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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6296

FusionGeneSummary for CD99L2_PACRGL

check button Fusion gene summary
Fusion gene informationFusion gene name: CD99L2_PACRGL
Fusion gene ID: 6296
HgeneTgene
Gene symbol

CD99L2

PACRGL

Gene ID

83692

133015

Gene nameCD99 molecule like 2parkin coregulated like
SynonymsCD99B|MIC2L1C4orf28
Cytomap

Xq28

4p15.31

Type of geneprotein-codingprotein-coding
DescriptionCD99 antigen-like protein 2MIC2 like 1MIC2-like protein 1PACRG-like proteinPARK2 co-regulated likePARK2 coregulated like
Modification date2018051920180519
UniProtAcc

Q8TCZ2

Q8N7B6

Ensembl transtripts involved in fusion geneENST00000346693, ENST00000370377, 
ENST00000355149, ENST00000437787, 
ENST00000466436, ENST00000320893, 
ENST00000503585, ENST00000360916, 
ENST00000295290, ENST00000444671, 
ENST00000502374, ENST00000538990, 
ENST00000502938, ENST00000507634, 
ENST00000513459, ENST00000508753, 
Fusion gene scores* DoF score8 X 7 X 2=1122 X 2 X 2=8
# samples 82
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CD99L2 [Title/Abstract] AND PACRGL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP219412CD99L2chrX

149936332

-PACRGLchr4

20703418

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000346693ENST00000503585CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000360916CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000295290CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000444671CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000502374CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000538990CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000502938CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000507634CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000346693ENST00000513459CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-3UTRENST00000346693ENST00000508753CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000503585CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000360916CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000295290CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000444671CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000502374CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000538990CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000502938CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000507634CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000370377ENST00000513459CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-3UTRENST00000370377ENST00000508753CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000503585CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000360916CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000295290CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000444671CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000502374CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000538990CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000502938CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000507634CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000355149ENST00000513459CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-3UTRENST00000355149ENST00000508753CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000503585CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000360916CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000295290CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000444671CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000502374CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000538990CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000502938CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000507634CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000437787ENST00000513459CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-3UTRENST00000437787ENST00000508753CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000503585CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000360916CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000295290CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000444671CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000502374CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000538990CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000502938CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000507634CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000466436ENST00000513459CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-3UTRENST00000466436ENST00000508753CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000503585CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000360916CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000295290CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000444671CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000502374CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000538990CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000502938CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000507634CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-intronENST00000320893ENST00000513459CD99L2chrX

149936332

-PACRGLchr4

20703418

+
intron-3UTRENST00000320893ENST00000508753CD99L2chrX

149936332

-PACRGLchr4

20703418

+

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FusionProtFeatures for CD99L2_PACRGL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD99L2

Q8TCZ2

PACRGL

Q8N7B6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD99L2_PACRGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD99L2_PACRGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CD99L2_PACRGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CD99L2_PACRGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource