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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6309

FusionGeneSummary for CDC123_RAB18

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC123_RAB18
Fusion gene ID: 6309
HgeneTgene
Gene symbol

CDC123

RAB18

Gene ID

8872

22931

Gene namecell division cycle 123RAB18, member RAS oncogene family
SynonymsC10orf7|D123RAB18LI1|WARBM3
Cytomap

10p14-p13

10p12.1

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 123 homologHT-1080PZ32cell division cycle 123 homologras-related protein Rab-18RAB18 small GTPase
Modification date2018052320180523
UniProtAcc

O75794

Q9NP72

Ensembl transtripts involved in fusion geneENST00000281141, ENST00000455773, 
ENST00000378900, 
ENST00000356940, 
ENST00000535776, ENST00000375802, 
ENST00000465772, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDC123 [Title/Abstract] AND RAB18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-4253-01ACDC123chr10

12252321

+RAB18chr10

27798804

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000281141ENST00000356940CDC123chr10

12252321

+RAB18chr10

27798804

+
Frame-shiftENST00000281141ENST00000535776CDC123chr10

12252321

+RAB18chr10

27798804

+
Frame-shiftENST00000281141ENST00000375802CDC123chr10

12252321

+RAB18chr10

27798804

+
5CDS-3UTRENST00000281141ENST00000465772CDC123chr10

12252321

+RAB18chr10

27798804

+
3UTR-3CDSENST00000455773ENST00000356940CDC123chr10

12252321

+RAB18chr10

27798804

+
3UTR-3CDSENST00000455773ENST00000535776CDC123chr10

12252321

+RAB18chr10

27798804

+
3UTR-3CDSENST00000455773ENST00000375802CDC123chr10

12252321

+RAB18chr10

27798804

+
3UTR-3UTRENST00000455773ENST00000465772CDC123chr10

12252321

+RAB18chr10

27798804

+
Frame-shiftENST00000378900ENST00000356940CDC123chr10

12252321

+RAB18chr10

27798804

+
Frame-shiftENST00000378900ENST00000535776CDC123chr10

12252321

+RAB18chr10

27798804

+
Frame-shiftENST00000378900ENST00000375802CDC123chr10

12252321

+RAB18chr10

27798804

+
5CDS-3UTRENST00000378900ENST00000465772CDC123chr10

12252321

+RAB18chr10

27798804

+

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FusionProtFeatures for CDC123_RAB18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC123

O75794

RAB18

Q9NP72

Required for S phase entry of the cell cycle.{ECO:0000250}. Plays a role in apical endocytosis/recycling. May beimplicated in transport between the plasma membrane and earlyendosomes. Plays a key role in eye and brain development andneurodegeneration. {ECO:0000269|PubMed:21473985}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CDC123_RAB18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CDC123_RAB18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CDC123LOC255308, TPM3, ZPR1, ABI1, ZNF512B, EIF2S2, HSPB1, PCM1, CEP120, CEP128, ODF2, CEP19, XPO1, TRIM25RAB18PDE6D, PPP2R1A, PPP2R1B, ADRB2, TAX1BP1, EGFR, SRPRB, ICAM2, HSD11B1, SLAMF1, VSIG4, PTGER3, ARL13B, TGOLN2, TNF, HEPACAM2, CNTROB, CENPJ, ERRFI1, PTAR1, RAB1A, RAB1B, TSSC1, GDI1, LAMP2, RAB2B, AGK, FAM107A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CDC123_RAB18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC123_RAB18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAB18C3280203WARBURG MICRO SYNDROME 31UNIPROT