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Fusion gene ID: 6317 |
FusionGeneSummary for CDC20_DEF8 |
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Fusion gene information | Fusion gene name: CDC20_DEF8 | Fusion gene ID: 6317 | Hgene | Tgene | Gene symbol | CDC20 | DEF8 | Gene ID | 991 | 54849 |
Gene name | cell division cycle 20 | differentially expressed in FDCP 8 homolog | |
Synonyms | CDC20A|bA276H19.3|p55CDC | - | |
Cytomap | 1p34.2 | 16q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cell division cycle protein 20 homologCDC20 cell division cycle 20 homologcell division cycle 20 homolog | differentially expressed in FDCP 8 homologDEF-8 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q12834 | Q6ZN54 | |
Ensembl transtripts involved in fusion gene | ENST00000310955, ENST00000372462, ENST00000478882, | ENST00000563594, ENST00000268676, ENST00000569453, ENST00000418391, ENST00000567874, ENST00000570182, ENST00000563795, ENST00000563848, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CDC20 [Title/Abstract] AND DEF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDC20 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 17443180 |
Hgene | CDC20 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-4255-01A | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000310955 | ENST00000563594 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000310955 | ENST00000268676 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000310955 | ENST00000569453 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
In-frame | ENST00000310955 | ENST00000418391 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000310955 | ENST00000567874 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000310955 | ENST00000570182 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000310955 | ENST00000563795 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
5CDS-3UTR | ENST00000310955 | ENST00000563848 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000372462 | ENST00000563594 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000372462 | ENST00000268676 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000372462 | ENST00000569453 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
In-frame | ENST00000372462 | ENST00000418391 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000372462 | ENST00000567874 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000372462 | ENST00000570182 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
Frame-shift | ENST00000372462 | ENST00000563795 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
5CDS-3UTR | ENST00000372462 | ENST00000563848 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000563594 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000268676 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000569453 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000418391 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000567874 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000570182 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3CDS | ENST00000478882 | ENST00000563795 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
3UTR-3UTR | ENST00000478882 | ENST00000563848 | CDC20 | chr1 | 43825454 | + | DEF8 | chr16 | 90025552 | + |
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FusionProtFeatures for CDC20_DEF8 |
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Hgene | Tgene |
CDC20 | DEF8 |
Required for full ubiquitin ligase activity of theanaphase promoting complex/cyclosome (APC/C) and may confersubstrate specificity upon the complex. Is regulated by MAD2L1: inmetaphase the MAD2L1-CDC20-APC/C ternary complex is inactive andin anaphase the CDC20-APC/C binary complex is active in degradingsubstrates. The CDC20-APC/C complex positively regulates theformation of synaptic vesicle clustering at active zone to thepresynaptic membrane in postmitotic neurons. CDC20-APC/C-induceddegradation of NEUROD2 induces presynaptic differentiation.{ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353,ECO:0000269|PubMed:9811605}. | Positively regulates lysosome peripheral distributionand ruffled border formation in osteoclasts. Involved in boneresorption. {ECO:0000250|UniProtKB:Q99J78}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDC20_DEF8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CDC20_ENST00000310955_chr1_43825454_+_DEF8_ENST00000418391_chr16_90025552_+_186aa MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEV ASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYPVWWPLAKHGQSKLNXLNMHFLVVLSTLDRAVLDEK >In-frame_CDC20_ENST00000372462_chr1_43825454_+_DEF8_ENST00000418391_chr16_90025552_+_186aa MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEV ASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYPVWWPLAKHGQSKLNXLNMHFLVVLSTLDRAVLDEK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CDC20_ENST00000310955_chr1_43825454_+_DEF8_ENST00000418391_chr16_90025552_+_558nt ATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGCGC AAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCT GGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTG GCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGAACATCAGAAAGCCTGGGCTTTGAACCTG AACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCACAAAATGCGCCAGAGGGCTATCCAGTGTGGTGGCCACTA GCCAAACATGGCCAGTCAAAGTTAAATTAACTAAATATGCATTTCCTCGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAA >In-frame_CDC20_ENST00000372462_chr1_43825454_+_DEF8_ENST00000418391_chr16_90025552_+_558nt ATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGCGC AAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCT GGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTG GCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGAACATCAGAAAGCCTGGGCTTTGAACCTG AACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCACAAAATGCGCCAGAGGGCTATCCAGTGTGGTGGCCACTA GCCAAACATGGCCAGTCAAAGTTAAATTAACTAAATATGCATTTCCTCGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CDC20_ENST00000310955_chr1_43825454_+_DEF8_ENST00000418391_chr16_90025552_+_815nt GAGGCTGTGATGGGTTGACAGGTGCGTGACAGTGGGAGCTGCTCTCGGCACAAGCATGTACGGCAAAGGCAAGAGTAACAGCAGCGCCGT CCCGTCCGACAGCCAGGCCCGGGAGAAGGCTCCGTAGGCACCAACTGCAAGGACCCCTCCCCCTGCGGGCGCTCCCATGGCACAGTTCGC GTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGCGCAAAGCCAAGGAAGC CGCAGGCCCGGCCCCCTCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCTGGCAAATCCAGTTC CAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTCCT GAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGAACATCAGAAAGCCTGGGCTTTGAACCTGAACGGTTTTGATGT AGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCACAAAATGCGCCAGAGGCACCTGCACAGGTGGGCCGAGACCCAGACGAGGAGTG AGGAATGAGAGAGACCAAAGTTCCTGCCTCCGCTGGGCTCACATTCAGATGTGAGCTATCCAGTGTGGTGGCCACTAGCCAAACATGGCC AGTCAAAGTTAAATTAACTAAATATGCATTTCCTCGTTGTACTGTCTACATTGGACAGGGCTGTTCTGGATGAGAAATTAAACTAGTGAA >In-frame_CDC20_ENST00000372462_chr1_43825454_+_DEF8_ENST00000418391_chr16_90025552_+_585nt GAGGCTGTGATGGGTTGACAGGTGCGTGACAGTGGGAGCTGCTCTCGGCACAAGCATGTACGGCAAAGGCAAGAGTAACAGCAGCGCCGT CCCGTCCGACAGCCAGGCCCGGGAGAAGCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATCCCCC ATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTCCTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAAGGAAC ATCAGAAAGCCTGGGCTTTGAACCTGAACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCACAAAATGCGCCAG AGGCACCTGCACAGGTGGGCCGAGACCCAGACGAGGAGTGAGGAATGAGAGAGACCAAAGTTCCTGCCTCCGCTGGGCTCACATTCAGAT GTGAGCTATCCAGTGTGGTGGCCACTAGCCAAACATGGCCAGTCAAAGTTAAATTAACTAAATATGCATTTCCTCGTTGTACTGTCTACA |
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FusionGenePPI for CDC20_DEF8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDC20 | KRT85, KRT31, KRT32, CCDC59, YARS2, KRTAP19-5, KRTAP9-3, KRTAP9-2, KRT33A, HDAC1, HDAC2, MAD2L1, MAD2L2, CDC27, SPATC1, BUB1B, AURKA, CDC16, FBXO5, CCNA1, CDC23, CDC20, ANAPC10, ANAPC11, ANAPC1, ANAPC7, CDT1, CDKN1A, UBE2C, KDM5B, CREBBP, EP300, FZR1, ANAPC2, CCNA2, IST1, FBXW5, RASSF1, PIM1, SKP2, BUB3, TAS2R13, HSF1, CCNB1, HSF2, TTK, UBE2S, CDR2, TK1, CDC6, ANAPC4, MXI1, CUEDC2, ID1, NINL, PTTG1, CLSPN, RNF34, CKS1B, MDC1, MAD2L1BP, BTRC, AURKB, USP37, COPS5, GMNN, APP, PAXIP1, ANAPC15, TRRAP, DAXX, TRIM33, ANAPC5, NEK2, PLK1, TP73, SIRT2, HDAC6, TUBG1, AXIN2, PHF8, HECW2, MAD1L1, CDK2, STAU1, TUBA1A, TUBB, CCT6A, TUBB4B, CCT5, CCT8, CCT2, TUBB2A, HSPA8, TCP1, HSPD1, CCT3, CCT4, TUBA1C, CDC26, CCT7, HSPA5, RPS3, CPVL, CAPNS1, RAVER1, HSPA9, FGFR1, HSPA1A, DSC1, PBRM1, HSPA1L, RPL23, TUBA4A, UBB, HNRNPF, FRY, ANAPC16, EIF2A, CILP, BUB1, FBXO43, CHFR, MOV10, E2F1, TFDP1, CDK1, KIF18A, SPINT2, PLEKHO2, UBR5, CEP128, XPO1, RNH1, HUWE1, TRIP13, PARK2, YBX1, CDC5L, UBC, PPP2R5E, PPP2CA, PPP2CB, PPP2R1A, CASC5, PCNA, PPP2R5A, DCPS, USP22, CDC25A, CDC25B, SSSCA1, CKS2, PCDHAC2, YAP1, CCNF, BANP, NUP98, HOXD13, LNP1, HHEX | DEF8 | WDFY3, PKN3, APAF1, PLCB1, RADIL, HPS5, KDM5C, MSTO1, ZMYM6, STIL, MCM8, C5orf22, TUBE1, PPIP5K2, NRD1, IFT122, EIF2AK4, DTL, GFER, PKN2, DMXL2, TRIP6, DPYSL4, TUBB3, DSTYK, ALMS1, ATG2B, PASK, ZNHIT2, UHRF1BP1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC20_DEF8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC20_DEF8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |