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Fusion gene ID: 6299 |
FusionGeneSummary for CD9_C6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CD9_C6 | Fusion gene ID: 6299 | Hgene | Tgene | Gene symbol | CD9 | C6 | Gene ID | 928 | 5688 |
| Gene name | CD9 molecule | proteasome subunit alpha 7 | |
| Synonyms | BTCC-1|DRAP-27|MIC3|MRP-1|TSPAN-29|TSPAN29 | C6|HEL-S-276|HSPC|RC6-1|XAPC7 | |
| Cytomap | 12p13.31 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CD9 antigen5H9 antigenBA-2/p24 antigenCD9 antigen (p24)antigen CD9cell growth-inhibiting gene 2 proteinleukocyte antigen MIC3motility related protein-1tetraspanin-29 | proteasome subunit alpha type-7epididymis secretory protein Li 276proteasome (prosome, macropain) subunit, alpha type, 7proteasome subunit RC6-1proteasome subunit XAPC7proteasome subunit alpha 4testicular tissue protein Li 151 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P21926 | P13671 | |
| Ensembl transtripts involved in fusion gene | ENST00000382518, ENST00000009180, ENST00000382515, ENST00000481267, | ENST00000337836, ENST00000263413, ENST00000475349, | |
| Fusion gene scores | * DoF score | 7 X 7 X 5=245 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/245*10)=-1.4447848426729 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CD9 [Title/Abstract] AND C6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD9 | GO:0007155 | cell adhesion | 7511626 |
| Hgene | CD9 | GO:0007342 | fusion of sperm to egg plasma membrane involved in single fertilization | 14575715 |
| Hgene | CD9 | GO:0051271 | negative regulation of cellular component movement | 8478605 |
| Hgene | CD9 | GO:0090331 | negative regulation of platelet aggregation | 18541721 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D3-A1Q9-06A | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000382518 | ENST00000337836 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| Frame-shift | ENST00000382518 | ENST00000263413 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 5CDS-intron | ENST00000382518 | ENST00000475349 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| Frame-shift | ENST00000009180 | ENST00000337836 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| Frame-shift | ENST00000009180 | ENST00000263413 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 5CDS-intron | ENST00000009180 | ENST00000475349 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 5UTR-3CDS | ENST00000382515 | ENST00000337836 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 5UTR-3CDS | ENST00000382515 | ENST00000263413 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 5UTR-intron | ENST00000382515 | ENST00000475349 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 3UTR-3CDS | ENST00000481267 | ENST00000337836 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 3UTR-3CDS | ENST00000481267 | ENST00000263413 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
| 3UTR-intron | ENST00000481267 | ENST00000475349 | CD9 | chr12 | 6334700 | + | C6 | chr5 | 41186310 | - |
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FusionProtFeatures for CD9_C6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD9 | C6 |
| Involved in platelet activation and aggregation.Regulates paranodal junction formation. Involved in cell adhesion,cell motility and tumor metastasis. Required for sperm-egg fusion.{ECO:0000269|PubMed:14575715, ECO:0000269|PubMed:7511626,ECO:0000269|PubMed:8478605}. | Constituent of the membrane attack complex (MAC) thatplays a key role in the innate and adaptive immune response byforming pores in the plasma membrane of target cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CD9_C6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CD9_C6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CD9 | CD82, KIT, CD63, CD81, ITGB1, IGSF8, ITGA3, CD46, ITGA5, TSPAN4, PTGFRN, CD53, CD19, CD36, SERPINH1, PRKCA, ELAVL1, LGALS3BP, ATP6V1B1, CLN8, VKORC1, ADRB2 | C6 | C5, FN1, SART3, FUS, KRAS, DPY19L3, ACOT9, B3GALTL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CD9_C6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD9_C6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CD9 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | CD9 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | CD9 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | CD9 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | CD9 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | CD9 | C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | CTD_human |
| Hgene | CD9 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | CD9 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | C6 | C0006663 | Calcinosis | 1 | CTD_human |
| Tgene | C6 | C0018824 | Heart valve disease | 1 | CTD_human |
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