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Fusion gene ID: 6318 |
FusionGeneSummary for CDC20_PIP4K2B |
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Fusion gene information | Fusion gene name: CDC20_PIP4K2B | Fusion gene ID: 6318 | Hgene | Tgene | Gene symbol | CDC20 | PIP4K2B | Gene ID | 991 | 8396 |
Gene name | cell division cycle 20 | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | |
Synonyms | CDC20A|bA276H19.3|p55CDC | PI5P4KB|PIP5K2B|PIP5KIIB|PIP5KIIbeta|PIP5P4KB | |
Cytomap | 1p34.2 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | cell division cycle protein 20 homologCDC20 cell division cycle 20 homologcell division cycle 20 homolog | phosphatidylinositol 5-phosphate 4-kinase type-2 beta1-phosphatidylinositol 5-phosphate 4-kinase 2-beta1-phosphatidylinositol-4-phosphate kinasePI(5)P 4-kinase type II betaPIP4KII-betaPTDINS(4)P-5-kinasediphosphoinositide kinase 2-betaphosphatidyli | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q12834 | P78356 | |
Ensembl transtripts involved in fusion gene | ENST00000310955, ENST00000372462, ENST00000478882, | ENST00000269554, ENST00000311500, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 7 X 6 X 4=168 |
# samples | 3 | 9 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDC20 [Title/Abstract] AND PIP4K2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDC20 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 17443180 |
Hgene | CDC20 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP428483 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000310955 | ENST00000269554 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
5CDS-intron | ENST00000310955 | ENST00000311500 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
5CDS-3UTR | ENST00000372462 | ENST00000269554 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
5CDS-intron | ENST00000372462 | ENST00000311500 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
intron-3UTR | ENST00000478882 | ENST00000269554 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
intron-intron | ENST00000478882 | ENST00000311500 | CDC20 | chr1 | 43828782 | + | PIP4K2B | chr17 | 36922526 | - |
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FusionProtFeatures for CDC20_PIP4K2B |
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Hgene | Tgene |
CDC20 | PIP4K2B |
Required for full ubiquitin ligase activity of theanaphase promoting complex/cyclosome (APC/C) and may confersubstrate specificity upon the complex. Is regulated by MAD2L1: inmetaphase the MAD2L1-CDC20-APC/C ternary complex is inactive andin anaphase the CDC20-APC/C binary complex is active in degradingsubstrates. The CDC20-APC/C complex positively regulates theformation of synaptic vesicle clustering at active zone to thepresynaptic membrane in postmitotic neurons. CDC20-APC/C-induceddegradation of NEUROD2 induces presynaptic differentiation.{ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353,ECO:0000269|PubMed:9811605}. | Participates in the biosynthesis of phosphatidylinositol4,5-bisphosphate. {ECO:0000269|PubMed:9038203}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDC20_PIP4K2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDC20_PIP4K2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC20_PIP4K2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC20_PIP4K2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |