAGGCCCTCTAACTTCAAAATGTTTTTAAATAAAGTAGACACCACTGAACAAGGAATGT ACTGAAATGACTTCCTTAGGGATAGAGCTAAGGGATAATAACTTGCACTAAATACATTTAAATACTTGATTCCATGAGTCAGTTTATTGT AGTTTTTGATTTCTGTAAAATAAGAGAAACTTTTGTATTTATTATTGAATAAGTGAATGAAGCTATTTTTAAATAAAGTTAGAAGAAAGC CAAGCTGCTGCTGTTACCTGCAGAACTAACAAACCCTGTTACTTTGTACAGATATGTAAATATTTTGAGAAAAAATACAGTATAAAAATA GTTATTGACCAAATGCTACCAGGCTCTGCAGCAGCTCGGGGGCTTATAAAATGTTCATAGGGATGTTACAATATAATTTTGTGTTATAAA ATATGCCATTATAATTATGTAATAACCAAAATTTCAACCTAGAGTGTTGGGGGTTTTTTGGAAACCGCAGTCTATTAGTACTCAATGGTT TTATACACCTTACTTCTGACAGAGCGGGGCGTATGCTACGACTACAACTTTTATAGCTGTTTTGGTAATTTAAACTAATTTTTTCATATT ATATTGTTGCATCCCTACTTCTTCAGTCAGGTTTTTTTGTGCTTACAATTTGTGATAACTGTGAATAACTGCTTAAAAATACACCCAAAT GGAGGCTGAATTTTTTCTTCAGCAAAAGTAGTTTTGATTAGAACTTTGTTTCAGCCACAGAGAATCATGTAAACGTAATAGGATCATGTA GCAGAAACTTAAATCTAACCCTTTAGCCTTCTATTTAACACAAAAATTTGAAAAAGTTAAAAAAAAAAAGGAGATGTGATTATGCTTACA GCTGCAGGACTCTGGCAATAGGGTTTTTGGAAGATGTAATTTTAAAATGTGTTTGTATGAACTGTTTGTTTACATTTCTTTAATAAAAAA AACACTGTTTTGTGTTTGCTTGTAGAAACTTAATCAGCATTTTGAACCAGGTTAGCTTTTTATTTTGTACTTAAAATTCTGGTACTGACA CTTCACAGGCTAAGTATAAAATGAAGTTTTGTGTGCACAATTCAAGTGGACTGTAAACTGTTGGTATATTCAGTGATGCAGTTCTGAACT TGTATATGGCATGATGTATTTTTATCTTACAGAATAAATCAATTGTATATATTTTTCTCTTGATAAATAGCTGTATGAAATTTGTTTCCT GAATATTTTTCTTCTCTTGTACAATATCCTGACATCCTACCAGTATTTGTCCTACCGGGTTTTTGTTGTTTTCTGTTCTGTATAATAGTA TCTAATGTTGGCAAAAATTGAATTTTTTGAAGTATACAGAGTGTTATGGGTTTTGGAATTTGTGGACACAGATTTAGAAGATCACCATTT >In-frame_CDC37_ENST00000222005_chr19_10514054_-_KMT2C_ENST00000355193_chr7_151836876_-_2452nt TGCTGCCGCCGTCGCCGCCACCCGAGCCGGAGCGGGCTGGGCCGCCAAGGCAAGATGGTGGACTACAGCGTGTGGGACCACATTGAGGTG TCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGCTGGCGGCATCAGGGGCTGGGCCTGTATGCTGCTCGA GACATTGAGAAACACACCATGGTCATTGAGTACATCGGGACTATCATTCGAAACGAAGTAGCCAACAGGAAAGAGAAGCTTTATGAGTCT CAGAACCGTGGTGTGTACATGTTCCGCATGGATAACGACCATGTGATTGACGCGACGCTCACAGGAGGGCCCGCAAGGTATATCAACCAT TCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTTGAGAGAGGACACAAAATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGGA GAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAAGATTCCGTGTCACTGTGGAGCTGTGAACTGCCGGAAGTGG ATGAACTGAAATGCATTCCTTGCTAGCTCAGCGGGCGGCTTGTCCCTAGGAAGAGGCGATTCAACACACCATTGGAATTTTGCAGACAGA AAGAGATTTTTGTTTTCTGTTTTATGACTTTTTGAAAAAGCTTCTGGGAGTTCTGATTTCCTCAGTCCTTTAGGTTAAAGCAGCGCCAGG AGGAAGCTGACAGAAGCAGCGTTCCTGAAGTGGCCGAGGTTAAACGGAATCACAGAATGGTCCAGCACTTTTGCTTTTTTTTCTTTTCCT TTTCTTTTTTTTTTGTTTGTTTTTTGTTTTGTTTTTCCCTTGTGGGTGGGTTTCATTGTTTTGGTTTTCTAGTCTCACTAAGGAGAAACT TTTACTGGGGCAAAGAGCCGATGGCTGCCCTGCCCCGGGCAGGGGCCTTCCTATGAATGTAAGACTGAAATCACCAGCGAGGGGGACAGA GAGTGCTGGCCACGGCCTTATTAAAAAGGGGCAGGCCCTCTAACTTCAAAATGTTTTTAAATAAAGTAGACACCACTGAACAAGGAATGT ACTGAAATGACTTCCTTAGGGATAGAGCTAAGGGATAATAACTTGCACTAAATACATTTAAATACTTGATTCCATGAGTCAGTTTATTGT AGTTTTTGATTTCTGTAAAATAAGAGAAACTTTTGTATTTATTATTGAATAAGTGAATGAAGCTATTTTTAAATAAAGTTAGAAGAAAGC CAAGCTGCTGCTGTTACCTGCAGAACTAACAAACCCTGTTACTTTGTACAGATATGTAAATATTTTGAGAAAAAATACAGTATAAAAATA GTTATTGACCAAATGCTACCAGGCTCTGCAGCAGCTCGGGGGCTTATAAAATGTTCATAGGGATGTTACAATATAATTTTGTGTTATAAA ATATGCCATTATAATTATGTAATAACCAAAATTTCAACCTAGAGTGTTGGGGGTTTTTTGGAAACCGCAGTCTATTAGTACTCAATGGTT TTATACACCTTACTTCTGACAGAGCGGGGCGTATGCTACGACTACAACTTTTATAGCTGTTTTGGTAATTTAAACTAATTTTTTCATATT ATATTGTTGCATCCCTACTTCTTCAGTCAGGTTTTTTTGTGCTTACAATTTGTGATAACTGTGAATAACTGCTTAAAAATACACCCAAAT GGAGGCTGAATTTTTTCTTCAGCAAAAGTAGTTTTGATTAGAACTTTGTTTCAGCCACAGAGAATCATGTAAACGTAATAGGATCATGTA GCAGAAACTTAAATCTAACCCTTTAGCCTTCTATTTAACACAAAAATTTGAAAAAGTTAAAAAAAAAAAGGAGATGTGATTATGCTTACA GCTGCAGGACTCTGGCAATAGGGTTTTTGGAAGATGTAATTTTAAAATGTGTTTGTATGAACTGTTTGTTTACATTTCTTTAATAAAAAA AACACTGTTTTGTGTTTGCTTGTAGAAACTTAATCAGCATTTTGAACCAGGTTAGCTTTTTATTTTGTACTTAAAATTCTGGTACTGACA CTTCACAGGCTAAGTATAAAATGAAGTTTTGTGTGCACAATTCAAGTGGACTGTAAACTGTTGGTATATTCAGTGATGCAGTTCTGAACT TGTATATGGCATGATGTATTTTTATCTTACAGAATAAATCAATTGTATATATTTTTCTCTTGATAAATAGCTGTATGAAATTTGTTTCCT GAATATTTTTCTTCTCTTGTACAATATCCTGACATCCTACCAGTATTTGTCCTACCGGGTTTTTGTTGTTTTCTGTTCTGTATAATAGTA TCTAATGTTGGCAAAAATTGAATTTTTTGAAGTATACAGAGTGTTATGGGTTTTGGAATTTGTGGACACAGATTTAGAAGATCACCATTT |
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FusionGenePPI for CDC37_KMT2C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDC37 | CDK4, SGK1, SMYD2, NEK6, MAP3K1, MAP3K3, TBK1, IKBKG, IKBKE, HSP90AA1, IKBKB, CHUK, AR, SRC, CDK7, CDK6, DMWD, ATG101, STK11, ULK1, CDK11B, AKT1, EMD, TERF1, TERF2, FGFR3, RYK, PRKAA1, PRKCI, MAP3K7, IRAK2, RIPK3, C19orf44, DEAF1, IMMT, CRYM, ZNF667, MTOR, PRMT1, CC2D1A, PPHLN1, PSME1, SPTBN4, ZNF205, CHGA, ZNF266, RPS15A, SQSTM1, SAFB, GCH1, BTBD10, NCOA5, MZT2B, LUC7L2, SNX5, DCTN1, ZNF235, EIF2AK1, NTRK1, CDK9, CDC37, UBE2I, PINK1, STK36, IRAK1, LRRK2, LRRK1, STK33, GRK5, NOS3, APOE, APP, CDK5, DNAJB1, ECSIT, ELAVL3, EXOSC1, FBXL12, GCDH, IFIT3, IFIT5, LONP1, LOXL4, MGEA5, PRAM1, PRDX2, RAD23A, RNF32, FBXW4, CYP2C9, STAMBPL1, PSEN1, A2M, RPS6KA6, EGFR, YWHAE, VCP, BRAF, PPP5C, MAP3K11, NPM1, HSP90AB1, MAPK7, FBXO6, CKS2, CKS1B, OGFR, PPP6R3, TPM1, USP7, RHOBTB2, AIP, RAF1, AURKB, FKBP5, FKBP4, USP19, AHSA1, SMYD3, CTTN, UPF1, STUB1, SKP1, UNC45A, CHORDC1, TTC4, TOMM34, RAE1, SYNE2, PPID, TTC9C, ARAF, CDK1, CDK11A, NUP98, FKBPL, FER, GLMN, DDX17, RPAP3, ABL2, TARS2, DNAJC7, HNRNPM, CDC37L1, FKBP6, PDZK1, AURKA, CDC25C, MOV10, NXF1, ULK3, RSG1, PSKH2, MYLK4, STK32C, PCBP1, CDKL1, CDKL2, AURKC, CDK15, CDK18, CDK13, STK4, RASSF3, STK38L, RPS6KB2, AHCYL1, PATL1, SSB, EWSR1, OFD1, CEP104, EVC2, NEK8, POC1B, STIL, PRPF4, FTSJ1, CDCA5, WDR6, PANX1, ERBB3, ESRRB, YWHAQ, SLC25A5, SLC25A6, CLK3, DDR1, DDX5, EIF2AK2, EEF1A1, EEF1A2, EEF1A1P5, EIF3B, ERBB2, GFAP, HSPA5, HSPA1A, HSPA8, PKM, RPS6KA1, RPS6KA3, RPS6KA4, MASP1, RPS2, RPS27, RPS27L, TUBA1B, TUBA1C, TUBB, U2AF2, EIF2S1, HCK, PTGES3, FLCN, FNIP1, FNIP2, STK35, AKT3, PDIK1L, BTK, YES1, ITK, MAP3K6, FYN, TNK2, MAP2K5, CYLD, DLD, DNM1L, EDEM3, SNRPE, BRCA1 | KMT2C | AK1, NCOA6, ASH2L, RBBP5, HIST2H3C, ASCL2, KDM6A, SMARCB1, MAPK14, JUN, PAXIP1, H3F3A, PAGR1, WDR82, CDC73, TSC22D1, KDM4B, ELAVL1, WDR5, HIST1H3A, APPL2, ERP44, HIST3H3, DPY30, MTNR1B, FOXA1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC37_KMT2C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC37_KMT2C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KMT2C | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | KMT2C | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | KMT2C | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Tgene | KMT2C | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | KMT2C | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | KMT2C | C0023897 | Liver Diseases, Parasitic | 1 | CTD_human |
| Tgene | KMT2C | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | KMT2C | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | KMT2C | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
| Tgene | KMT2C | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | KMT2C | C2239176 | Liver carcinoma | 1 | CTD_human |
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