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Fusion gene ID: 6341 |
FusionGeneSummary for CDC37_ELL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CDC37_ELL | Fusion gene ID: 6341 | Hgene | Tgene | Gene symbol | CDC37 | ELL | Gene ID | 11140 | 8178 |
| Gene name | cell division cycle 37 | elongation factor for RNA polymerase II | |
| Synonyms | P50CDC37 | C19orf17|ELL1|MEN|PPP1R68 | |
| Cytomap | 19p13.2 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hsp90 co-chaperone Cdc37CDC37 (cell division cycle 37, S. cerevisiae, homolog)CDC37 cell division cycle 37 homologcell division cycle 37 homologhsp90 chaperone protein kinase-targeting subunit | RNA polymerase II elongation factor ELLELL gene (11-19 lysine-rich leukemia gene)eleven-nineteen lysine-rich leukemia proteinelongation factor RNA polymerase IIprotein phosphatase 1, regulatory subunit 68 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q16543 | P55199 | |
| Ensembl transtripts involved in fusion gene | ENST00000222005, | ENST00000262809, ENST00000596124, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 6 X 10 X 5=300 |
| # samples | 6 | 14 | |
| ** MAII score | log2(6/60*10)=0 | log2(14/300*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CDC37 [Title/Abstract] AND ELL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ELL | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-05-4426-01A | CDC37 | chr19 | 10514054 | - | ELL | chr19 | 18583692 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000222005 | ENST00000262809 | CDC37 | chr19 | 10514054 | - | ELL | chr19 | 18583692 | - |
| 5CDS-5UTR | ENST00000222005 | ENST00000596124 | CDC37 | chr19 | 10514054 | - | ELL | chr19 | 18583692 | - |
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FusionProtFeatures for CDC37_ELL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDC37 | ELL |
| Co-chaperone that binds to numerous kinases and promotestheir interaction with the Hsp90 complex, resulting instabilization and promotion of their activity (PubMed:8666233).Inhibits HSP90AA1 ATPase activity (PubMed:23569206).{ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}. | Elongation factor component of the super elongationcomplex (SEC), a complex required to increase the catalytic rateof RNA polymerase II transcription by suppressing transientpausing by the polymerase at multiple sites along the DNA.Elongation factor component of the little elongation complex(LEC), a complex required to regulate small nuclear RNA (snRNA)gene transcription by RNA polymerase II and III (PubMed:22195968,PubMed:23932780). Specifically required for stimulating theelongation step of RNA polymerase II- and III-dependent snRNA genetranscription (PubMed:23932780). ELL also plays an early rolebefore its assembly into in the SEC complex by stabilizing RNApolymerase II recruitment/initiation and entry into the pausesite. Required to stabilize the pre-initiation complex and earlyelongation. {ECO:0000269|PubMed:16006523,ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948,ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557,ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ELL | chr19:10514054 | chr19:18583692 | ENST00000262809 | - | 0 | 12 | 445_459 | 45 | 622 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDC37_ELL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CDC37_ENST00000222005_chr19_10514054_-_ELL_ENST00000262809_chr19_18583692_-_611aa MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQDSVSLRPSIRFQGSQGHISIPQPDCPAEARTFSFYLSNIGRDNPQGSFDCIQQYVS SHGEVHLDCLGSIQDKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQFRKPAPGATDAVPSRKRATPINLASAIRKS GASAVSGGSGVSQRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQ QLLKRVLVRKLCQPQSTGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLANKKPRISHFTQRAQPAVNGKLGVPNGREALLPTPGP PASTDTLSSSTHLPPRLEPPRAHDPLADVSNDLGHSGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPHGSPSRSKPKKKSKKHKDKERA AEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTSTSETPDYLLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CDC37_ENST00000222005_chr19_10514054_-_ELL_ENST00000262809_chr19_18583692_-_1833nt ATGGTGGACTACAGCGTGTGGGACCACATTGAGGTGTCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGC TGGCGGCATCAGGATTCTGTTTCACTGAGGCCATCTATCCGATTTCAAGGAAGCCAAGGGCACATCTCCATCCCCCAGCCTGACTGCCCC GCAGAGGCGCGGACGTTCTCCTTCTACCTCTCCAACATCGGCCGCGACAACCCCCAGGGCAGCTTCGACTGCATCCAGCAGTATGTCTCC AGTCATGGGGAAGTTCACCTGGACTGCCTGGGCAGCATACAGGACAAGATCACGGTGTGTGCCACCGACGACTCCTACCAGAAGGCGCGG CAGAGCATGGCCCAGGCGGAGGAGGAGACGCGGAGCCGAAGTGCCATTGTCATCAAGGCTGGAGGCCGCTACCTGGGCAAGAAGGTTCAG TTTCGGAAACCAGCCCCAGGTGCAACAGACGCGGTGCCCTCCCGGAAGCGGGCAACCCCCATCAACTTGGCGAGTGCCATCAGGAAGAGT GGTGCCAGTGCCGTGAGTGGGGGCAGCGGGGTGTCCCAGAGGCCCTTCCGTGACCGAGTGCTGCACCTCCTGGCACTACGGCCCTACCGC AAGGCTGAGCTGCTGCTGCGACTGCAGAAGGACGGCCTGACGCAGGCGGACAAGGACGCGCTGGATGGCCTCCTCCAGCAGGTGGCCAAC ATGAGTGCTAAGGACGGCACGTGTACACTGCAGGACTGCATGTACAAGGATGTGCAGAAGGACTGGCCTGGCTACTCGGAGGGGGACCAG CAGCTGCTGAAGCGGGTGCTCGTCCGGAAGCTGTGCCAGCCACAGAGCACTGGCAGCCTCCTTGGAGACCCTGCTGCCTCCAGCCCCCCA GGCGAGCGTGGGCGCTCGGCCTCGCCCCCACAGAAGCGGCTGCAGCCTCCTGATTTCATCGACCCCCTAGCCAACAAGAAACCCCGGATA TCGCACTTCACTCAGAGAGCTCAGCCTGCCGTCAACGGGAAGCTGGGCGTGCCCAATGGCCGTGAGGCCTTGCTGCCCACCCCGGGCCCA CCAGCCAGCACGGACACCCTCAGCTCCAGCACTCACCTGCCCCCGCGGCTGGAGCCCCCGAGGGCCCACGACCCCCTGGCCGATGTCAGC AATGACCTGGGCCACAGCGGCCGAGACTGTGAGCACGGAGAGGCGGCTGCCCCAGCCCCCACTGTGCGCCTCGGCCTGCCCCTGCTGACG GACTGTGCCCAGCCCAGCAGGCCACACGGCAGCCCCTCGCGCAGCAAGCCCAAGAAGAAGTCCAAGAAGCACAAAGACAAGGAGAGGGCG GCTGAGGACAAGCCCCGGGCCCAGCTTCCAGACTGTGCACCTGCCACCCATGCCACCCCCGGAGCCCCAGCAGACACCCCAGGTTTAAAC GGAACCTGCAGCGTTTCCAGTGTTCCCACGTCCACGTCGGAGACGCCTGACTACTTGCTGAAGTACGCAGCCATCTCCTCTTCGGAGCAG CGCCAGAGCTACAAGAACGACTTCAATGCCGAGTACAGCGAGTACCGCGACCTGCACGCCCGCATTGAGCGCATCACGCGGCGGTTCACC CAGCTCGACGCCCAGCTCCGGCAGCTCTCCCAGGGCTCCGAGGAGTATGAGACTACTCGAGGGCAGATTTTGCAGGAATATCGAAAAATC AAAAAGACCAACACCAACTACAGCCAGGAGAAGCACCGCTGCGAGTACCTGCACAGCAAGCTGGCCCACATCAAGAGGCTCATCGCCGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CDC37_ENST00000222005_chr19_10514054_-_ELL_ENST00000262809_chr19_18583692_-_3976nt TGCTGCCGCCGTCGCCGCCACCCGAGCCGGAGCGGGCTGGGCCGCCAAGGCAAGATGGTGGACTACAGCGTGTGGGACCACATTGAGGTG TCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGCTGGCGGCATCAGGATTCTGTTTCACTGAGGCCATCT ATCCGATTTCAAGGAAGCCAAGGGCACATCTCCATCCCCCAGCCTGACTGCCCCGCAGAGGCGCGGACGTTCTCCTTCTACCTCTCCAAC ATCGGCCGCGACAACCCCCAGGGCAGCTTCGACTGCATCCAGCAGTATGTCTCCAGTCATGGGGAAGTTCACCTGGACTGCCTGGGCAGC ATACAGGACAAGATCACGGTGTGTGCCACCGACGACTCCTACCAGAAGGCGCGGCAGAGCATGGCCCAGGCGGAGGAGGAGACGCGGAGC CGAAGTGCCATTGTCATCAAGGCTGGAGGCCGCTACCTGGGCAAGAAGGTTCAGTTTCGGAAACCAGCCCCAGGTGCAACAGACGCGGTG CCCTCCCGGAAGCGGGCAACCCCCATCAACTTGGCGAGTGCCATCAGGAAGAGTGGTGCCAGTGCCGTGAGTGGGGGCAGCGGGGTGTCC CAGAGGCCCTTCCGTGACCGAGTGCTGCACCTCCTGGCACTACGGCCCTACCGCAAGGCTGAGCTGCTGCTGCGACTGCAGAAGGACGGC CTGACGCAGGCGGACAAGGACGCGCTGGATGGCCTCCTCCAGCAGGTGGCCAACATGAGTGCTAAGGACGGCACGTGTACACTGCAGGAC TGCATGTACAAGGATGTGCAGAAGGACTGGCCTGGCTACTCGGAGGGGGACCAGCAGCTGCTGAAGCGGGTGCTCGTCCGGAAGCTGTGC CAGCCACAGAGCACTGGCAGCCTCCTTGGAGACCCTGCTGCCTCCAGCCCCCCAGGCGAGCGTGGGCGCTCGGCCTCGCCCCCACAGAAG CGGCTGCAGCCTCCTGATTTCATCGACCCCCTAGCCAACAAGAAACCCCGGATATCGCACTTCACTCAGAGAGCTCAGCCTGCCGTCAAC GGGAAGCTGGGCGTGCCCAATGGCCGTGAGGCCTTGCTGCCCACCCCGGGCCCACCAGCCAGCACGGACACCCTCAGCTCCAGCACTCAC CTGCCCCCGCGGCTGGAGCCCCCGAGGGCCCACGACCCCCTGGCCGATGTCAGCAATGACCTGGGCCACAGCGGCCGAGACTGTGAGCAC GGAGAGGCGGCTGCCCCAGCCCCCACTGTGCGCCTCGGCCTGCCCCTGCTGACGGACTGTGCCCAGCCCAGCAGGCCACACGGCAGCCCC TCGCGCAGCAAGCCCAAGAAGAAGTCCAAGAAGCACAAAGACAAGGAGAGGGCGGCTGAGGACAAGCCCCGGGCCCAGCTTCCAGACTGT GCACCTGCCACCCATGCCACCCCCGGAGCCCCAGCAGACACCCCAGGTTTAAACGGAACCTGCAGCGTTTCCAGTGTTCCCACGTCCACG TCGGAGACGCCTGACTACTTGCTGAAGTACGCAGCCATCTCCTCTTCGGAGCAGCGCCAGAGCTACAAGAACGACTTCAATGCCGAGTAC AGCGAGTACCGCGACCTGCACGCCCGCATTGAGCGCATCACGCGGCGGTTCACCCAGCTCGACGCCCAGCTCCGGCAGCTCTCCCAGGGC TCCGAGGAGTATGAGACTACTCGAGGGCAGATTTTGCAGGAATATCGAAAAATCAAAAAGACCAACACCAACTACAGCCAGGAGAAGCAC CGCTGCGAGTACCTGCACAGCAAGCTGGCCCACATCAAGAGGCTCATCGCCGAGTACGACCAGCGGCAGCTGCAGGCTTGGCCCTAGCCG CCCTCCCCGATGGCGGGGATCTGGGAGGGTCGGGGGAGCAAAAGGCGGTGAGAGAGGATTTATTTAAAAAAATAAACCCGAGGAAGATGC TCATCTGAGCCAGCACCGCCGGCTTTCAGGGCAGCCCCTGCAGACGTCTGGCCCTGGCGGGTGGCTGCAAGCCCACCTCGGCCCTCCCTG CGCTTCCTGAGCAGTCCCTGCTTATGATGGGCTCCCCAGGAAGCCCACTGCCTCCTCCCTGGCTGCAGCCTCCGGGGTTCAGCCTCCTGT CTCGCCAGAAGACTCCTAGGCCCTTGGGGTGGCGCGCCTGCCTTTTCTAGTTTTATACAAAGACAGCCACTTTTAGCTACTGCTAATGAG ACTTGAGTCTATTTTTGTACAAAAGAGAAGCAAAATCTTTTTTCTAAACCTGTGCCTCCCTCTCCTCGGACACCCAGGGTCTAGCCGCTG CCCTGGGTCCTGCCTGCAGTATTACAGAGGTCGTCGAAAGGTGCAGCTGCGTTCTGAGGGCGTGGGGAATGGGCAGGTGGCCTCTGCTGG TCTCTGGCTCTACGTTTAGGCACCCCTTTCCCCAGCCTCTCCTCCTTGGGCAGGGTCTCTGCTCCAGCAAGCAAACAGGGTGGCCCAGGT GGCTATTTTGAGAACTCCAGCTGGTGCCCCCAGACAGCTGCTCAGAGCCAAGGGGGCAGAGGGCTTTCAGCGCCCCCAGGCCTGCCCTGC TATTTCAGGCCCTCAGCTGTCGGGGGCCACTGTGTTTCTGTGCTCCAAGTTGAGACTCGGCCGCAGCGGCGTCAGACTTTTCTTTGCGAT GTCCTCGGTTTCCCATTTGTTGCTGCTGCTGCTCATTCCACACTGTTGAGACCTTGTGGTCTCGATGCTGCTGGCCTCCCTCCGTCCCTC TGTCCACTTGTGGGTCCTGGGGTCGTCTTAGCAGAGCCACCGCCAAGGTTTGCACTCAGGGAGGGGCTGATGGAGGGCTGGGCGCCATGG GGTCAGGGAGGCCCCAGGGACCCATGGGCAGAGCTGGGGAGCCAGGAGGATGGGTCTGCCTGCTCTGGGGGTGCAGGCTCTGCAGACACC CCAATTGCTGCTCTGTTGCTGTGCCTAGTCTAGTGTCCCCCAAAGCATCGGGGGGCCACGCAAGTGTGGGTGTGTGAGTGTGCGTATGTG GGGACCCCCCAGGGCATGGTGGGGTCTGAGGCGTGTGTTCCCATTTAGGGCTGAATGAAGCCATGACTTGGAAAGGTGGTGGGGGGTGGA TGGCGGCTGTGACTCAGGGCCCAGGGATCACATGGGGGTCACTGCTGCCATCAGCAGTCAGGCAGGGAGAACAGAAATGCAAAAATACAG ATGTCTATTTTTCTAAACTGGGGGGTGGAGGGGTGCCTCCTGACAGCTTCCAAAGAGCTGACTGTGGAGGGCCCACAGTGTATCCCACCC CTGCCCGAGAGTCTCTCTCCTTTGGGACCCCCGGGTTCCCAGAGCTCCGAGGAAACTGATCCTTCATGTTTCAATAGCTGTTGTTGTTTT TCTCTTTGGGCCGGGCCGGGCCGGGGAAGGGCCGAGCAGGCTCCAGGAGGCCTCCAGAGTCAGCTGGACCTTGCTGTGTCGCCCGCAGGC AGCCCTGCAGACACCGGTGAGGTGGGATGATTTCAGGAGGTCCCAGCCCGGGACTGCCCGCCCCTCTGCCCTGGGAACCAGTCCAAGGGG CTGTCAGTTGAATTTGCCTTTTTGTTGTTGTTGTTGTTTTTGTTGTTTATTTGTTCTCCTTTTAAGGAATTATGAAGCTAAGAAAAGTTT TGTGTTTTGGGGGTTGGTGGACAAAGTTCTAGCTGATTAAATATGGTCTAACTTATTGATACTATTTTTTTTTCTTTTAATGTTGTACTG TGGAGAAAAACTATTTTGAGCCATGGGGTTGGTGTTTACAAGAACTTTCCACTTTTGCCAAAATGTTACAATTGAAAGGCATCTATCTGC GTCTTCAGTTTCCTGATATTTTCTTAAAAGATCTAGTGTCCTTTTTGTACACTAAACAGGTGAATGCTGACTTTTTTCATTCTCCAATAA |
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FusionGenePPI for CDC37_ELL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CDC37 | CDK4, SGK1, SMYD2, NEK6, MAP3K1, MAP3K3, TBK1, IKBKG, IKBKE, HSP90AA1, IKBKB, CHUK, AR, SRC, CDK7, CDK6, DMWD, ATG101, STK11, ULK1, CDK11B, AKT1, EMD, TERF1, TERF2, FGFR3, RYK, PRKAA1, PRKCI, MAP3K7, IRAK2, RIPK3, C19orf44, DEAF1, IMMT, CRYM, ZNF667, MTOR, PRMT1, CC2D1A, PPHLN1, PSME1, SPTBN4, ZNF205, CHGA, ZNF266, RPS15A, SQSTM1, SAFB, GCH1, BTBD10, NCOA5, MZT2B, LUC7L2, SNX5, DCTN1, ZNF235, EIF2AK1, NTRK1, CDK9, CDC37, UBE2I, PINK1, STK36, IRAK1, LRRK2, LRRK1, STK33, GRK5, NOS3, APOE, APP, CDK5, DNAJB1, ECSIT, ELAVL3, EXOSC1, FBXL12, GCDH, IFIT3, IFIT5, LONP1, LOXL4, MGEA5, PRAM1, PRDX2, RAD23A, RNF32, FBXW4, CYP2C9, STAMBPL1, PSEN1, A2M, RPS6KA6, EGFR, YWHAE, VCP, BRAF, PPP5C, MAP3K11, NPM1, HSP90AB1, MAPK7, FBXO6, CKS2, CKS1B, OGFR, PPP6R3, TPM1, USP7, RHOBTB2, AIP, RAF1, AURKB, FKBP5, FKBP4, USP19, AHSA1, SMYD3, CTTN, UPF1, STUB1, SKP1, UNC45A, CHORDC1, TTC4, TOMM34, RAE1, SYNE2, PPID, TTC9C, ARAF, CDK1, CDK11A, NUP98, FKBPL, FER, GLMN, DDX17, RPAP3, ABL2, TARS2, DNAJC7, HNRNPM, CDC37L1, FKBP6, PDZK1, AURKA, CDC25C, MOV10, NXF1, ULK3, RSG1, PSKH2, MYLK4, STK32C, PCBP1, CDKL1, CDKL2, AURKC, CDK15, CDK18, CDK13, STK4, RASSF3, STK38L, RPS6KB2, AHCYL1, PATL1, SSB, EWSR1, OFD1, CEP104, EVC2, NEK8, POC1B, STIL, PRPF4, FTSJ1, CDCA5, WDR6, PANX1, ERBB3, ESRRB, YWHAQ, SLC25A5, SLC25A6, CLK3, DDR1, DDX5, EIF2AK2, EEF1A1, EEF1A2, EEF1A1P5, EIF3B, ERBB2, GFAP, HSPA5, HSPA1A, HSPA8, PKM, RPS6KA1, RPS6KA3, RPS6KA4, MASP1, RPS2, RPS27, RPS27L, TUBA1B, TUBA1C, TUBB, U2AF2, EIF2S1, HCK, PTGES3, FLCN, FNIP1, FNIP2, STK35, AKT3, PDIK1L, BTK, YES1, ITK, MAP3K6, FYN, TNK2, MAP2K5, CYLD, DLD, DNM1L, EDEM3, SNRPE, BRCA1 | ELL | SIRT2, ZHX1, TP53, EAF1, EAF2, SNF8, USPL1, MLLT3, MLLT1, KMT2A, TFPT, UBC, MED26, ICE2, ICE1, AFF4, CDK9, MCM2, SNRPA1, ELL3, DENND2D, OFD1, DYNLL1, CTR9, HUWE1, NCBP2, FGFR1OP2, SIKE1, VWA9, ASPM, CAMKV, PIP4K2A, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC37_ELL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC37_ELL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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