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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6263

FusionGeneSummary for CD74_SOD2

check button Fusion gene summary
Fusion gene informationFusion gene name: CD74_SOD2
Fusion gene ID: 6263
HgeneTgene
Gene symbol

CD74

SOD2

Gene ID

972

6648

Gene nameCD74 moleculesuperoxide dismutase 2
SynonymsDHLAG|HLADG|II|Ia-GAMMAIPO-B|IPOB|MNSOD|MVCD6|Mn-SOD
Cytomap

5q33.1

6q25.3

Type of geneprotein-codingprotein-coding
DescriptionHLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated superoxide dismutase [Mn], mitochondrialMn superoxide dismutaseindophenoloxidase Bmanganese-containing superoxide dismutasemangano-superoxide dismutasesuperoxide dismutase 2, mitochondrial
Modification date2018052220180527
UniProtAcc

P04233

P04179

Ensembl transtripts involved in fusion geneENST00000377795, ENST00000353334, 
ENST00000524315, ENST00000009530, 
ENST00000546087, ENST00000538183, 
ENST00000367055, ENST00000367054, 
ENST00000444946, ENST00000337404, 
ENST00000452684, ENST00000535372, 
Fusion gene scores* DoF score33 X 31 X 10=102306 X 7 X 2=84
# samples 489
** MAII scorelog2(48/10230*10)=-4.41362792902417
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/84*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CD74 [Title/Abstract] AND SOD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

HgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

HgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

HgeneCD74

GO:0007165

signal transduction

12782713

HgeneCD74

GO:0008283

cell proliferation

12782713

HgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

HgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

HgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

HgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

HgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

HgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

HgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

HgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD74

GO:0051290

protein heterotetramerization

24942581

HgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581

TgeneSOD2

GO:0006801

superoxide metabolic process

12551919|14980699

TgeneSOD2

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

27021683

TgeneSOD2

GO:1905461

positive regulation of vascular associated smooth muscle cell apoptotic process

27021683

TgeneSOD2

GO:1905932

positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching

27021683


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA934677CD74chr5

149781401

+SOD2chr6

160106026

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000377795ENST00000546087CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000377795ENST00000538183CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000377795ENST00000367055CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000377795ENST00000367054CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000377795ENST00000444946CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000377795ENST00000337404CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000377795ENST00000452684CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000377795ENST00000535372CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000353334ENST00000546087CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000353334ENST00000538183CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000353334ENST00000367055CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000353334ENST00000367054CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000353334ENST00000444946CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000353334ENST00000337404CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000353334ENST00000452684CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000353334ENST00000535372CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000524315ENST00000546087CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000524315ENST00000538183CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000524315ENST00000367055CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000524315ENST00000367054CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000524315ENST00000444946CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000524315ENST00000337404CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000524315ENST00000452684CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000524315ENST00000535372CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000009530ENST00000546087CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000009530ENST00000538183CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000009530ENST00000367055CD74chr5

149781401

+SOD2chr6

160106026

+
intron-3CDSENST00000009530ENST00000367054CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000009530ENST00000444946CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000009530ENST00000337404CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000009530ENST00000452684CD74chr5

149781401

+SOD2chr6

160106026

+
intron-intronENST00000009530ENST00000535372CD74chr5

149781401

+SOD2chr6

160106026

+

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FusionProtFeatures for CD74_SOD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD74

P04233

SOD2

P04179


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CD74_SOD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CD74_SOD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CD74_SOD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD74_SOD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD74C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCD74C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCD74C0162557Liver Failure, Acute1CTD_human
HgeneCD74C1458155Mammary Neoplasms1CTD_human
TgeneSOD2C0033578Prostatic Neoplasms7CTD_human
TgeneSOD2C0027626Neoplasm Invasiveness6CTD_human
TgeneSOD2C0035126Reperfusion Injury6CTD_human
TgeneSOD2C0007621Neoplastic Cell Transformation5CTD_human
TgeneSOD2C0018801Heart failure5CTD_human
TgeneSOD2C0025500Mesothelioma4CTD_human
TgeneSOD2C0027627Neoplasm Metastasis4CTD_human
TgeneSOD2C0036341Schizophrenia4PSYGENET
TgeneSOD2C0037286Skin Neoplasms4CTD_human
TgeneSOD2C0038356Stomach Neoplasms4CTD_human
TgeneSOD2C1458155Mammary Neoplasms4CTD_human
TgeneSOD2C2239176Liver carcinoma4CTD_human
TgeneSOD2C0003873Rheumatoid Arthritis3CTD_human
TgeneSOD2C0007786Brain Ischemia3CTD_human
TgeneSOD2C0020538Hypertensive disease3CTD_human
TgeneSOD2C0024232Lymphatic Metastasis3CTD_human
TgeneSOD2C0029408Degenerative polyarthritis3CTD_human
TgeneSOD2C0030567Parkinson Disease3CTD_human
TgeneSOD2C0524851Neurodegenerative Disorders3CTD_human
TgeneSOD2C0002896Sideroblastic anemia2CTD_human
TgeneSOD2C0004153Atherosclerosis2CTD_human
TgeneSOD2C0005586Bipolar Disorder2PSYGENET
TgeneSOD2C0005695Bladder Neoplasm2CTD_human
TgeneSOD2C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneSOD2C0007137Squamous cell carcinoma2CTD_human
TgeneSOD2C0007193Cardiomyopathy, Dilated2CTD_human
TgeneSOD2C0009404Colorectal Neoplasms2CTD_human
TgeneSOD2C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneSOD2C0014859Esophageal Neoplasms2CTD_human
TgeneSOD2C0022116Ischemia2CTD_human
TgeneSOD2C0022658Kidney Diseases2CTD_human
TgeneSOD2C0026640Mouth Neoplasms2CTD_human
TgeneSOD2C0027540Necrosis2CTD_human
TgeneSOD2C0028754Obesity2CTD_human
TgeneSOD2C0032927Precancerous Conditions2CTD_human
TgeneSOD2C0042164Uveitis2CTD_human
TgeneSOD2C0162674Chronic progressive external ophthalmoplegia2CTD_human
TgeneSOD2C0242184Hypoxia2CTD_human
TgeneSOD2C0279626Squamous cell carcinoma of esophagus2CTD_human
TgeneSOD2C0919267ovarian neoplasm2CTD_human
TgeneSOD2C0001418Adenocarcinoma1CTD_human
TgeneSOD2C0001925Albuminuria1CTD_human
TgeneSOD2C0001969Alcoholic Intoxication1PSYGENET
TgeneSOD2C0002390Extrinsic allergic alveolitis1CTD_human
TgeneSOD2C0002395Alzheimer's Disease1CTD_human
TgeneSOD2C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneSOD2C0002871Anemia1CTD_human
TgeneSOD2C0003493Aortic Diseases1CTD_human
TgeneSOD2C0004045Asphyxia Neonatorum1CTD_human
TgeneSOD2C0004364Autoimmune Diseases1CTD_human
TgeneSOD2C0006118Brain Neoplasms1CTD_human
TgeneSOD2C0007134Renal Cell Carcinoma1CTD_human
TgeneSOD2C0007682CNS disorder1CTD_human
TgeneSOD2C0007787Transient Ischemic Attack1CTD_human
TgeneSOD2C0009375Colonic Neoplasms1CTD_human
TgeneSOD2C0011570Mental Depression1PSYGENET
TgeneSOD2C0011581Depressive disorder1PSYGENET
TgeneSOD2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSOD2C0011881Diabetic Nephropathy1CTD_human
TgeneSOD2C0014866Esophageal Stenosis1CTD_human
TgeneSOD2C0014868Esophagitis1CTD_human
TgeneSOD2C0015695Fatty Liver1CTD_human
TgeneSOD2C0015967Fever1CTD_human
TgeneSOD2C0016059Fibrosis1CTD_human
TgeneSOD2C0018200Granuloma, Respiratory Tract1CTD_human
TgeneSOD2C0018800Cardiomegaly1CTD_human
TgeneSOD2C0020542Pulmonary Hypertension1CTD_human
TgeneSOD2C0020550Hyperthyroidism1CTD_human
TgeneSOD2C0020615Hypoglycemia1CTD_human
TgeneSOD2C0021364Male infertility1CTD_human
TgeneSOD2C0021655Insulin Resistance1CTD_human
TgeneSOD2C0022665Kidney Neoplasm1CTD_human
TgeneSOD2C0022672Acute Kidney Tubular Necrosis1CTD_human
TgeneSOD2C0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneSOD2C0024115Lung diseases1CTD_human
TgeneSOD2C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSOD2C0024796Marfan Syndrome1CTD_human
TgeneSOD2C0025312Meningomyelocele1CTD_human
TgeneSOD2C0026764Multiple Myeloma1CTD_human
TgeneSOD2C0027051Myocardial Infarction1CTD_human
TgeneSOD2C0027726Nephrotic Syndrome1CTD_human
TgeneSOD2C0027746Nerve Degeneration1CTD_human
TgeneSOD2C0029456Osteoporosis1CTD_human
TgeneSOD2C0030297Pancreatic Neoplasm1CTD_human
TgeneSOD2C0030354Papilloma1CTD_human
TgeneSOD2C0031117Peripheral Neuropathy1CTD_human
TgeneSOD2C0032580Adenomatous Polyposis Coli1CTD_human
TgeneSOD2C0033860Psoriasis1CTD_human
TgeneSOD2C0033941Psychoses, Substance-Induced1CTD_human
TgeneSOD2C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneSOD2C0036202Sarcoidosis1CTD_human
TgeneSOD2C0036572Seizures1CTD_human
TgeneSOD2C0036980Shock, Cardiogenic1CTD_human
TgeneSOD2C0037268Skin Abnormalities1CTD_human
TgeneSOD2C0037274Dermatologic disorders1CTD_human
TgeneSOD2C0040411Tongue Neoplasms1CTD_human
TgeneSOD2C0041408Turner Syndrome1CTD_human
TgeneSOD2C0042373Vascular Diseases1CTD_human
TgeneSOD2C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneSOD2C0085207Gestational Diabetes1CTD_human
TgeneSOD2C0151526Premature Birth1CTD_human
TgeneSOD2C0151744Myocardial Ischemia1CTD_human
TgeneSOD2C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneSOD2C0162309Adrenoleukodystrophy1CTD_human
TgeneSOD2C0162671MELAS Syndrome1CTD_human
TgeneSOD2C0162871Aortic Aneurysm, Abdominal1CTD_human
TgeneSOD2C0206062Lung Diseases, Interstitial1CTD_human
TgeneSOD2C0206160Reticulocytosis1CTD_human
TgeneSOD2C0235974Pancreatic carcinoma1CTD_human
TgeneSOD2C0238461Anaplastic thyroid carcinoma1CTD_human
TgeneSOD2C0242698Ventricular Dysfunction, Left1CTD_human
TgeneSOD2C0242992Multiple Chemical Sensitivity1CTD_human
TgeneSOD2C0268255Farber Lipogranulomatosis1CTD_human
TgeneSOD2C0268583Methylmalonic acidemia1CTD_human
TgeneSOD2C0311375Arsenic Poisoning1CTD_human
TgeneSOD2C0345967Malignant mesothelioma1CTD_human
TgeneSOD2C0376618Endotoxemia1CTD_human
TgeneSOD2C0520459Necrotizing Enterocolitis1CTD_human
TgeneSOD2C0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneSOD2C0751651Mitochondrial Diseases1CTD_human
TgeneSOD2C0752347Lewy Body Disease1CTD_human
TgeneSOD2C0878544Cardiomyopathies1CTD_human
TgeneSOD2C0948089Acute Coronary Syndrome1CTD_human
TgeneSOD2C1134719Invasive Ductal Breast Carcinoma1CTD_human
TgeneSOD2C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneSOD2C1269683Major Depressive Disorder1CTD_human
TgeneSOD2C1859317Cataract and cardiomyopathy1CTD_human
TgeneSOD2C2931822Nasopharyngeal carcinoma1CTD_human
TgeneSOD2C4277682Chemical and Drug Induced Liver Injury1CTD_human