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Fusion gene ID: 6309 |
FusionGeneSummary for CDC123_RAB18 |
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Fusion gene information | Fusion gene name: CDC123_RAB18 | Fusion gene ID: 6309 | Hgene | Tgene | Gene symbol | CDC123 | RAB18 | Gene ID | 8872 | 22931 |
Gene name | cell division cycle 123 | RAB18, member RAS oncogene family | |
Synonyms | C10orf7|D123 | RAB18LI1|WARBM3 | |
Cytomap | 10p14-p13 | 10p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cell division cycle protein 123 homologHT-1080PZ32cell division cycle 123 homolog | ras-related protein Rab-18RAB18 small GTPase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75794 | Q9NP72 | |
Ensembl transtripts involved in fusion gene | ENST00000281141, ENST00000455773, ENST00000378900, | ENST00000356940, ENST00000535776, ENST00000375802, ENST00000465772, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CDC123 [Title/Abstract] AND RAB18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-4253-01A | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000281141 | ENST00000356940 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
Frame-shift | ENST00000281141 | ENST00000535776 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
Frame-shift | ENST00000281141 | ENST00000375802 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
5CDS-3UTR | ENST00000281141 | ENST00000465772 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
3UTR-3CDS | ENST00000455773 | ENST00000356940 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
3UTR-3CDS | ENST00000455773 | ENST00000535776 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
3UTR-3CDS | ENST00000455773 | ENST00000375802 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
3UTR-3UTR | ENST00000455773 | ENST00000465772 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
Frame-shift | ENST00000378900 | ENST00000356940 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
Frame-shift | ENST00000378900 | ENST00000535776 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
Frame-shift | ENST00000378900 | ENST00000375802 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
5CDS-3UTR | ENST00000378900 | ENST00000465772 | CDC123 | chr10 | 12252321 | + | RAB18 | chr10 | 27798804 | + |
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FusionProtFeatures for CDC123_RAB18 |
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Hgene | Tgene |
CDC123 | RAB18 |
Required for S phase entry of the cell cycle.{ECO:0000250}. | Plays a role in apical endocytosis/recycling. May beimplicated in transport between the plasma membrane and earlyendosomes. Plays a key role in eye and brain development andneurodegeneration. {ECO:0000269|PubMed:21473985}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CDC123_RAB18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CDC123_RAB18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CDC123 | LOC255308, TPM3, ZPR1, ABI1, ZNF512B, EIF2S2, HSPB1, PCM1, CEP120, CEP128, ODF2, CEP19, XPO1, TRIM25 | RAB18 | PDE6D, PPP2R1A, PPP2R1B, ADRB2, TAX1BP1, EGFR, SRPRB, ICAM2, HSD11B1, SLAMF1, VSIG4, PTGER3, ARL13B, TGOLN2, TNF, HEPACAM2, CNTROB, CENPJ, ERRFI1, PTAR1, RAB1A, RAB1B, TSSC1, GDI1, LAMP2, RAB2B, AGK, FAM107A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CDC123_RAB18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC123_RAB18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RAB18 | C3280203 | WARBURG MICRO SYNDROME 3 | 1 | UNIPROT |